Francisco Javier Vitorica Ferrández

Catedrático de Universidad
vitorica@us.es
Área de conocimiento: Bioquímica y Biología Molecular
Departamento: Bioquímica y Biología Molecular
Grupo: ENVEJECIMIENTO Y NEURODEGENERACIÓN (CTS-257)
Instituto de Inv.: IBIS
Prog. doctorado: Prog.Doct.en Biología Molecular, Biomedicina e Investigac.Clínica (RD.2011)
Tipo Año Título Fuente
Revisión2021 Animal and cellular models of Alzheimer’s disease: progress, promise, and future approaches Neuroscientist
Artículo2021 Non-productive angiogenesis disassembles Aß plaque-associated blood vessels. NATURE COMMUNICATIONS
Revisión2021 Reactive astrocyte nomenclature, definitions, and future directions NATURE NEUROSCIENCE
Revisión2021 Should we open fire on microglia? Depletion models as tools to elucidate microglial role in health and alzheimer’s disease INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2021 Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases NATURE COMMUNICATIONS
Artículo2020 Amyloid-β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease GLIA
Artículo2020 Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer’s disease model SCIENTIFIC REPORTS
Revisión2020 Human pluripotent stem cell-derived neural cells as a relevant platform for drug screening in alzheimer’s disease INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2020 Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells Stem cell research & therapy
Artículo2020 Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice Molecular Neurodegeneration
Resumen congreso2019 Dissecting the microglial response in transgenic models of amyloidogenesis and tauopathy GLIA
Artículo2019 Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients Brain Pathology
Artículo2019 Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease ACTA NEUROPATHOLOGICA
Revisión2019 Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform FUTURE MEDICINAL CHEMISTRY
Ponencia2018 Descifrando la contribución patológica de Aβ y tau al Alzheimer en modelos transgénicos de Aβ y tau Libro de actas del Workshop International Metabolic Reprograming as a Target for a Cancer and Other Diseases
Artículo2018 Distinct microglial responses in two transgenic murine models of TAU pathology FRONTIERS IN CELLULAR NEUROSCIENCE
Ponencia2018 Identificando los mecanismos implicados en la degeneración microglial presente en la enfermedad de Alzheimer Libro de actas del Workshop International Metabolic Reprograming as a Target for a Cancer and Other Diseases
Ponencia2018 Las estrategias de edición génica revelan degeneración microglial en la enfermedad de Alzheimer Libro de actas del Workshop International Metabolic Reprograming as a Target for a Cancer and Other Diseases
Ponencia2018 Las respuestas de la microglía en la enfermedad del Alzheimer Libro de actas del Workshop International Metabolic Reprograming as a Target for a Cancer and Other Diseases
Revisión2018 Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative FRONTIERS IN AGING NEUROSCIENCE
Ponencia2018 Patología amiloide en el hipocampo en los pacientes con enfermedad de Alzheimer y en ratones transgénicos Libro de actas del Workshop International Metabolic Reprograming as a Target for a Cancer and Other Diseases
Artículo2018 Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease GLIA
Artículo2018 Toward a New Concept of Alzheimer's Disease Models: A Perspective from Neuroinflammation JOURNAL OF ALZHEIMERS DISEASE
Ponencia2018 Toxicidad de las placas amiloides y su impacto en la progresión de la enfermedad del Alzheimer Libro de actas del Workshop International Metabolic Reprograming as a Target for a Cancer and Other Diseases
Artículo2017 Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-ß Peptide Generation In Vivo PLOS ONE
Artículo2017 Dual roles of A beta in proliferative processes in an amyloidogenic model of Alzheimer's disease SCIENTIFIC REPORTS
Artículo2016 Asp32 and Asp228 determine the selective inhibition of BACE1 as shown by docking and molecular dynamics simulations EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2016 Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-beta-Induced Neuronal Death JOURNAL OF ALZHEIMERS DISEASE
Artículo2016 Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration ACTA NEUROPATHOLOGICA
Ponencia2015 Abeta from young PS1/APP hippocampus induced early synaptic pathology in vivo and in vitro Neurodegenerative Diseases
Artículo2015 Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death CELL DEATH & DISEASE
Artículo2015 Application of metabolomics based on direct mass spectrometry analysis for the elucidation of altered metabolic pathways in serum from the APP/PS1 transgenic model of Alzheimer's disease JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Artículo2015 Deciphering metabolic abnormalities associated with Alzheimer's disease in the APP/PS1 mouse model using integrated metabolomic approaches BIOCHIMIE
Artículo2015 Expression of Gls and Gls2 glutaminase isoforms in astrocytes GLIA
Artículo2015 High throughput multiorgan metabolomics in the APP/PS1 mouse model of Alzheimer's disease ELECTROPHORESIS
Artículo2015 Metabolomic investigation of systemic manifestations associated with Alzheimer's disease in the APP/PS1 transgenic mouse model Molecular BioSystems
Artículo2015 Metabolomic research on the role of interleukin-4 in Alzheimer's disease Metabolomics
Artículo2015 Metabolomic screening of regional brain alterations in the APP/PS1 transgenic model of Alzheimer's disease by direct infusion mass spectrometry JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Artículo2015 Metabolomics reveals significant impairments in the immune system of the APP/PS1 transgenic mice of Alzheimer's disease ELECTROPHORESIS
Artículo2015 Neuroinflammation in Alzheimer's disease LANCET NEUROLOGY
Artículo2014 Disruption of Amyloid Plaques Integrity Affects the Soluble Oligomers Content from Alzheimer Disease Brains PLOS ONE
Artículo2014 Early Neuronal Loss and Axonal/Presynaptic Damage is Associated with Accelerated Amyloid-beta Accumulation in A beta PP/PS1 Alzheimer's Disease Mice Subiculum JOURNAL OF ALZHEIMERS DISEASE
Artículo2014 In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology ACTA NEUROPATHOLOGICA COMMUNICATIONS
Artículo2014 Increased levels of tumour necrosis factor alpha (TNF alpha) but not transforming growth factor-beta 1 (TGF beta 1) are associated with the severity of congenital hydrocephalus in the hyh mouse NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
Artículo2014 Lithium ameliorates the neuronal pathology in a ps1/app alzheimer's model by changing plaque toxicity Alzheimer's & Dementia
Artículo2014 Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Artículo2014 Microglial impairment in the human Alzheimer's disease dentate gyrus Alzheimer's & Dementia
Artículo2014 Region-specific metabolic alterations in the brain of the APP/PS1 transgenic mice of Alzheimer's disease BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Artículo2014 Synaptic/neuritic pathology in ps1/app alzheimer's mice hippocampus involves autophagic failure and presynaptic abeta accumulation Alzheimer's & Dementia
Ponencia2013 Litio como terapia neuroprotectora en el modelo appsl/ps1m146l de la enfermedad de Alzheimer XV Congreso Nacional de la Sociedad Española de Neurociencia (SENC) (2013).
Artículo2012 Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus ACTA NEUROPATHOLOGICA
Artículo2012 Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus Molecular Neurodegeneration
Artículo2012 Different activated microglial response in human hippocampus during Alzheimer's disease progression Alzheimer's & Dementia
Ponencia2012 Hippocampal GABAergic interneurons are highly vulnerable in Alzheimer's disease EUROPEAN JOURNAL OF NEUROLOGY
Artículo2012 Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus JOURNAL OF NEUROINFLAMMATION
Artículo2011 Age-dependent Accumulation of Soluble Amyloid beta (A beta) Oligomers Reverses the Neuroprotective Effect of Soluble Amyloid Precursor Protein-alpha (sAPP alpha) by Modulating Phosphatidylinositol 3-Kinase (PI3K)/Akt-GSK-3 beta Pathway in Alzheimer Mouse Model JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2011 Axonal neuritic pathology induces early presynaptic alterations in ps1/APP Alzheimer's mice hippocampus Alzheimer's & Dementia
Artículo2011 Cholinergic degenerative pathology in ps1m146l/APP751sl alzheimer transgenic model Alzheimer's & Dementia
Artículo2011 Regional difference in inflammatory response to LPS-injection in the brain: Role of microglia cell density JOURNAL OF NEUROIMMUNOLOGY
Artículo2011 Regulation of the phosphatase calcineurin by insulin-like growth factor I unveils a key role of astrocytes in Alzheimer's pathology MOLECULAR PSYCHIATRY
Artículo2011 Somatostatin interneurons are early targets in the hippocampus of APP-based Alzheimer transgenic mice Alzheimer's & Dementia
Artículo2010 Activity-Dependent Neuroprotective Protein (ADNP) Expression in the Amyloid Precursor Protein/Presenilin 1 Mouse Model of Alzheimer's Disease JOURNAL OF MOLECULAR NEUROSCIENCE
Artículo2010 Calretinin Interneurons are Early Targets of Extracellular Amyloid-beta Pathology in PS1/A beta PP Alzheimer Mice Hippocampus JOURNAL OF ALZHEIMERS DISEASE
Artículo2010 Degeneration of calretinin interneurons is associated to the early onset of extracellular amyloid pathology in Alzheimer mice hippocampus Alzheimer's & Dementia
Artículo2009 Age-related increase in the immunoproteasome content in rat hippocampus: molecular and functional aspects JOURNAL OF NEUROCHEMISTRY
Artículo2009 Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition AGING CELL
Artículo2009 Early synaptic degenerative changes in the hippocampus of PS1(M146L)xAPP(751SL) mouse model of Alzheimer's disease Alzheimer's & Dementia
Artículo2009 Extracellular Amyloid-beta and Cytotoxic Glial Activation Induce Significant Entorhinal Neuron Loss in Young PS1(M146L)/APP(751SL) Mice JOURNAL OF ALZHEIMERS DISEASE
Artículo2008 Inflammatory Response in the Hippocampus of PS1(M146L)/APP(751SL) Mouse Model of Alzheimer's Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic JOURNAL OF NEUROSCIENCE
Ponencia2008 Phenotypic and functional switch in microglial cells correlates with neurodegeneration in the hippocampus of aged PS1XAPP transgenic model of alzheimer's disease Alzheimer's & Dementia
Artículo2007 Inter-individual variability in the expression of the mutated form of hPS1M146L determined the production of A beta peptides in the PS1xAPP transgenic mice JOURNAL OF NEUROSCIENCE RESEARCH
Artículo2007 Molecular and cellular characterization of the age-related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons JOURNAL OF NEUROCHEMISTRY
Ponencia2007 Possible dual neuroprotective/neurotoxic effect of inflammatory reaction in the hippocampus of a PS1 x APP transgenic model of Alzheimer's disease JOURNAL OF NEUROCHEMISTRY
Artículo2006 Cellular environment facilitates protein accumulation in aged rat hippocampus NEUROBIOLOGY OF AGING
Artículo2006 Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1 x APP transgenic model of Alzheimer's disease NEUROBIOLOGY OF AGING
Artículo2006 Role of p38 and inducible nitric oxide synthase in the in vivo dopaminergic cells' degeneration induced by inflammatory processes after lipopolysaccharide injection NEUROSCIENCE
Artículo2004 Expression of alpha 5 GABA(A) receptor subunit in developing rat hippocampus DEVELOPMENTAL BRAIN RESEARCH
Artículo2004 Postnatal development of the alpha 1 containing GABA(A) receptor subunit in rat hippocampus DEVELOPMENTAL BRAIN RESEARCH
Artículo2003 Rat hippocampal GABAergic molecular markers are differentially affected by ageing JOURNAL OF NEUROCHEMISTRY
Artículo2001 Prevalence between different α subunits performing the benzodiazepine binding sites in native heterologous GABAA receptors containing the α2 subunit JOURNAL OF NEUROCHEMISTRY
Artículo2001 Rapid PCR-mediated synthesis of competitor molecules for accurate quantification of beta(2) GABA(A) receptor subunit mRNA BRAIN RESEARCH PROTOCOLS
Artículo2000 Distribution of the γ-aminobutyric acid(A) receptor complex alpha 5 subunit in chick brain. An immunocytochemical and autoradiographic study Neuroscience Letters
Artículo2000 GABA(A) and alpha-amino-3-hydroxy-5-methylsoxazole-4-propionate receptors are differentially affected by aging in the rat hippocampus JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2000 Subunit composition of rat ventral spinal cord GABA(A) receptors, assessed by single cell RT-multiplex PCR NEUROREPORT
Artículo1999 Native gamma-aminobutyric acid type A receptors from rat hippocampus, containing both alpha 1 and alpha 5 subunits, exhibit a single benzodiazepine binding site with alpha 5 pharmacological properties JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Artículo1998 Absence of association between δ and γ2 subunits in native GABA(A) receptors from rat brain EUROPEAN JOURNAL OF PHARMACOLOGY
Artículo1998 Pharmacological properties of the GABA(A) receptor complex from brain regions of (hypoemotional) Roman high- and (hyperemotional) low-avoidance rats EUROPEAN JOURNAL OF PHARMACOLOGY
Artículo1997 GABA(A) receptor subunit expression changes in the rat cerebellum and cerebral cortex during aging MOLECULAR BRAIN RESEARCH
Artículo1996 Age-related modifications on the GABA(A) receptor binding properties from Wistar rat prefrontal cortex BRAIN RESEARCH
Artículo1996 Aging-related subunit expression changes of the GABA(A) receptor in the rat hippocampus NEUROSCIENCE
Artículo1996 Molecular and pharmacological characterization of native cortical gamma-aminobutyric acid(A) receptors containing both alpha(1) and alpha(3) subunits JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1995 Aging‐Associated Changes in the Pharmacological Properties of the Benzodiazepine (ω) Receptor Isotypes in the Rat Hippocampus JOURNAL OF NEUROCHEMISTRY
Artículo1995 Implication of dopamine transporter system on 1-methyl-4-phenylpyridinium and rotenone effect in striatal synaptosomes EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION
Artículo1994 Differential expression of the short and long forms of the γ2 subunit of the GABAA/benzodiazepine receptors MOLECULAR BRAIN RESEARCH
Artículo1994 Molecular characterization of type-i GABA(a) receptor complex from rat cerebral-cortex and hippocampus MOLECULAR BRAIN RESEARCH
Nota1994 Molecular heterogeneity of the type-i GABA(a) benzodiazepine receptor complex EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION
Artículo1993 Absence of modifications of the pharmacological properties of the gaba(a) receptor complex during aging, as assessed in 3-month-old and 24-month-old rat cerebral-cortex EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION
Artículo1993 Comparative autoradiographic distribution of central omega (benzodiazepine) modulatory site subtypes with high, intermediate and low affinity for zolpidem and alpidem BRAIN RESEARCH
Artículo1993 Regional differences in the enhancement by gaba of [h-3] zolpidem binding to omega-1 sites in rat-brain membranes and sections BRAIN RESEARCH
Artículo1992 Heterogeneity in the allosteric interaction between the gamma-aminobutyric-acid (gaba) binding-site and 3 different benzodiazepine binding-sites of the gaba(a) benzodiazepine receptor complex in the rat nervous-system JOURNAL OF NEUROCHEMISTRY
Artículo1991 Changes of calcium homeostasis in nerve endings during aging ZEITSCHRIFT FUR GERONTOLOGIE
Artículo1991 Pharmacologic characterization of GABA(A)/benzodiazepine receptor in rat hippocampus during aging JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Artículo1991 Purification of the gamma-aminobutyric acida/benzodiazepine receptor complex by immunoaffinity chromatography JOURNAL OF NEUROCHEMISTRY
Artículo1990 Characterization with antibodies of the gamma-aminobutyric acida benzodiazepine receptor complex during development of the rat-brain JOURNAL OF NEUROCHEMISTRY
Artículo1990 Rapid postnatal developmental changes in the passive proton permeability of the inner membrane in rat liver mitochondria Journal of Biochemistry
Artículo1990 The GABA-A benzodiazepine receptor complex in rat-brain neuronal cultures - characterization by immunoprecipitation BRAIN RESEARCH
Artículo1989 Amino acid analysis on polyvinylidene difluoride membranes ANALYTICAL BIOCHEMISTRY
Artículo1989 Immunocytochemical localization of GABAA receptors in goldfish and chicken retinas JOURNAL OF COMPARATIVE NEUROLOGY
Artículo1989 Immunohistochemical localization of gabaa receptors in the retina of the new world primate saimiri-sciureus VISUAL NEUROSCIENCE
Ponencia1989 Inactivating and Noninactivating Components of K+‐Stimulated 45Ca2+ Uptake in Synaptosomes and Variations Due to Aging CALCIUM CHANNELS : STRUCTURE AND FUNCTION
Artículo1989 Reduction of k+-stimulated ca-45(2+) influx in synaptosomes with age involves inactivating and noninactivating calcium channels and is correlated with temporal modifications in protein dephosphorylation JOURNAL OF NEUROCHEMISTRY
Artículo1988 Cytosolic free calcium levels increase with age in rat-brain synaptosomes Neuroscience Letters
Artículo1988 Localization of the GABA(A) receptor in the rat brain with a monoclonal antibody to the 57,000 M(r) peptide of the GABA(A) receptor/benzodiazepine receptor/Cl- channel complex JOURNAL OF NEUROSCIENCE
Artículo1988 Measurement of insitu mitochondrial-membrane potential in ehrlich ascites tumor-cells during aerobic glycolysis BIOCHIMICA ET BIOPHYSICA ACTA
Artículo1988 Monoclonal antibodies and conventional antisera to the GABA(A) receptor/benzodiazepine receptor/Cl- channel complex JOURNAL OF NEUROSCIENCE
Artículo1987 Differential-effects of age on the pathways of calcium influx into nerve-terminals BRAIN RESEARCH
Nota1987 Immunocytochemical localization of the gaba-a receptor in the rat-brain EUROPEAN JOURNAL OF PHARMACOLOGY
Artículo1986 Involvement of mitochondria in the age-dependent decrease in calcium-uptake of rat-brain synaptosomes BRAIN RESEARCH
Artículo1986 The influence of age on the calcium-efflux pathway and matrix calcium buffering power in brain mitochondria BIOCHIMICA ET BIOPHYSICA ACTA
Artículo1985 Impairment of glutamate uptake and absence of alterations in the energy-transducing ability of old rat-brain mitochondria MECHANISMS OF AGEING AND DEVELOPMENT
Artículo1985 The pentose-phosphate cycle is regulated by nadph nadp ratio in rat-liver ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Artículo1985 The role of adp in the modulation of the calcium-efflux pathway in rat-brain mitochondria BIOCHEMICAL JOURNAL
Artículo1984 Age-dependent variations in peroxide-utilizing enzymes from rat-brain mitochondria and cytoplasm JOURNAL OF NEUROCHEMISTRY
Artículo1981 Age-related quantitative changes in enzyme-activities of rat-brain NEUROCHEMICAL RESEARCH
Artículo1981 Comparison between developmental and senescent changes in enzyme-activities linked to energy-metabolism in rat-heart MECHANISMS OF AGEING AND DEVELOPMENT
Artículo1981 Metabolic implications of ageing: Changes in activities of key lipogenic and gluconeogenic enzymes in the aged rat liver Enzyme

Tesis dirigidas/tutorizadas:13
Fecha lectura Título Rol
30/04/2021 VARIACIONES DE LA RESPUESTA MICROGLIAL SEGÚN EL CONTEXTO PATOLÓGICO EN LA ENFERMEDAD DE ALZHEIMER Tutor/a, Director/a
20/01/2021 IMPLICACIÓN DE LA DISFUNCIÓN GLIAL EN LA EVOLUCIÓN DE LA PATOLOGÍA EN PACIENTES DE ALZHEIMER Director/a
25/03/2019 CARACTERIZACIÓN DE LA RESPUESTA Y FUNCIÓN ASTROGLIAL EN MODELOS Y PACIENTES DE LA ENFERMEDAD DE ALZHEIMER Director/a, Tutor/a
15/01/2016 EFECTOS DE ACUMULACIÓN DEL PÉPTIDO BETA AMILOIDE EN TEJIDO CEREBRAL DE RATONES PS1XAPP MODELOS DE LA ENFERMEDAD DE ALZHEIMER Director/a
11/02/2015 CARACTERIZACIÓN DE LA RESPUESTA INFLAMATORIA EN TEJIDO CEREBRAL POSTMORTEM DE PACIENTES DE ALZHEIMER Director/a
11/05/2011 FACTORES IMPLICADOS EN LA NEURODEGENERACIÓN Y EL AUMENTO DE ABETA OLIGOMÉRICO SOLUBLE DURANTE EL PROCESO DE ENVEJECIMIENTO EN UN MODELO PS1M146LXAPPSL DE LA ENFERMEDAD DE ALZHEIMER Director/a
28/03/2008 PROCESOS NEUROINFLAMATORIOS RELACIONADOS CON EL PÉPTIDO B-AMILOIDE EN UN MODELO DOBLE TRANSGÉNICO, PS1XAPP, DE LA ENFERMEDAD DE ALZEHEIMER: NEUROPROTECCIÓN vs NEURODEGENERACIÓN Director/a
12/03/2008 ESTUDIO DE LOS MECANISMOS MOLECULARES RELACIONADOS CON LA NEUDEGENERACIÓN EN EL HIPOCAMPO DE RATA DURANTE EL PROCESO NORMAL DE ENVEJECIMIENTO: IMPLICACIÓN DE LA NEUROINFLAMACIÓN Y EL ESTRÉS DE RETÍCULO ENDOPLÁS Director/a
22/07/2005 CARACTERIZACIÓN DE LOS SISTEMAS GABAÉRGICO Y COLINÉRGICO EN HIPOCAMPO DE RATONES TRANSGÉNICOS MODELOS DE LA ENFERMEDAD DE ALZHEIMER Director/a
24/09/2004 ESTUDIO DEL SISTEMA GABAÉRGICO, DURANTE EL PROCESO NORMAL DE ENVEJECIMIENTO, EN EL HIPOCAMPO DE RATA Director/a
12/02/1993 Caracterización farmacológica de la proteína receptora GABAA en el sistema nervioso de la rata: Efecto del envejecimiento Director/a
2019 Caracterización de la potología amiloide y su relación con la microglía en modelos transgénicos de la enfermedad de Alzheimer Director/a
2007 Estudio histopatológico del hipocampo de un modelo animal transgénico PS1XAPP de la enfermedad de Alzheimer Director/a

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2016 31/12/2018 Responsable Evaluando la disfunción microglial y astroglial como base del proceso neurodegenerativo en la enfermedad de Alzheimer: nuevas aproximaciones terapéuticas (PI15/00957) FEDER - Ministerio de Economía y Competitividad (Instituto de Salud Carlos III) (Nacional)
01/01/2000 31/12/2001 Responsable Modificaciones debidas al envejecimiento en el sistema gabaergico de hipocampo de rata: repercusiones en la expresión de los receptores gabaa y glutamato. (FIS-00/0314) Ministerio de Sanidad y Consumo (Instituto de Salud Carlos III) (Nacional)
03/02/2010 03/02/2013 Responsable Control de la Diferenciación Microglial Como Posible Estrategia Terapéutica en la Enfermedad de Alzheimer (P09-CTS-4795) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
01/01/2013 30/06/2016 Responsable Oligómeros tóxicos del Abeta como agentes causantes de la disfunción del citoesqueleto y los procesos proteolíticos en la enfermedad de Alzheimer: Búsqueda de nuevas dianas terapéuticas (PI12/01439) Ministerio de Economía y Competitividad (Instituto de Carlos III) (Nacional)
01/02/2020 31/01/2022 Responsable Firma Molecular de los Astrocitos Reactivos en la Enfermedad de Alzheimer: Identificación de nuevas Dianas Terapéuticas (US-1262734) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico)
01/08/2003 31/03/2005 Responsable Establecimiento de un modelo in vivo para el desarrollo de fármacos contra la enfermedad de Alzheimer (PTR1995-0704-OP) Ministerio de Ciencia y Tecnología (Nacional)
17/10/2006 30/12/2009 Responsable Caracterización de modelos transgénicos de la enfermedad de Alzheimer: estudio molecular de campos neuropatológicos y mecanismos de neuroprotección endógenos en estadios tempranos (PI060567) Ministerio de Sanidad y Consumo (Instituto de Salud Carlos III) (Nacional)
30/01/2014 16/02/2019 Responsable Oligomerización y Toxicidad de los Péptidos de Abeta: Búsqueda de Nuevas Dianas de Interés Terapéutico en la Enfermedad de Alzheimer (P12-CTS-2035) Consejería de Economía, Innovación y Ciencia (Autonómico)
01/01/2019 31/12/2021 Responsable Descifrando la diversidad funcional de la respueta microglial y astroglial en la enfermedad de Alzheimer: potencial patológico y terapéutico (PI18/01556) Ministerio de Economía, Industria y Competitividad - Instituto de Salud Carlos III (Nacional)
01/01/2003 31/12/2005 Responsable Cambios durante el envejecimiento en los sistemas GABAérgico, colinérgico y glutamatérgico en modelos transgéncios de la enfermedad de alzheimer (SAF2002-03448) Ministerio de Ciencia y Tecnología (Nacional)
01/03/2006 28/02/2009 Responsable Mecanismos Moleculares y Celulares Implicados en los Procesos Neurodegenerativos Durante el Envejecimiento y en la Enfermedad de Alzheimer (EXC/2005/CVI-902) Junta de Andalucía (Plan Andaluz de Investigación) (Autonómico)
25/05/2015 24/05/2018 Responsable Desxifrant la relació ente la reactivitat des astròcits i el dany neuronal en la malaltia d'alzheimer (SUBCON2015/016) La Fundació La Marató de TV3 (Autonómico)
31/12/2005 31/12/2006 Responsable Marcadores moleculares de la patología de la enfermedad de Alzheimer en modelos transgénicos PS1xAPP (SAF2005-05338) Ministerio de Educación y Ciencia (Nacional)
01/01/2010 31/12/2012 Responsable Mecanismos de señalización de la respuesta inflamatoria en la enfermedad de alzheimer: control de la activación microglial como estrategia terapéutica neuroprotectora (PS09/00151) Ministerio de Ciencia e Innovación (Instituto de Salud Carlos III) (Nacional)

Contratos

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
08/07/2004 08/07/2005 Responsable Identification of early markers of disease progression in a murine transgenic model of Alzheimer disease (OG-129/04) Aventis Pharma. Recherche-Développement (Europeo)
05/05/2004 05/05/2005 Responsable Characterisation of the benzodiazepine receptor subtype specificity of (OG-090/04) Aventis Pharma. Recherche-Développement (Europeo)
26/10/2018 25/06/2019 Responsable Efecto del tratamiento con ozono sobre la conducta en ratones transgénicos (PS1delta9-APPI), obtención de muestras de cDNA y proteínas de hipocampo y corteza cerebral (3436/0438) Neural Therapies, S.L. (Nacional)
02/07/2003 02/07/2004 Responsable Identification of early markers of disease progression in a murine transgenic model of alzheimer disease (OG-079/03) Aventis Pharma. Recherche-Développement (Europeo)
01/01/2012 31/07/2013 Responsable SANOFI-AVENTIS (1414/0438) SANOFI-AVENTIS RECHERCHE & DEVELOPMENT (Europeo)
06/06/2001 06/06/2003 Responsable Caracterización molecular de cambios en el sistema GABAergic en el hippocampus de un ratón transgénico que expresa una mutación APP (OG-086/01) Aventis Pharma. Recherche-Développement (Europeo)
22/06/2010 21/12/2011 Responsable Investigaciones referentes al estudio de eficacia de compuesto de interés (01016/0438) NEURON Biopharma, S.A. (Autonómico)

Ayudas

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2004 31/12/2004 Responsable Establecimiento de un modelo in vivo para el desarrollo de fármacos contra la enfermedad de Alzeimer (OTRI/CTS-257) Universidad de Sevilla (Oficina de Transferencia de Resultados de Investigación) (Local)