Joaquín José Nieto Gutiérrez

Catedrático de Universidad
jjnieto@us.es
Área de conocimiento: Microbiología
Departamento: Microbiología y Parasitología
Grupo: BIOESTABILIZADORES DE ORIGEN MICROBIANO (BIO-320)
Prog. doctorado: Prog.Doct.en Biología Molecular, Biomedicina e Investigac.Clínica (RD.2011)
Tipo Año Título Fuente
Artículo2021 New insights into hydroxyectoine synthesis and its transcriptional regulation in the broad-salt growing halophilic bacterium Chromohalobacter salexigens MICROBIAL BIOTECHNOLOGY
Artículo2019 Fructose metabolism in Chromohalobacter salexigens: Interplay between the Embden-Meyerhof-Parnas and Entner-Doudoroff pathways MICROBIAL CELL FACTORIES
Artículo2018 Insights into metabolic osmoadaptation of the ectoines-producer bacterium Chromohalobacter salexigens through a high-quality genome scale metabolic model MICROBIAL CELL FACTORIES
Artículo2018 Quantitative RNA-seq Analysis Unveils Osmotic and Thermal Adaptation Mechanisms Relevant for Ectoine Production in Chromohalobacter salexigens FRONTIERS IN MICROBIOLOGY
Artículo2017 Understanding the interplay of carbon and nitrogen supply for ectoines production and metabolic overflow in high density cultures of Chromohalobacter salexigens MICROBIAL CELL FACTORIES
Artículo2015 Contribution of RpoS to metabolic efficiency and ectoines synthesis during the osmo- and heat-stress response in the halophilic bacterium Chromohalobacter salexigens ENVIRONMENTAL MICROBIOLOGY REPORTS
Artículo2013 Role of Central Metabolism in the Osmoadaptation of the Halophilic Bacterium Chromohalobacter salexigens JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2013 Temperature- and Salinity-Decoupled Overproduction of Hydroxyectoine by Chromohalobacter salexigens APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Artículo2012 An Extended Suite of Genetic Tools for Use in Bacteria of the Halomonadaceae: An Overview RECOMBINANT GENE EXPRESSION: REVIEWS AND PROTOCOLS, THIRD EDITION
Artículo2012 Isoprenyl-thiourea and urea derivatives as new farnesyl diphosphate analogues: Synthesis and in vitro antimicrobial and cytotoxic activities EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2012 Role of trehalose in heat and desiccation tolerance in the soil bacterium Rhizobium etli BMC MICROBIOLOGY
Artículo2012 Role of Trehalose in Salinity and Temperature Tolerance in the Model Halophilic Bacterium Chromohalobacter salexigens PLOS ONE
Artículo2011 Complete genome sequence of the halophilic and highly halotolerant Chromohalobacter salexigens type strain (1H11(T)) STANDARDS IN GENOMIC SCIENCES
Artículo2010 Biosynthesis of compatible solutes in rhizobial strains isolated from Phaseolus vulgaris nodules in Tunisian fields BMC MICROBIOLOGY
Revisión2010 Ectoines in cell stress protection: Uses and biotechnological production BIOTECHNOLOGY ADVANCES
Artículo2010 Interplay between Iron Homeostasis and the Osmotic Stress Response in the Halophilic Bacterium Chromohalobacter salexigens APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Artículo2010 Involvement of EupR, a response regulator of the NarL/FixJ family, in the control of the uptake of the compatible solutes ectoines by the halophilic bacterium Chromohalobacter salexigens BMC MICROBIOLOGY
Artículo2010 Phenotypic and genotypic characterization of rhizobia associated with Acacia saligna (Labill.) Wendl. in nurseries from Algeria SYSTEMATIC AND APPLIED MICROBIOLOGY
Artículo2009 Synchronous diagnosis of multiple tumours in a postmenopausal woman ARCHIVES OF GYNECOLOGY AND OBSTETRICS
Artículo2008 Unravelling the adaptation responses to osmotic and temperature stress in Chromohalobacter salexigens, a bacterium with broad salinity tolerance Saline Systems
Artículo2006 Ectoines as compatible solutes and carbon and energy sources for the halophilic bacterium Chromohalobacter salexigens JOURNAL OF APPLIED MICROBIOLOGY
Artículo2006 Osmoprotection of Salmonella enterica serovar Typhimurium by N-gamma-acetyldiaminobutyrate, the precursor of the compatible solute ectoine SYSTEMATIC AND APPLIED MICROBIOLOGY
Artículo2006 The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens JOURNAL OF BACTERIOLOGY
Artículo2005 Contribution of chemical changes in membrane lipids to the osmoadaptation of the halophilic bacterium Chromohalobacter salexigens SYSTEMATIC AND APPLIED MICROBIOLOGY
Artículo2004 Complex regulation of the synthesis of the compatible solute ectoine in the halophilic bacterium Chromohalobacter salexigens DSM 3043 MICROBIOLOGY-SGM
Artículo2004 Gene transfer and expression of recombinant proteins in moderately halophilic bacteria. HOST-PATHOGEN INTERACTIONS: METHODS AND PROTOCOLS
Artículo2004 Genetic tools for the manipulation of moderately halophilic bacteria of the family Halomonadaceae. HOST-PATHOGEN INTERACTIONS: METHODS AND PROTOCOLS
Ponencia2004 Membrane lipid alterations in Chromohalobacter salexigens in response to salinity CHEMISTRY AND PHYSICS OF LIPIDS
Artículo2001 Chromohalobacter salexigens sp nov., a moderately halophilic species that includes Halomonas elongata DSM 3043 and ATCC 33174 INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
Artículo2000 Cloning and expression of alpha-amylase from the hyperthermophilic archaeon Pyrococcus woesei in the moderately halophilic bacterium Halomonas elongata JOURNAL OF APPLIED MICROBIOLOGY
Artículo2000 Genes for the synthesis of the osmoprotectant glycine betaine from choline in the moderately halophilic bacterium Halomonas elongata DSM 3043 MICROBIOLOGY-SGM
Artículo2000 Production and biochemical characterization of an alpha-amylase from the moderate halophile Halomonas meridiana FEMS MICROBIOLOGY LETTERS
Artículo2000 Release of cell-free ice nuclei from Halomonas elongata expressing the ice nucleation gene inaZ of Pseudomonas syringae JOURNAL OF APPLIED MICROBIOLOGY
Artículo2000 The alpha-amylase gene amyH of the moderate halophile Halomonas meridiana: cloning and molecular characterization MICROBIOLOGY-SGM
Artículo1999 Analysis of the replication region of the cryptic plasmid pHE1 from the moderate halophile Halomonas elongata MOLECULAR & GENERAL GENETICS
Artículo1999 Genetic organization of the mobilization region of the plasmid pHE1 from Halomonas elongata SYSTEMATIC AND APPLIED MICROBIOLOGY
Artículo1999 Role of N gamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Artículo1998 Analysis of the genome of the gram-negative moderate halophiles Halomonas and Chromohalobacter by using pulsed-field gel electrophoresis EXTREMOPHILES
Revisión1998 Biology of moderately halophilic aerobic bacteria MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
Artículo1998 Characterization of the genes for the biosynthesis of the compatible solute ectoine in the moderately halophilic bacterium Halomonas elongata DSM 3043 SYSTEMATIC AND APPLIED MICROBIOLOGY
Corrección1998 Isolation and characterization of salt-sensitive mutants of the moderate halophile Halomonas elongata and cloning of the ectoine synthesis genes (vol 272, pg 25794, 1997) JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1998 Numerical taxonomy of heavy metal-tolerant nonhalophilic bacteria isolated from hypersaline environments INTERNATIONAL MICROBIOLOGY
Artículo1998 Synthesis of glycine betaine from exogenous choline in the moderately halophilic bacterium Halomonas elongata APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Artículo1997 Analysis of the genome of Vibrio costicola: Pulsed-field gel electrophoretic analysis of genome size and plasmid content SYSTEMATIC AND APPLIED MICROBIOLOGY
Artículo1997 Host range, stability and compatibility of broad host-range-plasmids and a shuttle vector in moderately halophilic bacteria. Evidence of intrageneric and intergeneric conjugation in moderate halophiles SYSTEMATIC AND APPLIED MICROBIOLOGY
Artículo1997 Identification of a promoter region on the Halomonas elongata cryptic plasmid pHE1 employing the inaZ reporter gene of Pseudomonas syringae FEMS MICROBIOLOGY LETTERS
Artículo1997 Isolation and characterization of salt-sensitive mutants of the moderate halophile Halomonas elongata and cloning of the ectoine synthesis genes JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1997 Salt-sensitive and auxotrophic mutants of Halomonas elongata and H-meridiana by use of hydroxylamine mutagenesis CURRENT MICROBIOLOGY
Artículo1996 Analysis of 16S rRNA gene sequences of Vibrio costicola strains: Description of Salinivibrio costicola gen nov, comb nov INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY
Artículo1996 Osmoprotectants in Halomonas elongata: High-affinity betaine transport system and choline-betaine pathway JOURNAL OF BACTERIOLOGY
Artículo1995 Biotechnological applications and potentialities of halophilic microorganisms WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
Artículo1995 Characterization of the basic replicon of pcm1, a narrow-host-range plasmid from the moderate halophile chromohalobacter-marismortui JOURNAL OF BACTERIOLOGY
Artículo1995 Construction of novel shuttle vectors for use between moderately halophilic bacteria and Escherichia coli PLASMID
Artículo1995 Development of a gene reporter system in moderately halophilic bacteria by employing the ice nucleation gene of pseudomonas-syringae APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Artículo1995 Influence of salt concentration on the susceptibility of moderately halophilic bacteria to antimicrobials and its potential use for genetic transfer studies CURRENT MICROBIOLOGY
Artículo1995 Isolation of cryptic plasmids from moderately halophilic eubacteria of the genus halomonas - characterization of a small plasmid from h-elongata and its use for shuttle vector construction MOLECULAR & GENERAL GENETICS
Artículo1995 Phylogenetic inferences and taxonomic consequences of 16s ribosomal dna-sequence comparison of chromohalobacter-marismortui, volcaniella-eurihalina, and deleya-salina and reclassification of volcaniella-eurihalina as halomonas-eurihalina comb-nov INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY
Ponencia1994 Isolation and characterization of new plasmids from moderately halophilic eubacteria: developing of cloning vectors IMMOBILIZED CELLS: BASICS AND APPLICATIONS
Artículo1993 DNA-rRNA hybridization studies on Halococcus saccharolyticus and other halobacteria FEMS MICROBIOLOGY LETTERS
Artículo1993 Survey of antimicrobial susceptibility of moderately halophilic eubacteria and extremely halophilic aerobic archaeobacteria - utilization of antimicrobial resistance as a genetic-marker SYSTEMATIC AND APPLIED MICROBIOLOGY
Artículo1992 Characterization of a plasmid from moderately halophilic eubacteria Journal of General Microbiology
Artículo1992 Ethyl methanesulfonate mutagenesis in extremely halophilic archaebacteria - isolation of auxotrophic mutants of haloferax-mediterranei and haloferax-gibbonsii CURRENT MICROBIOLOGY
Ponencia1992 Physical map of a 257 kilobase-pairs region from the genome of Halococcus saccharolyticus BIOCHEMICAL SOCIETY TRANSACTIONS
Artículo1991 Physical map of a 257 kilobase-pairs region from the genome of the archaebacterium halococcus-saccharolyticus CURRENT MICROBIOLOGY
Ponencia1991 The response of halophilic bacteria to heavy metals GENERAL AND APPLIED ASPECTS OF HALOPHILIC MICROORGANISMS
Artículo1990 Efficient hydroxylamine mutagenesis of Haloferax-mediterranei and other extremely halophilic archaebacteria CURRENT MICROBIOLOGY
Artículo1989 Survey of metal tolerance in moderately halophilic eubacteria APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Artículo1989 Toxicity of heavy-metals to archaebacterial halococci SYSTEMATIC AND APPLIED MICROBIOLOGY
Artículo1988 Isolation and partial characterization of a plasmid in the extremely halophilic archaebacterium halococcus-morrhuae ccm-537 Journal of General Microbiology
Nota1987 Susceptibility of halobacteria to heavy-metals APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Artículo1987 The susceptibility of the moderate halophile vibrio-costicola to heavy-metals JOURNAL OF APPLIED BACTERIOLOGY
Artículo1986 Occurrence of megaplasmids in halobacteria JOURNAL OF APPLIED BACTERIOLOGY
Artículo1984 Divisional and regenerative morphogenesis in the Hypotrichous ciliate, Histriculus sp Acta Protozoologica
Artículo1984 Etude ultratructurale de la morphogenese corticale de regeneration chez le cilie hypotriche histriculus similis Protistologica (Paris. 1965)
Artículo1984 Lethality and mutagenicity in halobacterium-mediterranei caused by n-methyl-n'-nitro-n-nitrosoguanidine CURRENT MICROBIOLOGY
Artículo1984 Ultrastructural-study of the cortical morphogenesis of regeneration in the hypotrich ciliate histriculus-similis Protistologica (Paris. 1965)
Artículo1983 Light as an energy-source in continuous cultures of bacteriorhodopsin-containing halobacteria APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Artículo1982 Ciclo celular de histriculus muscorum Boletín de la Real Sociedad Española de Historia Natural. Sección geológica
Artículo1981 Regeneration of gastrostyla-steinii Acta Protozoologica
Artículo1980 Cellular-cycle in Gastrostyla-steinii Acta Protozoologica

Tesis dirigidas/tutorizadas:10
Fecha lectura Título Rol
11/07/2014 ANÁLISIS MULTI-ÓMICO DE LA RESPUESTA A ESTRÉS OSMÓTICO Y TÉRMICO EN LA BACTERIA EXTREMÓFILA CRHOMOHALOBACTER SALEXIGENS Director/a
11/02/2011 MANIPULACIÓN GENÉTICA DE LA BACTERIA HALÓFILA CHROMOHALOBACTER SALEXIGENS PARA LA PRODUCCIÓN DE LOS BIOESTABILIZADORES ECTOÍNA E HIDROXIECTOÍNA Director/a
12/03/2010 PAPEL DE LOS SOLUTOS COMPATIBLES HIDROXIECTOÍNA Y TREHALOSA EN LA TOLERANCIA AL ESTRÉS TÉRMICO Y A LA DESECACIÓN EN LAS BACTERIAS CHROMOHALOBACTER SALEXIGENS Y RHIZOBIUM ETLI Director/a
05/05/2006 CARACTERIZACIÓN FISIOLÓGICA Y MOLECULAR DE LA SÍNTESIS DEL SOLUTO COMPATIBLE HIDROXIECTOÍNA EN LA BACTERIA HALÓFILA CHROMOHALOBACTER SALEXIGENS Director/a
06/05/2003 Genética de solutos compatibles en bacterias halófilas moderada Director/a
05/02/1999 Transferencia genética en bacterias halófilas moderadas. Caracterización y clonación de una α-amilasa producida por Halomonas meridiana Director/a
22/01/1999 Bases moleculares de los mecanismos de osmorregulación en bacterias halófilas moderadas Director/a
1995 Bacterias halofilas moderadas: filogenia y construccion de vectores de clonacion Director/a
1994 Estudio de la microbiota autóctona en piscifactorías dedicadas al cultivo de Dorada española (Sparus aurata), con especial atención al patógeno oportunista Vibrio alginolyticus Director/a
1987 Producción de poli-β-hidroxibutirato y mutagénesis química en Haloferax mediterranei y otras halobacterias Director/a

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2016 31/12/2019 Investigador/a Nuevas Estrategias de Ingeniería Metabólica en Chromohalobacter Salexigens: Uso Racional de la Biología de Sistemas y la Biología Sintética Aplicada a la Producción de Ectoínas (BIO2015-63949-R) Ministerio de Economía y Competitividad (Nacional)
01/09/2007 31/08/2011 Investigador/a Obtención y Evaluación de Phaseolus vulgaris y Zea mays tolerantes a la sequía (AGROSEQ) (107PIC-0312) CYTED : Programa Iberoamericano de Ciencia y Tecnología (C/ Amaniel, 4 28015 Madrid ESPAÑA) (Europeo)
01/06/2020 31/05/2023 Investigador/a Ampliación de la Ingeniería Metabólica de Sistemas de C. Salexigens para la Producción de Ectoínas; Aplicaciones Biomédicas (PID2019-111273RB-I00) Ministerio de Ciencia, Innovación y Universidades (Nacional)
01/01/2009 31/12/2011 Investigador/a Producción biotecnológica de bioestabilizadores por la bacteria chromohalobacter salexigens (BIO2008-04117) Ministerio de Ciencia e Innovación (Nacional)
13/01/2009 31/07/2012 Responsable Desarrollo de la Biología de Sistemas de Chromohalobacter Salexigens para la Producción de Bioestabilizadores con Aplicación en Biomedicina (P08-CVI-03724) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
01/06/2009 31/12/2011 Responsable Desarrollo de la biología de sistemas de chromohalobacter salexigens para la producción de bioestabilizadores con aplicación en biomedicina (CCP08-CVI-03724) Universidad de Murcia (Nacional)
28/12/2001 27/12/2004 Responsable Síntesis de compuestos osmoprotectores por bacterias halófilas moderadas: mecanismos de regulación y su aplicación a la agricultura de suelos áridos (BIO2001-2663) Ministerio de Ciencia y Tecnología (Nacional)
01/01/2012 31/12/2014 Investigador/a Integración de las Redes Metabólicas y Reguladoras de la Bacteria Halófila Productora de Ectoina(S) Chromohalobacter Salexigens (BIO2011-22833) Ministerio de Ciencia e Innovación (Nacional)
01/10/2000 31/12/2003 Responsable Agriculture under extreme environmental conditions in Latin America by using osmoprotection genes to generate stress-resistant potato and bean plants (AGRECILA) (ICA4-CT-2000-30041) Commission of the European Communities (Research Directorate-General) (Europeo)
26/03/2013 30/09/2016 Investigador/a Uso de la Bacteria Extremófila Chromohalobacter Salexigens como Factoría Celular de Compuestos de Interés Biomédico (Extremed) (P11-CVI-7293) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
31/12/2005 31/12/2008 Responsable Producción de hidroxiectoina por la bacteria halófila chromohalobacter salexigens con fines industriales y uso de los genes biosintéticos en la ingeniería metabólica de bacterias con interés agrícola (BIO2005-06343-C02-01) Ministerio de Educación y Ciencia (Nacional)

Ayudas

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
13/03/2006 31/12/2007 Responsable Unravilling the osmoregulatory network in the extremophilic bacterium chromohalobacter salexigens: from genome analysis to biochemical function (HG2005-0018) Ministerio de Educación y Ciencia (Nacional)
25/01/2007 25/07/2007 Investigador/a Preparación de una propuesta para el VII Programa Marco de la UE dentro de la convocatoria FP7-KBBE-2007-1 (OTRI/06-PC08) Universidad de Sevilla(Oficina de Transferencia de Resultados de Investigación) (Local)
01/01/2008 31/12/2008 Investigador/a Preparación de una propuesta de un proyecto para la convocatoria KBBE-2007-1 del VII Programa Marco de la Unión Europea (AGL2007-29774-E) Ministerio de Educación y Ciencia (Nacional)
19/01/2007 19/01/2008 Responsable Etude des mécanismes physiologiques et moléculaires impliqués dans l’osmoregulation chez des souches de Rhizobium nodulant la féve et le pois chiche isolées de sols afectés par la sécheresse (A/6574/06) Agencia Española de Cooperación Internacional (Internacional)
30/12/2008 30/04/2009 Investigador/a Establecimiento de contactos con empresas de biotecnología andaluzas (OTRI/08-PC39) Universidad de Sevilla (Oficina de Transferencia de Resultados de Investigación) (Local)