Alberto Machado Quintana

Profesor Emérito
Área de conocimiento: Sin área de conocimiento
Departamento: Bioquímica y Biología Molecular
Grupo: BIOQUIMICA DEL ENVEJECIMIENTO (BIO-158)
Tipo Año Título Fuente
Artículo2018 Divergent Effects of Metformin on an Inflammatory Model of Parkinson's Disease FRONTIERS IN CELLULAR NEUROSCIENCE
Ponencia2017 Ulcerative colitis induces the activation of microglia in the ventral mesencephalon along with dopaminergic neuronal death GLIA
Artículo2012 In vitro and in vivo protection by melatonin against the decline of elongation factor-2 caused by lipid peroxidation: preservation of protein synthesis JOURNAL OF PINEAL RESEARCH
Artículo2011 Inflammatory animal models for parkinson's disease: the intranigral injection of LPS induced the inflammatory process along with the selective degeneration of nigrostriatal dopaminergic neurons ISRN Neurology
Artículo2011 Stress is critical for LPS-induced activation of microglia and damage in the rat hippocampus NEUROBIOLOGY OF AGING
Artículo2010 Degeneration of dopaminergic neurons induced by thrombin injection in the substantia nigra of the rat is enhanced by dexamethasone: Role of monoamine oxidase enzyme NEUROTOXICOLOGY
Ponencia2010 Effect of aging and oxidative stress on elongation factor-2 in hypothalamus and hypophysis FEBS JOURNAL
Revisión2010 Proaging effects of stress: a review APPROACHES TO AGING CONTROL
Artículo2009 Zocor Forte (R) (simvastatin) has a neuroprotective effect against LPS striatal dopaminergic terminals injury, whereas against MPP+ does not EUROPEAN JOURNAL OF PHARMACOLOGY
Artículo2007 Blood–brain barrier disruption induces in vivo degeneration of nigral dopaminergic neurons JOURNAL OF NEUROCHEMISTRY
Revisión2007 Mitochondrial toxins and neurodegenerative diseases FRONTIERS IN BIOSCIENCE-LANDMARK
Artículo2006 Acute perfusion of BMAA in the rat's striatum by in vivo microdialysis TOXICOLOGY LETTERS
Artículo2006 Oxidative stress is increased in critically ill patients according to antioxidant vitamins intake, independent of severity: a cohort study CRITICAL CARE
Artículo2005 Divergent regulatory mechanisms governing BDNF mRNA expression in cerebral cortex and substantia nigra in response to striatal target ablation EXPERIMENTAL NEUROLOGY
Artículo2004 Dopamine-dependent neurotoxicity of lipopolysaccharide in substantia nigra FASEB JOURNAL
Revisión2004 Importance of Aquaporins in the Physiopathology of Brain Edema CURRENT PHARMACEUTICAL DESIGN
Revisión2004 Inflammatory process as a determinant factor for the degeneration of substantia nigra dopaminergic neurons: possible relevance to the etiology of Parkinson's disease CURRENT MEDICINAL CHEMISTRY
Artículo2003 Comparison of methods for sample preparation of individual rat cerebrospinal fluid samples prior to two-dimensional polyacrylamide gel electrophoresis BIOTECHNOLOGY LETTERS
Artículo2003 Evidence for dopamine-derived hydroxyl radical formation in the nigrostriatal system in response to axotomy FREE RADICAL BIOLOGY AND MEDICINE
Artículo2003 Expression of BDNF mRNA in substantia nigra is dependent on target integrity and independent of neuronal activation JOURNAL OF NEUROCHEMISTRY
Artículo2002 DCG-IV but not other group-II metabotropic receptor agonists induces microglial BDNF mRNA expression in the rat striatum. Correlation with neuronal injury NEUROSCIENCE
Artículo2002 Decrease of 1-methyl-1,2,3,4-tetrahydroisoquinoline synthesizing enzyme activity in the brain areas of aged rat BRAIN RESEARCH
Artículo2002 Differential regulation of glutamic acid decarboxylase mRNA and tyrosine hydroxylase mRNA expression in the aged manganese-treated rats MOLECULAR BRAIN RESEARCH
Artículo2002 Melatonin induces tyrosine hydroxylase mRNA expression in the ventral mesencephalon but not in the hypothalamus JOURNAL OF PINEAL RESEARCH
Artículo2002 The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh-TNF-alpha, IL-1 beta and IFN-gamma JOURNAL OF NEUROCHEMISTRY
Artículo2001 Aquaporins in the central nervous system PROGRESS IN NEUROBIOLOGY
Artículo2001 Group II metabotropic glutamate receptor activation protects striatal dopaminergic nerve terminals against MPP+-induced neurotoxicity along with brain-derived neurotrophic factor induction JOURNAL OF NEUROCHEMISTRY
Artículo2001 Long-lasting induction of brain-derived neurotrophic factor is restricted to resistant cell populations in an animal model of status epilepticus NEUROSCIENCE
Artículo2001 Validity of a quantitative technique to study striatal dopaminergic neurodegeneration by in vivo microdialysis JOURNAL OF NEUROSCIENCE METHODS
Artículo2000 Decreased messenger RNA expression of key markers of the nigrostriatal dopaminergic system following vitamin E deficiency in the rat NEUROSCIENCE
Artículo2000 Histamine infusion induces a selective dopaminergic neuronal death along with an inflammatory reaction in rat substantia nigra JOURNAL OF NEUROCHEMISTRY
Artículo2000 Low selenium diet induces tyrosine hydroxylase enzyme in nigrostriatal system of the rat MOLECULAR BRAIN RESEARCH
Artículo2000 Neurotoxic relationship between dopamine and iron in the striatal dopaminergic nerve terminals BRAIN RESEARCH
Artículo2000 Protective effect of melatonin against the 1-methyl-4-phenylpyridinium-induced inhibition of Complex I of the mitochondrial respiratory chain JOURNAL OF PINEAL RESEARCH
Artículo2000 The endogenous amine 1-methyl-1,2,3,4-tetrahydroisoquinoline prevents the inhibition of complex I of the respiratory chain produced by MPP+ JOURNAL OF NEUROCHEMISTRY
Artículo2000 Upregulation of BDNF mRNA and trkB mRNA in the nigrostriatal system and in the lesion site following unilateral transection of the medial forebrain bundle EXPERIMENTAL NEUROLOGY
Artículo1999 Delayed apoptotic pyramidal cell death in CA4 and CA1 hippocampal subfields after a single intraseptal injection of kainate NEUROSCIENCE
Artículo1999 Detailed localization of aquaporin-4 messenger RNA in the CNS: Preferential expression in periventricular organs NEUROSCIENCE
Artículo1999 Differential upregulation of aquaporin-4 mRNA expression in reactive astrocytes after brain injury: Potential role in brain edema NEUROBIOLOGY OF DISEASE
Artículo1999 Effects of aging on the various steps of protein synthesis: Fragmentation of elongation factor 2 FREE RADICAL BIOLOGY AND MEDICINE
Artículo1999 Induced mono-(ADP)-ribosylation of rat liver cytosolic proteins by lipid peroxidant agents FREE RADICAL BIOLOGY AND MEDICINE
Artículo1999 Serotonin hyperinnervation in the adult rat ventral mesencephalon following unilateral transection of the medial forebrain bundle. Correlation with reactive microglial and astroglial populations NEUROSCIENCE
Artículo1999 The non-NMDA glutamate receptor antagonists 6-cyano-7-nitroquinoxaline-2,3-dione and 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline, but not NMDA antagonists, block the intrastriatal neurotoxic effect of MPP+ JOURNAL OF NEUROCHEMISTRY
Ponencia1998 Dopamine and iron synergistic neurotoxic effect in striatal dopaminergic nerve terminals. EUROPEAN JOURNAL OF NEUROSCIENCE
Artículo1998 Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system JOURNAL OF NEUROCHEMISTRY
Artículo1998 Use of Rotofor preparative isoelectrofocusing cell in protein purification procedure Applied Biochemistry and Biotechnology
Artículo1997 (-)-Deprenyl treatment restores serum insulin-like growth factor-I (IGF-I) levels in aged rats to young rat level EUROPEAN JOURNAL OF PHARMACOLOGY
Artículo1997 Deprenyl induces GFAP immunoreactivity in the intact and injured dopaminergic nigrostriatal system but fails to counteract axotomy-induced degenerative changes GLIA
Artículo1997 Deprenyl induces the tyrosine hydroxylase enzyme in the rat dopaminergic nigrostriatal system MOLECULAR BRAIN RESEARCH
Artículo1997 Increased activity and expression of tyrosine hydroxylase in the rat substantia nigra after chronic treatment with nomifensine MOLECULAR PHARMACOLOGY
Artículo1997 Involvement of iron in MPP+ toxicity in substantia nigra: Protection by desferrioxamine BRAIN RESEARCH
Artículo1997 Lack of involvement of glutamate-induced excitotoxicity in MPP+ toxicity in striatal dopaminergic terminals: Possible involvement of ascorbate BRITISH JOURNAL OF PHARMACOLOGY
Artículo1997 Less induced 1-methyl-4-phenylpyridinium ion neurotoxicity on striatal slices from guinea-pigs fed with a vitamin C-deficient diet NEUROSCIENCE
Artículo1997 Low selenium diet increases the dopamine turnover in prefrontal cortex of the rat NEUROCHEMISTRY INTERNATIONAL
Artículo1997 Neuroprotective effect of the iron chelator desferrioxamine against MPP+ toxicity on striatal dopaminergic terminals JOURNAL OF NEUROCHEMISTRY
Artículo1997 Time course changes in the dopaminergic nigrostriatal system following transection of the medial forebrain bundle: detection of oxidatively modified proteins in substantia nigra JOURNAL OF NEUROCHEMISTRY
Artículo1996 Effect of reducing protection against oxidation in neurotransmitters of the strionigral tract in the rat: Possible implications in Parkinson's Revista Española de Geriatría y Gerontología
Artículo1995 A convenient procedure for quantitative-analysis of stained or immunostained blotting membranes by densitometry BIOTECHNOLOGY TECHNIQUES
Artículo1995 Changes in the histidine-residues of cu/zn superoxide-dismutase during aging FEBS LETTERS
Artículo1995 Increase in dopamine turnover and tyrosine-hydroxylase enzyme in hippocampus of rats fed on low selenium diet JOURNAL OF NEUROSCIENCE RESEARCH
Artículo1995 Intrastriatal quinolinic acid injections protect against 6-hydroxydopamine induced lesions of the dopaminergic nigrostriatal system BRAIN RESEARCH
Artículo1995 One-step electroblotting of 2- to 100-kDa proteins onto a PVDF membrane Applied Biochemistry and Biotechnology
Artículo1994 Molecular characterization of type-i GABA(a) receptor complex from rat cerebral-cortex and hippocampus MOLECULAR BRAIN RESEARCH
Nota1994 Molecular heterogeneity of the type-i GABA(a) benzodiazepine receptor complex EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION
Nota1994 Reduction of 1-methyl 1,2,3,4-tetrahydroisoquinoline level in substantia-nigra of the aged rat BRAIN RESEARCH
Ponencia1994 Study of the 5-HT(3) agonist-induced dopamine release MONITORING MOLECULES IN NEUROSCIENCE
Artículo1994 The effect of a vitamin-e-deficient diet on amino-acid levels in the substantia-nigra, striatum and hippocampus of rats LIFE SCIENCES
Artículo1993 Absence of modifications of the pharmacological properties of the gaba(a) receptor complex during aging, as assessed in 3-month-old and 24-month-old rat cerebral-cortex EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION
Artículo1993 Changes in neurotransmitters in superior colliculus after neonatal enucleation - biochemical and immunocytochemical studies NEUROSCIENCE
Artículo1993 Characterization of enzymatic sunflower protein hydrolysates JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo1993 Direct quantitative determination of peptides and proteins in PVDF transfer membrane using a computing densitometer. PEPTIDE RESEARCH
Artículo1993 Effects of a short-period of vitamin e-deficient diet in the turnover of different neurotransmitters in substantia-nigra and striatum of the rat NEUROSCIENCE
Artículo1993 Low selenium diet affects monoamine turnover differentially in substantia-nigra and striatum JOURNAL OF NEUROCHEMISTRY
Artículo1993 Protective effect of deprenyl against 1-methyl-4-phenylpyridinium neurotoxicity in rat striatum Neuroscience Letters
Artículo1993 Regional differences in the enhancement by gaba of [h-3] zolpidem binding to omega-1 sites in rat-brain membranes and sections BRAIN RESEARCH
Artículo1993 Sunflower peptones - use as nitrogen-source for the formulation of fermentation media PROCESS BIOCHEMISTRY
Artículo1993 Turnover of monoamines in hippocampus of rats fed on vitamin-e-deficient diet BRAIN RESEARCH
Artículo1992 Changes in the turnover of monoamines in prefrontal cortex of rats fed on vitamin-e-deficient diet JOURNAL OF NEUROCHEMISTRY
Artículo1992 Effects of neonatal enucleation on catecholamine and serotonin turnover and amino acid levels in lateral geniculate nucleus and visual cortex of the adult rat. BRAIN RESEARCH
Artículo1992 Heterogeneity in the allosteric interaction between the gamma-aminobutyric-acid (gaba) binding-site and 3 different benzodiazepine binding-sites of the gaba(a) benzodiazepine receptor complex in the rat nervous-system JOURNAL OF NEUROCHEMISTRY
Artículo1991 Age-dependent changes in the activity and isoenzymatic pattern of the phosphofructokinase in different areas of the central nervous systems Neuroscience Letters
Ponencia1991 Dopamine release in adult and aged rats: comparison by microdialysis MONITORING MOLECULES IN NEUROSCIENCE
Artículo1991 Effects of neonatal bilateral eye enucleation on postnatal-development of the monoamines in posterior thalamus of the rat JOURNAL OF NEURAL TRANSMISSION
Artículo1991 Involvement of diminution of glutathione, produced by deficiency of methionine in the diet, in the elevation of malic enzyme level in rat-liver BIOCHIMICA ET BIOPHYSICA ACTA
Artículo1991 Pharmacologic characterization of GABA(A)/benzodiazepine receptor in rat hippocampus during aging JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Artículo1991 Production of soluble enzymatic protein hydrolysate from industrially defatted nondehulled sunflower meal JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo1991 Relationship between enzymatic-activity loss and posttranslational protein modification in aging ARCHIVES OF GERONTOLOGY AND GERIATRICS
Artículo1990 Composition and fractionation of sunflower meal - use of the lignocellulosic fraction as substrate in solid-state fermentation BIOLOGICAL WASTES
Artículo1990 Effects of enucleation on postnatal-development of catecholamines and serotonin metabolism in the superior colliculus of the rat BRAIN RESEARCH
Artículo1990 Neonatal enucleation alters catecholamine and serotonin metabolism in the lateral geniculate and visual-cortex in developing rats NEUROCHEMISTRY INTERNATIONAL
Artículo1990 Recovery of streptokinase by immunoprecipitation with anti-SK polyclonal antibodies bound to porous glass beads (SIKUGR) BIOTECHNOLOGY TECHNIQUES
Artículo1989 Age-related changes of catecholamines and their metabolites content in the visual system of the rat MECHANISMS OF AGEING AND DEVELOPMENT
Artículo1989 CHANGES IN MONOAMINES AND THEIR METABOLITE LEVELS IN SUBSTANTIA NIGRA OF AGED RATS MECHANISMS OF AGEING AND DEVELOPMENT
Artículo1989 Implication of lysine residues in the loss of enzimatic activity in rat liver 6-phosphogluyconate dehydrogenase found in aging JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1988 Changes in biogenic-amines in rat hippocampus during development and aging LIFE SCIENCES
Artículo1988 Possible involvement of histidine residues in the loss of enzymatic activity of rat liver malic enzyme during aging JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1987 Age-related-changes of serotonin and its metabolites content in the visual-system of the rat MECHANISMS OF AGEING AND DEVELOPMENT
Artículo1986 Cell removal from fermentation broth by flocculation + sedimentation BIOTECHNOLOGY LETTERS
Artículo1986 The change with age in biogenic-amines and their metabolites in the striatum of the rat ARCHIVES OF GERONTOLOGY AND GERIATRICS
Artículo1986 Ultrafiltration as concentration step in hyaluronate lyase production BIOTECHNOLOGY LETTERS
Artículo1985 Increase of hyaluronate lyase productivity by repeated batch fermentation BIOTECHNOLOGY LETTERS
Artículo1983 NADPH/NADP+ ratio: regulatory implications in yeast glyoxylic acid cycle MOLECULAR AND CELLULAR BIOCHEMISTRY
Artículo1981 Metabolic implications of ageing: Changes in activities of key lipogenic and gluconeogenic enzymes in the aged rat liver Enzyme
Libro1973 Isocitrato deshidrogenasa (NAD y NADP) y 2 oxoglutarato deshidrogenasa de saccharomyces cerevisiae en distintas condiciones de hipoxia... Isocitrato deshidrogenasa (NAD y NADP) y 2 oxoglutarato deshidrogenasa de saccharomyces cerevisiae en distintas condiciones de hipoxia...
Tesis dirigidas/tutorizadas:19
Fecha lectura Título Rol
17/09/2010 Influencia de la inflamación periférica en la degeneración del sistema dopaminergico de la rata Director/a
30/01/2009 El estrés crónico como elemento potenciador de la degeneración de las neuronas del hipocampo inducida por inflamación. Posible implicación en enfermedades neurodegenerativas Director/a
13/07/2007 EFECTO DE COMPUESTOS ANTIOXIDANTES Y PROTECTORES SOBRE LOS NIVELES DEL FACTOR DE ELONGACIÓN-2 EN CONDICIONES DE ESTRÉS OXIDATIVO Director/a
15/12/2006 Efecto sinérgico del estrés y la inflamación en la degeneración de las neuronas de la corteza prefrontal. posible implicación en el desarrollo de enfermedades neurodegenerativas Director/a
29/09/2006 ESTUDIO DE LAS ALTERACIONES EN EL ESTADO REDOX DE LA MADRE Y DEL FETO, ASÍ COMO DE LA COMPOSICIÓN PROTEICA DEL LÍQUIDO AMNIÓTICO PRODUCIDAS POR DIFERENTES CONDICIONES FISIOLÓGICAS Y PATOLÓGICAS Director/a
19/11/2004 Regulación de la expresión de bndf en los ganglios basales en distintos modelos de la enfermedad de Huntington Director/a
12/11/2004 ESTUDIO PROTEÓMICO Y DE MARCADORES DE OXIDACIÓN EN SITUACIONES PATOLÓGICAS RELACIONADAS CON EL ESTRÉS OXIDATIVO: EFECTO PROTECTOR DEL ÁCIDO FÓLICO Y DEL GLUTATION Director/a
28/06/2002 Estudio del proceso neurodegenerativo en el estriado de la rata inducido mediante la inhibición del metabolismo energético mitocondrial: implicación de las hormonas sexuales y de la concentración de dopamina Director/a
20/12/2001 EFECTO PROTECTOR DE COMPUESTOS ANTIOXIDANTES Y NEUROPROTECTORES (MELATONINA Y l-METILTETRAHIDROISOQUINOLINA) SOBRE LA DISFUNCIÓN MITOCONDRIAL, SÍNTESIS DE PROTEINAS Y ESTRÉS OXIDATIVO Director/a
06/03/2000 EFECTO DE LA DISMINUCION DE LA CAPACIDAD DE PROTECCION FRENTE A OXIDACIONES SOBRE EL SISTEMA DOPAMINERGICO NIGRO-ESTRIATAL Director/a
1981 Diferenciación enzimática en distintos organos de rata enzimas implicadas en el metabolismo energético y del NADPH en el corazón Director/a
1990 Distribución trasplacentaria de mercurio en humanos y animales de experimentación Director/a
1986 Efecto del bezafibrato sobre el metabolismo lipídico Director/a
1986 Estudio de las glicoproteinas del sistema mayor de histocompatibilidad en una línea tumoral humana (MSM). Regulación por agentes biológicos y farmacológicos Director/a
1989 Estudio de las modificaciones post-traducionales de proteínas durante el proceso de envejecimiento Director/a
1994 Estudio del efecto de la vitamina e, el selenio, el deprenilo y la acetil-l-carnitina sobre la acción tóxica del 1-metil-4-fenilpiridinio Director/a
1975 Inducción de diversas enzimas por aireación de células de Saccharomyces Cerevisiae cultivada en anaerobiosis estudio de la influencia de los sistemas de síntesis de proteínas mitocondrial y citoplasmático Director/a
1983 La razón NADPH-NADP como parámetro regulador del metabolismo Director/a
1982 Regulación de la glutamato deshigrogenasa-NADP de levadura por síntesis y degradación de la poteína enzimática Director/a

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/03/2006 28/02/2009 Responsable La enfermedad de Parkinson: Diagnostico en estado subclinico (EXC/2005/CTS-1014) Junta de Andalucía (Plan Andaluz de Investigación) (Autonómico)
31/12/2005 31/12/2008 Responsable Estudio de degeneración retrograda del sistema dopaminérgico producida por trombina y estudio de la relación entre la concentración de aquaporina y el volumen amníotico (SAF2005-02847) Ministerio de Educación y Ciencia (Nacional)
15/03/2011 30/04/2016 Investigador/a Estudio de los Mecanismos Moleculares que Regulan la Inflamación Cerebral y la Longevidad. Diseño de Estrategias Farmacológicas Encaminadas a Minimizar el Daño Neuronal Asociado a la Inflamación Cerebral en Modelos Animales de Enfermedades Neurodegenerativas (P10-CTS-6494) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
01/01/2004 31/03/2007 Investigador/a Estudio del mecanismo de inhibición de la síntesis de proteínas por el envejecimiento y el estrés oxidativo y prevención de esta inhibición mediante el uso de compuestos antioxidantes y protectores (PI031233) Ministerio de Sanidad y Consumo (Instituto de Salud Carlos III) (Nacional)
03/03/2011 03/03/2015 Responsable Estudio de los Cambios que Experimentan con el Envejecimiento las Rutas que Promueven la Supervivencia Celular y la Inflamación Cerebral: Modulación de las Mismas para Conseguir un Envejecimiento Saludable y Minimizar la Neurodegeneración (P09-CTS-5244) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
01/12/2002 01/12/2005 Responsable Estudio de la implicación de la inflamación en la degeneración del sistema dopaminergico nigro-estriatal de la rata (SAF2002-01952) Ministerio de Ciencia y Tecnología (Nacional)
01/01/2009 31/12/2011 Responsable Estudio de la posible influencia de los procesos inflamatorios periféricos sobre la degeneración del sistema dopaminérgico negro- estriatal (SAF2008-04366) Ministerio de Ciencia e Innovación (Nacional)