Francisco Romero Portillo

Catedrático de Universidad
frport@us.es
Área de conocimiento: Microbiología
Departamento: Microbiología
Grupo: TRANSMISION DE SENAL EN CELULAS DE MAMIFEROS (BIO-211)
Prog. doctorado: Prog.Doct.en Biología Molecular, Biomedicina e Investigac.Clínica (RD.2011)
Tipo Año Título Fuente
Artículo2020 EDIL3 promotes epithelial–mesenchymal transition and paclitaxel resistance through its interaction with integrin αVβ3 in cancer cells Cell Death Discovery
Artículo2020 p53 and FBXW7: Sometimes Two Guardians Are Worse than One CANCERS
Artículo2020 Tubulin Folding Cofactor TBCB is a Target of the Salmonella Effector Protein SseK1 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2019 SCF(FBXW7)-mediated degradation of p53 promotes cell recovery after UV-induced DNA damage FASEB JOURNAL
Artículo2018 Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells CANCERS
Ponencia2018 Role of SCF(FBXW7) on cell proliferation recovery after UV treatment FEBS OPEN BIO
Artículo2017 Both p62/SQSTM1-HDAC6-dependent autophagy and the aggresome pathway mediate CDK1 degradation in human breast cancer SCIENTIFIC REPORTS
Artículo2017 G(1)/S phase progression is regulated by PLK1 degradation through the CDK1/beta TrCP axis FASEB JOURNAL
Ponencia2017 HSP90 regulates the G1/S transition and cell cycle progression in a PLK1-dependent manner FEBS JOURNAL
Artículo2016 Loss of FBXW7 and accumulation of MCL1 and PLK1 promote paclitaxel resistance in breast cancer ONCOTARGET
Artículo2016 Loss of PKC delta Induces Prostate Cancer Resistance to Paclitaxel through Activation of Wnt/beta-Catenin Pathway and Mcl-1 Accumulation MOLECULAR CANCER THERAPEUTICS
Artículo2015 Breast cancer cell line MCF7 escapes from G(1)/S arrest induced by proteasome inhibition through a GSK-3 beta dependent mechanism SCIENTIFIC REPORTS
Ponencia2015 Breast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3 beta dependent mechanism FEBS JOURNAL
Capítulo2015 Ciclo celular y tumorogénesis hipofisaria Actualización en neuroendocrinología
Artículo2014 betaTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy ONCOTARGET
Artículo2014 Prostate Cancer Cell Response to Paclitaxel Is Affected by Abnormally Expressed Securin PTTG1 MOLECULAR CANCER THERAPEUTICS
Artículo2014 SCFFBXW7a modulates the intra-S-phase DNA-damage checkpoint by regulating Polo like kinase-1 stability ONCOTARGET
Artículo2013 A single mutation in Securin induces chromosomal instability and enhances cell invasion EUROPEAN JOURNAL OF CANCER
Ponencia2012 A single mutation in Securin induces chromosomal instability and enhances cell invasion FEBS JOURNAL
Ponencia2012 Disabled-1 protein in the intestine Genes & Nutrition
Ponencia2012 Downregulation of protein tyrosine phosphatase PTPL1 alters cell cycle and upregulates invasion-related genes in prostate cancer cells FEBS JOURNAL
Ponencia2012 SCF-FBW7 alpha targets polo-like kinase 1 for degradation in a cell cycle-dependent manner FEBS JOURNAL
Ponencia2012 Ubiquitin-mediated lysosomal degradation of cyclin-dependent kinase 1 FEBS JOURNAL
Artículo2011 Glycogen Synthase Kinase-3 beta (GSK3 beta) Negatively Regulates PTTG1/Human Securin Protein Stability, and GSK3 beta Inactivation Correlates with Securin Accumulation in Breast Tumors JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2008 UV-induced degradation of securin is mediated by SKP1-CUL1-beta TrCP E3 ubiquitin ligase JOURNAL OF CELL SCIENCE
Artículo2006 Protein phosphatase 2A stabilizes human securin, whose phosphorylated forms are degraded via the SCF ubiquitin ligase MOLECULAR AND CELLULAR BIOLOGY
Artículo2005 Characterization of VIK-1: a new Vav-interacting Kruppel-like protein ONCOGENE
Artículo2004 Securin is a target of the UV response pathway in mammalian cells MOLECULAR AND CELLULAR BIOLOGY
Artículo2004 The effect of FITA mutations on the symbiotic properties of Sinorhizobium fredii varies in a chromosomal-background-dependent manner ARCHIVES OF MICROBIOLOGY
Artículo2002 Expression of hpttg proto-oncogene in lymphoid neoplasias ONCOGENE
Artículo2002 Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis NATURE GENETICS
Ponencia2001 Characterization of a new kruppel like protein as a putative cell cycle regulated partner of vav BIOLOGY OF THE CELL
Artículo2001 Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase NUCLEIC ACIDS RESEARCH
Artículo2000 Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product ONCOGENE
Artículo1999 Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization EMBO JOURNAL
Artículo1999 Brèves M S-MEDECINE SCIENCES
Artículo1999 hpttg is over-expressed in pituitary adenomas and other primary epithelial neoplasias ONCOGENE
Artículo1999 hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways MOLECULAR AND CELLULAR BIOLOGY
Artículo1998 Grb2 and its apoptotic isoform Grb3-3 associate with heterogeneous nuclear ribonucleoprotein C, and these interactions are modulated by poly(U) RNA JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1998 hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG ONCOGENE
Artículo1998 Vav binding to heterogeneous nuclear ribonucleoprotein (hnRNP) C - Evidence for Vav-hnRNP interactions in an RNA-dependent manner JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1997 A conditionally expressed third partner stabilizes or prevents the formation of a transcriptional activator in a three-hybrid system JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1997 A new member of the amphiphysin family connecting endocytosis and signal transduction pathways JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1997 Expression of the Rhizobium leguminosarum biovar phaseoli melA gene in other rhizobia does not require the presence of the nifA gene AUSTRALIAN JOURNAL OF PLANT PHYSIOLOGY
Artículo1997 Vav, a protein with multiple signaling domains M S-MEDECINE SCIENCES
Artículo1996 Detection of a physical and functional interaction between Csk and Lck which involves the SH2 domain of Csk and is mediated by autophosphorylation of Lck on tyrosine 394 JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1996 P95(vav) associates with the nuclear protein Ku-70 MOLECULAR AND CELLULAR BIOLOGY
Artículo1996 Structure and function of vav CELLULAR SIGNALLING
Artículo1995 Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1995 The proline-rich region of Vav binds to Grb2 and Grb3-3 ONCOGENE
Artículo1993 Broad-host-range effective mutants of rhizobium-fredii strains JOURNAL OF APPLIED BACTERIOLOGY
Artículo1990 Propiedades Simbióticas y Alteraciones en los Perfiles de Plásmidos de Dos Estirpes de Rhizobium Fredii Portadoras del Plásmido Simbiótico P42d de Rhizobium Leguminosarum Biovariedad Phaseoli Investigacion Agraria. Produccion y Proteccion Vegetales
Artículo1989 Inter and Intraspecific Transfer of a Rhizobium fredii Symbiotic Plasmid: Expression and Incompatibility of Symbiotic Plasmids SYSTEMATIC AND APPLIED MICROBIOLOGY

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2018 31/12/2020 Responsable La Desregulación de la Estabilidad de las Proteínas como Mecanismo de Sensibilización a las Quimioterapias Basadas en Platinos (SAF2017-87358-C2-1-R) Ministerio de Economía y Competitividad (Nacional)
01/12/2002 01/12/2005 Investigador/a Papel de la hSecurina/hPTTG en la transformación y crecimiento tumoral (SAF2002-04177-C04-03) Ministerio de Ciencia y Tecnología (Nacional)
31/12/2005 31/12/2008 Investigador/a Anáisis funcional de la fosforilación de securina, papel de la securina en la respuesta de la célula a los daños en el ADN (SAF2005-07713-C03-01) Ministerio de Educación y Ciencia (Nacional)
01/01/2009 31/12/2011 Responsable Las alteraciones de la degradación de las proteínas que controlan el ciclo celular como mecanismo de tumorigénesis (SAF2008-03095) Ministerio de Ciencia e Innovación (Nacional)
13/01/2009 31/12/2013 Investigador/a Cáncer y Degradoma: Estabilización de Oncoproteínas y Desestabilización de Supresores Tumorales. (P08-CVI-03603) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
01/01/2012 31/12/2014 Responsable Nuevos Sustratos de la E3 Ubiquitín Ligasa Skp1-Cul1-F Box (SAF2011-30003-C02-01) Ministerio de Ciencia e Innovación (Nacional)
01/01/2015 30/09/2018 Responsable La Degradación de Proteínas Mediada por Ubiquitinación en el Cáncer: Implicaciones Terapéuticas (SAF2014-53799-C2-1-R) Ministerio de Economía y Competitividad (Nacional)