María Luisa Vizuete Chacón

Catedrática de Universidad
mvizuete@us.es
Área de conocimiento: Bioquímica y Biología Molecular
Departamento: Bioquímica y Biología Molecular
Grupo: ENVEJECIMIENTO Y NEURODEGENERACIÓN (CTS-257)
Instituto de Inv.: IBIS
Prog. doctorado: Prog.Doct.en Biología Molecular, Biomedicina e Investigac.Clínica (RD.2011)
Tipo Año Título Fuente
Revisión2021 Should we open fire on microglia? Depletion models as tools to elucidate microglial role in health and alzheimer’s disease INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2020 Amyloid-β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease GLIA
Artículo2020 Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer’s disease model SCIENTIFIC REPORTS
Resumen congreso2019 Dissecting the microglial response in transgenic models of amyloidogenesis and tauopathy GLIA
Ponencia2018 Descifrando la contribución patológica de Aβ y tau al Alzheimer en modelos transgénicos de Aβ y tau Libro de actas del Workshop International Metabolic Reprograming as a Target for a Cancer and Other Diseases
Artículo2018 Distinct microglial responses in two transgenic murine models of TAU pathology FRONTIERS IN CELLULAR NEUROSCIENCE
Revisión2018 Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative FRONTIERS IN AGING NEUROSCIENCE
Ponencia2018 Patología amiloide en el hipocampo en los pacientes con enfermedad de Alzheimer y en ratones transgénicos Libro de actas del Workshop International Metabolic Reprograming as a Target for a Cancer and Other Diseases
Artículo2018 Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease GLIA
Artículo2017 Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-ß Peptide Generation In Vivo PLOS ONE
Artículo2017 Dual roles of A beta in proliferative processes in an amyloidogenic model of Alzheimer's disease SCIENTIFIC REPORTS
Artículo2016 Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration ACTA NEUROPATHOLOGICA
Ponencia2015 Abeta from young PS1/APP hippocampus induced early synaptic pathology in vivo and in vitro Neurodegenerative Diseases
Artículo2014 Disruption of Amyloid Plaques Integrity Affects the Soluble Oligomers Content from Alzheimer Disease Brains PLOS ONE
Artículo2014 Early Neuronal Loss and Axonal/Presynaptic Damage is Associated with Accelerated Amyloid-beta Accumulation in A beta PP/PS1 Alzheimer's Disease Mice Subiculum JOURNAL OF ALZHEIMERS DISEASE
Artículo2014 In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology ACTA NEUROPATHOLOGICA COMMUNICATIONS
Artículo2014 Microglial impairment in the human Alzheimer's disease dentate gyrus Alzheimer's & Dementia
Artículo2014 Synaptic/neuritic pathology in ps1/app alzheimer's mice hippocampus involves autophagic failure and presynaptic abeta accumulation Alzheimer's & Dementia
Ponencia2013 Litio como terapia neuroprotectora en el modelo appsl/ps1m146l de la enfermedad de Alzheimer XV Congreso Nacional de la Sociedad Española de Neurociencia (SENC) (2013).
Artículo2012 Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus ACTA NEUROPATHOLOGICA
Artículo2012 Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus Molecular Neurodegeneration
Artículo2012 Different activated microglial response in human hippocampus during Alzheimer's disease progression Alzheimer's & Dementia
Ponencia2012 Hippocampal GABAergic interneurons are highly vulnerable in Alzheimer's disease EUROPEAN JOURNAL OF NEUROLOGY
Artículo2011 Age-dependent Accumulation of Soluble Amyloid beta (A beta) Oligomers Reverses the Neuroprotective Effect of Soluble Amyloid Precursor Protein-alpha (sAPP alpha) by Modulating Phosphatidylinositol 3-Kinase (PI3K)/Akt-GSK-3 beta Pathway in Alzheimer Mouse Model JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2011 Axonal neuritic pathology induces early presynaptic alterations in ps1/APP Alzheimer's mice hippocampus Alzheimer's & Dementia
Artículo2011 Cholinergic degenerative pathology in ps1m146l/APP751sl alzheimer transgenic model Alzheimer's & Dementia
Artículo2011 Regional difference in inflammatory response to LPS-injection in the brain: Role of microglia cell density JOURNAL OF NEUROIMMUNOLOGY
Artículo2011 Somatostatin interneurons are early targets in the hippocampus of APP-based Alzheimer transgenic mice Alzheimer's & Dementia
Artículo2010 Calretinin Interneurons are Early Targets of Extracellular Amyloid-beta Pathology in PS1/A beta PP Alzheimer Mice Hippocampus JOURNAL OF ALZHEIMERS DISEASE
Artículo2010 Degeneration of calretinin interneurons is associated to the early onset of extracellular amyloid pathology in Alzheimer mice hippocampus Alzheimer's & Dementia
Artículo2009 Early synaptic degenerative changes in the hippocampus of PS1(M146L)xAPP(751SL) mouse model of Alzheimer's disease Alzheimer's & Dementia
Artículo2009 Extracellular Amyloid-beta and Cytotoxic Glial Activation Induce Significant Entorhinal Neuron Loss in Young PS1(M146L)/APP(751SL) Mice JOURNAL OF ALZHEIMERS DISEASE
Artículo2008 Inflammatory Response in the Hippocampus of PS1(M146L)/APP(751SL) Mouse Model of Alzheimer's Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic JOURNAL OF NEUROSCIENCE
Ponencia2008 Phenotypic and functional switch in microglial cells correlates with neurodegeneration in the hippocampus of aged PS1XAPP transgenic model of alzheimer's disease Alzheimer's & Dementia
Artículo2007 Inter-individual variability in the expression of the mutated form of hPS1M146L determined the production of A beta peptides in the PS1xAPP transgenic mice JOURNAL OF NEUROSCIENCE RESEARCH
Artículo2007 Molecular and cellular characterization of the age-related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons JOURNAL OF NEUROCHEMISTRY
Artículo2006 Role of p38 and inducible nitric oxide synthase in the in vivo dopaminergic cells' degeneration induced by inflammatory processes after lipopolysaccharide injection NEUROSCIENCE
Artículo2001 Aquaporins in the central nervous system PROGRESS IN NEUROBIOLOGY
Artículo2001 Potential role of endogenous brain-derived neurotrophic factor in long-term neuronal reorganization of the superior colliculus after bilateral visual deprivation NEUROBIOLOGY OF DISEASE
Artículo2000 Decreased messenger RNA expression of key markers of the nigrostriatal dopaminergic system following vitamin E deficiency in the rat NEUROSCIENCE
Artículo2000 Histamine infusion induces a selective dopaminergic neuronal death along with an inflammatory reaction in rat substantia nigra JOURNAL OF NEUROCHEMISTRY
Artículo2000 Upregulation of BDNF mRNA and trkB mRNA in the nigrostriatal system and in the lesion site following unilateral transection of the medial forebrain bundle EXPERIMENTAL NEUROLOGY
Artículo1999 Detailed localization of aquaporin-4 messenger RNA in the CNS: Preferential expression in periventricular organs NEUROSCIENCE
Artículo1999 Differential upregulation of aquaporin-4 mRNA expression in reactive astrocytes after brain injury: Potential role in brain edema NEUROBIOLOGY OF DISEASE
Artículo1999 Localization of Aquaporin-3 mRNA and protein along the gastrointestinal tract of Wistar rats PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Artículo1999 The non-NMDA glutamate receptor antagonists 6-cyano-7-nitroquinoxaline-2,3-dione and 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline, but not NMDA antagonists, block the intrastriatal neurotoxic effect of MPP+ JOURNAL OF NEUROCHEMISTRY
Ponencia1998 Localization of the mRNAs for several aquaporins along the gastrointestinal tract of rats JOURNAL OF PHYSIOLOGY-LONDON
Artículo1997 (-)-Deprenyl treatment restores serum insulin-like growth factor-I (IGF-I) levels in aged rats to young rat level EUROPEAN JOURNAL OF PHARMACOLOGY
Artículo1997 Deprenyl induces the tyrosine hydroxylase enzyme in the rat dopaminergic nigrostriatal system MOLECULAR BRAIN RESEARCH
Artículo1997 Detailed mapping of the histamine H-2 receptor and its gene transcripts in guinea-pig brain NEUROSCIENCE
Artículo1997 Developmental expression of 5-HT7 receptor mRNA in rat brain visual structures after neonatal enucleation NEUROREPORT
Artículo1997 Expression of 5-HT7 receptor mRNA in rat brain during postnatal development Neuroscience Letters
Artículo1997 In vivo protection of striatal dopaminergic system against 1-methyl-4-phenylpyridinium neurotoxicity by phenobarbital JOURNAL OF NEUROSCIENCE RESEARCH
Artículo1997 Increased activity and expression of tyrosine hydroxylase in the rat substantia nigra after chronic treatment with nomifensine MOLECULAR PHARMACOLOGY
Artículo1996 Effect of reducing protection against oxidation in neurotransmitters of the strionigral tract in the rat: Possible implications in Parkinson's Revista Española de Geriatría y Gerontología
Artículo1995 Endogenous histamine induces c-fos expression within paraventricular and supraoptic nuclei NEUROREPORT
Artículo1995 The guinea pig histamine H2 receptor: Gene cloning, tissue expression and chromosomal localization of its human counterpart BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Artículo1994 [125I]Iodoproxyfan, a new antagonist to label and visualize cerebral histamine H3 receptors JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Artículo1994 1-methyl-4-phenylpyridinium has greater neurotoxic effect after selenium deficiency than after vitamin e deficiency in rat striatum. EUROPEAN JOURNAL OF PHARMACOLOGY
Artículo1994 Localization of the histamine H2-receptor and gene transcripts in rat stomach: Back to parietal cells BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Artículo1994 The effect of a vitamin-e-deficient diet on amino-acid levels in the substantia-nigra, striatum and hippocampus of rats LIFE SCIENCES
Artículo1993 Changes in neurotransmitters in superior colliculus after neonatal enucleation - biochemical and immunocytochemical studies NEUROSCIENCE
Artículo1993 Protective effect of deprenyl against 1-methyl-4-phenylpyridinium neurotoxicity in rat striatum Neuroscience Letters
Artículo1993 Turnover of monoamines in hippocampus of rats fed on vitamin-e-deficient diet BRAIN RESEARCH
Artículo1992 Effects of neonatal enucleation on catecholamine and serotonin turnover and amino acid levels in lateral geniculate nucleus and visual cortex of the adult rat. BRAIN RESEARCH
Artículo1992 Heterogeneity in the allosteric interaction between the gamma-aminobutyric-acid (gaba) binding-site and 3 different benzodiazepine binding-sites of the gaba(a) benzodiazepine receptor complex in the rat nervous-system JOURNAL OF NEUROCHEMISTRY
Artículo1991 Effects of neonatal bilateral eye enucleation on postnatal-development of the monoamines in posterior thalamus of the rat JOURNAL OF NEURAL TRANSMISSION
Artículo1990 Effects of enucleation on postnatal-development of catecholamines and serotonin metabolism in the superior colliculus of the rat BRAIN RESEARCH
Artículo1990 Neonatal enucleation alters catecholamine and serotonin metabolism in the lateral geniculate and visual-cortex in developing rats NEUROCHEMISTRY INTERNATIONAL

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/02/2020 31/01/2022 Responsable Firma Molecular de los Astrocitos Reactivos en la Enfermedad de Alzheimer: Identificación de nuevas Dianas Terapéuticas (US-1262734) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico)
01/03/2006 28/02/2009 Investigador/a Mecanismos Moleculares y Celulares Implicados en los Procesos Neurodegenerativos Durante el Envejecimiento y en la Enfermedad de Alzheimer (EXC/2005/CVI-902) Junta de Andalucía (Plan Andaluz de Investigación) (Autonómico)
30/01/2014 16/02/2019 Investigador/a Oligomerización y Toxicidad de los Péptidos de Abeta: Búsqueda de Nuevas Dianas de Interés Terapéutico en la Enfermedad de Alzheimer (P12-CTS-2035) Consejería de Economía, Innovación y Ciencia (Autonómico)
31/12/2005 31/12/2006 Investigador/a Marcadores moleculares de la patología de la enfermedad de Alzheimer en modelos transgénicos PS1xAPP (SAF2005-05338) Ministerio de Educación y Ciencia (Nacional)
01/01/2010 31/12/2012 Investigador/a Mecanismos de señalización de la respuesta inflamatoria en la enfermedad de alzheimer: control de la activación microglial como estrategia terapéutica neuroprotectora (PS09/00151) Ministerio de Ciencia e Innovación (Instituto de Salud Carlos III) (Nacional)
01/01/2019 31/12/2021 Investigador/a Descifrando la diversidad funcional de la respueta microglial y astroglial en la enfermedad de Alzheimer: potencial patológico y terapéutico (PI18/01556) Ministerio de Economía, Industria y Competitividad - Instituto de Salud Carlos III (Nacional)
01/01/2004 30/12/2006 Investigador/a Estudio de la implicación de la inflamación y del estrés celular en los proceso neurodegenerativos relacionados con la edad: envejecimiento normal y enfermedad de Alzheimer (PI030177) Ministerio de Sanidad y Consumo (Instituto de Salud Carlos III) (Nacional)
03/02/2010 03/02/2013 Investigador/a Control de la Diferenciación Microglial Como Posible Estrategia Terapéutica en la Enfermedad de Alzheimer (P09-CTS-4795) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
01/01/2016 31/12/2018 Investigador/a Evaluando la disfunción microglial y astroglial como base del proceso neurodegenerativo en la enfermedad de Alzheimer: nuevas aproximaciones terapéuticas (PI15/00957) FEDER - Ministerio de Economía y Competitividad (Instituto de Salud Carlos III) (Nacional)
01/08/2003 31/03/2005 Investigador/a Establecimiento de un modelo in vivo para el desarrollo de fármacos contra la enfermedad de Alzheimer (PTR1995-0704-OP) Ministerio de Ciencia y Tecnología (Nacional)
17/10/2006 30/12/2009 Investigador/a Caracterización de modelos transgénicos de la enfermedad de Alzheimer: estudio molecular de campos neuropatológicos y mecanismos de neuroprotección endógenos en estadios tempranos (PI060567) Ministerio de Sanidad y Consumo (Instituto de Salud Carlos III) (Nacional)
01/01/2013 30/06/2016 Investigador/a Oligómeros tóxicos del Abeta como agentes causantes de la disfunción del citoesqueleto y los procesos proteolíticos en la enfermedad de Alzheimer: Búsqueda de nuevas dianas terapéuticas (PI12/01439) Ministerio de Economía y Competitividad (Instituto de Carlos III) (Nacional)

Ayudas

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2004 31/12/2004 Investigador/a Establecimiento de un modelo in vivo para el desarrollo de fármacos contra la enfermedad de Alzeimer (OTRI/CTS-257) Universidad de Sevilla (Oficina de Transferencia de Resultados de Investigación) (Local)