Francisco Javier Villadiego Luque

Profesor Titular de Universidad
fvilladiego@us.es
Área de conocimiento: Fisiología
Departamento: Fisiología Médica y Biofísica
Grupo: FISIOLOGIA MOLECULAR (CTS-517)
Instituto de Inv.: IBIS
Tipo Año Título Fuente
Artículo2021 Aquaporin-4 mediates permanent brain alterations in a mouse model of hypoxia-aged hydrocephalus INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2021 Evaluation of aquaporins in the cerebrospinal fluid in patients with idiopathic normal pressure hydrocephalus PLOS ONE
Artículo2021 Non-productive angiogenesis disassembles Aß plaque-associated blood vessels. NATURE COMMUNICATIONS
Artículo2020 Is Carotid Body Infection Responsible for Silent Hypoxemia in COVID-19 Patients? Function
Artículo2019 AQP1 and AQP4 Contribution to Cerebrospinal Fluid Homeostasis Cells
Artículo2019 Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes BLOOD
Artículo2018 Combined effects of aquaporin-4 and hypoxia produce age-related hydrocephalus BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Artículo2018 Immunization with alpha-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model GLIA
Artículo2018 Long-term immunosuppression for CNS mouse xenotransplantation: Effects on nigrostriatal neurodegeneration and neuroprotective carotid body cell therapy XENOTRANSPLANTATION
Artículo2018 Synaptic Regulator alpha-Synuclein in Dopaminergic Fibers Is Essentially Required for the Maintenance of Subependymal Neural Stem Cells JOURNAL OF NEUROSCIENCE
Ponencia2016 Antiparkinsonian cell therapy with carotid body is affected by age-related epigenetic regulation of hypoxic GDNF expression HUMAN GENE THERAPY
Artículo2016 Chaperome screening leads to identification of Grp94/Gp96 and FKBP4/52 as modulators of the alpha-synuclein-elicited immune response FASEB JOURNAL
Artículo2016 Chronic and progressive Parkinson's disease MPTP model in adult and aged mice JOURNAL OF NEUROCHEMISTRY
Artículo2016 Comparative Analysis for the Presence of IgG Anti-Aquaporin-1 in Patients with NMO-Spectrum Disorders INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2015 Neurotrophic Properties, Chemosensory Responses and Neurogenic Niche of the Human Carotid Body Advances in Experimental Medicine and Biology
Artículo2014 An immunoassay that distinguishes real neuromyelitis optica signals from a labeling detected in patients receiving natalizumab BMC NEUROLOGY
Artículo2014 Chaperoned amyloid proteins for immune manipulation: alpha-Synuclein/Hsp70 shifts immunity toward a modulatory phenotype IMMUNITY INFLAMMATION AND DISEASE
Capítulo2013 Carotid body transplants as a therapy for Parkinson's disease EMERGING DRUGS AND TARGETS FOR PARKINSON'S DISEASE
Artículo2013 Cellular properties and chemosensory responses of the human carotid body JOURNAL OF PHYSIOLOGY-LONDON
Artículo2013 Direct confocal acquisition of fluorescence from X-gal staining on thick tissue sections SCIENTIFIC REPORTS
Ponencia2013 Expansion of differentiated GDNF-producing carotid body cells by reversible lentiviral gene transfer. Potential use in cell therapy HUMAN GENE THERAPY
Artículo2013 Neuroprotective and reparative effects of carotid body grafts in a chronic MPTP model of Parkinson's disease NEUROBIOLOGY OF AGING
Ponencia2013 Protection and repair of thedopaminergic nigrostriatal pathway by striatal xenografts of in vitro expanded CB cells in a chronic Parkinson's disease model HUMAN GENE THERAPY
Artículo2012 Cografting of carotid body cells improves the long-term survival, fiber outgrowth and functional effects of grafted dopaminergic neurons REGENERATIVE MEDICINE
Capítulo2011 Neuroprotection in Parkinson's disease ANIMAL MODELS FOR NEURODEGENERATIVE DISEASE
Artículo2010 AQP1 mediates water transport in the carotid body PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Artículo2010 Bag1-L is a phosphorylation-dependent coactivator of c-Jun during neuronal apoptosis MOLECULAR AND CELLULAR BIOLOGY
Ponencia2009 Substantia Nigra Dopaminergic Neurons Are Protected by Intraestriatal Carotid Body Grafts in a Chronic MPTP Mouse Model of Parkinson's Disease HUMAN GENE THERAPY
Artículo2009 The neurogenic niche in the carotid body and its applicability to antiparkinsonian cell therapy JOURNAL OF NEURAL TRANSMISSION
Artículo2007 Carotid body autotransplantation in Parkinson disease: a clinical and positron emission tomography study JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Artículo2006 Neuroprotection by transgenic expression of glucose-6-phosphate dehydrogenase in dopaminergic nigrostriatal neurons of mice JOURNAL OF NEUROSCIENCE
Artículo2005 Selective glial cell line-derived neurotrophic factor production in adult dopaminergic carotid body cells in situ and after intrastriatal transplantation JOURNAL OF NEUROSCIENCE

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2013 31/12/2016 Investigador/a Estudio del papel de AQP1 en el desarrollo de la hidrocefalia asociada a hipoxia cerebral (PI12/01882) Ministerio de Economía y Competitividad (Instituto de Carlos III) (Nacional)
01/06/2020 31/05/2023 Responsable Envejecimiento y Regulación de la Expresión de GDNF en el Cuerpo Carotídeo: Relevancia Neuroprotectora (PID2019-105995RB-I00) Ministerio de Ciencia, Innovación y Universidades (Nacional)
30/01/2014 16/05/2019 Investigador/a Terapia Celular en la Enfermedad de Parkinson (P12-CTS-2739) Consejería de Economía, Innovación y Ciencia (Autonómico)
01/01/2015 31/12/2018 Investigador/a Desarrollo de una terapia para el tratamiento de variantes genéticas de alfa-sinucleína en la enfermedad de parkinson (RTC-2015-3309-1) Ministerio de Economía y Competitividad (Nacional)
01/01/2012 01/01/2014 Investigador/a Convenio de colaboración en materia de apoyo a la transferencia tecnológica en el campo de la biotecnología (CVFB12/005) Fundación Marcelino Botín (Nacional)
01/01/2013 31/12/2016 Investigador/a Uso de cuerpo carotideo en terapia celular en la enfermedad de Parkinson (PI12/02574) Ministerio de Economía y Competitividad (Instituto de Carlos III) (Nacional)