Miguel López Lázaro

Profesor Titular de Universidad
mlopezlazaro@us.es
Área de conocimiento: Farmacología
Departamento: Farmacología
Grupo: CÁNCER (CTS-657)
Prog. doctorado: Programa de Doctorado en Farmacia (RD. 99/2011)
Tipo Año Título Fuente
Artículo2021 Carbohydrate-based NK1R antagonists with broad-spectrum anticancer activity. JOURNAL OF MEDICINAL CHEMISTRY
Artículo2021 Cholesterol levels affect the performance of aunps-decorated thermo-sensitive liposomes as nanocarriers for controlled doxorubicin delivery PHARMACEUTICS
Artículo2021 Screening for selective anticancer activity of 65 extracts of plants collected in Western Andalusia, Spain. Plants
Artículo2020 Meroterpenoids from the brown alga cystoseira usneoides as potential anti-inflammatory and lung anticancer agents MARINE DRUGS
Artículo2019 Mannose-coated polydiacetylene (PDA)-based nanomicelles: synthesis, interaction with concanavalin A and application in the water solubilization and delivery of hydrophobic molecules JOURNAL OF MATERIALS CHEMISTRY B
Artículo2019 Screening for selective anticancer activity of plants from Grazalema Natural Park, Spain Natural Product Research
Artículo2018 A 30-s exposure to ethanol 20% is cytotoxic to human keratinocytes: possible mechanistic link between alcohol-containing mouthwashes and oral cancer CLINICAL ORAL INVESTIGATIONS
Letter2018 Are most cancer cases a consequence of an immune deficiency caused by thymic involution? PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Artículo2018 Avoiding the ingestion of cytotoxic concentrations of ethanol may reduce the risk of cancer associated with alcohol consumption DRUG AND ALCOHOL DEPENDENCE
Artículo2018 Cancer etiology: Variation in cancer risk among tissues is poorly explained by the number of gene mutations GENES CHROMOSOMES & CANCER
Artículo2018 Selective cytotoxic activity and DNA damage by an epoxyalkyl galactopyranoside DRUG DEVELOPMENT RESEARCH
Artículo2018 The Cockayne syndrome protein B is involved in the repair of 5-AZA-2'-deoxycytidine-induced DNA lesions ONCOTARGET
Revisión2018 The stem cell division theory of cancer CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Artículo2017 Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2017 Zebularine induces replication-dependent double-strand breaks which are preferentially repaired by homologous recombination DNA REPAIR
Editorial2016 A local mechanism by which alcohol consumption causes cancer ORAL ONCOLOGY
Artículo2016 Cells Deficient in the Fanconi Anemia Protein FANCD2 are Hypersensitive to the Cytotoxicity and DNA Damage Induced by Coffee and Caffeic Acid TOXINS
Ponencia2016 Efecto del aceite de acebuche sobre la hipertensión arterial y la actividad antioxidante sistémica Hipertensión y Riesgo Vascular
Ponencia2016 Wild olive oil intake reduces blood pressure and improves antioxidant capacity and endothelial function in nitric oxide-depleted hypertensive rats JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
Artículo2015 A Simple and Reliable Approach for Assessing Anticancer Activity In Vitro CURRENT MEDICINAL CHEMISTRY
Artículo2015 Antiproliferative Activity of seco-Oxacassanes from Acacia schaffneri NATURAL PRODUCT COMMUNICATIONS
Letter2015 Bufalin Is a Steroid Receptor Coactivator Inhibitor-Letter CANCER RESEARCH
Editorial2015 Cancer arises from stem cells: opportunities for anticancer drug discovery DRUG DISCOVERY TODAY
Letter2015 Does the Nerium oleander extract PBI-05204 have potential for pancreatic cancer therapy? INVESTIGATIONAL NEW DRUGS
Artículo2015 Effect of DNA repair deficiencies on the cytotoxicity of resveratrol WebmedCentral.com
Editorial2015 How many times should we screen a chemical library to discover an anticancer drug? DRUG DISCOVERY TODAY
Artículo2015 In vitro and in vivo evaluation of Delta(9)-tetrahidrocannabinol/PLGA nanoparticles for cancer chemotherapy INTERNATIONAL JOURNAL OF PHARMACEUTICS
Artículo2015 Selective amino acid restriction therapy (SAART): A nonpharmacological strategy against all types of cancer cells Oncoscience
Editorial2015 Stem cell division theory of cancer CELL CYCLE
Artículo2015 The migration ability of stem cells can explain the existence of cancer of unknown primary site. Rethinking metastasis Oncoscience
Artículo2015 Two preclinical tests to evaluate anticancer activity and to help validate drug candidates for clinical trials Oncoscience
Artículo2015 Understanding why aspirin prevents cancer and why consuming very hot beverages and foods increases esophageal cancer risk. Controlling the division rates of stem cells is an important strategy to prevent cancer Oncoscience
Artículo2014 Cytotoxic activity of hirsutanone, a diarylheptanoid isolated from Alnus glutinosa leaves PHYTOMEDICINE
Revisión2014 Effect of DNA Repair Deficiencies on the Cytotoxicity of Drugs Used in Cancer Therapy - A Review CURRENT MEDICINAL CHEMISTRY
Revisión2014 Evaluating the Cancer Therapeutic Potential of Cardiac Glycosides BIOMED RESEARCH INTERNATIONAL
Artículo2014 Induction of apoptosis and cell cycle arrest in human colon carcinoma cells by Corema album leaves NATURAL PRODUCT COMMUNICATIONS
Artículo2014 Sulforaphane homologues: Enantiodivergent synthesis of both enantiomers, activation of the Nrf2 transcription factor and selective cytotoxic activity EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Letter2014 The in vivo antitumor activity of cardiac glycosides in mice xenografted with human cancer cells is probably an experimental artifact ONCOGENE
Artículo2014 The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2 '-deoxycytidine lesions NUCLEIC ACIDS RESEARCH
Artículo2013 5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair NUCLEIC ACIDS RESEARCH
Artículo2013 A Hydroalcoholic Extract from the Leaves of Nerium oleander Inhibits Glycolysis and Induces Selective Killing of Lung Cancer Cells PLANTA MEDICA
Artículo2013 Alpha, beta-unsaturated lactones 2-furanone and 2-pyrone induce cellular DNA damage, formation of topoisomerase I- and II-DNA complexes and cancer cell death TOXICOLOGY LETTERS
Artículo2013 Antioxidant and cytotoxic activities of Sideritis perezlarae (Borja) Rosello, Stubing and Peris Natural Product Research
Artículo2013 Aziridines from alkenyl-beta-D-galactopyranoside derivatives: Stereoselective synthesis and in vitro selective anticancer activity EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Letter2013 Comment on 'Quiescence and gamma H2AX in neuroblastoma are regulated by Ouabain/Na,K-ATPase': ouabain and cancer BRITISH JOURNAL OF CANCER
Artículo2013 Consumption of the Dietary Flavonoids Quercetin, Luteolin and Kaempferol and Overall Risk of Cancer - A Review and Meta-Analysis of the Epidemiological Data WebmedCentral.com
Artículo2013 Cytotoxic activity of dihydrochalcones isolated from corema album leaves against HT-29 colon cancer cells NATURAL PRODUCT COMMUNICATIONS
Artículo2013 Dichloroacetate, 2-Deoxyglucose and a Hydroalcoholic Extract from the Skin of the Fruit of Solanum melongena (Aubergine) Induce Selective Anticancer Activity against Melanoma Cells WebmedCentral.com
Artículo2013 Phenolic acids, flavonols and anthocyanins in Corema album (L.) D. Don berries JOURNAL OF FOOD COMPOSITION AND ANALYSIS
Artículo2013 Selective Cytotoxic Activity of New Lipophilic Hydroxytyrosol Alkyl Ether Derivatives JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo2013 The Cardiac Glycosides Digitoxin, Digoxin and Ouabain Induce a Potent Inhibition of Glycolysis in Lung Cancer Cells WebmedCentral.com
Artículo2013 Vitamin C and the Red Wine Polyphenol Resveratrol - but not Curcumin and the Glycolysis Inhibitors 2- Deoxyglucose, Dichloroacetate and 3-Bromopyruvate - Induce Selective Cytotoxicity against Lung Cancer Cells. WebmedCentral.com
Artículo2012 Chemo-protective activity and characterization of phenolic extracts from Corema album FOOD RESEARCH INTERNATIONAL
Artículo2012 Guanidine-reactive agent phenylglyoxal induces DNA damage and cancer cell death PHARMACOLOGICAL REPORTS
Artículo2012 Isoprenyl-thiourea and urea derivatives as new farnesyl diphosphate analogues: Synthesis and in vitro antimicrobial and cytotoxic activities EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Revisión2012 Pro-Oxidant Natural Products as Anticancer Agents CURRENT DRUG TARGETS
Artículo2012 Stereoselective Dihydroxylation Reaction of Alkenyl ss-D-Hexopyranosides: A Methodology for the Synthesis of Glycosylglycerol Derivatives and 1-O-Acyl-3-O-ss-D-glycosyl-sn-glycerol Analogues EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2012 The Coffee Constituent Chlorogenic Acid Induces Cellular DNA Damage and Formation of Topoisomerase I- and II-DNA Complexes in Cells JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Revisión2011 A review on the dietary flavonoid kaempferol MINI-REVIEWS IN MEDICINAL CHEMISTRY
Artículo2011 Green tea constituents (-)-epigallocatechin-3-gallate (EGCG) and gallic acid induce topoisomerase I- and topoisomerase II-DNA complexes in cells mediated by pyrogallol-induced hydrogen peroxide MUTAGENESIS
Letter2011 More research is needed to establish the benefit-risk profile of curcumin INTERNATIONAL JOURNAL OF CANCER
Artículo2011 Role of the Intracellular pH in the Metabolic Switch between Oxidative Phosphorylation and AerobicGlycolysis - Relevance to Cancer WebmedCentral.com
Revisión2010 A New View of Carcinogenesis and an Alternative Approach to Cancer Therapy MOLECULAR MEDICINE
Letter2010 The dark side of curcumin INTERNATIONAL JOURNAL OF CANCER
Artículo2010 The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
Letter2009 Digoxin, HIF-1, and cancer PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Revisión2009 Distribution and Biological Activities of the Flavonoid Luteolin MINI-REVIEWS IN MEDICINAL CHEMISTRY
Revisión2009 Role of Oxygen in Cancer: Looking Beyond Hypoxia ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
Revisión2008 Anticancer and carcinogenic properties of curcumin: Considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent MOLECULAR NUTRITION & FOOD RESEARCH
Ponencia2008 Cytotoxic activity of extracts from pharmacologically active plants METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
Artículo2008 Selenite induces topoisomerase I and II-DNA complexes in K562 leukemia cells INTERNATIONAL JOURNAL OF CANCER
Revisión2008 The Warburg effect: Why and how do cancer cells activate glycolysis in the presence of oxygen? ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
Artículo2007 Cells lacking DNA topoisomerase II beta are resistant to genistein JOURNAL OF NATURAL PRODUCTS
Artículo2007 Curcumin induces high levels of topoisomerase I- and II DNA complexes in K562 leukemia cells JOURNAL OF NATURAL PRODUCTS
Revisión2007 Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved EXPERT OPINION ON THERAPEUTIC TARGETS
Revisión2007 Dual role of hydrogen peroxide in cancer: Possible relevance to cancer chemoprevention and therapy CANCER LETTERS
Letter2007 Excessive superoxide anion generation plays a key role in carcinogenesis INTERNATIONAL JOURNAL OF CANCER
Artículo2007 Why do tumors metastasize? CANCER BIOLOGY & THERAPY
Artículo2006 Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells LEUKEMIA RESEARCH
Letter2006 Does hypoxia really control tumor growth? CELLULAR ONCOLOGY
Artículo2006 Granulocyte colony-stimulating factor (G-CSF): a novel anticancer therapy based on the universal dynamics of tumor growth? Experimental Oncology
Artículo2006 HIF-1: hypoxia-inducible factor or dysoxia-inducible factor? FASEB JOURNAL
Editorial2006 Hypoxia-inducible factor 1 as a possible target for cancer chemoprevention CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
Artículo2005 Cytotoxic activity of methanolic extract and two alkaloids extracted from seeds of Peganum harmala L Journal of Natural Remedies
Artículo2005 Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients JOURNAL OF NATURAL PRODUCTS
Artículo2004 A 4 year follow-up analysis of genotoxic damage in birds of the Donana area (south west Spain) in the wake of the 1998 mining waste spill MUTAGENESIS
Artículo2003 Anti-tumour activity of Digitalis purpurea L. subsp. heywoodii PLANTA MEDICA
Artículo2003 Curcumin as a DNA topoisomerase II poison JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Artículo2003 Cytotoxic effect of Plantago spp. on cancer cell lines JOURNAL OF ETHNOPHARMACOLOGY
Artículo2003 Synthesis and cytotoxic activity of different open indolocarbazole alkaloid analogues BIOORGANIC & MEDICINAL CHEMISTRY
Artículo2002 Cytotoxicity of flavonoids on cancer cell lines. Structure-activity relationship STUDIES IN NATURAL PRODUCTS CHEMISTRY, VOL 53
Revisión2002 Flavonoids as anticancer agents: structure-activity relationship study Current medicinal chemistry. Anti-cancer agents
Artículo2002 Flavonoids as DNA topoisomerase I poisons JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Artículo2001 A cytotoxic diarylheptanoid from Viscum cruciatum PHYTOCHEMISTRY
Artículo2001 Assessment of genotoxic damage by the comet assay in white storks (Ciconia ciconia) after the Donana Ecological Disaster MUTAGENESIS
Artículo2001 Cytotoxic compounds from Annonaceus species as DNA topoisomerase I poisons Anticancer Research: international journal of cancer research and treatment
Artículo2001 DNA damage in birds after the mining waste spill in southwestern Spain: A comet assay evaluation Journal of Environmental Pathology, Toxicology and Oncology
Artículo2000 Cytotoxic activity of flavonoids and extracts from Retama sphaerocarpa boissier ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES
Artículo2000 Glucosylated isoflavones as DNA topoisomerase II poisons JOURNAL OF ENZYME INHIBITION
Artículo2000 Retamatrioside, a new flavonol triglycoside from Retama sphaerocarpa JOURNAL OF NATURAL PRODUCTS
Artículo2000 Two new flavonol glycosides as DNA topoisomerase I poisons ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES
Artículo1999 Flavonoids of Retama sphaerocarpa PLANTA MEDICA
Artículo1999 Novel flavonol glycoside from Retama sphaerocarpa Boissier PHYTOCHEMISTRY
Artículo1998 An isoflavone glucoside from Retama sphaerocarpa Boissier PHYTOCHEMISTRY

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2009 31/12/2011 Investigador/a Funcionalidad de la fracción insaponificable del aceite de oliva virgen extra en la prevención del cáncer colorrectal (AGL2008-02475) Ministerio de Ciencia e Innovación (Nacional)
13/04/2007 12/04/2010 Investigador/a Compuestos anticancerosos derivados de azúcares: preparación química y evaluación terapéutica in vitro e in vivo (P06-FQM-01885) Junta de Andalucía (Plan Andaluz de Investigación) (Autonómico)
05/10/2021 31/12/2022 Investigador/a Fármacos multidiana estructuralmente relacionados con isotiocianatos naturales: diseño, síntesis y aplicaciones terapéuticas (P20_01171) Consejería de Economía, Conocimiento, Empresas y Universidad (Autonómico)
31/12/2005 31/12/2008 Investigador/a Influencia de dietas enriquecidas con aceite de oliva virgen extra y curcumina en la prevención de cáncer colorrectal asociado a colits experimental (AGL2005-05132) Ministerio de Educación y Ciencia (Nacional)
30/01/2014 31/07/2018 Investigador/a Interés de los Polifenoles en Inflamación Crónica y Cáncer: Papel en los Sistemas Celulares de Regulación Mitocondrial y del Inflamasoma. Polfanat-II (P12-AGR-430) Consejería de Economía, Innovación y Ciencia (Autonómico)

Contratos

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
29/01/2010 29/07/2010 Investigador/a Estudio de la composición química y posible actividad antioxidante y antitumoral del acebuche u olivo salvaje (Olea europaea, var. sulvestris) (0302/0180) Empresa de Gestión Medioambiental, S.A. (Autonómico)
30/06/2018 29/06/2022 Responsable Dietas artificiales basadas en restricciones selectivas de aminoácidos para el tratamiento de cánceres metastásicos (3388/0836) AMINOVITA, S.L. (Local)
01/07/2016 31/12/2017 Responsable Evaluación preclinica de nuevas estrategias anticancerosas orientadas al paciente oncológico (2812/0836) Asociación para el Desarrollo de la Oncología (ADEON) (Local)
01/06/2015 31/05/2018 Investigador/a Characterization of the clastogenic effects, SCE and micronuclei in neuroblastoma stem cells after MTH 1 inhibitors and combinations (2594/0594) THE HELLEDAY FOUNDATION (Internacional)
01/10/2012 01/10/2013 Investigador/a "On the mechanism of demethylating agents-induced DNA damege". (1674/0594) Instituto Karolinska (Europeo)
31/12/2020 31/12/2022 Investigador/a Importancia de MYCN en la sensibilidad en células madre de neuroblastoma a inhibidores de MTH1 (4045/1078) NEN - Asociación de familias y amigos de pacientes enfermos de neuroblastoma (Nacional)

Ayudas

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2020 31/12/2020 Responsable Ayudas para el uso de los Servicios Generales de Investigación (PPI544/2020) Universidad de Sevilla (Local)