Diego Ruano Caballero

Catedrático de Universidad
ruano@us.es
Área de conocimiento: Bioquímica y Biología Molecular
Departamento: Bioquímica y Biología Molecular
Grupo: ENVEJECIMIENTO Y NEURODEGENERACIÓN (CTS-257)
Instituto de Inv.: IBIS
Prog. doctorado: Prog.Doct.en Biología Molecular, Biomedicina e Investigac.Clínica (RD.2011)
Tipo Año Título Fuente
Revisión2021 Proteostasis dysfunction in aged mammalian cells. The stressful role of inflammation FRONTIERS IN MOLECULAR BIOSCIENCES
Artículo2020 Autophagic receptor p62 protects against glycation-derived toxicity and enhances viability AGING CELL
Artículo2018 SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons CELL DEATH & DISEASE
Artículo2017 Neuroinflammation alters cellular proteostasis by producing endoplasmic reticulum stress, autophagy activation and disrupting ERAD activation SCIENTIFIC REPORTS
Revisión2016 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) AUTOPHAGY
Corrección2016 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd edition) (vol 12, pg 1, 2015) AUTOPHAGY
Artículo2015 Age-related dysfunctions of the autophagy lysosomal pathway in hippocampal pyramidal neurons under proteasome stress NEUROBIOLOGY OF AGING
Artículo2015 Anti-inflammatory activity of phenolic extracts from different parts of prickly pear on lipopolysaccharide-stimulated N13 microglial cells International Journal of Phytomedicine
Artículo2015 Breast cancer cell line MCF7 escapes from G(1)/S arrest induced by proteasome inhibition through a GSK-3 beta dependent mechanism SCIENTIFIC REPORTS
Ponencia2015 Breast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3 beta dependent mechanism FEBS JOURNAL
Artículo2014 Learning improvement after PI3K activation correlates with de novo formation of functional small spines FRONTIERS IN MOLECULAR NEUROSCIENCE
Artículo2013 GSK-3 beta signaling determines autophagy activation in the breast tumor cell line MCF7 and inclusion formation in the non-tumor cell line MCF10A in response to proteasome inhibition CELL DEATH & DISEASE
Artículo2012 Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus ACTA NEUROPATHOLOGICA
Artículo2012 Age-related differences in the dynamics of hippocampal proteasome recovery JOURNAL OF NEUROCHEMISTRY
Artículo2012 Anti-inflammatory Activity of a Honey Flavonoid Extract on Lipopolysaccharide-Activated N13 Microglial Cells JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo2012 Centrosomal aggregates and Golgi fragmentation disrupt vesicular trafficking of DAT NEUROBIOLOGY OF AGING
Artículo2012 Different activated microglial response in human hippocampus during Alzheimer's disease progression Alzheimer's & Dementia
Artículo2012 Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus JOURNAL OF NEUROINFLAMMATION
Artículo2011 Age-dependent Accumulation of Soluble Amyloid beta (A beta) Oligomers Reverses the Neuroprotective Effect of Soluble Amyloid Precursor Protein-alpha (sAPP alpha) by Modulating Phosphatidylinositol 3-Kinase (PI3K)/Akt-GSK-3 beta Pathway in Alzheimer Mouse Model JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2011 Axonal neuritic pathology induces early presynaptic alterations in ps1/APP Alzheimer's mice hippocampus Alzheimer's & Dementia
Artículo2011 Regional difference in inflammatory response to LPS-injection in the brain: Role of microglia cell density JOURNAL OF NEUROIMMUNOLOGY
Artículo2011 Somatostatin interneurons are early targets in the hippocampus of APP-based Alzheimer transgenic mice Alzheimer's & Dementia
Artículo2010 Age and meloxicam attenuate the ischemia/reperfusion-induced down-regulation in the NMDA receptor genes NEUROCHEMISTRY INTERNATIONAL
Artículo2010 Calretinin Interneurons are Early Targets of Extracellular Amyloid-beta Pathology in PS1/A beta PP Alzheimer Mice Hippocampus JOURNAL OF ALZHEIMERS DISEASE
Artículo2010 Degeneration of calretinin interneurons is associated to the early onset of extracellular amyloid pathology in Alzheimer mice hippocampus Alzheimer's & Dementia
Artículo2009 Age-related increase in the immunoproteasome content in rat hippocampus: molecular and functional aspects JOURNAL OF NEUROCHEMISTRY
Artículo2009 Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition AGING CELL
Artículo2009 Extracellular Amyloid-beta and Cytotoxic Glial Activation Induce Significant Entorhinal Neuron Loss in Young PS1(M146L)/APP(751SL) Mice JOURNAL OF ALZHEIMERS DISEASE
Artículo2008 Distribution of NADPH-diaphorase and nitric oxide synthase reactivity in the central nervous system of the goldfish (Carassius auratus) JOURNAL OF CHEMICAL NEUROANATOMY
Artículo2008 Inflammatory Response in the Hippocampus of PS1(M146L)/APP(751SL) Mouse Model of Alzheimer's Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic JOURNAL OF NEUROSCIENCE
Ponencia2008 Phenotypic and functional switch in microglial cells correlates with neurodegeneration in the hippocampus of aged PS1XAPP transgenic model of alzheimer's disease Alzheimer's & Dementia
Artículo2007 Inter-individual variability in the expression of the mutated form of hPS1M146L determined the production of A beta peptides in the PS1xAPP transgenic mice JOURNAL OF NEUROSCIENCE RESEARCH
Artículo2007 Molecular and cellular characterization of the age-related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons JOURNAL OF NEUROCHEMISTRY
Ponencia2007 Possible dual neuroprotective/neurotoxic effect of inflammatory reaction in the hippocampus of a PS1 x APP transgenic model of Alzheimer's disease JOURNAL OF NEUROCHEMISTRY
Artículo2006 Cellular environment facilitates protein accumulation in aged rat hippocampus NEUROBIOLOGY OF AGING
Artículo2006 Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1 x APP transgenic model of Alzheimer's disease NEUROBIOLOGY OF AGING
Artículo2006 Nucleus-specific abnormalities of GABAergic synaptic transmission in a genetic model of absence seizures JOURNAL OF NEUROPHYSIOLOGY
Artículo2006 Role of p38 and inducible nitric oxide synthase in the in vivo dopaminergic cells' degeneration induced by inflammatory processes after lipopolysaccharide injection NEUROSCIENCE
Artículo2004 Expression of alpha 5 GABA(A) receptor subunit in developing rat hippocampus DEVELOPMENTAL BRAIN RESEARCH
Artículo2004 Postnatal development of the alpha 1 containing GABA(A) receptor subunit in rat hippocampus DEVELOPMENTAL BRAIN RESEARCH
Ponencia2004 The gabaergic system is preferentially affected in PS1XAPP transgenic mice NEUROBIOLOGY OF AGING
Artículo2003 Rat hippocampal GABAergic molecular markers are differentially affected by ageing JOURNAL OF NEUROCHEMISTRY
Ponencia2002 The hippocampal gabaergic system is preferentially affected in APPxPS1 transgenic mice NEUROBIOLOGY OF AGING
Artículo2001 Prevalence between different α subunits performing the benzodiazepine binding sites in native heterologous GABAA receptors containing the α2 subunit JOURNAL OF NEUROCHEMISTRY
Artículo2001 Rapid PCR-mediated synthesis of competitor molecules for accurate quantification of beta(2) GABA(A) receptor subunit mRNA BRAIN RESEARCH PROTOCOLS
Artículo2000 GABA(A) and alpha-amino-3-hydroxy-5-methylsoxazole-4-propionate receptors are differentially affected by aging in the rat hippocampus JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2000 Subunit composition of rat ventral spinal cord GABA(A) receptors, assessed by single cell RT-multiplex PCR NEUROREPORT
Artículo1999 Native gamma-aminobutyric acid type A receptors from rat hippocampus, containing both alpha 1 and alpha 5 subunits, exhibit a single benzodiazepine binding site with alpha 5 pharmacological properties JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Artículo1998 Absence of association between δ and γ2 subunits in native GABA(A) receptors from rat brain EUROPEAN JOURNAL OF PHARMACOLOGY
Artículo1998 Pharmacological properties of the GABA(A) receptor complex from brain regions of (hypoemotional) Roman high- and (hyperemotional) low-avoidance rats EUROPEAN JOURNAL OF PHARMACOLOGY
Artículo1997 Expression of GABA(A) receptor subunit mRNAs by layer V pyramidal cells of the rat primary visual cortex EUROPEAN JOURNAL OF NEUROSCIENCE
Artículo1997 GABA(A) receptor subunit expression changes in the rat cerebellum and cerebral cortex during aging MOLECULAR BRAIN RESEARCH
Artículo1996 Age-related modifications on the GABA(A) receptor binding properties from Wistar rat prefrontal cortex BRAIN RESEARCH
Artículo1996 Aging-related subunit expression changes of the GABA(A) receptor in the rat hippocampus NEUROSCIENCE
Artículo1996 Molecular and pharmacological characterization of native cortical gamma-aminobutyric acid(A) receptors containing both alpha(1) and alpha(3) subunits JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1995 Aging‐Associated Changes in the Pharmacological Properties of the Benzodiazepine (ω) Receptor Isotypes in the Rat Hippocampus JOURNAL OF NEUROCHEMISTRY
Artículo1995 Kainate receptor subunits expressed in single cultured hippocampal-neurons - molecular and functional variants by rna editing NEURON
Artículo1994 Molecular characterization of type-i GABA(a) receptor complex from rat cerebral-cortex and hippocampus MOLECULAR BRAIN RESEARCH
Nota1994 Molecular heterogeneity of the type-i GABA(a) benzodiazepine receptor complex EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION
Artículo1993 Absence of modifications of the pharmacological properties of the gaba(a) receptor complex during aging, as assessed in 3-month-old and 24-month-old rat cerebral-cortex EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION
Artículo1993 Comparative autoradiographic distribution of central omega (benzodiazepine) modulatory site subtypes with high, intermediate and low affinity for zolpidem and alpidem BRAIN RESEARCH
Artículo1993 Regional differences in the enhancement by gaba of [h-3] zolpidem binding to omega-1 sites in rat-brain membranes and sections BRAIN RESEARCH
Artículo1992 Heterogeneity in the allosteric interaction between the gamma-aminobutyric-acid (gaba) binding-site and 3 different benzodiazepine binding-sites of the gaba(a) benzodiazepine receptor complex in the rat nervous-system JOURNAL OF NEUROCHEMISTRY
Artículo1991 Pharmacologic characterization of GABA(A)/benzodiazepine receptor in rat hippocampus during aging JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/03/2006 28/02/2009 Investigador/a Mecanismos Moleculares y Celulares Implicados en los Procesos Neurodegenerativos Durante el Envejecimiento y en la Enfermedad de Alzheimer (EXC/2005/CVI-902) Junta de Andalucía (Plan Andaluz de Investigación) (Autonómico)
17/10/2006 30/12/2009 Responsable Modificaciones relacionadas con la edad en la respuesta del estrés de retículo y en el sistema glutamatérgico frente a agentes inductores del daño celular: similitud con procesos neurodegenerativos (PI060781) Ministerio de Sanidad y Consumo (Instituto de Salud Carlos III) (Nacional)
03/02/2010 03/02/2013 Investigador/a Control de la Diferenciación Microglial Como Posible Estrategia Terapéutica en la Enfermedad de Alzheimer (P09-CTS-4795) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
01/01/2010 31/12/2012 Responsable Papel de la autofagia en procesos neurodegenerativos inducidos por disfunción del proteasoma o daño isquémico: implicación del envejecimiento y la inflamación (PS09/00848) Ministerio de Ciencia e Innovación (Instituto de Salud Carlos III) (Nacional)
01/01/2003 31/12/2005 Investigador/a Cambios durante el envejecimiento en los sistemas GABAérgico, colinérgico y glutamatérgico en modelos transgéncios de la enfermedad de alzheimer (SAF2002-03448) Ministerio de Ciencia y Tecnología (Nacional)
30/01/2014 16/02/2019 Investigador/a Oligomerización y Toxicidad de los Péptidos de Abeta: Búsqueda de Nuevas Dianas de Interés Terapéutico en la Enfermedad de Alzheimer (P12-CTS-2035) Consejería de Economía, Innovación y Ciencia (Autonómico)
01/08/2003 31/03/2005 Investigador/a Establecimiento de un modelo in vivo para el desarrollo de fármacos contra la enfermedad de Alzheimer (PTR1995-0704-OP) Ministerio de Ciencia y Tecnología (Nacional)
01/01/2013 30/04/2016 Responsable Efecto de la neuroinflamacion sobre la activación de las vías UPR, ERAD Y Akt/GSK3/b-catenina en respuesta al bloqueo del proteosoma. Relación con la neurodegeneración hipocampal (PI12/00445) Ministerio de Economía y Competitividad (Instituto de Carlos III) (Nacional)
01/01/2004 30/12/2006 Responsable Estudio de la implicación de la inflamación y del estrés celular en los proceso neurodegenerativos relacionados con la edad: envejecimiento normal y enfermedad de Alzheimer (PI030177) Ministerio de Sanidad y Consumo (Instituto de Salud Carlos III) (Nacional)

Contratos

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
06/06/2001 06/06/2003 Investigador/a Caracterización molecular de cambios en el sistema GABAergic en el hippocampus de un ratón transgénico que expresa una mutación APP (OG-086/01) Aventis Pharma. Recherche-Développement (Europeo)
05/05/2004 05/05/2005 Investigador/a Characterisation of the benzodiazepine receptor subtype specificity of (OG-090/04) Aventis Pharma. Recherche-Développement (Europeo)
08/07/2004 08/07/2005 Investigador/a Identification of early markers of disease progression in a murine transgenic model of Alzheimer disease (OG-129/04) Aventis Pharma. Recherche-Développement (Europeo)

Ayudas

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2004 31/12/2004 Investigador/a Establecimiento de un modelo in vivo para el desarrollo de fármacos contra la enfermedad de Alzeimer (OTRI/CTS-257) Universidad de Sevilla (Oficina de Transferencia de Resultados de Investigación) (Local)