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Macarena Martinez Bailen

Profesor Sustituto
mmartinez45@us.es
Área de conocimiento: Química Orgánica
Departamento: Química Orgánica
Grupo: QUÍMICA DE BIOMOLÉCULAS Y ANÁLOGOS - FQM-345 (Universidad de Sevilla)
Tipo Año Título Fuente
Revisión2023 Multivalent glycosystems for human lectins CHEMICAL SOCIETY REVIEWS
Artículo2023 Stereoselective Synthesis of Heavily Hydroxylated Azepane Iminosugars via Osmium-Catalyzed Tethered Aminohydroxylation ORGANIC LETTERS
Artículo2022 Antimicrobial activity of phenolics isolated from the pruning wood residue of European plum (Prunus domestica L.) INDUSTRIAL CROPS AND PRODUCTS
Artículo2022 Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease BIOORGANIC CHEMISTRY
Artículo2022 Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars BIOORGANIC CHEMISTRY
Revisión2022 GCase Enhancers: A Potential Therapeutic Option for Gaucher Disease and Other Neurological Disorders PHARMACEUTICALS
Artículo2022 Structure-based identification and biological characterization of new NAPRT inhibitors PHARMACEUTICALS
Artículo2022 Synthesis of a New beta-Galactosidase Inhibitor Displaying Pharmacological Chaperone Properties for GM1 Gangliosidosis MOLECULES
Artículo2021 Piperidine Azasugars Bearing Lipophilic Chains: Stereoselective Synthesis and Biological Activity as Inhibitors of Glucocerebrosidase (GCase) JOURNAL OF ORGANIC CHEMISTRY
Artículo2020 Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B CHEMISTRY-A EUROPEAN JOURNAL
Artículo2020 Glucocerebrosidase (GCase) activity modulation by 2-alkyl trihydroxypiperidines: Inhibition and pharmacological chaperoning BIOORGANIC CHEMISTRY
Artículo2020 Regioselectivity of the 1,3-Dipolar Cycloaddition of Organic Azides to 7-Heteronorbornadienes. Synthesis of beta-Substituted Furans/Pyrroles JOURNAL OF ORGANIC CHEMISTRY
Artículo2020 Synthesis of "all-cis" trihydroxypiperidines from a carbohydrate-derived ketone: Hints for the design of new β-gal and gcase inhibitors MOLECULES
Artículo2020 Synthesis of multimeric pyrrolidine iminosugar inhibitors of human β-glucocerebrosidase and α-galactosidase A: First example of a multivalent enzyme activity enhancer for Fabry disease EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2019 Exploring substituent diversity on pyrrolidine-aryltriazole iminosugars: Structural basis of beta-glucocerebrosidase inhibition BIOORGANIC CHEMISTRY
Artículo2019 Preparation of water-soluble glycopolymers derived from five-membered iminosugars EUROPEAN POLYMER JOURNAL
Artículo2019 Structural basis of the inhibition of GH1 β-glucosidases by multivalent pyrrolidine iminosugars BIOORGANIC CHEMISTRY
Artículo2017 Tuning of beta-glucosidase and alpha-galactosidase inhibition by generation and in situ screening of a library of pyrrolidine-triazole hybrid molecules EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
30/12/2016 31/12/2020 Investigador/a Diseño y Síntesis de Moléculas de Interés Biológico Mediante el Desarrollo de Metodologías Sintéticas (CTQ2016-77270-R) Ministerio de Economía y Competitividad (Nacional)
01/01/2013 31/12/2015 Investigador/a Nuevas Aproximaciones Sintéticas para la Preparación de Moléculas Bioactivas (CTQ2012-31247) Ministerio de Economía y Competitividad (Nacional)
El investigador no tiene ningún resultado de investigación asociado