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Ver Investigador - - Prisma - Unidad de Bibliometría

Oscar López López

Catedrático de Universidad
osc-lopez@us.es
Área de conocimiento: Química Orgánica
Departamento: Química Orgánica
Grupo: QUÍMICA FINA DE CARBOHIDRATOS - FQM-134 (Universidad de Sevilla)
Prog. doctorado: Programa de Doctorado en Química (RD. 99/2011)
Tipo Año Título Fuente
Artículo2024 Coumarins-lipophilic cations conjugates: Efficient mitocans targeting carbonic anhydrases BIOORGANIC CHEMISTRY
Revisión2024 Schiff bases and their metal complexes to target and overcome (multidrug) resistance in cancer EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2023 A Multitarget Approach against Neuroinflammation: Alkyl Substituted Coumarins as Inhibitors of Enzymes Involved in Neurodegeneration ANTIOXIDANTS
Artículo2023 Biotinylated selenocyanates: potent and selective cytostatic agents BIOORGANIC CHEMISTRY
Artículo2023 Conformationally restricted glycoconjugates derived from arylsulfonamides and coumarins: new families of tumour-associated carbonic anhydrase inhibitors INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2023 Design and synthesis of sulfonamides incorporating a biotin moiety: Carbonic anhydrase inhibitory effects, antiproliferative activity and molecular modeling studies BIOORGANIC & MEDICINAL CHEMISTRY
Artículo2023 Investigation of the enantioselectivity of acetylcholinesterase and butyrylcholinesterase upon inhibition by tacrine-iminosugar heterodimers. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Artículo2023 N-Substituted 3-Aminooxindoles and N-Propargyl Derivatives: Potential Biological Activities against Alzheimer's Disease Results in Chemistry
Artículo2023 Revisiting purine nucleoside cholinesterase inhibitors - An experimental glycon structure/activity relationship study. MEDICINAL CHEMISTRY
Artículo2022 2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Artículo2022 A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans CHEMICAL COMMUNICATIONS
Artículo2022 A hybrid of 1-deoxynojirimycin and benzotriazole induces preferential inhibition of butyrylcholinesterase (BuChE) over acetylcholinesterase (AChE). JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Revisión2022 Butyrylcholinesterase inhibitors as potential anti-Alzheimer’s agents: an updated patent review (2018-present) EXPERT OPINION ON THERAPEUTIC PATENTS
Artículo2022 Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease BIOORGANIC CHEMISTRY
Artículo2022 Chemoselective Preparation of New Families of Phenolic-Organoselenium Hybrids-A Biological Assessment. MOLECULES
Artículo2022 Evaluation of chromane derivatives: Promising privileged scaffolds for lead discovery within Alzheimer's disease BIOORGANIC & MEDICINAL CHEMISTRY
Artículo2022 Functionalized d - And l - no -Pyrrolidines as Potent and Selective Glycosidase Inhibitors SYNTHESIS-STUTTGART
Revisión2022 Iridium-and palladium-based catalysts in the pharmaceutical industry CATALYSTS
Artículo2022 Squaramide-tethered sulfonamides and coumarins: synthesis, inhibition of tumor-associated CAs IX and XII and docking simulations INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2022 Straightforward access to novel mitochondriotropics derived from 2-arylethanol as potent and selective antiproliferative agents EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2022 Survey of new, small-molecule isatin-based oxindole hybrids as multi-targeted drugs for the treatment of Alzheimer’s disease SYNTHESIS-STUTTGART
Artículo2022 Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Artículo2021 Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Revisión2021 Metal- and metalloid-based compounds to target and reverse cancer multidrug resistance DRUG RESISTANCE UPDATES
Artículo2021 Novel 1,2,3-triazole epicinchonas: transitioning from organocatalysis to biological activities SYNTHETIC COMMUNICATIONS
Artículo2021 Tacrine-sugar mimetic conjugates as enhanced cholinesterase inhibitors. ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2021 Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Artículo2021 Ugi reaction synthesis of oxindole-lactam hybrids as selective butyrylcholinesterase inhibitors ACS MEDICINAL CHEMISTRY LETTERS
Artículo2020 1,4-Dideoxy-1,4-imino- d -arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors ACS OMEGA
Revisión2020 Carbohydrates: Potential Sweet Tools against Cancer CURRENT MEDICINAL CHEMISTRY
Artículo2020 Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease JOURNAL OF MEDICINAL CHEMISTRY
Artículo2020 Masked phenolic-selenium conjugates: Potent and selective antiproliferative agents overcoming p-gp resistance PHARMACEUTICALS
Artículo2020 N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study BIOORGANIC CHEMISTRY
Artículo2019 Bicyclic 1-Azafagomine Derivatives: Synthesis and Glycosidase Inhibitory Testing SYNTHESIS-STUTTGART
Artículo2019 Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and A beta(1-42)-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells PHARMACEUTICALS
Artículo2019 In silico, NMR and pharmacological evaluation of an hydroxyoxindole cholinesterase inhibitor BIOORGANIC & MEDICINAL CHEMISTRY
Artículo2019 Selenocoumarins as new multitarget antiproliferative agents: Synthesis, biological evaluation and in silico calculations EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Nota2019 Síntesis de nuevos selenoheterociclos derivados de carbohidratos Revista Latinoamericana de Quimica
Artículo2019 Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2018 Chalcogen-containing phenolics as antiproliferative agents FUTURE MEDICINAL CHEMISTRY
Artículo2018 Debates: An Useful Tool to Promote Students Deeper Thinking in Stem Disciplines Proceedings (MDPI)
Artículo2018 Synthesis of unprecedented steroidal Spiro heterocycles as potential antiproliferative drugs EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2017 New selenosteroids as antiproliferative agents ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2017 New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2017 Selenoureas for anion binding as molecular logic gates CHEMICAL COMMUNICATIONS
Artículo2017 Sugar hydrazide imides: a new family of glycosidase inhibitors ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2017 Synthesis and antiproliferative activity of sulfa-Michael adducts and thiochromenes derived from carbohydrates NEW JOURNAL OF CHEMISTRY
Artículo2016 A Straightforward Access to New Families of Lipophilic Polyphenols by Using Lipolytic Bacteria PLOS ONE
Artículo2016 Design of chalcogen-containing norepinephrines: efficient GPx mimics and strong cytotoxic agents against HeLa cells FUTURE MEDICINAL CHEMISTRY
Capítulo2016 Green Chemical Synthesis and Click Reactions Click Reactions in Organic Synthesis
Artículo2016 Selenoureido-iminosugars: A new family of multitarget drugs EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2015 Diosgenin-based thio(seleno)ureas and triazolyl glycoconjugates as hybrid drugs. Antioxidant and antiproliferative profile EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2015 Effects of dietary virgin olive oil polyphenols: hydroxytyrosyl acetate and 3, 4-dihydroxyphenylglycol on DSS-induced acute colitis in mice JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Artículo2015 Phenolic thio- and selenosemicarbazones as multi-target drugs EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Ponencia2015 Synthesis of fluorescent O-Coumarin glycosides as Potential drug delivery systems for MAO inhibitors 19TH INTERNATIONAL ELECTRONIC CONFERENCE ON SYNTHETIC ORGANIC CHEMISTRY
Artículo2015 Synthesis of Organoselenium Derivatives of Biological Relevance SELENIUM: CHEMISTRY, ANALYSIS, FUNCTION AND EFFECTS
Artículo2014 An Alternative, Large-Scale Synthesis of 1,2:5,6-Di-O-isopropylidene-alpha-D-ribo-hex-3-ulofuranose CARBOHYDRATE CHEMISTRY: PROVEN SYNTHETIC METHODS, VOL 2
Artículo2014 Eco-friendly preparation of 5-hydroxymethylfurfural from sucrose using ion-exchange resins CHEMICAL ENGINEERING SCIENCE
Artículo2014 Phenolic compounds and antioxidant capacity of virgin olive oil FOOD CHEMISTRY
Capítulo2014 Sulfur compounds as antioxidants: Beneficial effects on health Advances in Chemistry Research
Artículo2013 Enzyme inhibition by iminosugars: Analysis and insight into the glycosidase-iminosugar dependency of pH BIOORGANIC & MEDICINAL CHEMISTRY
Artículo2013 Synthesis and antioxidant activity of O-alkyl selenocarbamates, selenoureas and selenohydantoins EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Artículo2012 A uronic acid analogue of isofagomine lactam as a nanomolar glucuronidase inhibitor TETRAHEDRON LETTERS
Artículo2012 Biological Properties of Hydroxytyrosol and Its Derivatives OLIVE OIL - CONSTITUENTS, QUALITY, HEALTH PROPERTIES AND BIOCONVERSIONS
Artículo2012 Glycosidase inhibitors: versatile tools in glycobiology CARBOHYDRATE CHEMISTRY: CHEMICAL AND BIOLOGICAL APPROACHES, VOL 38
Artículo2012 Intramolecular cyclization of alkoxyaminosugars: access to novel glycosidase inhibitor families ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2012 L-Isofucoselenofagomine and derivatives: dual activities as antioxidants and as glycosidase inhibitors TETRAHEDRON
Artículo2012 Synthesis of conformationally-constrained thio(seleno)hydantoins and alpha-triazolyl lactones from D-arabinose as potential glycosidase inhibitors TETRAHEDRON
Artículo2012 Unprecedented spiro-annelated sugar isoureas, guanidines and amidines as new families of glycosidase inhibitors RSC ADVANCES
Artículo2011 Alkoxyamine-cyanoborane adducts: efficient cyanoborane transfer agents CHEMICAL COMMUNICATIONS
Artículo2011 An Isofagomine Analogue with an Amidine at the Pseudoanomeric Position ORGANIC LETTERS
Artículo2011 Classical Insecticides: Past, Present and Future GREEN TRENDS IN INSECT CONTROL
Artículo2010 A green procedure for the regio- and chemoselective hydrophosphonylation of unsaturated systems using CaO under solventless conditions GREEN CHEMISTRY
Artículo2010 Complexation of hydroxytyrosol with beta-cyclodextrins. An efficient photoprotection TETRAHEDRON
Artículo2010 Spiranic D-gluco-configured N-substituted thiohydantoins as potential enzymatic inhibitors TETRAHEDRON
Ponencia2010 Use of cooperative learning in stereochemistry teaching for organic compounds 3RD INTERNATIONAL CONFERENCE OF EDUCATION, RESEARCH AND INNOVATION (ICERI2010)
Ponencia2010 Use of moodle online platform in learning nomenclature of organic compounds 3RD INTERNATIONAL CONFERENCE OF EDUCATION, RESEARCH AND INNOVATION (ICERI2010)
Artículo2009 Difluoromethylenated polyhydroxylated pyrrolidines: facile synthesis, crystal structure and biological evaluation FUTURE MEDICINAL CHEMISTRY
Artículo2009 Synthesis and characterization of mercury(II)-sugar thioureas complexes POLYHEDRON
Artículo2009 Synthesis of sugar-derived isoselenocyanates, selenoureas, and selenazoles TETRAHEDRON
Artículo2009 Synthesis of the First Selenium-Containing Acyclic Nucleosides and Anomeric Spironucleosides from Carbohydrate Precursors EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2008 cis-Fused bicyclic sugar thiocarbamates. Reactivity towards amines TETRAHEDRON
Artículo2008 Effective synthesis of negatively charged cyclodextrins. Selective access to phosphate cyclodextrins TETRAHEDRON
Revisión2008 Hydroxytyrosol and derivatives: Isolation, synthesis, and biological properties CURRENT ORGANIC CHEMISTRY
Capítulo2008 Isofagomine, Noeuromycin and other 1-Azasugars, Iminosugar-Related Glycosidase Inhibitors Iminosugars: From Synthesis to Therapeutic Applications
Artículo2008 Taurine isothiocyanate: a versatile intermediate for the preparation of ureas, thioureas, and guanidines. Taurine-derived cyclodextrins TETRAHEDRON LETTERS
Artículo2007 Active site protonation of 1-azafagomine in glucosidases studied by solid-state NMR spectroscopy EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2007 Anorner-selective glycosidase inhibition by 2-N-alkylated 1-azafagomines CHEMBIOCHEM
Revisión2007 Click chemistry - What's in a name? Triazole synthesis and beyond SYNTHESIS-STUTTGART
Capítulo2007 Glycosidase Inhibitors: Structure, Activity, Synthesis, and Medical Relevance Comprehensive Glycoscience: From Chemistry to Systems Biology
Artículo2007 Heterocycles from Carbohydrate Isothiocyanates HETEROCYCLES FROM CARBOHYDRATE PRECURSORS
Artículo2007 New cup-shaped alpha-cyclodextrin derivatives and a study of their catalytic properties in oxidation reactions TETRAHEDRON
Artículo2007 Synthesis of Heterocycles from Glycosylamines and Glycosyl Azides HETEROCYCLES FROM CARBOHYDRATE PRECURSORS
Artículo2005 New synthetic approaches to sugar ureas. Access to ureido-beta-cyclodextrins TETRAHEDRON
Revisión2005 New trends in pest control: the search for greener insecticides GREEN CHEMISTRY
Artículo2004 Conformational effects on glycoside reactivity: Study of the high reactive conformer of glucose JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Artículo2004 Simple and efficient synthesis of O-unprotected glycosyl thiourea and isourea derivatives from glycosylamines TETRAHEDRON
Artículo2004 Synthesis of O-unprotected glycosyl selenoureas. A new access to bicyclic sugar isoureas TETRAHEDRON LETTERS
Artículo2003 A facile access to ureido sugars. Synthesis of urea-bridged beta-cyclodextrins TETRAHEDRON LETTERS
Artículo2003 Aziridines as a structural motif to conformational restriction of azasugars ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2003 Synthesis of furan 4 '-thio-C-nucleosides, their methylsulfonium and sulfoxide derivatives. Evaluation as glycosidase inhibitors TETRAHEDRON
Editorial2003 Titanium tetraisopropoxide SYNLETT
Artículo2002 Expeditious synthesis of cyclic isourea derivatives of beta-D-glucopyranosylamine TETRAHEDRON LETTERS
Artículo2001 A practical one-pot synthesis of O-unprotected glycosyl thioureas TETRAHEDRON LETTERS
Artículo1999 Stereoselective synthesis of imidazolidine, imidazoline and imidazole C- and N-pseudonucleosides TETRAHEDRON-ASYMMETRY
Ureas, tioureas y selenoureas en la química de carbohidratos. Nuevas aproximaciones sintéticas (2003)
Dirigida por: José María Fernández-Bolaños Guzmán, José Fuentes Mota
Tesis dirigidas/tutorizadas:9
Fecha lectura Título Rol
08/07/2022 Nuevos tio- y selenoderivados de carbohidratos en enfermedades degenerativas: cáncer y Alzheimer Tutor/a, Director/a
07/07/2022 Nuevos sistemas de reconocimiento molecular basados en organocalcógenos. Agentes antiparasitarios y antiproliferativos Tutor/a, Director/a
13/03/2020 SINTESIS Y EVALUACIÓN DE NUEVAS MOLÉCULAS MULTIDIANA EN LA PREVENCIÓN DE ENFERMEDADES DEGENERATIVAS Director/a
20/09/2019 Síntesis, aislamiento y evaluación de nuevos biofenoles como potenciales agentes antiproliferativos Director/a
19/02/2015 NEOGLICÓSIDOS MULTIVALENTES Y AMINALES MACROCÍCLICOS BASADOS EN N-ALCOXIAMINAS. DISEÑO Y SÍNTESIS DE ANTIOXIDANTES DERIVADOS DE CATECOLAMINAS. Director/a
26/02/2014 SÍNTESIS DE NUEVOS ANTIOXIDANTES DERIVADOS DEL HIDROXITIROSOL. INTERACCIÓN CON CICLODEXTRINAS Director/a
04/11/2011 NUEVO SISTEMA DE GLICODIVERSIFICACIÓN BASADO EN N-ALCOXIAMINAS Director/a
17/10/2011 SÍNTESIS ESTEREOCONTROLADA DE ESPIROAZÚCARES Y DE SELENO-DERIVADOS DE AZÚCARES DE INTERÉS BIOLÓGICO Director/a
07/03/2008 COMPUESTOS ORGANOSELÉNICOS DERIVADOS DE CARBOHIDRATOS. ISOSELENOCIANATOS, SELENOUREAS Y SELENOHETEROCICLOS Director/a

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2022 31/05/2023 Investigador/a Secoiridoides del olivo en la terapia nutricional de la artritis reumatoide: implicaciones epigenéticas y metabolómicas (US-1380592) Consejería de Economía, Conocimiento, Empresas y Universidad (Autonómico)
01/09/2021 31/08/2024 Responsable Sistemas químicos para la vectorización y liberación selectiva de nuevos inhibidores enzimáticos citotóxicos (PID2020-116460RB-I00) Ministerio de Ciencia e Innovación (Nacional)
30/12/2016 29/12/2019 Investigador/a Moléculas y Macromoléculas con Actividad Multidiana frente a enfermedades Degenerativas (CTQ2016-78703-P) Ministerio de Economía y Competitividad (Nacional)
26/03/2013 25/09/2016 Investigador/a Extremozimas Lipolíticas como Catalizadores Regioselectivos útiles en la Síntesis de Carbohidratos y Polifenoles Lipófilos (P11-CVI-7427) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
13/01/2009 31/12/2013 Investigador/a Optimización del Aislamiento de Polifenoles de la Aceituna. Complejación con Ciclodextrinas, Derivatización y Evaluación Como Agentes Antioxidantes. (P08-AGR-03751) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
01/01/2009 30/06/2013 Investigador/a Glicodiversificación de moléculas bioactivas (CTQ2008-02813) Ministerio de Educación y Ciencia (Nacional)
31/12/2005 31/12/2008 Investigador/a Derivados de carbohidratos como intermedios quirales clave en la síntesis de moléculas bioactivas (CTQ2005-01830) Ministerio de Educación y Ciencia (Nacional)
13/12/2004 13/12/2005 Investigador/a Derivados de carbohidratos que contienen nitrógeno, azufre y/o selenio como intermedios quirales clave en la síntesis de moléculas de interés biológico (CTQ2004-01178) Ministerio de Ciencia y Tecnología (Nacional)
28/12/2001 27/09/2005 Investigador/a Síntesis estereocontroladas de iminociclitoles, de N- y C-glicósidos y de (tio, seleno) carbomoil azúcares de interés biológico a partir de aminoazúcares y de sulfatos cíclicos (BQU2001-3740) Ministerio de Ciencia y Tecnología (Nacional)

Contratos

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/04/2010 31/03/2011 Investigador/a Estudio sobre la descomposición de alcaloides contenidos en las aguas de desamargamiento de la semilla de altramuz (Lupinus Albus). (0679/0335) HERMABAR, S.L. (Desconocido)
05/05/2008 05/02/2009 Investigador/a Estudio de los alcaloides quinolizidinicos y proteinas contenidos en extractos de lupinus albus (Principalmente Lupanima) (OG-054/08) Biofal 2002 S.L. (Desconocido)

Ayudas

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2007 31/12/2008 Investigador/a Nitroalkanes as carbanions in the sugar chemistry (HI2006-0130) Ministerio de Educación y Ciencia (Nacional)

Patentes

Nº Solicitud Fecha Solicitud Fecha Concesión Nombre
P201500146 05/05/2014 03/10/2016 Derivados acilados de polifenoles y/o carbohidratos, métodos de obtención y usos de los mismos
P201500145 05/05/2014 20/10/2016 Derivados acilados de carbohidratos, métodos de obtención y usos de los mismos
P201131161 08/07/2011 09/04/2014 Procedimiento para la obtención de extracto de hidroxitirosol, extracto mezcla de hidroxitirosol y 3,4-dihidroxifenilglicol, y extracto de acetato de hidroxitirosilo, a partir de subproductos del olivo y su purificación.
P201400568 30/06/2014 15/04/2016 Uso como antioxidantes de compuestos organoselénicos fenólicos y sus composiciones
P201400374 05/05/2014 05/05/2016 Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación
P201500558 05/05/2014 08/08/2016 Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación
P201930815 20/09/2019 - Procedimiento para la extracción en hoja de olivo de oleuropeína en una fracción fenólica, composición alimentaria funcional y uso