Antonio José Moreno Vargas

Profesor Titular de Universidad
ajmoreno@us.es
Área de conocimiento: Química Orgánica
Departamento: Química Orgánica
Grupo: QUÍMICA DE BIOMOLÉCULAS Y ANÁLOGOS (FQM-345)
Prog. doctorado: Programa de Doctorado en Química (RD. 99/2011)
Tipo Año Título Fuente
Artículo2020 Influence of the surfactant degree of oligomerization on the formation of cyclodextrin: surfactant inclusion complexes Arabian Journal of Chemistry
Artículo2020 Regioselectivity of the 1,3-Dipolar Cycloaddition of Organic Azides to 7-Heteronorbornadienes. Synthesis of beta-Substituted Furans/Pyrroles JOURNAL OF ORGANIC CHEMISTRY
Artículo2020 Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Artículo2020 Synthesis of multimeric pyrrolidine iminosugar inhibitors of human β-glucocerebrosidase and α-galactosidase A: First example of a multivalent enzyme activity enhancer for Fabry disease EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2019 Azabicyclic vinyl sulfones for residue-specific dual protein labelling Electronic supplementary information (ESI) available: Detailed methods and additional characterisation. See DOI: 10.1039/c9sc00125e CHEMICAL SCIENCE
Artículo2019 Dual targeting of PTP1B and glucosidases with new bifunctional iminosugar inhibitors to address type 2 diabetes BIOORGANIC CHEMISTRY
Artículo2019 Exploring substituent diversity on pyrrolidine-aryltriazole iminosugars: Structural basis of beta-glucocerebrosidase inhibition BIOORGANIC CHEMISTRY
Artículo2019 Structural basis of the inhibition of GH1 β-glucosidases by multivalent pyrrolidine iminosugars BIOORGANIC CHEMISTRY
Artículo2018 Discovery of a Potent alpha-Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine-(Thio)urea Hybrid Molecules Generated via Click Chemistry JOURNAL OF ORGANIC CHEMISTRY
Artículo2018 Harnessing pyrrolidine iminosugars into dimeric structures for the rapid discovery of divalent glycosidase inhibitors EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2017 Mechanistic Insight into the Binding of Multivalent Pyrrolidines to alpha-Mannosidases CHEMISTRY-A EUROPEAN JOURNAL
Artículo2017 Tuning of beta-glucosidase and alpha-galactosidase inhibition by generation and in situ screening of a library of pyrrolidine-triazole hybrid molecules EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Revisión2016 Diels-Alder Approaches for the Synthesis of Bridged Bicyclic Systems: Synthetic Applications of (7-hetero)norbornadienes CURRENT ORGANIC CHEMISTRY
Artículo2016 Expanding the library of divalent fucosidase inhibitors with polyamino and triazole-benzyl bridged bispyrrolidines ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2016 Exploring the divalent effect in fucosidase inhibition with stereoisomeric pyrrolidine dimers ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2015 Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Artículo2015 Gold nanoparticles are suitable cores for building tunable iminosugar multivalency RSC ADVANCES
Artículo2015 Synthesis of 1,2,3-triazole-linked glycohybrids in the gluco-, gulo-, and allopyranose series CHEMISTRY OF HETEROCYCLIC COMPOUNDS
Artículo2014 6-Azido hyacinthacine A(2) gives a straightforward access to the first multivalent pyrrolizidine architectures ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2014 Polyhydroxyamino-Piperidine-Type Iminosugars and Pipecolic Acid Analogues from a D-Mannose-Derived Aldehyde EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2014 Rapid discovery of potent alpha-fucosidase inhibitors by in situ screening of a library of (pyrrolidin-2-yl)triazoles ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2014 Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives ARKIVOC
Artículo2014 Synthesis of 7-Oxabicyclo[2.2.1]heptane and Derivatives SYNTHESIS OF SATURATED OXYGENATED HETEROCYCLES I: 5- AND 6- MEMBERED RINGS
Artículo2014 Synthesis of pyrrolidine 3,4-diol derivatives with anticancer activity on pancreatic tumor cells HETEROCYCLES
Artículo2013 Exploring a Multivalent Approach to alpha-L-Fucosidase Inhibition EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2013 Strain-promoted retro-Dieckmann-type condensation on [2.2.2]- and [2.2.1]bicyclic systems: a fragmentation reaction for the preparation of functionalized heterocycles and carbocycles ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2013 Synthesis and Glycosidase Inhibition Studies of 5-Methyl-Substituted Tetrahydroxyindolizidines and -pyrrolizidines Related to Natural Hyacinthacines B EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2013 Synthesis, Biological Evaluation, WAC and NMR Studies of S-Galactosides and Non-Carbohydrate Ligands of Cholera Toxin Based on Polyhydroxyalkylfuroate Moieties CHEMISTRY-A EUROPEAN JOURNAL
Artículo2013 Three dimensional structure of a bacterial alpha-L-fucosidase with a 5-membered iminocyclitol inhibitor BIOORGANIC & MEDICINAL CHEMISTRY
Artículo2012 Synthesis of novel 3-deoxy-3-C-triazolylmethyl-allose derivatives and evaluation of their biological activity CENTRAL EUROPEAN JOURNAL OF CHEMISTRY
Artículo2011 Diversity-oriented syntheses of 7-substituted lentiginosines TETRAHEDRON
Artículo2011 Exploiting the Ring Strain in Bicyclo[2.2.1]heptane Systems for the Stereoselective Preparation of Highly Functionalized Cyclopentene, Dihydrofuran, Pyrroline, and Pyrrolidine Scaffolds ORGANIC LETTERS
Artículo2011 Monosaccharides and Analogues from Simple Achiral Unsaturated Compounds CHIMIA
Artículo2011 Syntheses and Biological Activities of 1,4-Iminoalditol Derivatives as alpha-L-Fucosidase Inhibitors CHIMIA
Artículo2011 Syntheses and Biological Activities of Iminosugars as alpha-L-Fucosidase Inhibitors Current Organic Synthesis
Artículo2011 Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers SYNTHESIS-STUTTGART
Artículo2011 Total Asymmetric Synthesis of Monosaccharides and Analogues CHIMIA
Artículo2010 New Methodology for the Stereoselective Synthesis of alpha-Furfurylamines from Sugars: Application to the Synthesis of Furyl Amino Acids and 3-Furylisoserines EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2010 Synthesis and inhibitory activities of novel C-3 substituted azafagomines: A new type of selective inhibitors of alpha-L-fucosidases BIOORGANIC & MEDICINAL CHEMISTRY
Artículo2010 Synthesis of a C-3-Symmetric Furyl-Cyclopeptide Platform with Anion Recognition Properties EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2010 Synthesis of Novel 3-Amino(Hydroxy)methyl-L-fuco-Azafagomines as Leads for Selective Inhibitors of alpha-L-Fucosidases SYNLETT
Artículo2010 The regioselectivity of the addition of benzeneselenyl chloride to 7-azanorborn-5-ene-2-yl derivatives is controlled by the 2-substituent: new entry into 3-and 4-hydroxy-5-substituted prolines TETRAHEDRON
Artículo2009 Allenyl Sulfones and Allenyl Sulfides in the Synthesis of 3-Pyrrolines. A Novel Nucleophilic [3+2] Cycloaddition on Allenyl Sulfones Giving Rearranged Cycloadducts ORGANIC LETTERS
Artículo2009 Stereoselective synthesis of 1,2-cis-glycosylic linkages CARBOHYDRATE CHEMISTRY: CHEMICAL AND BIOLOGICAL APPROACHES, VOL 35
Artículo2009 Synthesis of novel pyrrolidine 3,4-diol derivatives as inhibitors of alpha-L-fucosidases ORGANIC & BIOMOLECULAR CHEMISTRY
Revisión2008 Glycosylation methods in oligosaccharide synthesis. Part 1 Current Organic Synthesis
Revisión2008 Glycosylation methods in oligosaccharide synthesis. Part 2 Current Organic Synthesis
Artículo2008 Mixtures of monomeric and dimeric surfactants: Hydrophobic chain length and spacer group length effects on non ideality JOURNAL OF PHYSICAL CHEMISTRY B
Artículo2008 Synthesis and biological evaluation of S-neofucopeptides as E- and P-selectin inhibitors EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2007 Stereoselective synthesis of novel five-membered homoazasugars. A convenient route to all-cis tetrasubstituted pyrrolidines TETRAHEDRON LETTERS
Artículo2007 Synthesis and anti-HIV activity of trivalent CD4-mimetic miniproteins BIOORGANIC & MEDICINAL CHEMISTRY
Artículo2007 Synthesis and conformational analysis of novel trimeric maleimide cross-linking reagents JOURNAL OF ORGANIC CHEMISTRY
Artículo2006 Cyanodeoxy-glycosyl derivatives as substrates for enzymatic reactions EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Corrección2006 Cyanodeoxy-glycosyl derivatives as substrates for enzymatic reactions (April, pg 1876, 2006) EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2006 Stereoselective synthesis of chiral furan amino acid analogues of D- and L-serine from D-sugars SYNLETT
Capítulo2005 Programa de equipos docentes para la formación de profesores noveles La formación del profesorado universitario: programa de equipos docentes de la Universidad de Sevilla, curso 2003-2004
Artículo2005 Stereoselective synthesis of (2S,3S,4R,5S)-5-methylpyrrolidine-3,4-diol derivatives that are highly selective alpha-L-fucosidase inhibitors CHEMICAL COMMUNICATIONS
Revisión2004 Glycosidase inhibitors as potential HIV entry inhibitors? CURRENT DRUG METABOLISM
Artículo2004 Synthesis of D- and L-2,3-trans-3,4-cis-4,5-trans-3,4-dihydroxy-5-hydroxymethylproline and tripeptides containing them JOURNAL OF ORGANIC CHEMISTRY
Artículo2003 Efficient resolution of N-Boc-7-azabicyclo[2.2.1]hept-5-en-2-one: formal syntheses of natural epibatidine and its enantiomer TETRAHEDRON-ASYMMETRY
Artículo2003 Hetaryleneaminopolyols and hetarylenecarbopeptoids: a new type of glyco- and peptidomimetics. Syntheses and studies on solution conformation and dynamics JOURNAL OF ORGANIC CHEMISTRY
Artículo2003 Regioselective rearrangement of 7-azabicyclo[2.2.1]hept-2-aminyl radicals: first synthesis of 2,8-diazabicyclo[3.2.1]oct-2-enes and their conversion into 5-(2-aminoethyl)-2,3,4-trihydroxypyrrolidines, new inhibitors of alpha-mannosidases TETRAHEDRON LETTERS
Artículo2003 Synthesis and glycosidase inhibitory activities of 5-(1 ',4 '-dideoxy-1 ',4 '-imino-D-erythrosyl)-2-methyl-3-furoic acid (=5-[3S, 4R)-3,4-dihydroxypyrrolidin-2-yl]-2-methylfuran-3-carboxylic acid) derivitives: New leads as selective alpha-L-fucosidase and beta-galactosidase inhibitors HELVETICA CHIMICA ACTA
Artículo2003 Synthesis of enantiomerically pure 1,2-diamine derivatives of 7-azabicyclo[2.2.1]heptane. New leads as glycosidase inhibitors and rigid scaffolds for the preparation of peptide analogues JOURNAL OF ORGANIC CHEMISTRY
Artículo2002 Synthesis of [(2S,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]-5-methylfuran-4-carboxylic acid derivatives: New leads as selective beta-galactosidase inhibitors BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Artículo2001 New leads for selective inhibitors of alpha-L-fucosidases. Synthesis and glycosidase inhibitory activities of [(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]furan derivatives BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Artículo2001 Reactivity of polyhydroxyalkyl-heterocycles towards Lewis acids TETRAHEDRON-ASYMMETRY
Artículo2001 Solution and solid phase synthesis of hetarylene-carbopeptoids. A new type of peptidomimetics TETRAHEDRON LETTERS
Artículo1998 Oxidation of polyhydroxyalkyl-heterocycles by cerium - (IV). A convenient route to pyrrole-2,5-dicarbaldehydes. TETRAHEDRON LETTERS

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/12/2007 30/11/2008 Investigador/a Diseño y síntesis de nuevos inhibidores enzimáticos, de análogos del sialil lewis X y de antibióticos aminoglicosídicos. Evaluación biológica (CTQ2007-61254) Ministerio de Educación y Ciencia (Nacional)
01/01/2013 31/12/2015 Investigador/a Nuevas Aproximaciones Sintéticas para la Preparación de Moléculas Bioactivas (CTQ2012-31247) Ministerio de Economía y Competitividad (Nacional)
01/01/2004 30/06/2007 Investigador/a Targeting Replication and Integration of HIV (TRIoH) (LSHB-CT-2003-503480) Commission of the European Communities (Europeo)
01/03/2011 28/02/2016 Investigador/a Integrating chemical approaches to treat pancreatic cancer: making new leads for a cure - (Nº 256986) PANACREAS (256986) Comisión Europea (Europeo)
01/11/2018 30/10/2022 Investigador/a Integrating chemical and biological approaches to target NAD production and signaling in cancerIntegrating chemical and biological approaches to target NAD productión and signaling in cáncer - INTEGRATA (H2020-813284) Comisión Europea (Europeo)
13/12/2004 13/12/2007 Investigador/a Nuevas metodologías para la síntesis de inhibidores enzimáticos específicos, prolinas polifuncionales y peptidomiméticos (CTQ2004-00649) Ministerio de Ciencia y Tecnología (Nacional)
01/01/2009 31/12/2012 Investigador/a Nuevas metodologías sintéticas para la preparación de moléculas bioactivas y de sus análogos (CTQ2008-01565) Ministerio de Educación y Ciencia (Nacional)
30/12/2016 31/12/2020 Responsable Diseño y Síntesis de Moléculas de Interés Biológico Mediante el Desarrollo de Metodologías Sintéticas (CTQ2016-77270-R) Ministerio de Economía y Competitividad (Nacional)
28/12/2001 27/12/2004 Investigador/a Miméticos de biomoléculas. Nuevas síntesis, nuevas metodologías, nuevos fármacos (BQU2001-3779) Ministerio de Ciencia y Tecnología (Nacional)
31/01/2008 31/12/2012 Investigador/a Preparación y Estudio de Nuevos Surfactantes Multicatenarios de Alto Valor Añadido a partir de Materias Primas Renovables (P07-FQM-03056) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
30/01/2014 16/06/2019 Investigador/a Nuevos Tensioactivos Biodegradables. Estudio de sus Propiedades Fisicoquímicas y Biológicas y de sus Interacciones con Especies de Potencial Interés Aplicado (P12-FQM-1105) Consejería de Economía, Innovación y Ciencia (Autonómico)

Contratos

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
21/10/2010 20/10/2012 Investigador/a Estrategias de utilización de ingredientes (minerales y de nueva síntesis) para mejorar la salud intestinal de los lechones al destete. (0903/0400) Universidad Autónoma de Barcelona (Nacional)

Ayudas

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2006 01/01/2007 Investigador/a Targeting replication and integration of hiv (SAF2004-22949-E) Ministerio de Educación y Ciencia (Nacional)