Manuel Sarmiento Soto

Profesor Contratado Doctor Interino
msarmiento@us.es
Área de conocimiento: Bioquímica y Biología Molecular
Departamento: Bioquímica y Biología Molecular
Grupo: MECANISMOS DE MUERTE CELULAR EN ENFERMEDADES NEURODEGENERATIVAS (BIO-113)
Instituto de Inv.: IBIS
Tipo Año Título Fuente
Artículo2021 A novel molecular magnetic resonance imaging agent targeting activated leukocyte cell adhesion molecule as demonstrated in mouse brain metastasis models JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Artículo2020 STAT3-Mediated Astrocyte Reactivity Associated with Brain Metastasis Contributes to Neurovascular Dysfunction CANCER RESEARCH
Artículo2020 VCAM-1 targeted alpha-particle therapy for early brain metastases NEURO-ONCOLOGY
Revisión2019 Reformulating Pro-Oxidant Microglia in Neurodegeneration JOURNAL OF CLINICAL MEDICINE
Artículo2019 VCAM-1-targeted MRI Enables Detection of Brain Micrometastases from Different Primary Tumors CLINICAL CANCER RESEARCH
Ponencia2018 Anti-vcam-1 targeted mri allows earlier detection of brain metastases in a xenograft melanoma mouse model NEURO-ONCOLOGY
Artículo2018 Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases THERANOSTICS
Ponencia2018 Monte Carlo evaluation of radionuclides for early brain metastases targeting INTERNAL MEDICINE JOURNAL
Artículo2018 Optimization of molecularly targeted MRI in the brain: empirical comparison of sequences and particles INTERNATIONAL JOURNAL OF NANOMEDICINE
Artículo2018 The Multifarious Role of Microglia in Brain Metastasis FRONTIERS IN CELLULAR NEUROSCIENCE
Ponencia2017 A brain metastasis therapy tweak, for the better? concomitant stereotactic radiotherapy & molecular-targeted therapy NEURO-ONCOLOGY
Artículo2017 Anti-inflammatory Microglia/Macrophages As a Potential Therapeutic Target in Brain Metastasis FRONTIERS IN ONCOLOGY
Artículo2017 Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI NATURE COMMUNICATIONS
Ponencia2017 Development of two xenograft mouse models of brain metastasis for evaluation of anti-VCAM-1 targeted magnetic resonance imaging for micrometastasis detection CLINICAL & EXPERIMENTAL METASTASIS
Ponencia2017 The ambiguity of brain metastasis response to radiotherapy driven by cellular adhesion molecules NEURO-ONCOLOGY
Ponencia2016 Astrocyte activation by brain metastases alters neurovascular coupling JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Ponencia2016 Characterization of circulating monocyte infiltration in brain metastasis CANCER RESEARCH
Ponencia2016 Development of an early brain metastasis geometric model for Geant4-DNA simulation EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Artículo2016 Disruption of tumour-host communication by downregulation of LFA-1 reduces COX-2 and e-NOS expression and inhibits brain metastasis growth ONCOTARGET
Ponencia2016 Mechanistic pathways underlying altered neurovascular coupling in brain metastasis JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Artículo2016 Mouse Models of Brain Metastasis for Unravelling Tumour Progression Advances in Experimental Medicine and Biology
Artículo2015 Alternate RASSF1 Transcripts Control SRC Activity, E-Cadherin Contacts, and YAP-Mediated Invasion CURRENT BIOLOGY
Ponencia2015 Cellular adhesion molecules and brain metastasis; how friends become foes CLINICAL & EXPERIMENTAL METASTASIS
Artículo2015 Synergistic Deleterious Effect of Chronic Stress and Sodium Azide in the Mouse Hippocampus CHEMICAL RESEARCH IN TOXICOLOGY
Artículo2014 ASPP2 controls epithelial plasticity and inhibits metastasis through beta-catenin-dependent regulation of ZEB1 NATURE CELL BIOLOGY
Artículo2014 Chronic stress as a risk factor for Alzheimer's disease REVIEWS IN THE NEUROSCIENCES
Artículo2014 Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation JOURNAL OF NEUROINFLAMMATION
Artículo2014 Functional role of endothelial adhesion molecules in the early stages of brain metastasis NEURO-ONCOLOGY
Artículo2014 Glial Activation in the Early Stages of Brain Metastasis: TSPO as a Diagnostic Biomarker JOURNAL OF NUCLEAR MEDICINE
Artículo2014 Role of dopamine in the recruitment of immune cells to the nigro-striatal dopaminergic structures NEUROTOXICOLOGY
Artículo2014 Structural and functional effects of metastases in rat brain determined by multimodal MRI INTERNATIONAL JOURNAL OF CANCER
Artículo2013 Magnetic resonance imaging reveals therapeutic effects of interferon-beta on cytokine-induced reactivation of rat model of multiple sclerosis JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Artículo2013 Use of Confocal Microscopy in the Study of Microglia in a Brain Metastasis Model HOST-PATHOGEN INTERACTIONS: METHODS AND PROTOCOLS
Artículo2012 Molecular MRI enables early and sensitive detection of brain metastases PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Artículo2012 Peripheral inflammation increases the deleterious effect of CNS inflammation on the nigrostriatal dopaminergic system NEUROTOXICOLOGY
Artículo2011 Inflammatory animal models for parkinson's disease: the intranigral injection of LPS induced the inflammatory process along with the selective degeneration of nigrostriatal dopaminergic neurons ISRN Neurology
Revisión2011 Peripheral Inflammation Increases the Damage in Animal Models of Nigrostriatal Dopaminergic Neurodegeneration: Possible Implication in Parkinson's Disease Incidence PARKINSONS DISEASE
Artículo2010 Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: potential risk factor in Parkinson's disease JOURNAL OF NEUROCHEMISTRY
Artículo2009 Respiratory response to systemic inhibition of the Na+/H+ exchanger type 3 in intact rats RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Artículo2009 Systemic Inhibition of the Na+/H+ Exchanger Type 3 in Intact Rats Activates Brainstem Respiratory Regions Advances in Experimental Medicine and Biology

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2009 31/12/2011 Investigador/a Estudio de la posible influencia de los procesos inflamatorios periféricos sobre la degeneración del sistema dopaminérgico negro- estriatal (SAF2008-04366) Ministerio de Ciencia e Innovación (Nacional)
01/02/2019 31/01/2021 Investigador/a A novel innunotherrapy against brain metastasis: Anti-Galectin-3 (Gal3-BrainMets) (H2020-795695) Comisión Europea (Europeo)
01/03/2006 28/02/2009 Investigador/a La enfermedad de Parkinson: Diagnostico en estado subclinico (EXC/2005/CTS-1014) Junta de Andalucía (Plan Andaluz de Investigación) (Autonómico)
01/01/2019 31/12/2021 Investigador/a Papel de la Galectina-3 en la Respuesta Inmune Asociada a Enfermedades del Sistema Nervioso Central. Implicación en Enfermedades Neurodegenerativas y Glioblastoma Multiforme (RTI2018-098645-B-I00) Ministerio de Ciencia, Innovación y Universidades (Nacional)
15/03/2011 30/04/2016 Investigador/a Estudio de los Mecanismos Moleculares que Regulan la Inflamación Cerebral y la Longevidad. Diseño de Estrategias Farmacológicas Encaminadas a Minimizar el Daño Neuronal Asociado a la Inflamación Cerebral en Modelos Animales de Enfermedades Neurodegenerativas (P10-CTS-6494) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
03/03/2011 03/03/2015 Investigador/a Estudio de los Cambios que Experimentan con el Envejecimiento las Rutas que Promueven la Supervivencia Celular y la Inflamación Cerebral: Modulación de las Mismas para Conseguir un Envejecimiento Saludable y Minimizar la Neurodegeneración (P09-CTS-5244) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
01/02/2020 31/01/2022 Responsable Anti -Galectin-3 as a Novel Immunotherapy for Globastoma Multiforme (US-1264152) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico)

Ayudas

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
03/07/2010 07/07/2010 Responsable 7th Fens Forum of European Neuroscience (PP2010-06-008) Universidad de Sevilla (Local)