Cintia Roodveldt

Profesora Titular de Universidad
croodveldt@us.es
Área de conocimiento: Bioquímica y Biología Molecular
Departamento: Bioquímica Médica y Biología Molecular e Inmunología
Grupo: TERAPIAS AVANZADAS EN INMUNOMODULACION Y NEUROPROTECCION (CTS-677)
Tipo Año Título Fuente
Artículo2021 Distinct responses of human peripheral blood cells to different misfolded protein oligomers IMMUNOLOGY
Revisión2021 Immune signaling kinases in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2019 Differential Interactome and Innate Immune Response Activation of Two Structurally Distinct Misfolded Protein Oligomers ACS CHEMICAL NEUROSCIENCE
Artículo2018 Immunization with alpha-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model GLIA
Nota2017 Commentary: Immunochemical markers of the amyloid cascade in the hippocampus in motor neuron diseases FRONTIERS IN NEUROLOGY
Editorial2017 Editorial: Molecular Chaperones and Neurodegeneration FRONTIERS IN NEUROSCIENCE
Artículo2017 Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia FASEB JOURNAL
Artículo2017 The chaperonin CCT inhibits assembly of alpha-synuclein amyloid fibrils by a specific, conformation-dependent interaction SCIENTIFIC REPORTS
Artículo2016 Chaperome screening leads to identification of Grp94/Gp96 and FKBP4/52 as modulators of the alpha-synuclein-elicited immune response FASEB JOURNAL
Revisión2016 The 'Omics' of Amyotrophic Lateral Sclerosis TRENDS IN MOLECULAR MEDICINE
Artículo2015 Structural characterization of toxic oligomers that are kinetically trapped during alpha-synuclein fibril formation PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Artículo2014 Chaperoned amyloid proteins for immune manipulation: alpha-Synuclein/Hsp70 shifts immunity toward a modulatory phenotype IMMUNITY INFLAMMATION AND DISEASE
Artículo2013 Hsp70 Oligomerization Is Mediated by an Interaction between the Interdomain Linker and the Substrate-Binding Domain PLOS ONE
Artículo2013 Preconditioning of Microglia by alpha-Synuclein Strongly Affects the Response Induced by Toll-like Receptor (TLR) Stimulation PLOS ONE
Artículo2012 A Rationally Designed Six-Residue Swap Generates Comparability in the Aggregation Behavior of alpha-Synuclein and beta-Synuclein BIOCHEMISTRY
Capítulo2012 Alpha-synuclein and the immune response in Parkinson’s disease Towards New Therapies for Parkinson's Disease
Artículo2012 Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Capítulo2012 The Hsp70 chaperone system in Parkinson’s disease Etiology and Pathophysiology of Parkinson's Disease
Artículo2010 Glial Innate Immunity Generated by Non-Aggregated Alpha-Synuclein in Mouse: Differences between Wild-type and Parkinson's Disease-Linked Mutants PLOS ONE
Artículo2009 Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip EMBO JOURNAL
Revisión2008 Immunological features of alpha-synuclein in Parkinson's disease JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Revisión2006 Enzyme promiscuity: evolutionary and mechanistic aspects Current Opinion in Chemical Biology
Capítulo2006 High-throughput Screens and Selections of Enzyme-encoding Genes Enzyme Assays: High-throughput Screening, Genetic Selection and Fingerprinting
Artículo2006 The latent promiscuity of newly identified microbial lactonases is linked to a recently diverged phosphotriesterase BIOCHEMISTRY
Artículo2005 Directed evolution of phosphotriesterase from Pseudomonas diminuta for heterologous expression in Escherichia coli results in stabilization of the metal-free state PROTEIN ENGINEERING DESIGN & SELECTION
Revisión2005 Directed evolution of proteins for heterologous expression and stability Current Opinion in Structural Biology
Artículo2005 Shared promiscuous activities and evolutionary features in various members of the amidohydrolase superfamily BIOCHEMISTRY
Artículo2005 The 'evolvability' of promiscuous protein functions NATURE GENETICS
Artículo2005 Use of full-length recombinant calflagin and its C fragment for improvement of diagnosis of Trypanosoma cruzi infection JOURNAL OF CLINICAL MICROBIOLOGY
Artículo2003 Purification of the 67-kDa lectin-like glycoprotein of Trypanosoma cruzi, LLGP-67, and its evaluation as a relevant antigen for the diagnosis of human infection FEMS MICROBIOLOGY LETTERS
Artículo2002 Trypanosoma cruzi: identification of a galactose-binding protein that binds to cell surface of human erythrocytes and is involved in cell invasion by the parasite EXPERIMENTAL PARASITOLOGY

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
05/10/2021 31/12/2022 Responsable Mecanismos moleculares de una proteína de la familia BET en la respuesta neuroinflamatoria asociada a proteinopatías neurodegenerativas (P20_01097) Consejería de Economía, Conocimiento, Empresas y Universidad (Autonómico)
03/04/2019 03/04/2022 Responsable Caracterización funcional y de los mecanismos de acción mediados por la kinasa de señalización MOK en la neuroinflamación asociada a la Esclerosis Lateral Amiotrófica (ELA) (2019/FARECES/CROODVELT) Fundación Ramón Areces (Nacional)
01/01/2010 31/12/2012 Investigador/a Estudio de la capacidad inmunoreguladora del péptido intestinal vasoactivo (VIP) sobre células madre derivadas de tejido adiposo (CMDA) en el modelo preclínico de esclerosis múltiple (PS09/02252) Ministerio de Ciencia e Innovación (Instituto de Salud Carlos III) (Nacional)
01/02/2020 31/01/2022 Responsable Caracterización funcional y de los mecanismos de acción mediados por MOK en la neuroinflamación asociada a proteinopatías neurodegenerativas: Esclerosis Lateral Amiotrófica (ELA) y Enfermedad de Parkinson (US-1265227) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico)
01/01/2019 31/12/2022 Responsable Caracterización Funcional e Intervención de una Nueva Ruta de Señalización de la Neuroinflamación Mediada por Microglia en Esclerosis Lateral Amiotrófica (Ela) (RTI2018-098432-B-I00) Ministerio de Ciencia, Innovación y Universidades (Nacional)