Elena Matilde Sánchez Fernández

Profesora Titular de Universidad
esanchez4@us.es
Área de conocimiento: Química Orgánica
Departamento: Química Orgánica
Grupo: QUIMICA BIOORGANICA DE CARBOHIDRATOS (FQM-308)
Prog. doctorado: Programa de Doctorado en Química (RD. 99/2011)
Tipo Año Título Fuente
Artículo2021 Anti-inflammatory (M2) response is induced by a sp(2)-iminosugar glycolipid sulfoxide in diabetic retinopathy FRONTIERS IN IMMUNOLOGY
Artículo2020 Amplified Detection of Breast Cancer Autoantibodies Using MUC1-Based Tn Antigen Mimics JOURNAL OF MEDICINAL CHEMISTRY
Capítulo2020 sp2-Iminosugars as chemical mimics for glycodrug design Small molecule drug discovery: methods, molecules and applications
Artículo2020 Stereoselective Synthesis of Iminosugar 2-Deoxy(thio)glycosides from Bicyclic Iminoglycal Carbamates Promoted by Cerium(IV) Ammonium Nitrate and Cooperative Bronsted Acid-Type Organocatalysis JOURNAL OF ORGANIC CHEMISTRY
Artículo2020 Synthesis, conformational analysis and: In vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment CHEMICAL SCIENCE
Artículo2019 Mannose-coated polydiacetylene (PDA)-based nanomicelles: synthesis, interaction with concanavalin A and application in the water solubilization and delivery of hydrophobic molecules JOURNAL OF MATERIALS CHEMISTRY B
Artículo2019 sp(2)-Iminosugar glycolipids as inhibitors of lipopolysaccharide-mediated human dendritic cell activation in vitro and of acute inflammation in mice in vivo EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2019 Synthesis of polyfluoroalkyl sp2-iminosugar glycolipids and evaluation of their immunomodulatory properties towards anti-tumor, anti-leishmanial and anti-inflammatory therapies EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2019 Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp(2)-Iminosugar Glycolipids MOLECULES
Artículo2018 Nuevas estrategias en el proceso de enseñanza-aprendizaje de la asignatura Experimentación Química II del Grado en Ingeniería Química Industrial Jornadas de Formación e Innovación Docente del Profesorado
Artículo2018 The sp(2)-iminosugar glycolipid 1-dodecylsulfony1-5N,6O-oxomethylidenenojirimycin (DSO2-ONJ) as selective anti-inflammatory agent by modulation of hemeoxygenase-1 in Bv.2 microglial cells and retinal explants FOOD AND CHEMICAL TOXICOLOGY
Artículo2017 Fluorinated Chaperone-beta-Cyclodextrin Formulations for beta-Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease JOURNAL OF MEDICINAL CHEMISTRY
Ponencia2017 Fluorinated chaperone-beta-cyclodextrin formulations for neuronopathic Gaucher disease MOLECULAR GENETICS AND METABOLISM
Artículo2017 sp(2)-Iminosugar -glucosidase inhibitor 1-C-octyl-2-oxa-3-oxocastanospermine specifically affected breast cancer cell migration through Stim1, 1-integrin, and FAK signaling pathways JOURNAL OF CELLULAR PHYSIOLOGY
Artículo2016 Conformationally-locked C-glycosides: tuning aglycone interactions for optimal chaperone behaviour in Gaucher fibroblasts ORGANIC & BIOMOLECULAR CHEMISTRY
Corrección2016 Generalized Anomeric Effect in gem-Diamines: Stereoselective Synthesis of alpha-N-Linked Disaccharide Mimics (vol 11, pg 3306, 2009) ORGANIC LETTERS
Artículo2016 Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, G(M1)-gangliosidosis and Fabry diseases CHEMICAL COMMUNICATIONS
Artículo2016 Influence of the configurational pattern of sp(2)-iminosugar pseudo N-, S-, O- and C-glycosides on their glycoside inhibitory and antitumor properties CARBOHYDRATE RESEARCH
Ponencia2016 Modulation of microglia polarization dynamics by a sp2-iminosugar derivative during diabetic retinophaty in db/db mice EUROPEAN JOURNAL OF OPHTHALMOLOGY
Artículo2016 Modulation of microglia polarization dynamics during diabetic retinopathy in db/db mice BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Artículo2016 Tn Antigen Mimics Based on sp(2)-Iminosugars with Affinity for an anti-MUC1 Antibody ORGANIC LETTERS
Artículo2016 Tuning of glyconanomaterial shape and size for selective bacterial cell agglutination JOURNAL OF MATERIALS CHEMISTRY B
Artículo2015 Antileishmanial activity of sp(2)-iminosugar derivatives RSC ADVANCES
Artículo2014 Synthesis of Multibranched Australine Derivatives from Reducing Castanospermine Analogues through the Amadori Rearrangement of gem-Diamine Intermediates: Selective Inhibitors of beta-Glucosidase JOURNAL OF ORGANIC CHEMISTRY
Artículo2013 Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase BIOCHEMICAL JOURNAL
Artículo2013 N-Thiocarbonyl Iminosugars: Synthesis and Evaluation of Castanospermine Analogues Bearing Oxazole-2(3H)-thione Moieties EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2013 New Castanospermine Glycoside Analogues Inhibit Breast Cancer Cell Proliferation and Induce Apoptosis without Affecting Normal Cells PLOS ONE
Artículo2012 Efficient transfection of hepatocytes mediated by mRNA complexed to galactosylated cyclodextrins BIOCONJUGATE CHEMISTRY
Artículo2012 sp2-Iminosugar O-, S-, and N-Glycosides as Conformational Mimics of a-Linked Disaccharides; Implications for Glycosidase Inhibition CHEMISTRY-A EUROPEAN JOURNAL
Artículo2010 Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral alpha-glucosidase inhibitory activity as antitumour agents CHEMICAL COMMUNICATIONS
Artículo2009 Generalized Anomeric Effect in gem-Diamines: Stereoselective Synthesis of alpha-N-Linked Disaccharide Mimics ORGANIC LETTERS
Revisión2008 Asymmetric synthesis of N,O,O,O-tetra-acetyl D-lyxo-phytosphingosine, jaspine B (pachastrissamine), 2-epi-jaspine B, and deoxoprosophylline via lithium amide conjugate addition ORGANIC & BIOMOLECULAR CHEMISTRY
Corrección2008 Asymmetric synthesis of N,O,O,O-tetra-acetyl D-lyxo-phytosphingosine, jaspine B (pachastrissamine), 2-epi-jaspine B, and deoxoprosophylline via lithium amide conjugate addition (vol 6, pg 1665, 2008) ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2007 Asymmetric synthesis of N,O,O,O-tetra-acetyl D-lyxo-phytosphingosine, jaspine B (pachastrissamine) and its C(2)-epimer TETRAHEDRON-ASYMMETRY
Artículo2007 Couplings of benzylic halides mediated by titanocene chloride: synthesis of bibenzyl derivatives JOURNAL OF ORGANIC CHEMISTRY
Artículo2007 Mild TiIII- and Mn/ZrIV-catalytic reductive coupling of allylic halides: Efficient synthesis of symmetric terpenes JOURNAL OF ORGANIC CHEMISTRY
Artículo2006 Asymmetric synthesis of alpha-mercapto-beta-amino acid derivatives: application to the synthesis of polysubstituted thiomorpholines TETRAHEDRON-ASYMMETRY
Artículo2006 Chemical composition of the essential oil from the leaves of juniperus phoenicea l. from north africa Journal of Essential Oil Research
Artículo2006 Regio- and diastereoselective reductive coupling of vinylepoxides catalyzed by titanocene chloride ORGANIC LETTERS
Artículo2006 Solid-phase selenium-catalyzed selective allylic chlorination of polyprenoids: facile syntheses of biologically active terpenoids JOURNAL OF ORGANIC CHEMISTRY
Artículo2006 Synthesis of five- to seven-membered polyfunctional terpenic carbocycles via ti(iii)-catalyzed radical cyclizations of epoxypolyprenes: nature-inspired approaches to chemical synthesis TETRAHEDRON
Revisión2006 Titanocene-mediated radical cyclization: an emergent method towards the synthesis of natural products EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2006 Transannular cyclization of epoxycaryophyllenes catalyzed by ti-iii: an efficient synthesis of tricyclo[6.3.0.0(2,5)]undecanes EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2005 Mild protocols for generating molecular complexity: A comparative study of hetero-domino reactions based on the oxidant and the substitution pattern EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2005 Modeling the effect of substitution on the pb(oac) 4 mediated oxidative cleavage of steroidal 1,2-diols JOURNAL OF ORGANIC CHEMISTRY
Artículo2005 Reductive coupling of terpenic allylic halides catalyzed by cp2ticl: a short and efficient asymmetric synthesis of onocerane triterpenes ORGANIC LETTERS
Artículo2005 Sulfanyl radical-induced cyclization of linalyl acetate to the iridane skeleton: a short synthesis of (+/-)-dehydroiridomyrmecin SYNLETT
Artículo2003 Lead tetraacetate mediated domino reactions on (R)-(-)-carvone-derived bicyclic unsaturated 1,2-diols and further rearrangements TETRAHEDRON-ASYMMETRY
Sintesis estereoselectivas de terpenoides bioactivos via procesos radicalarios (2006)
Dirigida por: Alejandro Fernández Barrero, María del Mar Herrador

Tesis dirigidas/tutorizadas:1
Fecha lectura Título Rol
06/05/2016 GLICOTERAPIAS CONTRA EL CANCER, LA LEISHMANIASIS Y ENFERMEDADES DE DEPÓSITO LISOSOMAL Director/a

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
13/01/2009 31/12/2013 Investigador/a Diseño de Inhibidores de Glicosidasas para el Tratamiento de Enfermedades Lisosomiales: Sintesis de Sp2-Azucares y Evaluación en Terapias de Acompañante Químico (P08-FQM-03711) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
30/12/2016 31/12/2020 Investigador/a Terapias Basadas en Glicomiméticos para el Tratamiento de Enfermedades de Plegamiento de Proteínas, Inflamación y Cáncer. (SAF2016-76083-R) Ministerio de Economía y Competitividad (Nacional)
01/07/2013 30/06/2017 Investigador/a Glycodrugs: new strategies for controlling the activity of glycosidase enzymes and their application in therapies for lysosomal storage diseases and cancer (GLYCODRUGS) (333594) Commission of the European Communities (Europeo)
01/01/2014 31/12/2017 Investigador/a Chaperonas, Inhibidores y Nutracéuticos Basados en Carbohidratos para Aplicaciones Biomédicas: Desórdenes de Depósito Lisosomal, Cáncer y Enfermedad de Crohn (SAF2013-44021-R) Ministerio de Economía y Competitividad (Nacional)
16/03/2010 16/03/2013 Investigador/a Iminoazúcares sp2 como chaperonas químicas: una estrategia general para el tratamiento de desórdenes de almacenamiento lisosomial (FRA2009-001) Fundación Ramón Areces (Nacional)
01/06/2020 31/05/2023 Investigador/a Miméticos de Glicoconjugados: Nuevas Estrategias en Glicomedicina Dirigidas a Enfermedades Neurológicas y del Sistema Immune (PID2019-105858RB-I00) Ministerio de Ciencia, Innovación y Universidades (Nacional)