Raimundo Goberna Ortiz

Profesor Emérito
Área de conocimiento: Sin área de conocimiento
Departamento: Bioquímica Méd.y Biol.Molecular e Inmun.
Grupo: BIOQUIMICA MEDICA (CTS-151)
Tipo Año Título Fuente
Libro2015 Actualizaciones en bioquímica clínica Actualizaciones en bioquímica clínica
Capítulo2015 Diagnóstico por el laboratorio de la diabetes mellitus Actualizaciones en bioquímica clínica
Capítulo2015 Papel del POCT en bioquímica Actualizaciones en bioquímica clínica
Artículo2011 Evaluation of two HbA1c point-of-care analyzers CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Artículo2010 Detección de deficiencia de yodo en el sur de España mediante el cribado del hipotiroidismo congénito ANALES DE PEDIATRIA
Artículo2010 Glycated hemoglobin vs. the oral glucose tolerance test for the exclusion of impaired glucose tolerance in high-risk individuals CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Artículo2010 MAPK and PI3K activities are required for leptin stimulation of protein synthesis in human trophoblastic cells BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Artículo2009 Armonización de resultados de HbA1c en España Revista del laboratorio clínico
Artículo2009 Documento de consenso para la armonización de resultados de HbA1c en España AVANCES EN DIABETOLOGIA
Ponencia2009 Haemoglobin A1c: Comparison of three point of care analysers with the central laboratory assay CLINICAL CHEMISTRY
Ponencia2009 Improvement of glycemic control of diabetic patients from primary care by an educational intervention together with an on-line quality control system from the central laboratory of Clinical Biochemistry CLINICAL CHEMISTRY
Artículo2009 Leptin Stimulates Protein Synthesis-Activating Translation Machinery in Human Trophoblastic Cells BIOLOGY OF REPRODUCTION
Artículo2008 Leptin prevents apoptosis of trophoblastic cells by activation of MAPK pathway ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Artículo2008 Leptin promotes cell survival and activates Jurkat T lymphocytes by stimulation of mitogen-activated protein kinase CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Artículo2008 Resultados de la implantación de un sistema de control de calidad para los glucómetros del Área Hospitalaria Virgen Macarena, con conexión on-line al Laboratorio de Bioquímica Clínica, durante el período 2003–2007, Revista del laboratorio clínico
Artículo2005 Educational intervention together with an on-line quality control program achieve recommended analytical goals for bedside blood glucose monitoring in a 1200-bed university hospital. CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Artículo2005 Sam68 is tyrosine phosphorylated and recruited to signalling in peripheral blood mononuclear cells from HIV infected patients CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Ponencia2004 An on-line quality control system for the portable glucose meters in a 1200 bed university hospital CLINICAL CHEMISTRY
Artículo2004 Expression of activation molecules in neutrophils, monocytes and lymphocytes from patients with unstable angina treated with stent implantation CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Revisión2003 Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Artículo2002 Elevated plasma total homocysteine levels in hyperinsulinemic obese subjects JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Artículo2002 Inflammatory response to coronary stent implantation in patients with unstable angina CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Artículo2002 Leptin receptor (Ob-R) expression is induced in peripheral blood mononuclear cells by in vitro activation and in vivo in HIV-infected patients CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Artículo2000 Human leptin enhances activation and proliferation of human circulating T lymphocytes Cellular Immunology
Ponencia1999 Analytical endogenous interferences on the Glucocard meter Glucocard Memory 2 CLINICAL CHEMISTRY
Corrección1999 Erratum: Increased plasma pancreastatin-like levels in gestational diabetes (Diabetes Care (1998) 21 (1951-1954)) DIABETES CARE
Artículo1999 Human leptin stimulates proliferation and activation of human circulating monocytes Cellular Immunology
Corrección1999 Increased plasma pancreastatin-like levels in gestational diabetes. (vol 21, pg 1951, 1998) DIABETES CARE
Artículo1999 Physiological levels of melatonin contribute to the antioxidant capacity of human serum JOURNAL OF PINEAL RESEARCH
Artículo1998 Circadian variations in the rat serum total antioxidant status: Correlation with melatonin levels JOURNAL OF PINEAL RESEARCH
Artículo1998 Increased plasma pancreastatin-like levels in gestational diabetes - Correlation with catecholamine levels DIABETES CARE
Artículo1998 Involvement of nuclear binding sites for melatonin in the regulation of IL-2 and IL-6 production by human blood mononuclear cells JOURNAL OF NEUROIMMUNOLOGY
Artículo1997 Melatonin Enhances IL-2, IL-6, and IFN-γ Production by Human Circulating CD4+ Cells: A Possible Nuclear Receptor-Mediated Mechanism Involving T Helper Type 1 Lymphocytes and Monocytes JOURNAL OF IMMUNOLOGY
Artículo1997 Normal pancreastatin-like and increased post-glucose insulin levels in young offspring of insulin-resistant non-obese essential hypertensive patients JOURNAL OF ENDOCRINOLOGY
Artículo1996 Carbohydrate-deficient transferrin utility in alcoholics detection. Comparison with other biochemical quantities Revista de la Sociedad Española de Química Clínica
Revisión1996 Pancreastatin action in the liver: Dual coupling to different G proteins CELLULAR SIGNALLING
Revisión1996 Pancreastatin: Further evidence for its consideration as a regulatory peptide Journal of Molecular Endocrinology
Artículo1995 High-affinity binding of melatonin by human circulating T lymphocytes (CD4+) FASEB JOURNAL
Artículo1995 Increased plasma pancreastatin-like immunoreactivity levels in non-obese patients with essential hypertension JOURNAL OF HYPERTENSION
Artículo1995 PLASMA PANCREASTATIN-LIKE IMMUNOREACTIVITY CORRELATES WITH PLASMA NOREPINEPHRINE LEVELS IN ESSENTIAL-HYPERTENSION NEUROPEPTIDES
Artículo1994 Diminished insulin-receptors on erythrocyte-ghosts in nonobese patients with essential-hypertension independent of hyperinsulinemia JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
Artículo1994 Pancreastatin activates pertussis-toxin-sensitive guanylate-cyclase and pertussis toxin-insensitive phospholipase-C in rat-liver membranes JOURNAL OF CELLULAR BIOCHEMISTRY
Artículo1994 PANCREASTATIN ACTIVATES PROTEIN-KINASE-C BY STIMULATING THE FORMATION OF 1,2-DIACYLGLYCEROL IN RAT HEPATOCYTES BIOCHEMICAL JOURNAL
Artículo1994 PANCREASTATIN INHIBITS INSULIN-STIMULATED GLYCOGEN-SYNTHESIS BUT NOT GLYCOLYSIS IN RAT HEPATOCYTES REGULATORY PEPTIDES
Artículo1994 Receptors for pancreastatin in rat liver membranes: Molecular identification and characterization by covalent cross-linking MOLECULAR PHARMACOLOGY
Artículo1993 PANCREASTATIN (33-49) ENHANCES THE PRIMING EFFECT OF GLUCOSE IN THE RAT PANCREAS EXPERIENTIA
Artículo1993 PANCREASTATIN DECREASES PLASMA EPINEPHRINE LEVELS IN SURGICAL STRESS IN THE RAT PEPTIDES
Artículo1993 PANCREASTATIN INCREASES FREE CYTOSOLIC CA2+ IN RAT HEPATOCYTES, INVOLVING BOTH PERTUSSIS-TOXIN-SENSITIVE AND PERTUSSIS-TOXIN-INSENSITIVE MECHANISMS BIOCHEMICAL JOURNAL
Nota1993 SENSITIVITY OF INSULIN-SECRETING RIN-M5F CELLS TO UNDERGOING APOPTOSIS BY THE PROTEIN-KINASE-C INHIBITOR STAUROSPORINE EXPERIMENTAL CELL RESEARCH
Nota1992 DECREASED PROTEIN-KINASE-C ACTIVITY IS ASSOCIATED WITH PROGRAMMED CELL-DEATH (APOPTOSIS) IN FRESHLY ISOLATED RAT HEPATOCYTES BIOSCIENCE REPORTS
Artículo1992 Guanine-nucleotide regulation of vip binding to rat peritoneal macrophage membranes PEPTIDES
Artículo1992 PANCREASTATIN INCREASES CYTOSOLIC CA2+ IN INSULIN SECRETING RINM5F CELLS MOLECULAR AND CELLULAR ENDOCRINOLOGY
Artículo1992 Somatostatin inhibition of vip-stimulated and isoproterenol-stimulated cyclic-amp production in rat peritoneal-macrophages NEUROPEPTIDES
Artículo1992 STIMULATORY EFFECT OF VASOACTIVE-INTESTINAL-PEPTIDE (VIP) ON CYCLIC-AMP PRODUCTION IN RAT PERITONEAL-MACROPHAGES REGULATORY PEPTIDES
Artículo1991 Characterization of functional receptors for vasoactive intestinal peptide (vip) in rat peritoneal macrophages REGULATORY PEPTIDES
Artículo1991 CHARACTERIZATION OF MELATONIN BINDING-SITES IN THE HARDERIAN-GLAND AND MEDIAN-EMINENCE OF THE RAT LIFE SCIENCES
Artículo1990 ONTOGENY OF TYPE-II THYROXINE 5'-DEIODINASE, N-ACETYLTRANSFERASE, AND HYDROXYINDOLE-O-METHYLTRANSFERASE ACTIVITIES IN THE RAT HARDERIAN-GLAND LIFE SCIENCES
Artículo1989 DECREASED BINDING OF VASOACTIVE INTESTINAL PEPTIDE TO INTESTINAL EPITHELIAL-CELLS FROM HYPOTHYROID RATS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Artículo1988 Evaluation of maternal serum alpha-fetoprotein assay using dry blood spot samples JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY
Artículo1988 Evaluation of Maternal Serum α-Foetoprotein Assay Using Dry Blood Spot Samples CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Artículo1988 Time-resolved immunofluorometric assay for alpha-fetoprotein in dried-blood samples collected on filter paper. CLINICAL CHEMISTRY
Artículo1986 INTERACTION OF A BOVINE THYMIC PEPTIDE EXTRACT WITH VASOACTIVE-INTESTINAL-PEPTIDE (VIP) RECEPTORS BIOSCIENCE REPORTS
Artículo1986 INTERACTION OF VASOACTIVE-INTESTINAL-PEPTIDE (VIP) WITH HUMAN PERIPHERAL-BLOOD LYMPHOCYTES - SPECIFIC BINDING AND CYCLIC-AMP PRODUCTION GENERAL PHARMACOLOGY
Artículo1986 INTERACTION OF VASOACTIVE-INTESTINAL-PEPTIDE (VIP) WITH RAT LYMPHOID-CELLS PEPTIDES
Artículo1986 VASOACTIVE-INTESTINAL-PEPTIDE (VIP) BINDING TO SOLUBILIZED MATERIAL FROM RAT-LIVER PLASMA-MEMBRANES BIOSCIENCE REPORTS
Artículo1985 THE INTERACTION OF VASOACTIVE INTESTINAL PEPTIDE (VIP) WITH ISOLATED BOVINE THYROID PLASMA-MEMBRANES BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Ponencia1983 Receptors for vasoactive intestinal peptide (VIP) in lymphoid cells of rat REGULATORY PEPTIDES
Artículo1981 Effects of fasting and refeeding on insulin binding to liver plasma membranes and hepatocytes from normal rats HORMONE AND METABOLIC RESEARCH
Artículo1981 Guanyl nucleotide regulation of vasoactive intestinal peptide interaction with rat liver membranes Revista Española de Fisiología
Artículo1981 INTERACTION OF VASOACTIVE INTESTINAL PEPTIDE WITH A CELL-LINE (HELA) DERIVED FROM HUMAN CARCINOMA OF THE CERVIX - BINDING TO SPECIFIC SITES AND STIMULATION OF ADENYLATE-CYCLASE MOLECULAR AND CELLULAR BIOCHEMISTRY
Artículo1981 Interaction of vasoactive intestinal peptide with Hela cells: Activation of cyclic AMP-dependent protein kinase and lack of effect on DNA synthesis BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Artículo1981 INTERACTION OF VASOACTIVE INTESTINAL PEPTIDE WITH HUMAN-BLOOD MONONUCLEAR-CELLS MOLECULAR AND CELLULAR ENDOCRINOLOGY
Artículo1981 Properties of vasoactive intestinal peptide-receptor interaction in rat liver membranes Revista Española de Fisiología
Artículo1980 No effect of starvation on vasoactive intestinal peptide (VIP) receptors in intestinal epithelial cells HORMONE AND METABOLIC RESEARCH
Tesis dirigidas/tutorizadas:14
Fecha lectura Título Rol
29/01/2016 EFICACIA DE LOS MARCADORES BIOQUÍMICOS PARA EL DIAGNÓSTICO Y PRONÓSTICO DE LA ARTRITIS REUMATOIDE EN PACIENTES QUE ACUDEN A UNA CONSULTA DE ATENCIÓN ESPECIALIZADA Tutor/a
07/06/2010 PAPEL DE SAM68 EN LA SEÑAL DEL RECEPTOR DE LEPTINA EN CÉLULAS DE PLACENTA Tutor/a
17/11/2008 NT-PROBNP 1-76 Y SÍNDROME CORONARIO AGUDO Director/a
22/04/2008 LA HEMOGLOBINA GLICOSILADA (HbA1c) EN LA INTOLERANCIA A LA GLUCOSA Director/a
28/06/2007 ACCIÓN Y MECANISMO DE ACCIÓN DE LA LEPTINA HUMANA EN LA PLACENTA Director/a
04/07/2006 MECANISMOS DE INMUNOMODULACIÓN DE LA LEPTINA EN CÉLULAS T JURKAT Director/a
13/06/2006 LEPTINA. ESTUDIO SOBRE ESTRÉS OXIDATIVO Y LA VÍA DE SEÑALIZACIÓN CELULAR EN MONOCITOS DE PACIENTES VIH POSITIVOS Director/a
06/06/2002 ACCIÓN Y MECANISMO DE ACCIÓN DE LA LEPTINA HUMANA EN SISTEMA INMUNE Director/a
1982 Acción del peptido intestinal vasoactivo a través de su receptor sobre la actividad adenilciclasa y proteinquinasa en células mononucleares sanguíneas humanas Director/a
1986 Evaluacion de los inmunocomplejos circulantes en patologia humana Director/a
1991 Papel de la pancreastatina en la homeostasis de la glucosa Director/a
1993 Proteinas de fase aguda en el diagnostico etiológico de infecciones en pacientes HIV Director/a
1980 Regulación de la secreción de los islotes de langerhans durante el ayuno Director/a
1985 Solubilización de receptores para el péptido intestinal vasoactivo (VIP) en membranas plasmáticas de hígado de rata Director/a

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/03/2006 30/12/2009 Responsable La hemoglobina glicosilada en el diagnóstico de la intolerancia a la glucosa (prediabetes) y el riesgo cardiovascular (EXC/2005/CTS-572) Junta de Andalucía (Plan Andaluz de Investigación) (Autonómico)