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Apparatus and method for mass producing a monodisperse microbubble agent

Tipo: Patente
Titulares:
Universiteit Twente (Holanda) (50%)
UNIVERSIDAD DE SEVILLA (50%)
Inventores:
Van Hoeve, Willem
Versluis, Andreas Michael
Lohse, Detlof
Solicitud
PCT/NL2012/050179
22-03-2012
Concesión
10-10-2017
Familia
WO2013141695A1
An apparatus (1) for mass producing monodisperse microbubbles, comprising a microfluidic flow focusing device (2) including a dispersed phase fluid supply channel (110) having an outlet (114) that discharges into a flow focusing junction (140); a continuous phase fluid supply channel (120, 120') having an outlet (124) that discharges into the flow focusing junction; and a bubble formation channel (130) having an inlet (132) disposed at the flow focusing junction. The configuration of the flow focusing junction (140) is such that, in operation, a flow of dispersed phase fluid (12) discharging from the outlet (114) of the dispersed phase fluid supply channel (110) is engageable in co-flow by a focusing flow of continuous phase fluid discharging from the outlet of the at least one continuous phase fluid supply channel under formation of a gradually thinning jet of dispersed phase fluid that extends into the inlet of the bubble formation channel.
Materia: Necesidades corrientes de la vida / Técnicas industriales Diversas; Transportes
CIP: A61K49/22 (2006.1); B01F13/00 (2006.1)