Martiniano Santiago Pavón

Catedrático de Universidad
msantiago@us.es
Área de conocimiento: Bioquímica y Biología Molecular
Departamento: Bioquímica y Biología Molecular
Grupo: MECANISMOS DE MUERTE CELULAR EN ENFERMEDADES NEURODEGENERATIVAS (BIO-113)
Instituto de Inv.: IBIS
Tipo Año Título Fuente
Artículo2021 Antioxidant Effect of Hydroxytyrosol, Hydroxytyrosol Acetate and Nitrohydroxytyrosol in a Rat MPP+ Model of Parkinson’s Disease NEUROCHEMICAL RESEARCH
Artículo2021 Galectin-3 Deletion Reduces LPS and Acute Colitis-Induced Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon FRONTIERS IN PHARMACOLOGY
Artículo2021 Selective deletion of Caspase-3 gene in the dopaminergic system exhibits autistic-like behaviour PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Artículo2020 Hydroxycinnamic acid derivatives isolated from hempseed and their effects on central nervous system enzymes INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
Revisión2019 Reformulating Pro-Oxidant Microglia in Neurodegeneration JOURNAL OF CLINICAL MEDICINE
Artículo2018 Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson's Disease FRONTIERS IN CELLULAR NEUROSCIENCE
Artículo2016 Metformin, besides exhibiting strong in vivo anti-inflammatory properties, increases mptp-induced damage to the nigrostriatal dopaminergic system TOXICOLOGY AND APPLIED PHARMACOLOGY
Artículo2015 Deletion of caspase-8 in mouse myeloid cells blocks microglia proinflammatory activation and confers protection in MPTP neurodegeneration model AGING-US
Artículo2015 Effect of intracerebral hydroxytyrosol and its nitroderivatives on striatal dopamine metabolism: A study by in vivo microdialysis LIFE SCIENCES
Artículo2015 Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation CELL REPORTS
Artículo2014 Chronic stress as a risk factor for Alzheimer's disease REVIEWS IN THE NEUROSCIENCES
Ponencia2014 Effect of nitroderivatives of hydroxytyrosol on oxidative status and catechol-O-methyl transferase activity in rat's tissue BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Artículo2014 In vivo Effect of Apomorphine and Haloperidol on MPP+ Neurotoxicity PHARMACOLOGY
Artículo2014 In vivo striatal measurement of hydroxytyrosol, and its metabolite (homovanillic alcohol), compared with its derivative nitrohydroxytyrosol Neuroscience Letters
Artículo2014 Role of dopamine in the recruitment of immune cells to the nigro-striatal dopaminergic structures NEUROTOXICOLOGY
Artículo2014 The effect of hydroxytyrosol and its nitroderivatives on catechol-O-methyl transferase activity in rat striatal tissue RSC ADVANCES
Artículo2012 Peripheral inflammation increases the deleterious effect of CNS inflammation on the nigrostriatal dopaminergic system NEUROTOXICOLOGY
Artículo2011 Inflammatory animal models for parkinson's disease: the intranigral injection of LPS induced the inflammatory process along with the selective degeneration of nigrostriatal dopaminergic neurons ISRN Neurology
Revisión2011 Peripheral Inflammation Increases the Damage in Animal Models of Nigrostriatal Dopaminergic Neurodegeneration: Possible Implication in Parkinson's Disease Incidence PARKINSONS DISEASE
Ponencia2011 Synthesis of hydroxytyrosol nitroderivatives as COMT inhibitors BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Artículo2010 Effect of in vivo striatal perfusion of lipopolysaccharide on dopamine metabolites Neuroscience Letters
Artículo2010 Striatal ablation of GABAergic neurons prevents the in vivo neuroprotective effect of DCG-IV against the MPP+-induced neurotoxicity on dopaminergic nerve terminals NEUROCHEMISTRY INTERNATIONAL
Artículo2009 Zocor Forte (R) (simvastatin) has a neuroprotective effect against LPS striatal dopaminergic terminals injury, whereas against MPP+ does not EUROPEAN JOURNAL OF PHARMACOLOGY
Artículo2008 Endogenous dopamine enhances the neurotoxicity of 3-nitropropionic acid in the striatum through the increase of mitochondrial respiratory inhibition and free radicals production NEUROTOXICOLOGY
Artículo2008 Simvastatin prevents the inflammatory process and the dopaminergic degeneration induced by the intranigral injection of lipopolysaccharide JOURNAL OF NEUROCHEMISTRY
Artículo2006 Acute perfusion of BMAA in the rat's striatum by in vivo microdialysis TOXICOLOGY LETTERS
Artículo2003 Evidence for dopamine-derived hydroxyl radical formation in the nigrostriatal system in response to axotomy FREE RADICAL BIOLOGY AND MEDICINE
Artículo2002 DCG-IV but not other group-II metabotropic receptor agonists induces microglial BDNF mRNA expression in the rat striatum. Correlation with neuronal injury NEUROSCIENCE
Artículo2001 Group II metabotropic glutamate receptor activation protects striatal dopaminergic nerve terminals against MPP+-induced neurotoxicity along with brain-derived neurotrophic factor induction JOURNAL OF NEUROCHEMISTRY
Artículo2001 Validity of a quantitative technique to study striatal dopaminergic neurodegeneration by in vivo microdialysis JOURNAL OF NEUROSCIENCE METHODS
Artículo2000 Decreased messenger RNA expression of key markers of the nigrostriatal dopaminergic system following vitamin E deficiency in the rat NEUROSCIENCE
Artículo2000 Histamine infusion induces a selective dopaminergic neuronal death along with an inflammatory reaction in rat substantia nigra JOURNAL OF NEUROCHEMISTRY
Artículo2000 Neurotoxic relationship between dopamine and iron in the striatal dopaminergic nerve terminals BRAIN RESEARCH
Ponencia1998 Dopamine and iron synergistic neurotoxic effect in striatal dopaminergic nerve terminals. EUROPEAN JOURNAL OF NEUROSCIENCE
Artículo1998 Influence of serotoninergic drugs on in vivo dopamine extracellular output in rat striatum JOURNAL OF NEUROSCIENCE RESEARCH
Artículo1997 Involvement of iron in MPP+ toxicity in substantia nigra: Protection by desferrioxamine BRAIN RESEARCH
Artículo1997 Lack of involvement of glutamate-induced excitotoxicity in MPP+ toxicity in striatal dopaminergic terminals: Possible involvement of ascorbate BRITISH JOURNAL OF PHARMACOLOGY
Artículo1997 Neuroprotective effect of the iron chelator desferrioxamine against MPP+ toxicity on striatal dopaminergic terminals JOURNAL OF NEUROCHEMISTRY
Artículo1996 MK-801 partially protects against the acute MPP(+) depleting effect on dopamine levels in rat striatal slices NEUROCHEMISTRY INTERNATIONAL
Artículo1996 Nigral and striatal comparative study of the neurotoxic action of 1-methyl-4-phenylpyridinium ion: Involvement of dopamine uptake system JOURNAL OF NEUROCHEMISTRY
Ponencia1996 The iron chelator desferrioxamine protects against MPP+ neurotoxicity. JOURNAL OF NEUROCHEMISTRY
Artículo1995 5-ht3 receptor agonist-induced carrier-mediated release of dopamine in rat striatum in-vivo BRITISH JOURNAL OF PHARMACOLOGY
Artículo1995 Analysis of ceftriaxone and ceftazidime distribution in cerebrospinal-fluid of and cerebral extracellular-space in awake rats by in-vivo microdialysis ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Artículo1995 Complex-i inhibitor effect on the nigral and striatal release of dopamine in the presence and absence of nomifensine EUROPEAN JOURNAL OF PHARMACOLOGY
Artículo1995 Effect of intraventricular-injection of 1-methyl-4-phenylpyridinium - protection by acetyl-l-carnitine Human & Experimental Toxicology: An International Journal
Artículo1994 Do nerve-terminals and cell-bodies of nigrostriatal dopaminergic-neurons of the rat contain similar receptors Neuroscience Letters
Artículo1994 Effect of L-arginine nitric-oxide pathway on mpp(+)-induced cell injury in the striatum of rats BRITISH JOURNAL OF PHARMACOLOGY
Ponencia1994 Study of the 5-HT(3) agonist-induced dopamine release MONITORING MOLECULES IN NEUROSCIENCE
Artículo1993 Are bilateral nigrostriatal dopaminergic pathways functionally linked in the rat-brain - a microdialysis study in conscious rats BRAIN RESEARCH
Artículo1993 Effects of age and dopamine agonists and antagonists on striatal dopamine release in the rat - an invivo microdialysis study MECHANISMS OF AGEING AND DEVELOPMENT
Artículo1993 In-vivo release of dopamine from rat striatum, substantia-nigra and prefrontal cortex - differential modulation by baclofen BRITISH JOURNAL OF PHARMACOLOGY
Artículo1993 Regulation of prefrontal cortical dopamine release by dopamine-receptor agonists and antagonists EUROPEAN JOURNAL OF PHARMACOLOGY
Artículo1993 Regulation of the prefrontal cortical dopamine release by GABA(A) and GABA(B) receptor agonists and antagonists BRAIN RESEARCH
Artículo1992 Fast sodium-channel dependency of the somatodendritic release of dopamine in the rats brain Neuroscience Letters
Artículo1992 Invivo evidence for a concordant response of terminal and dendritic dopamine release during intranigral infusion of drugs NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
Artículo1992 Invivo protection of striatum from mpp+ neurotoxicity by n-methyl-d-aspartate antagonists BRAIN RESEARCH
Artículo1992 Simultaneous recording of the release of nigral and striatal dopamine in the awake rat NEUROCHEMISTRY INTERNATIONAL
Artículo1992 The release of dopamine from nerve-terminals and dendrites of nigrostriatal neurons induced by excitatory amino-acids in the conscious rat NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
Artículo1992 The role of GABA receptors in the control of nigrostriatal dopaminergic-neurons - dual-probe microdialysis study in awake rats EUROPEAN JOURNAL OF PHARMACOLOGY
Artículo1991 Acute effects of intranigral application of mpp+ on nigral and bilateral striatal release of dopamine simultaneously recorded by microdialysis BRAIN RESEARCH
Artículo1991 Characterization and pharmacological responsiveness of dopamine release recorded by microdialysis in the substantia-nigra of conscious rats JOURNAL OF NEUROCHEMISTRY
Ponencia1991 Dopamine release in adult and aged rats: comparison by microdialysis MONITORING MOLECULES IN NEUROSCIENCE
Artículo1991 Effects of neonatal bilateral eye enucleation on postnatal-development of the monoamines in posterior thalamus of the rat JOURNAL OF NEURAL TRANSMISSION
Artículo1991 Responsiveness of striatal dopamine release in awake animals after chronic 1-methyl-4-phenylpyridinium ion-induced lesions of the substantia-nigra JOURNAL OF NEUROCHEMISTRY
Ponencia1991 The connections of nigrostriatal dopaminergic-neurons studied by dual-probe microdialysis MONITORING MOLECULES IN NEUROSCIENCE
Artículo1991 The regulation of dopamine release from nigrostriatal neurons in conscious rats - the role of somatodendritic autoreceptors EUROPEAN JOURNAL OF PHARMACOLOGY
Artículo1990 Characterization of the in vivo release of dopamine as recorded by different types of intracerebral microdialysis probes NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
Artículo1990 Effects of enucleation on postnatal-development of catecholamines and serotonin metabolism in the superior colliculus of the rat BRAIN RESEARCH
Artículo1990 Neonatal enucleation alters catecholamine and serotonin metabolism in the lateral geniculate and visual-cortex in developing rats NEUROCHEMISTRY INTERNATIONAL
Artículo1990 Role of adenylate-cyclase in the modulation of the release of dopamine - a microdialysis study in the striatum of the rat JOURNAL OF NEUROCHEMISTRY
Artículo1989 Age-related changes of catecholamines and their metabolites content in the visual system of the rat MECHANISMS OF AGEING AND DEVELOPMENT
Artículo1989 Determination of monoamines and both forms of monoamine-oxidase in the rats substantia nigra during postnatal-development LIFE SCIENCES
Artículo1988 Changes in biogenic-amines in rat hippocampus during development and aging LIFE SCIENCES
Artículo1987 Age-related-changes of serotonin and its metabolites content in the visual-system of the rat MECHANISMS OF AGEING AND DEVELOPMENT
Artículo1986 The change with age in biogenic-amines and their metabolites in the striatum of the rat ARCHIVES OF GERONTOLOGY AND GERIATRICS

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/03/2006 28/02/2009 Investigador/a La enfermedad de Parkinson: Diagnostico en estado subclinico (EXC/2005/CTS-1014) Junta de Andalucía (Plan Andaluz de Investigación) (Autonómico)
15/03/2011 30/04/2016 Investigador/a Estudio de los Mecanismos Moleculares que Regulan la Inflamación Cerebral y la Longevidad. Diseño de Estrategias Farmacológicas Encaminadas a Minimizar el Daño Neuronal Asociado a la Inflamación Cerebral en Modelos Animales de Enfermedades Neurodegenerativas (P10-CTS-6494) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
01/02/2020 31/01/2022 Investigador/a Papel de la Galectina -3 en el Envejecimiento Cerebral (US-1264806) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico)
03/03/2011 03/03/2015 Investigador/a Estudio de los Cambios que Experimentan con el Envejecimiento las Rutas que Promueven la Supervivencia Celular y la Inflamación Cerebral: Modulación de las Mismas para Conseguir un Envejecimiento Saludable y Minimizar la Neurodegeneración (P09-CTS-5244) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
01/01/2019 31/12/2021 Investigador/a Papel de la Galectina-3 en la Respuesta Inmune Asociada a Enfermedades del Sistema Nervioso Central. Implicación en Enfermedades Neurodegenerativas y Glioblastoma Multiforme (RTI2018-098645-B-I00) Ministerio de Ciencia, Innovación y Universidades (Nacional)
13/12/2004 13/12/2007 Investigador/a Estudio de la influencia de la dopamina y el estrés en los procesos inflamatorios y degenerativos inducidos por la inyección de lipopolisacárido en el SNC (SAF2004-06601) Ministerio de Ciencia y Tecnología (Nacional)
03/02/2010 02/08/2014 Investigador/a Aprovechamiento de Subproductos de la Industria Olivarera. Síntesis y Evaluación de Nuevos Antioxidantes con Potencial Aplicación en el Tratamiento del Parkinson (P09-AGR-5098) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
01/01/2016 31/12/2018 Investigador/a Funciones Apoptóticas y no Apoptóticas de las Caspasas Asesinas en el Sistema Nervioso Central en Condiciones Normales y Patológicas (SAF2015-64171-R) Ministerio de Economía y Competitividad (Nacional)
01/06/2020 31/05/2023 Investigador/a Contribución de las Caspasas-3 & 7 en la Etiología de la Enfermedad de Alzheimer (PID2019-107948RA-I00) Ministerio de Ciencia, Innovación y Universidades (Nacional)
28/12/2001 27/12/2004 Investigador/a Degeneración del sistema dopaminérgico negro-estriado: marcadores de la velocidad de degeneración (Posible diagnóstico del estadio subclínico de la enfermedad de Parkinson); estudio de los mecanismos de supervivencia producido por GDNF y deprenilo (BFI2001-3600) Ministerio de Ciencia y Tecnología (Nacional)
01/10/2007 04/10/2011 Responsable Estudio del proceso de eliminación de sinapsis: implicación en enfermedades degenerativas, Parkinson y Alzheimer (SAF2007-62425) Ministerio de Educación y Ciencia (Nacional)
01/01/2013 31/12/2015 Investigador/a Papel de la Caspasa-8 en el Proceso de Inflamación Cerebral Asociado a la Neurodegeneración (SAF2012-39029) Ministerio de Economía y Competitividad (Nacional)
01/01/2020 31/12/2022 Investigador/a Modulación de la activación microglial asociada a neurodegeneración, relevancia en enfermedades neurodegenerativas (P18-RT-1372) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico)