Andrés Aguilera López

Catedrático de Universidad
aguilo@us.es
Área de conocimiento: Genética
Departamento: Genética
Grupo: INESTABILIDAD GENOMICA Y CANCER (BIO-102)
Prog. doctorado: Prog.Doct.en Biología Molecular, Biomedicina e Investigac.Clínica (RD.2011)
Tipo Año Título Fuente
Artículo2022 A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability. GENETICS
Resumen congreso2022 Chromatin modifications upon transcription-dependent or independent replication stress ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
Capítulo2022 Detection of R-Loops by In Vivo and In Vitro Cytosine Deamination in Saccharomyces cerevisiae Methods in molecular biology
Capítulo2022 Genome-Wide Analysis of DNA-RNA Hybrids in Yeast by DRIPc-Seq and DRIP-Seq Methods in molecular biology
Resumen congreso2022 Mechanisms for RNA-mediated genome instability ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
Artículo2022 MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells CELL REPORTS
Capítulo2022 RNase H1 Hybrid-Binding Domain-Based Tools for Cellular Biology Studies of DNA–RNA Hybrids in Mammalian Cells Methods in molecular biology
Artículo2022 Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability CELL REPORTS
Artículo2022 WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage. NATURE COMMUNICATIONS
Artículo2021 A CDK-regulated chromatin segregase promoting chromosome replication. NATURE COMMUNICATIONS
Revisión2021 A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin MOLECULAR & CELLULAR ONCOLOGY
Artículo2021 A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells NATURE COMMUNICATIONS
Artículo2021 ADAR-mediated RNA editing of DNA: RNA hybrids is required for DNA double strand break repair. NATURE COMMUNICATIONS
Capítulo2021 Analysis of repair of replication-born double-strand breaks by sister chromatid recombination in yeast Methods in Enzymology
Artículo2021 BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair EMBO JOURNAL
Corrección2021 Corrigendum: UAP56/DDX39B is a major cotranscriptional RNA-DNA helicase that unwinds harmful R loops genome-wide. GENES & DEVELOPMENT
Capítulo2021 Detection of DNA Double-Strand Breaks by γ-H2AX Immunodetection Homologous recombination: methods and protocols
Artículo2021 DNA-RNA hybrids at DSBs interfere with repair by homologous recombination. eLife
Artículo2021 Harmful R-loops are prevented via different cell cycle-specific mechanisms NATURE COMMUNICATIONS
Revisión2021 Heterogeneity of DNA damage incidence and repair in different chromatin contexts DNA REPAIR
Editorial2021 Homologous recombination methods and protocols preface Homologous recombination: methods and protocols
Libro2021 Homologous recombination: methods and protocols Homologous recombination: methods and protocols
Revisión2021 Origin matters: spontaneous DNA–RNA hybrids do not form in trans as a source of genome instability CURRENT GENETICS
Editorial2021 Preface Methods in molecular biology
Artículo2021 R-loop-mediated ssDNA breaks accumulate following short-term exposure to the HDAC inhibitor romidepsin. MOLECULAR CANCER RESEARCH
Artículo2021 The human nucleoporin Tpr protects cells from RNA-mediated replication stress. NATURE COMMUNICATIONS
Artículo2021 The role of chromatin at transcription-replication conflicts as a genome safeguard. BIOCHEMICAL SOCIETY TRANSACTIONS
Capítulo2021 The sister-chromatid exchange assay in human cells Homologous recombination: methods and protocols
Artículo2021 The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription-replication conflicts NATURE GENETICS
Nota2021 The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential MOLECULAR & CELLULAR ONCOLOGY
Artículo2021 THSC/TREX-2 deficiency causes replication stress and genome instability in Caenorhabditis elegans JOURNAL OF CELL SCIENCE
Artículo2021 VID22 counteracts G-quadruplex-induced genome instability. NUCLEIC ACIDS RESEARCH
Artículo2020 Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner eLife
Revisión2020 Histone deacetylases facilitate the accurate repair of broken forks MOLECULAR & CELLULAR ONCOLOGY
Artículo2020 Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage MICROBIAL CELL
Artículo2020 Homologous recombination and Mus81 promote replication completion in response to replication fork blockage EMBO REPORTS
Revisión2020 Looping the (R) Loop in DSB Repair via RNA Methylation MOLECULAR CELL
Revisión2020 Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle CELL CYCLE
Artículo2020 TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loopmediated DNA damage PLOS GENETICS
Artículo2020 UAP56/DDX39B is a major cotranscriptional RNA-DNA helicase that unwinds harmful R loops genome-wide GENES & DEVELOPMENT
Nota2019 A conversation with Andrés Aguilera COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES
Artículo2019 A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs CELL REPORTS
Artículo2019 Depletion of the MFAP1/SPP381 splicing factor causes R-loop-independent genome instability CELL REPORTS
Artículo2019 Elongation factor TFIIS prevents transcription stress and R-loop accumulation to maintain genome stability MOLECULAR CELL
Revisión2019 Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways MICROBIAL CELL
Revisión2019 R Loops: From Physiological to Pathological Roles CELL
Artículo2019 R-Loops as Promoters of Antisense Transcription MOLECULAR CELL
Artículo2019 Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion NATURE COMMUNICATIONS
Artículo2019 The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability MOLECULAR CANCER RESEARCH
Artículo2019 The DNA damage response acts as a safeguard against harmful DNA-RNA hybrids of different origins EMBO REPORTS
Artículo2019 The Nup84 complex coordinates the DNA damage response to warrant genome integrity NUCLEIC ACIDS RESEARCH
Artículo2019 The THO complex as a paradigm for the prevention of cotranscriptional R-loops COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES
Revisión2019 Transcription-mediated replication hindrance: A major driver of genome instability GENES & DEVELOPMENT
Revisión2019 What causes an RNA-DNA hybrid to compromise genome integrity? DNA REPAIR
Artículo2018 Coordinated activity of Y family TLS polymerases and EXO1 protects non-S phase cells from UV-induced cytotoxic lesions MOLECULAR CELL
Corrección2018 Coordinated Activity of Y Family TLS Polymerases and EXO1 Protects Non-S Phase Cells from UV-Induced Cytotoxic Lesions (vol 70, pg 34, 2018) MOLECULAR CELL
Capítulo2018 Detection of DNA-RNA hybrids in vivo GENOME INSTABILITY: METHODS AND PROTOCOLS
Artículo2018 Epigenetic features of human telomeres NUCLEIC ACIDS RESEARCH
Artículo2018 Gene gating at nuclear pores prevents the formation of R loops MOLECULAR & CELLULAR ONCOLOGY
Artículo2018 Guidelines and recomendations on yeast cell death nomenclature MICROBIAL CELL
Artículo2018 Human mitochondrial degradosome prevents harmful mitochondria! R loops and mitochondrial genome instability PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Artículo2018 Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts NATURE COMMUNICATIONS
Artículo2018 Yra1-bound RNA-DNA hybrids cause orientation-independent transcription-replication collisions and telomere instability GENES & DEVELOPMENT
Artículo2017 A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination PLOS GENETICS
Artículo2017 Differential effect of the overexpression of Rad2/XPG family endonucleases on genome integrity in yeast and human cells DNA REPAIR
Corrección2017 Distinct Roles of Mus81, Yen1, Slx1-Slx4, and Rad1 Nucleases in the Repair of Replication-Born Double-Strand Breaks by Sister Chromatid Exchange (vol 32, 1592, 2012) MOLECULAR AND CELLULAR BIOLOGY
Revisión2017 DNA-RNA hybrids: the risks of DNA breakage during transcription NATURE STRUCTURAL & MOLECULAR BIOLOGY
Artículo2017 Histone Mutants Separate R Loop Formation from Genome Instability Induction MOLECULAR CELL
Artículo2017 Human THO-Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability EMBO JOURNAL
Artículo2017 Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Revisión2017 The need to regulate replication fork speed SCIENCE
Revisión2017 The Role of Replication-Associated Repair Factors on R-Loops GENES
Artículo2017 The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage PLOS GENETICS
Artículo2016 Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening PLOS GENETICS
Artículo2016 FANCD2 Facilitates Replication through Common Fragile Sites MOLECULAR CELL
Artículo2016 High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast PLOS GENETICS
Ponencia2016 Role of Chromatin and the DNA Damage Response in RNA-Mediated Genome Instability. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
Artículo2016 Roles of human POLD1 and POLD3 in genome stability SCIENTIFIC REPORTS
Corrección2016 The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell Cycle and Development (vol 7, e52447, 2012) PLOS ONE
Revisión2016 Transcription as a Threat to Genome Integrity ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85
Revisión2016 Transcription-replication conflicts: how they occur and how they are resolved NATURE REVIEWS MOLECULAR CELL BIOLOGY
Artículo2015 A unified model for the molecular basis of Xeroderma pigmentosum - Cockayne Syndrome RARE DISEASES
Artículo2015 Interdependence of the Rad50 Hook and Globular Domain Functions MOLECULAR CELL
Artículo2015 Methods to Study Transcription-Coupled Repair in Chromatin CHROMATIN PROTOCOLS, 3RD EDITION
Artículo2015 Polycomb RING1A-and RING1B-dependent histone H2A monoubiquitylation at pericentromeric regions promotes S-phase progression JOURNAL OF CELL SCIENCE
Revisión2015 R loops: new modulators of genome dynamics and function NATURE REVIEWS GENETICS
Ponencia2015 R-loop-mediated genome instability in histone mutants YEAST
Ponencia2015 R-loops as a source of genome instability in yeast and cancer cells YEAST
Revisión2015 Replication stress and cancer Nature Reviews. Cancer
Artículo2015 RNA polymerase II contributes to preventing transcription-mediated replication fork stalls EMBO JOURNAL
Artículo2015 Role for RNA: DNA hybrids in origin-independent replication priming in a eukaryotic system PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Artículo2015 The Fanconi anemia pathway protects genome integrity from R-loops PLOS GENETICS
Ponencia2015 The role of the Mlp1 in genomic stability YEAST
Artículo2014 A genome-wide function of THSC/TREX-2 at active genes prevents transcription-replication collisions NUCLEIC ACIDS RESEARCH
Artículo2014 BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2 NATURE
Artículo2014 Cleavage Factor I Links Transcription Termination to DNA Damage Response and Genome Integrity Maintenance in Saccharomyces cerevisiae PLOS GENETICS
Artículo2014 Npl3, a new link between RNA-binding proteins and the maintenance of genome integrity CELL CYCLE
Artículo2014 The rem Mutations in the ATP-Binding Groove of the Rad3/XPD Helicase Lead to Xeroderma pigmentosum-Cockayne Syndrome-Like Phenotypes PLOS GENETICS
Artículo2014 The yeast and human FACT chromatinreorganizing complexes solve R-loop-mediated transcription-replication conflicts GENES & DEVELOPMENT
Artículo2014 Transcription and Recombination: When RNA Meets DNA COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Artículo2014 Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability MOLECULAR CELL
Revisión2013 Causes of Genome Instability ANNUAL REVIEW OF GENETICS, VOL 47
Artículo2013 Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination NUCLEIC ACIDS RESEARCH
Artículo2013 Coordinated control of replication and transcription by a SAPK protects genomic integrity NATURE
Artículo2013 Histone H3K56 Acetylation, Rad52, and Non-DNA Repair Factors Control Double-Strand Break Repair Choice with the Sister Chromatid PLOS GENETICS
Artículo2013 R loops are linked to histone H3 S10 phosphorylation and chromatin condensation MOLECULAR CELL
Artículo2013 R-Loop Mediated Transcription-Associated Recombination in trf4 Delta Mutants Reveals New Links between RNA Surveillance and Genome Integrity PLOS ONE
Capítulo2013 R-Loops Brenner's Encyclopedia of Genetics: Second Edition
Ponencia2013 Replication impairment as a source of transcription- and R-loop-associated recombination JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
Artículo2013 The Npl3 hnRNP prevents R-loop-mediated transcription-replication conflicts and genome instability GENES & DEVELOPMENT
Revisión2013 Transcription coupled repair at the interface between transcription elongation and mRNP biogenesis BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Revisión2013 Transcription-Associated Genome Instability CHEMICAL REVIEWS
Artículo2013 Yeast Pol4 Promotes Tel1-Regulated Chromosomal Translocations PLOS GENETICS
Artículo2012 Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor EMBO JOURNAL
Artículo2012 Complex Chromosomal Rearrangements Mediated by Break-Induced Replication Involve Structure-Selective Endonucleases PLOS GENETICS
Artículo2012 Distinct Roles of Mus81, Yen1, Slx1-Slx4, and Rad1 Nucleases in the Repair of Replication-Born Double-Strand Breaks by Sister Chromatid Exchange MOLECULAR AND CELLULAR BIOLOGY
Ponencia2012 Histone 3 K4, K14 and K56 post-translational modifications are not affected in hpr1 Delta FEBS JOURNAL
Revisión2012 New clues to understand the role of THO and other functionally related factors in mRNP biogenesis BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Ponencia2012 New insights into the function of THO/TREX mRNP biogenesis and export factor in yeast and human cells FEBS JOURNAL
Revisión2012 R Loops: From Transcription Byproducts to Threats to Genome Stability MOLECULAR CELL
Artículo2012 R-loops cause replication impairment and genome instability during meiosis EMBO REPORTS
Ponencia2012 R-loops in recombination-mediated genome instability FEBS JOURNAL
Artículo2012 The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell Cycle and Development PLOS ONE
Artículo2012 Topological constraints impair RNA polymerase II transcription and causes instability of plasmid-borne convergent genes NUCLEIC ACIDS RESEARCH
Ponencia2012 Topological stress and genome integrity maintenance FEBS JOURNAL
Artículo2011 A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors EMBO JOURNAL
Artículo2011 AID Induces Double-Strand Breaks at Immunoglobulin Switch Regions and c-MYC Causing Chromosomal Translocations in Yeast THO Mutants PLOS GENETICS
Artículo2011 Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Artículo2011 Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers BMC CANCER
Revisión2011 Dna strand break repair and human genetic disease ENCYCLOPEDIA OF LIFE SCIENCES (ELS)
Capítulo2011 Genetic and Molecular Analysis of Mitotic Recombination in Saccharomyces cerevisiae DNA Recombination: Methods and Protocols
Artículo2011 Genome instability and transcription elongation impairment in human cells depleted of THO/TREX PLOS GENETICS
Artículo2011 Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles EMBO JOURNAL
Artículo2011 Nab2 functions in the metabolism of RNA driven by polymerases II and III MOLECULAR BIOLOGY OF THE CELL
Artículo2011 New Suppressors of THO Mutations Identify Thp3 (Ypr045c)-Csn12 as a Protein Complex Involved in Transcription Elongation MOLECULAR AND CELLULAR BIOLOGY
Artículo2011 The Rad50 coiled-coil domain is indispensable for Mre11 complex functions NATURE STRUCTURAL & MOLECULAR BIOLOGY
Artículo2011 The Replication Checkpoint Protects Fork Stability by Releasing Transcribed Genes from Nuclear Pores CELL
Artículo2011 Yeast Sen1 Helicase Protects the Genome from Transcription-Associated Instability MOLECULAR CELL
Artículo2011 Zim17/Tim15 links mitochondrial iron-sulfur cluster biosynthesis to nuclear genome stability NUCLEIC ACIDS RESEARCH
Artículo2010 A Postincision-Deficient TFIIH Causes Replication Fork Breakage and Uncovers Alternative Rad51-or Pol32-Mediated Restart Mechanisms MOLECULAR CELL
Artículo2010 Replication fork breakage and re-start New insights into Rad3/XPD-associated deficiencies CELL CYCLE
Revisión2010 The interface between transcription and mRNP export: From THO to THSC/TREX-2 BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Revisión2010 The THO complex as a key mrnp biogénesis factor in development and cell differentiation Journal Of Biology (London. Print)
Artículo2009 Chromosomal Translocations Caused by Either Pol32-Dependent or Pol32-Independent Triparental Break-Induced Replication MOLECULAR AND CELLULAR BIOLOGY
Revisión2009 DNA Repair in Mammalian Cells CELLULAR AND MOLECULAR LIFE SCIENCES
Artículo2009 Genome-Wide Analysis of Factors Affecting Transcription Elongation and DNA Repair: A New Role for PAF and Ccr4-Not in Transcription-Coupled Repair PLOS GENETICS
Artículo2009 Methods to study transcription-coupled repair in chromatin. CHROMATIN PROTOCOLS, 3RD EDITION
Artículo2009 R-loops do not accumulate in transcription-defective hpr1-101 mutants: implications for the functional role of THO/TREX NUCLEIC ACIDS RESEARCH
Artículo2009 Sem1 is a functional component of the nuclear pore complex-associated messenger RNA export machinery JOURNAL OF CELL BIOLOGY
Artículo2009 Stimulation of direct-repeat recombination by RNA polymerase III transcription DNA REPAIR
Artículo2009 The Dot1 Histone Methyltransferase and the Rad9 Checkpoint Adaptor Contribute to Cohesin-Dependent Double-Strand Break Repair by Sister Chromatid Recombination in Saccharomyces cerevisiae GENETICS
Artículo2009 The S-Phase Checkpoint Is Required To Respond to R-Loops Accumulated in THO Mutants MOLECULAR AND CELLULAR BIOLOGY
Artículo2009 The Stress-activated Protein Kinase Hog1 Mediates S Phase Delay in Response to Osmostress MOLECULAR BIOLOGY OF THE CELL
Editorial2009 Transcription at the proximity of the nuclear pore A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex RNA BIOLOGY
Artículo2008 A Novel Class of mRNA-containing Cytoplasmic Granules Are Produced in Response to UV-Irradiation MOLECULAR BIOLOGY OF THE CELL
Artículo2008 A reduction in RNA polymerase II initiation rate suppresses hyper-recombination and transcription-elongation impairment of THO mutants MOLECULAR GENETICS AND GENOMICS
Revisión2008 Biogenesis of mRNPs: integrating different processes in the eukaryotic nucleus CHROMOSOMA
Artículo2008 CDK targets Sae2 to control DNA-end resection and homologous recombination NATURE
Artículo2008 Different physiological relevance of yeast THO/TREX subunits in gene expression and genome integrity MOLECULAR GENETICS AND GENOMICS
Revisión2008 Genome instability: a mechanistic view of its causes and consequences NATURE REVIEWS GENETICS
Artículo2008 The THP1-SAC3-SUS1-CDC31 Complex Works in Transcription Elongation-mRNA Export Preventing RNA-mediated Genome Instability MOLECULAR BIOLOGY OF THE CELL
Artículo2007 A new connection of mRNP biogenesis and export with transcription-coupled repair NUCLEIC ACIDS RESEARCH
Artículo2007 Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Artículo2007 Different genetic requirements for repair of replication-born double-strand breaks by sister-chromatid recombination and break-induced replication NUCLEIC ACIDS RESEARCH
Editorial2007 How to exchange your partner. Workshop on recombination mechanisms and the maintenance of genomic stability EMBO REPORTS
Artículo2007 Impairment of transcription elongation by R-loops in vitro BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Libro2007 Molecular genetics of recombination Molecular genetics of recombination
Artículo2007 Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes MOLECULAR BIOLOGY OF THE CELL
Artículo2007 Sister chromatid recombination Topics in Current Genetics
Artículo2007 SMC proteins, new players in the maintenance of genomic stability CELL CYCLE
Artículo2006 An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination MOLECULAR AND CELLULAR BIOLOGY
Editorial2006 DNA repair: From molecular mechanism to human disease DNA REPAIR
Artículo2006 Double-strand breaks arising by replication through a nick are repaired by cohesin-dependent sister-chromatid exchange EMBO REPORTS
Artículo2006 Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex MOLECULAR AND CELLULAR BIOLOGY
Artículo2006 Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination NATURE CELL BIOLOGY
Artículo2006 Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutants MOLECULAR AND CELLULAR BIOLOGY
Revisión2005 Cotranscriptional mRNP assembly: from the DNA to the nuclear pore CURRENT OPINION IN CELL BIOLOGY
Artículo2005 Impairment of replication fork progression mediates RNA polII transcription-associated recombination EMBO JOURNAL
Artículo2005 Interdependence between transcription and mRNP processing and export, and its impact on genetic stability MOLECULAR CELL
Editorial2005 mRNA processing and genomic instability NATURE STRUCTURAL & MOLECULAR BIOLOGY
Artículo2005 Partial depletion of histone h4 increases homologous recombination-mediated genetic instability MOLECULAR AND CELLULAR BIOLOGY
Artículo2004 A novel yeast mutation, rad52-L89F, causes a specific defect in Rad51-independent recombination that correlates with a reduced ability of RAD52-L89F to interact with RAD59 GENETICS
Letter2004 A unified nomenclature for protein subunits of Mediator complexes linking transcriptional regulators to RNA polymerase II MOLECULAR CELL
Artículo2004 Molecular evidence indicating that the yeast PAF complex is required for transcription elongation EMBO REPORTS
Artículo2004 The absence of the yeast chromatin assembly factor Asf1 increases genomic instability and sister chromatid exchange EMBO REPORTS
Ponencia2003 Analysis of replication fork movement in mutants defective in RNA polymerase II transcription elongation. YEAST
Editorial2003 Control of cross-over by single-strand DNA resection TRENDS IN GENETICS
Artículo2003 Cotranscriptionally formed DNA : RNA hybrids mediate transcription elongation impairment and transcription-associated recombination MOLECULAR CELL
Artículo2003 Equal sister chromatid exchange is a major mechanism of double-strand break repair in yeast MOLECULAR CELL
Ponencia2003 Equal sister-chromatid exchange is a major mechanism of double-strand-break repair in yeast YEAST
Ponencia2003 Impairment of chromatin assembly confers hyperrecombination. YEAST
Revisión2003 Mitotic recombination in Saccharomyces cerevisiae CURRENT GENETICS
Artículo2003 Molecular evidence for a positive role of Spt4 in transcription elongation EMBO JOURNAL
Artículo2003 Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2003 Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2003 Recombinogenic effects of DNA-damaging agents are synergistically increased by transcription in Saccharomyces cerevisiae: New insights into transcription-associated recombination GENETICS
Artículo2003 Relationship between G+C content, ORF-length and mRNA concentration in Saccharomyces cerevisiae YEAST
Artículo2002 Characterization of two highly similar Rad51 homologs of Physcomitrella patens JOURNAL OF MOLECULAR BIOLOGY
Artículo2002 Defective nucleotide excision repair in yeast hpr1 and tho2 mutants NUCLEIC ACIDS RESEARCH
Artículo2002 La recombinación homóloga del ADN Investigación y Ciencia
Revisión2002 The connection between transcription and genomic instability EMBO JOURNAL
Artículo2002 The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability EMBO JOURNAL
Artículo2002 Transcription and double-strand breaks induce similar mitotic recombination events in Saccharomyces cerevisiae GENETICS
Artículo2002 TREX is a conserved complex coupling transcription with messenger RNA export NATURE
Artículo2001 A new hyperrecombination mutation identifies a novel yeast gene, THP1, connecting transcription elongation with mitotic recombination GENETICS
Editorial2001 Double-strand break repair: are Rad51/RecA-DNA joints barriers to DNA replication? TRENDS IN GENETICS
Ponencia2001 Genetic and molecular characterization of THO1, a multicopy supressor of, hpr1. YEAST
Ponencia2001 Genetics and molecular analysis of thp1, a yeast gene controlling transcription and recombination. YEAST
Artículo2001 Hpr1 is preferentially required for transcription of either long or G+C-Rich DNA sequences in Saccharomyces cerevisiae MOLECULAR AND CELLULAR BIOLOGY
Ponencia2001 Isolation and genetic analysis of novel HPR1 and THO2 mutations that differentially affect transcription and recombination. YEAST
Capítulo2001 Mechanisms and genetic control of dna repeat recombination in s. cerevisiae Recent Research Developments in Human Genetics
Artículo2001 Yeast spt6-140 mutation, affecting chromatin and transcription, preferentially increases recombination in which Rad51p-mediated strand exchange is dispensable GENETICS
Artículo2000 A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae EMBO JOURNAL
Revisión2000 Mitotic recombination in yeast: elements controlling its incidence YEAST
Artículo2000 RAD52-dependent and -independent homologous recombination initiated by Flp recombinase at a single FRT site flanked by direct repeats MOLECULAR & GENERAL GENETICS
Artículo1999 Construction and genetic analysis of S-cerevisiae deletants of six novel ORFs from chromosome II YEAST
Artículo1998 A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination EMBO JOURNAL
Artículo1998 Genetic stability and DNA rearrangements associated with a 2 x 1.1-kb perfect palindrome in Escherichia coli MOLECULAR & GENERAL GENETICS
Artículo1997 Recombination between DNA repeats in yeast hpr1 Delta cells is linked to transcription elongation EMBO JOURNAL
Artículo1997 The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability GENES & DEVELOPMENT
Artículo1997 The yeast HRS1 gene is involved in positive and negative regulation of transcription and shows genetic characteristics similar to SIN4 and GAL11 GENETICS
Artículo1996 Differential intrachromosomal hyper-recombination phenotype of spt4 and spt6 mutants of S-cerevisiae CURRENT GENETICS
Artículo1996 La recombinación genética y su relación con la transcripción Industria Farmacéutica
Revisión1996 Mutations in the yeast SRB2 general transcription factor suppress hpr1- induced recombination and show defects in DNA repair GENETICS
Artículo1996 The yeast HRS1 gene encodes a polyglutamine-rich nuclear protein required for spontaneous and hpr1-induced deletions between direct repeats GENETICS
Artículo1995 Genetic-evidence for different rad52-dependent intrachromosomal recombination pathways in saccharomyces-cerevisiae CURRENT GENETICS
Artículo1995 Isolation and genetic analysis of extragenic suppressors of the hyper- deletion phenotype of the Saccharomyces cerevisiae hpr1Δ mutation GENETICS
Corrección1995 Isolation and genetic analysis of extragenic suppressors of the hyper-deletion phenotype of the Saccharomyces cerevisiae hpr1Δ mutation (Genetics (January, 1995) 139 (57-66)) GENETICS
Capítulo1995 Recombinación y estabilidad de secuencias repetidas de ADN en levaduras Microbiología y genética molecular
Artículo1995 Role of reciprocal exchange, one-ended invasion crossover and single- strand annealing on inverted and direct repeat recombination in yeast: Different requirements for the RAD1, RAD10, and RAD52 genes GENETICS
Artículo1994 Formamide sensitivity: A novel conditional phenotype in yeast GENETICS
Artículo1994 Increase in incidence of chromosome instability and nonconservative recombination between repeats in saccharomyces-cerevisiae hpr1-delta strains MOLECULAR & GENERAL GENETICS
Nota1994 New in-vivo cloning methods by homologous recombination in yeast CURRENT GENETICS
Artículo1991 The hyper-gene conversion hpr5-1 mutation of Saccharomyces cerevisiae is an allele of the SRS2/RADH gene GENETICS
Artículo1990 High-levels of chromosome instability in polyploids of saccharomyces-cerevisiae Mutation Research
Artículo1990 Hpr1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the saccharomyces-cerevisiae top1 gene MOLECULAR AND CELLULAR BIOLOGY
Artículo1990 Molecular analysis of RGP1, a new yeast gene required for proper mitotic growth NUCLEIC ACIDS RESEARCH
Artículo1990 Nucleotide-sequence and characterization of temperature-sensitive pol1 mutants of saccharomyces-cerevisiae GENE
Resumen congreso1989 ANALYSIS OF HYPER-RECOMBINATION MUTANTS OF YEAST GENETICS
Artículo1989 Genetic and molecular analysis of recombination events in Saccharomyces cerevisiae occurring in the presence of the hyper-recombination mutation hpr1 GENETICS
Artículo1989 Synergistic effects of ethanol and temperature on yeast mitochondria CURRENT MICROBIOLOGY
Artículo1989 The phosphofructokinase genes of yeast evolved from two duplication events GENE
Artículo1989 Yeast intrachromosomal recombination: long gene conversion tracts are preferentially associated with reciprocal exchange and require the RAD1 and RAD3 gene products GENETICS
Artículo1988 Genetic control of intrachromosomal recombination in Saccharomyces cerevisiae. I. Isolation and genetic characterization of hyper-recombination mutations. GENETICS
Artículo1988 Mitotic gene conversion of large DNA heterologies in saccharomyces-cerevisiae MOLECULAR & GENERAL GENETICS
Nota1988 Relationship between growth, fermentation, and respiration rates in saccharomyces cerevisiae - a study based on the analysis of the yield ypx BIOTECHNOLOGY AND BIOENGINEERING
Artículo1987 Mutations suppressing the effects of a deletion of the phosphoglucose isomerase gene pgi1 in saccharomyces-cerevisiae CURRENT GENETICS
Artículo1986 Deletion of the phosphoglucose isomerase structural gene makes growth and sporulation glucose dependent in saccharomyces-cerevisiae MOLECULAR & GENERAL GENETICS
Artículo1986 Ethanol-sensitive mutants of Saccharomyces-cerevisiae ARCHIVES OF MICROBIOLOGY
Artículo1986 Isolation and molecular analysis of the phosphoglucose isomerase structural gene of saccharomyces-cerevisiae MOLECULAR & GENERAL GENETICS
Artículo1985 Role of mitochondria in ethanol tolerance of saccharomyces-cerevisiae ARCHIVES OF MICROBIOLOGY
Artículo1985 Specific gene probes as tools in yeast taxonomy CURRENT GENETICS
Artículo1984 Instability of saccharomyces-cerevisiae heterokaryons CURRENT GENETICS
Artículo1983 Alcohol-and sucrose- tolerant wine yeast strains. CIENCIA BIOLÓGICA
Artículo1983 Selection of wine yeasts for growth and fermentation in the presence of ethanol and sucrose APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Tesis dirigidas/tutorizadas:40
Fecha lectura Título Rol
22/04/2022 Global Dynamics of Topoisomerase II Activity Director/a
28/10/2021 DDX47 and MECP2, two novel human functions controlling R-loop-mediated genome integrity Director/a, Tutor/a
02/06/2021 INFLUENCE OF CHROMATIN FACTORS AND DNA-RNA HYBRIDS IN THE REPAIR OF REPLICATION-BORN DSBS Tutor/a, Director/a
07/07/2020 THE INFLUENCE OF CHROMATIN IN DNA-RNA HYBRID METABOLISM Director/a
12/02/2020 PAPEL DE LA HELICASA UAP56/DDX39B Y OTROS FACTORES ASOCIADOS AL METABOLISMO DEL ARN EN LA INTEGRIDAD DEL GENOMA Director/a
08/11/2019 REGULATION OF BLOCKED-DSB REPAIR BY DNA-PKCS AND ATM KINASES Tutor/a
23/10/2019 NEW FACTORS INVOLVED IN TRANSCRIPTION-ASSOCIATED GENOME INSTABILITY Director/a
12/07/2019 New cellular elements associated with DNA:RNA hybrid homeostasis in eukaryotes  Director/a
06/07/2018 INESTABILIDAD GENÉTICA ASOCIADA A R-LOOPS Director/a
29/09/2017 REGULATION OF TDP2 FUNCTION BY SUMO INTERACTIONS Tutor/a
25/09/2017 PAPEL DE FACTORES DE LA TRANSCRIPCIÓN Y LA REPLICACIÓN DEL ADN EN EL ORIGEN DE LA INESTABILIDAD GENÓMICA Director/a
22/09/2017 NEW INSIGHTS INTO CTIP PROTEIN: EXPRESSION IN BREAST CANCER AND REGULATION BY SUMOYLATION Tutor/a
13/09/2017 NUEVOS GENES HUMANOS ASOCIADOS A LA BIOGÉNESIS DE MRNPS NECESARIOS PARA LA INTEGRIDAD DEL GENOMA Director/a
08/09/2017 PAPEL DE LA CROMATINA EN LA FORMACIÓN DE R-LOOPS Director/a
11/07/2017 FUNCIÓN DE LA SUMOILACIÓN EN EL DESARROLLO DEL SISTEMA NERVIOSO CENTRAL DE VERTEBRADOS Tutor/a
16/06/2017 IDENTIFICACIÓN DE NUEVAS PROTEÍNAS QUE INTERACCIONAN CON CTIP: IMPLICACIÓN DE PRMT5 Y CCAR2 EN LA RESECCIÓN DEL ADN Tutor/a
03/02/2017 ROLE OF ATM IN THE REPAIR OF BLOCKED DNA DOUBLE-STRAND BREAKS Tutor/a
20/01/2017 CONSECUENCIAS DE LAS ALTERACIONES EN LA EXPRESIÓN DE AURORA QUINASA B SOBRE LA SEGREGACIÓN CROMOSÓMICA Y LA PROGRESIÓN DEL CICLO CELULAR Tutor/a
19/12/2014 Implicación de los complejos TFIIH y FACT en el mantenimiento de la integridad del genoma Director/a
15/07/2014 PAPEL DE NPL3, NUP84 Y OTROS FACTORES DE TRANSPORTE DE MRNA EN EL MANTENIMIENTO DE LA INTEGRIDAD DEL GENOMA Director/a
20/12/2013 INESTABILIDAD GENÉTICA Y CAMBIOS EN LA CROMATINA EN MUTANTES DEL COMPLEJO THO EN MITOSIS Y MEIOSIS DE EUCARIOTAS MODELO Director/a
14/09/2012 IMPLICACIÓN DE LA MAQUINARIA DE TRANSCRIPCIÓN EN EL ORIGEN DE LA INESTABILIDAD GENÉTICA Director/a
23/02/2012 FENÓMENOS DE INESTABILIDAD GENÓMICA LIGADOS A LA TRANSCRIPCIÓN DEL DNA EN EUCARIOTAS Director/a
03/03/2011 ANÁLISIS DE FACTORES QUE INTERVIENEN EN LA BIOGÉNESIS DEL ARNM Y LA ESTABILIDAD GENÓMICA EN CÉLULAS DE MAMÍFEROS Director/a
02/03/2011 FACTORES IMPLICADOS EN LA REPARACIÓN DE ROTURAS DE DOBLE CADENA POR RECOMBINACIÓN ENTRE CROMÁTIDAS HERMANAS Director/a
23/07/2010 INESTABILIDAD GENÉTICA ASOCIADA A DEFECTOS EN EL COMPLEJO TFIIH Director/a
17/09/2009 CONEXIÓN ENTRE TRANSCRIPCIÓN, RECOMBINACIÓN Y TOPOLOGÍA DEL DNA Director/a
03/07/2009 NEW SYSTEMS AND NEW FACTORS IN NUCLEAR AND MITOCHONDRIAL GENOMIC INSTABILITY IN YEAST Director/a
10/06/2009 PAPEL DE THSC Y OTROS FACTORES DE BIOGÉNESIS DE LOS MRNAS EN TRANSCRIPCIÓN E INTEGRIDAD DE LOS GENOMAS Director/a
05/03/2009 INESTABILIDAD GENÉTICA ASOCIADA A TRANSCRIPCIÓN Director/a
21/07/2006 Reparación postreplicativa de cortes de doble cadena en Saccharomyces cerevisiae Director/a
31/03/2005 CONEXIÓN ENTRE LA BIOGÉNESIS DEL mRNA Y LA INESTABILIDAD GENÓMICA Director/a
07/06/2004 PAPEL DEL RNA EN EXPRESIÓN GENÉTICA Y RECOMBINACIÓN EN Saccharomyces cerevisiae Director/a
07/03/2003 ELONGACIÓN DE LA TRANSCRIPCIÓN EN S CEREVISIAE:EL COMPLEJO THO Y FACTORES RELACIONADOS FUNCIONALMENTE Director/a
27/02/2003 CONEXIÓN ENTRE RECOMBINACIÓN Y BIOGÉNESIS DE RNA: THPL Y OTRAS PROTEÍNAS FUNCIONALMENTE RELACIONADAS Director/a
05/04/2002 RELACIÓN ENTRE REPARACIÓN, RECOMBINACIÓN, Y TRANSCRIPCIÓN EN LEVADURAS Director/a
19/07/2000 Recombinación mitótica entre repeticiones invertidas de ADN en Saccharomyces cerevisiae Director/a
1996 Control genético de las deleciones entre secuencias repetidas directas en Saccaromyces cerevisiae Director/a
1996 Recombinación entre secuencias repetidas e S. Cerevisiae: Análisis genético y molecular de la mutación HPR1 y de genes supresores de la misma Director/a
1998 Relación de la transcripción con la recombinación entre secuencias repetidas en S. cerevisiae Director/a

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2022 31/05/2023 Investigador/a Replication fork stability and arrest in eukaryotic cells (US-1380058) Consejería de Economía, Conocimiento, Empresas y Universidad (Autonómico)
01/10/2021 01/03/2024 Responsable Replication and post-replication signalling pathways Regulating R-loop-associated Telomere instability in human cells – RteRloop (101027467) Comisión Europea (Europeo)
01/06/2020 30/05/2023 Responsable Mecanismos de Inestabilidad Genómica Mediada por ARN y Reparación (PID2019-104270GB-I00) Ministerio de Ciencia, Innovación y Universidades (Nacional)
01/02/2020 30/04/2022 Responsable Modificaciones de histonas y proteínas de unión a ARN en el origen de la inestabilidad genética (US-1258654) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico)
01/01/2020 31/03/2023 Responsable Respuesta transcriptional en cis a la presencia de daño en el DNA (P18-FR-655) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico)
30/12/2016 31/12/2020 Responsable Transcription y Replication como Fuentes de Inestabilidad Genética (BFU2016-75058-P) Ministerio de Economía y Competitividad (Nacional)
01/09/2016 31/12/2019 Responsable Descubrimiento de antitumorales innovadores dirigidos contra dianas oncológicas: sistema topoisomerasa y regulación la respuesta inmune- INMUNOTOP (RTC-2016-4611-1) Ministerio de Economía, Industria y Competitividad (Nacional)
01/12/2015 30/11/2021 Responsable R-loops as a major modulator of transcription-associated recombination and chromatin dynamics (TARLOOP) (2628/0721) Comisión Europea (Europeo)
01/01/2015 31/12/2017 Responsable RNA-DNA Hybrids as a source of genome instability in cancer (15-0098) Worldwide Cancer Research (Europeo)
30/01/2014 16/02/2019 Responsable Origen de la Inestabilidad Cromosómica Asociada a Defectos en Transcripción y Replicación (P12-BIO-1238) Consejería de Economía, Innovación y Ciencia (Autonómico)
01/01/2014 30/06/2017 Responsable Inestabilidad Genómica Asociada a Transcripción e Híbridos DNA-RNA (BFU2013-42918-P) Ministerio de Economía y Competitividad (Nacional)
01/01/2011 30/11/2014 Responsable Roturas de ADN Asociadas a Replicación y Reparación por Recombinación de Genomas Eucarióticos (BFU2010-16372) Ministerio de Ciencia e Innovación (Nacional)
03/02/2010 01/12/2013 Responsable Bases Genéticas y Moleculares del Origen de la Inestabilidad Genomica en Eucariotas (P09-CVI-4567) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
31/01/2008 30/11/2011 Responsable Genómica Funcional de la Interconexión Transcripción -Transporte de ARN (P07-CVI-02549) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
01/10/2007 09/12/2013 Responsable Inestabilidad genómica (CSD2007-00015) Ministerio de Educación y Ciencia (Nacional)
01/10/2006 30/09/2011 Responsable Bases genéticas y moleculares de la inestabilidad genómica y su relación con la biogénesis de los mRNPs de eucariotas (BFU2006-05260) Ministerio de Educación y Ciencia (Nacional)
01/03/2006 28/02/2009 Responsable Bases genéticas y moleculares del origen de la inestabilidad genética en eucariotas (EXC/2005/CVI-624) Junta de Andalucía (Plan Andaluz de Investigación) (Autonómico)
15/11/2003 14/04/2007 Responsable Inestabilidad genética asociada a transcripción en eucariotas (SAF2003-00204) Ministerio de Ciencia y Tecnología (Nacional)
28/12/2001 27/12/2004 Responsable Saccharomyces cerevisiae como modelo eucariótico para el estudio genómico y proteómico de la respuesta celular al estres (GEN2001-4707-C08-02) Ministerio de Ciencia y Tecnología (Nacional)
20/12/2000 20/12/2003 Responsable Recombinación entre secuencias repetidas e inestabilidad genética en saccharomyces cerevisiae: un modelo funcional eucarionte (BMC2000-0439) Ministerio de Ciencia y Tecnología (Nacional)
01/10/1997 31/07/2000 Responsable EUROPEAN NETWORK FOR THE FUNCTIONAL ANALYSIS OF YEAST GENES DISCOVERED BY SYSTEMATIC DNA SEGUENCING. PHASE 2 (BIO4-CT97-2294)
01/12/1995 31/10/1998 Responsable EUROPEAN NETWORK FOR THE FUNCTIONAL ANALYSIS OF YEAST GENES DISCOVERED BY SYSTEMATIC DNA SEQUENCING. PHASE 1 EUROFAN (BIO4-CT95-0080)

Contratos

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/09/2017 31/08/2018 Responsable Exploring the Molecular Mechanism of Lurbinectedin as an Antitumoral Target in BRCA2-/-HUMAN CELL LINES (3129/0721) PharmaMar, S.A. (Desconocido)
29/12/2014 28/12/2015 Investigador/a Saccharomyces cerevisiae recombinant strains for dodecanol production. (2399/0747) Abengoa Bioenergía Nuevas Tecnologías (Desconocido)
01/06/2014 31/05/2015 Responsable Modificación Genética de microorganismos para producción de Biofuel (2287/0721) ABENGOA RESEARCH S.L. (Desconocido)
01/05/2014 30/04/2017 Responsable Mechanism of action of Yondelis as an R-loop-mediated genome instability inducer (2213/0721) Pharma Mar, S.A. (Desconocido)

Ayudas

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/07/2011 30/06/2013 Responsable Mecanismos de recombinación e inestabilidad genómica (BFU2011-14518-E) Ministerio de Ciencia e Innovación (Nacional)
01/12/2007 30/11/2010 Responsable Vigilancia del ARN nuclear en la expresión génica (BFU2007-28647-E) Ministerio de Educación y Ciencia (Nacional)
24/05/2004 24/05/2005 Responsable European Research Conference on Gene Transcription in Yeast (BIO2002-12861-E) Ministerio de Educación y Ciencia (Nacional)

Redes de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2020 30/10/2022 Responsable Inestabilidad Genómica (RED2018-102372-T) Ministerio de Ciencia, Innovación y Universidades (Desconocido)
01/07/2017 31/12/2019 Responsable Inestabilidad Genomica (BFU2016-81796-REDC) Ministerio de Economía y Competitividad (Nacional)
01/12/2014 30/11/2016 Responsable Inestabilidad Genómica (BFU2014-51672-REDC) Ministerio de Economía y Competitividad (Nacional)
El investigador no tiene ningún resultado de investigación asociado