Carmen Vargas Macías

Catedrática de Universidad
cvargas@us.es
Área de conocimiento: Microbiología
Departamento: Microbiología y Parasitología
Grupo: BIOESTABILIZADORES DE ORIGEN MICROBIANO (BIO-320)
Prog. doctorado: Prog.Doct.en Biología Molecular, Biomedicina e Investigac.Clínica (RD.2011)
Tipo Año Título Fuente
Artículo2021 New insights into hydroxyectoine synthesis and its transcriptional regulation in the broad-salt growing halophilic bacterium Chromohalobacter salexigens MICROBIAL BIOTECHNOLOGY
Artículo2019 Fructose metabolism in Chromohalobacter salexigens: Interplay between the Embden-Meyerhof-Parnas and Entner-Doudoroff pathways MICROBIAL CELL FACTORIES
Artículo2018 Insights into metabolic osmoadaptation of the ectoines-producer bacterium Chromohalobacter salexigens through a high-quality genome scale metabolic model MICROBIAL CELL FACTORIES
Artículo2018 Quantitative RNA-seq Analysis Unveils Osmotic and Thermal Adaptation Mechanisms Relevant for Ectoine Production in Chromohalobacter salexigens FRONTIERS IN MICROBIOLOGY
Artículo2017 Understanding the interplay of carbon and nitrogen supply for ectoines production and metabolic overflow in high density cultures of Chromohalobacter salexigens MICROBIAL CELL FACTORIES
Artículo2015 Contribution of RpoS to metabolic efficiency and ectoines synthesis during the osmo- and heat-stress response in the halophilic bacterium Chromohalobacter salexigens ENVIRONMENTAL MICROBIOLOGY REPORTS
Artículo2014 The Global Response Regulator RegR Controls Expression of Denitrification Genes in Bradyrhizobium japonicum PLOS ONE
Artículo2013 Burkholderia phymatum improves salt tolerance of symbiotic nitrogen fixation in Phaseolus vulgaris PLANT AND SOIL
Artículo2013 Role of Central Metabolism in the Osmoadaptation of the Halophilic Bacterium Chromohalobacter salexigens JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2013 Temperature- and Salinity-Decoupled Overproduction of Hydroxyectoine by Chromohalobacter salexigens APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Artículo2012 An Extended Suite of Genetic Tools for Use in Bacteria of the Halomonadaceae: An Overview RECOMBINANT GENE EXPRESSION: REVIEWS AND PROTOCOLS, THIRD EDITION
Artículo2012 Isoprenyl-thiourea and urea derivatives as new farnesyl diphosphate analogues: Synthesis and in vitro antimicrobial and cytotoxic activities EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2012 Role of trehalose in heat and desiccation tolerance in the soil bacterium Rhizobium etli BMC MICROBIOLOGY
Artículo2012 Role of Trehalose in Salinity and Temperature Tolerance in the Model Halophilic Bacterium Chromohalobacter salexigens PLOS ONE
Artículo2011 Complete genome sequence of the halophilic and highly halotolerant Chromohalobacter salexigens type strain (1H11(T)) STANDARDS IN GENOMIC SCIENCES
Libro2011 Guía del Farmacéutico Tutor de Farmacia Hospitalaria Guía del Farmacéutico Tutor de Farmacia Hospitalaria
Artículo2010 Biosynthesis of compatible solutes in rhizobial strains isolated from Phaseolus vulgaris nodules in Tunisian fields BMC MICROBIOLOGY
Revisión2010 Ectoines in cell stress protection: Uses and biotechnological production BIOTECHNOLOGY ADVANCES
Artículo2010 Interplay between Iron Homeostasis and the Osmotic Stress Response in the Halophilic Bacterium Chromohalobacter salexigens APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Artículo2010 Involvement of EupR, a response regulator of the NarL/FixJ family, in the control of the uptake of the compatible solutes ectoines by the halophilic bacterium Chromohalobacter salexigens BMC MICROBIOLOGY
Artículo2010 Phenotypic and genotypic characterization of rhizobia associated with Acacia saligna (Labill.) Wendl. in nurseries from Algeria SYSTEMATIC AND APPLIED MICROBIOLOGY
Artículo2008 Experiencia en la docencia virtual de la asignatura "Prácticas Tuteladas" en la Facultad de Farmacia Revista de Enseñanza Universitaria
Ponencia2008 Studies on the recombinant expression of the ectoine pathway in Zymomonas mobilis FEBS JOURNAL
Artículo2008 Unravelling the adaptation responses to osmotic and temperature stress in Chromohalobacter salexigens, a bacterium with broad salinity tolerance Saline Systems
Artículo2006 Ectoines as compatible solutes and carbon and energy sources for the halophilic bacterium Chromohalobacter salexigens JOURNAL OF APPLIED MICROBIOLOGY
Artículo2006 Osmoprotection of Salmonella enterica serovar Typhimurium by N-gamma-acetyldiaminobutyrate, the precursor of the compatible solute ectoine SYSTEMATIC AND APPLIED MICROBIOLOGY
Artículo2006 The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens JOURNAL OF BACTERIOLOGY
Artículo2005 Contribution of chemical changes in membrane lipids to the osmoadaptation of the halophilic bacterium Chromohalobacter salexigens SYSTEMATIC AND APPLIED MICROBIOLOGY
Artículo2004 Complex regulation of the synthesis of the compatible solute ectoine in the halophilic bacterium Chromohalobacter salexigens DSM 3043 MICROBIOLOGY-SGM
Artículo2004 Gene transfer and expression of recombinant proteins in moderately halophilic bacteria. HOST-PATHOGEN INTERACTIONS: METHODS AND PROTOCOLS
Artículo2004 Genetic tools for the manipulation of moderately halophilic bacteria of the family Halomonadaceae. HOST-PATHOGEN INTERACTIONS: METHODS AND PROTOCOLS
Ponencia2004 Membrane lipid alterations in Chromohalobacter salexigens in response to salinity CHEMISTRY AND PHYSICS OF LIPIDS
Artículo2001 Chromohalobacter salexigens sp nov., a moderately halophilic species that includes Halomonas elongata DSM 3043 and ATCC 33174 INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
Artículo2001 Potential role of endogenous brain-derived neurotrophic factor in long-term neuronal reorganization of the superior colliculus after bilateral visual deprivation NEUROBIOLOGY OF DISEASE
Artículo2000 Cloning and expression of alpha-amylase from the hyperthermophilic archaeon Pyrococcus woesei in the moderately halophilic bacterium Halomonas elongata JOURNAL OF APPLIED MICROBIOLOGY
Artículo2000 Genes for the synthesis of the osmoprotectant glycine betaine from choline in the moderately halophilic bacterium Halomonas elongata DSM 3043 MICROBIOLOGY-SGM
Artículo2000 Production and biochemical characterization of an alpha-amylase from the moderate halophile Halomonas meridiana FEMS MICROBIOLOGY LETTERS
Artículo2000 Release of cell-free ice nuclei from Halomonas elongata expressing the ice nucleation gene inaZ of Pseudomonas syringae JOURNAL OF APPLIED MICROBIOLOGY
Artículo2000 The alpha-amylase gene amyH of the moderate halophile Halomonas meridiana: cloning and molecular characterization MICROBIOLOGY-SGM
Artículo2000 Upregulation of BDNF mRNA and trkB mRNA in the nigrostriatal system and in the lesion site following unilateral transection of the medial forebrain bundle EXPERIMENTAL NEUROLOGY
Artículo1999 Analysis of the replication region of the cryptic plasmid pHE1 from the moderate halophile Halomonas elongata MOLECULAR & GENERAL GENETICS
Artículo1999 Differential upregulation of aquaporin-4 mRNA expression in reactive astrocytes after brain injury: Potential role in brain edema NEUROBIOLOGY OF DISEASE
Artículo1999 Genetic organization of the mobilization region of the plasmid pHE1 from Halomonas elongata SYSTEMATIC AND APPLIED MICROBIOLOGY
Artículo1999 Role of N gamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Artículo1998 Characterization of the genes for the biosynthesis of the compatible solute ectoine in the moderately halophilic bacterium Halomonas elongata DSM 3043 SYSTEMATIC AND APPLIED MICROBIOLOGY
Corrección1998 Isolation and characterization of salt-sensitive mutants of the moderate halophile Halomonas elongata and cloning of the ectoine synthesis genes (vol 272, pg 25794, 1997) JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1998 Sulfation of nod factors via nodHPQ is nodD independent in Rhizobium tropici CIAT899 MOLECULAR PLANT-MICROBE INTERACTIONS
Artículo1998 Synthesis of glycine betaine from exogenous choline in the moderately halophilic bacterium Halomonas elongata APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Artículo1997 Expression of 5-HT7 receptor mRNA in rat brain during postnatal development Neuroscience Letters
Artículo1997 Host range, stability and compatibility of broad host-range-plasmids and a shuttle vector in moderately halophilic bacteria. Evidence of intrageneric and intergeneric conjugation in moderate halophiles SYSTEMATIC AND APPLIED MICROBIOLOGY
Artículo1997 Identification of a promoter region on the Halomonas elongata cryptic plasmid pHE1 employing the inaZ reporter gene of Pseudomonas syringae FEMS MICROBIOLOGY LETTERS
Artículo1997 Isolation and characterization of salt-sensitive mutants of the moderate halophile Halomonas elongata and cloning of the ectoine synthesis genes JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1997 Salt-sensitive and auxotrophic mutants of Halomonas elongata and H-meridiana by use of hydroxylamine mutagenesis CURRENT MICROBIOLOGY
Artículo1996 Identification of symbiosis-specific c-type cytochromes and a putative oxidase in bacteroids of Rhizobium leguminosarum biovar viciae MICROBIOLOGY-SGM
Artículo1996 Osmoprotectants in Halomonas elongata: High-affinity betaine transport system and choline-betaine pathway JOURNAL OF BACTERIOLOGY
Artículo1996 The cytochrome bc(1) complex but not CycM is necessary for symbiotic nitrogen fixation by Rhizobium leguminosarum MICROBIOLOGY-SGM
Artículo1995 Characterization of the cycHJKL genes involved in cytochrome c biogenesis and symbiotic nitrogen fixation in Rhizobium leguminosarum JOURNAL OF BACTERIOLOGY
Artículo1995 Development of a gene reporter system in moderately halophilic bacteria by employing the ice nucleation gene of pseudomonas-syringae APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Artículo1995 Influence of salt concentration on the susceptibility of moderately halophilic bacteria to antimicrobials and its potential use for genetic transfer studies CURRENT MICROBIOLOGY
Artículo1995 Isolation of cryptic plasmids from moderately halophilic eubacteria of the genus halomonas - characterization of a small plasmid from h-elongata and its use for shuttle vector construction MOLECULAR & GENERAL GENETICS
Artículo1994 Identification of a gene encoding a thioredoxin-like product necessary for cytochrome c biosynthesis and symbiotic nitrogen fixation in Rhizobium leguminosarum JOURNAL OF BACTERIOLOGY
Ponencia1994 Isolation and characterization of new plasmids from moderately halophilic eubacteria: developing of cloning vectors IMMOBILIZED CELLS: BASICS AND APPLICATIONS
Artículo1993 Detection of c-type cytochromes using enhanced chemiluminescence ANALYTICAL BIOCHEMISTRY
Artículo1992 Characterization of a plasmid from moderately halophilic eubacteria Journal of General Microbiology
Artículo1990 Identification and cloning of nodulation genes and host specificity determinants of the broad host‐range Rhizobium leguminosarum biovar phaseoli strain CIAT899 MOLECULAR MICROBIOLOGY

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/06/2021 31/05/2025 Investigador/a Sustainable Exploitation of bio-based Compounds Revealed and Engineered from natural Sources" (SECRETed) (4150/1099) Comisión Europea (Europeo)
31/12/2005 31/12/2008 Investigador/a Producción de hidroxiectoina por la bacteria halófila chromohalobacter salexigens con fines industriales y uso de los genes biosintéticos en la ingeniería metabólica de bacterias con interés agrícola (BIO2005-06343-C02-01) Ministerio de Educación y Ciencia (Nacional)
01/01/2012 31/12/2014 Responsable Integración de las Redes Metabólicas y Reguladoras de la Bacteria Halófila Productora de Ectoina(S) Chromohalobacter Salexigens (BIO2011-22833) Ministerio de Ciencia e Innovación (Nacional)
01/06/2020 31/05/2023 Responsable Ampliación de la Ingeniería Metabólica de Sistemas de C. Salexigens para la Producción de Ectoínas; Aplicaciones Biomédicas (PID2019-111273RB-I00) Ministerio de Ciencia, Innovación y Universidades (Nacional)
01/03/2004 31/08/2007 Responsable Modulation of plant-bacteria interactions to enhance tolerance to water deficit for grain legumes in the Mediterranean dry lands (AQUARHIZ) (INCO-CT-2004-509115) Commission of the European Communities (Europeo)
13/01/2009 31/07/2012 Investigador/a Desarrollo de la Biología de Sistemas de Chromohalobacter Salexigens para la Producción de Bioestabilizadores con Aplicación en Biomedicina (P08-CVI-03724) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
01/01/2016 31/12/2019 Responsable Nuevas Estrategias de Ingeniería Metabólica en Chromohalobacter Salexigens: Uso Racional de la Biología de Sistemas y la Biología Sintética Aplicada a la Producción de Ectoínas (BIO2015-63949-R) Ministerio de Economía y Competitividad (Nacional)
28/12/2001 27/12/2004 Investigador/a Síntesis de compuestos osmoprotectores por bacterias halófilas moderadas: mecanismos de regulación y su aplicación a la agricultura de suelos áridos (BIO2001-2663) Ministerio de Ciencia y Tecnología (Nacional)
01/01/2009 31/12/2011 Responsable Producción biotecnológica de bioestabilizadores por la bacteria chromohalobacter salexigens (BIO2008-04117) Ministerio de Ciencia e Innovación (Nacional)
26/03/2013 30/09/2016 Responsable Uso de la Bacteria Extremófila Chromohalobacter Salexigens como Factoría Celular de Compuestos de Interés Biomédico (Extremed) (P11-CVI-7293) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
01/09/2007 31/08/2011 Responsable Obtención y Evaluación de Phaseolus vulgaris y Zea mays tolerantes a la sequía (AGROSEQ) (107PIC-0312) CYTED : Programa Iberoamericano de Ciencia y Tecnología (C/ Amaniel, 4 28015 Madrid ESPAÑA) (Europeo)

Ayudas

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
30/12/2008 30/04/2009 Responsable Establecimiento de contactos con empresas de biotecnología andaluzas (OTRI/08-PC39) Universidad de Sevilla (Oficina de Transferencia de Resultados de Investigación) (Local)
01/01/2008 31/12/2008 Responsable Preparación de una propuesta de un proyecto para la convocatoria KBBE-2007-1 del VII Programa Marco de la Unión Europea (AGL2007-29774-E) Ministerio de Educación y Ciencia (Nacional)
25/01/2007 25/07/2007 Responsable Preparación de una propuesta para el VII Programa Marco de la UE dentro de la convocatoria FP7-KBBE-2007-1 (OTRI/06-PC08) Universidad de Sevilla(Oficina de Transferencia de Resultados de Investigación) (Local)
13/03/2006 31/12/2007 Investigador/a Unravilling the osmoregulatory network in the extremophilic bacterium chromohalobacter salexigens: from genome analysis to biochemical function (HG2005-0018) Ministerio de Educación y Ciencia (Nacional)