José López Barneo

Catedrático de Universidad (V)
lbarneo@us.es
Área de conocimiento: Fisiología
Departamento: Fisiología Médica y Biofísica
Grupo: FISIOLOGIA CELULAR Y BIOFISICA (CTS-516)
Instituto de Inv.: IBIS
Prog. doctorado: Prog.Doct.en Biología Molecular, Biomedicina e Investigac.Clínica (RD.2011)
Tipo Año Título Fuente
Artículo2021 Lactate sensing mechanisms in arterial chemoreceptor cells NATURE COMMUNICATIONS
Artículo2021 Using redox-sensitive fluorescent probes to record real-time reactive oxygen species production in cells from mouse carotid body slices STAR Protocols
Artículo2020 Acute O-2 sensing through HIF2 alpha-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors SCIENCE SIGNALING
Artículo2020 Cellular adaptation to oxygen deficiency beyond the Nobel award NATURE COMMUNICATIONS
Corrección2020 Erratum: Publisher Correction: Cellular adaptation to oxygen deficiency beyond the Nobel award (Nature communications (2020) 11 1 (607)) NATURE COMMUNICATIONS
Libro2020 Fifteen Years of Baeza's Workshops: Current Trends in Biomedicine (2004-2019) Fifteen Years of Baeza's Workshops: Current Trends in Biomedicine (2004-2019)
Revisión2020 Molecular mechanisms of acute oxygen sensing by arterial chemoreceptor cells. Role of Hif2α FRONTIERS IN PHYSIOLOGY
Artículo2020 Molecular targets for endogenous glial cell line-derived neurotrophic factor modulation in striatal parvalbumin interneurons Brain Communications
Revisión2020 Neurotransmitter modulation of carotid body germinal niche INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Revisión2020 Physiology of the Carotid Body: From Molecules to Disease ANNUAL REVIEW OF PHYSIOLOGY
Artículo2020 Role of glial cell line-derived neurotrophic factor in the maintenance of adult mesencephalic catecholaminergic neurons MOVEMENT DISORDERS
Artículo2020 Unexpected obesity, rather than tumorigenesis, in a conditional mouse model of mitochondrial complex II deficiency FASEB JOURNAL
Revisión2019 Acute oxygen sensing-Role of metabolic specifications in peripheral chemoreceptor cells RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Artículo2019 Differential deletion of GDNF in the auditory system leads to altered sound responsiveness JOURNAL OF NEUROSCIENCE RESEARCH
Artículo2019 Mitochondrial Complex I Function Is Essential for Neural Stem/Progenitor Cells Proliferation and Differentiation FRONTIERS IN NEUROSCIENCE
Artículo2018 Acute O-2 Sensing: Role of Coenzyme QH(2)/Q Ratio and Mitochondrial ROS Compartmentalization CELL METABOLISM
Editorial2018 All for one - O-2-sensitive K+ channels that mediate carotid body activation JOURNAL OF PHYSIOLOGY-LONDON
Artículo2018 Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia EMBO REPORTS
Artículo2018 Glial-derived neurotrophic factor is essential for blood-nerve barrier functional recovery in an experimental murine model of traumatic peripheral neuropathy TISSUE BARRIERS
Artículo2018 HIF-2 alpha is essential for carotid body development and function eLife
Corrección2018 HIF-2 alpha is essential for carotid body development and function (corrección) eLife
Artículo2018 Monitoring Functional Responses to Hypoxia in Single Carotid Body Cells HYPOXIA: METHODS AND PROTOCOLS
Revisión2018 Oxygen sensing and stem cell activation in the hypoxic carotid body CELL AND TISSUE RESEARCH
Artículo2018 Testing Acute Oxygen Sensing in Genetically Modified Mice: Plethysmography and Amperometry HYPOXIA: METHODS AND PROTOCOLS
Artículo2018 The role of Olfr78 in the breathing circuit of mice NATURE
Artículo2017 Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-ß Peptide Generation In Vivo PLOS ONE
Artículo2017 Gene expression analyses reveal metabolic specifications in acute O-2-sensing chemoreceptor cells JOURNAL OF PHYSIOLOGY-LONDON
Artículo2017 Genetic Rescue of Mitochondrial and Skeletal Muscle Impairment in an Induced Pluripotent Stem Cells Model of Coenzyme Q(10) Deficiency STEM CELLS
Artículo2017 Highly Efficient Neural Conversion of Human Pluripotent Stem Cells in Adherent and Animal-Free Conditions STEM CELLS TRANSLATIONAL MEDICINE
Capítulo2017 Mi amistad con Joan Rodés y su influencia en el Instituto de Biomedicina de Sevilla Homenaje a Juan Rodés: trayectoria y facetas de un visionario : 50 testimonios
Revisión2017 Redox signaling in acute oxygen sensing REDOX BIOLOGY
Artículo2017 Sdhd ablation promotes thyroid tumorigenesis by inducing a stem-like phenotype ENDOCRINE-RELATED CANCER
Ponencia2016 Antiparkinsonian cell therapy with carotid body is affected by age-related epigenetic regulation of hypoxic GDNF expression HUMAN GENE THERAPY
Revisión2016 Carotid body oxygen sensing and adaptation to hypoxia PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Artículo2016 Chronic and progressive Parkinson's disease MPTP model in adult and aged mice JOURNAL OF NEUROCHEMISTRY
Artículo2016 Gene expression profiling supports the neural crest origin of adult rodent carotid body stem cells and identifies CD10 as a marker for mesectoderm-committed progenitors STEM CELLS
Editorial2016 Hypoxia in health and disease MOLECULAR ASPECTS OF MEDICINE
Revisión2016 Mature neurons modulate neurogenesis through chemical signals acting on neural stem cells DEVELOPMENT GROWTH & DIFFERENTIATION
Revisión2016 Oxygen sensing by the carotid body: mechanisms and role in adaptation to hypoxia AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Revisión2016 Oxygen-sensing by arterial chemoreceptors: Mechanisms and medical translation MOLECULAR ASPECTS OF MEDICINE
Artículo2016 Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion JOURNAL OF PHYSIOLOGY-LONDON
Artículo2016 Striatal GDNF Production Is Independent to Circulating Estradiol Level Despite Pan-Neuronal Activation in the Female Mouse PLOS ONE
Artículo2015 Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients EMBO Molecular Medicine
Letter2015 Comment on Potter and Moon's viewpoint: "Why do some patients stop breathing after taking narcotics? Ventilatory chemosensitivity as a predictor of opioid-induced respiratory depression" JOURNAL OF APPLIED PHYSIOLOGY
Letter2015 GDNF is not required for catecholaminergic neuron survival in vivo Reply NATURE NEUROSCIENCE
Revisión2015 GDNF-based therapies, GDNF-producing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson's disease FRONTIERS IN NEUROANATOMY
Artículo2015 Hypoxic induction of T-type Ca2+ channels in rat cardiac myocytes: role of HIF-1 and RhoA/ROCK signalling JOURNAL OF PHYSIOLOGY-LONDON
Artículo2015 Neurotrophic Properties, Chemosensory Responses and Neurogenic Niche of the Human Carotid Body Advances in Experimental Medicine and Biology
Artículo2015 Oxygen Sensing by Arterial Chemoreceptors Depends on Mitochondrial Complex I Signaling CELL METABOLISM
Artículo2015 Resistance of glia-like central and peripheral neural stem cells to genetically induced mitochondrial dysfunctiondifferential effects on neurogenesis EMBO REPORTS
Artículo2015 Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival HYPOXIA
Artículo2015 Tissue Dynamics of the Carotid Body Under Chronic Hypoxia: A Computational Study Advances in Experimental Medicine and Biology
Artículo2014 A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21(WAF1/Cip1) Induction and Mitochondrial Dysfunction PLOS ONE
Artículo2014 An O-2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hypoxia CELL
Artículo2014 Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia EMBO Molecular Medicine
Artículo2014 Effect of hypoxia on lung gene expression and proteomic profile: Insights into the pulmonary surfactant response JOURNAL OF PROTEOMICS
Revisión2014 Glucose sensing by carotid body glonnus cells: potential implications in disease FRONTIERS IN PHYSIOLOGY
Artículo2014 How to unfasten the Spanish Stroke Belt? Andalusia chooses research International Journal of Stroke
Artículo2014 Low-dose combination of Rho kinase and L-type Ca2+ channel antagonists for selective inhibition of depolarization-induced sustained arterial contraction EUROPEAN JOURNAL OF PHARMACOLOGY
Revisión2013 A new metabotropic role for L-type Ca2+ channels in vascular smooth muscle contraction CURRENT VASCULAR PHARMACOLOGY
Artículo2013 Age-Mediated Transcriptomic Changes in Adult Mouse Substantia Nigra PLOS ONE
Capítulo2013 Carotid body transplants as a therapy for Parkinson's disease EMERGING DRUGS AND TARGETS FOR PARKINSON'S DISEASE
Artículo2013 Cellular properties and chemosensory responses of the human carotid body JOURNAL OF PHYSIOLOGY-LONDON
Artículo2013 Direct confocal acquisition of fluorescence from X-gal staining on thick tissue sections SCIENTIFIC REPORTS
Ponencia2013 Expansion of differentiated GDNF-producing carotid body cells by reversible lentiviral gene transfer. Potential use in cell therapy HUMAN GENE THERAPY
Artículo2013 GDNF is required for neural colonization of the pancreas DEVELOPMENT
Artículo2013 Neuroprotective and reparative effects of carotid body grafts in a chronic MPTP model of Parkinson's disease NEUROBIOLOGY OF AGING
Capítulo2013 Potassium Channels in Adrenocortical and Parathyroid Cells Advances in Experimental Medicine and Biology
Ponencia2013 Protection and repair of thedopaminergic nigrostriatal pathway by striatal xenografts of in vitro expanded CB cells in a chronic Parkinson's disease model HUMAN GENE THERAPY
Artículo2012 Alpha-Haemoglobin regulates sympathoadrenal cell metabolism to maintain a catecholaminergic phenotype BIOCHEMICAL JOURNAL
Artículo2012 Differential Impairment of Catecholaminergic Cell Maturation and Survival by Genetic Mitochondrial Complex II Dysfunction MOLECULAR AND CELLULAR BIOLOGY
Artículo2012 Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease EMBO Molecular Medicine
Artículo2012 GDNF Is Predominantly Expressed in the PV plus Neostriatal Interneuronal Ensemble in Normal Mouse and after Injury of the Nigrostriatal Pathway JOURNAL OF NEUROSCIENCE
Revisión2012 Metabotropic Regulation of RhoA/Rho-Associated Kinase by L-Type Ca2+ Channels Trends in Cardiovascular Medicine
Artículo2012 Mitochondrial complex II is essential for hypoxia-induced pulmonary vasoconstriction of intra- but not of pre-acinar arteries CARDIOVASCULAR RESEARCH
Artículo2012 NEURAL STEM CELLS AND TRANSPLANTATION STUDIES IN PARKINSON'S DISEASE Advances in Experimental Medicine and Biology
Ponencia2012 Prolyl hydroxylase-dependent modulation of eukaryotic elongation factor 2 activity and protein translation under acute hipoxia FEBS JOURNAL
Artículo2012 Prolyl Hydroxylase-dependent Modulation of Eukaryotic Elongation Factor 2 Activity and Protein Translation under Acute Hypoxia JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2012 T-type Ca2+ channels in mouse embryonic stem cells: modulation during cell cycle and contribution to self-renewal AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Artículo2012 Tonic arterial contraction mediated by L-type Ca2+ channels requires sustained Ca2+ influx, G protein-associated Ca2+ release, and RhoA/ROCK activation EUROPEAN JOURNAL OF PHARMACOLOGY
Resumen congreso2012 Vascular niche factor regulate rodent adult carotid body stem cell activity FEBS JOURNAL
Artículo2011 Functional and Transcriptional Induction of Aquaporin-1 Gene by Hypoxia; Analysis of Promoter and Role of Hif-1 alpha PLOS ONE
Revisión2011 GDNF and protection of adult central catecholaminergic neurons Journal of Molecular Endocrinology
Artículo2011 HEAT SHOCK PROTEIN 70 KDA OVER-EXPRESSION AND 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-INDUCED NIGROSTRIATAL DEGENERATION IN MICE NEUROSCIENCE
Artículo2011 Intermediate alleles at the FRAXA and FRAXE loci in Parkinson's disease PARKINSONISM & RELATED DISORDERS
Artículo2011 Metabotropic Regulation of RhoA/Rho-Associated Kinase by L-type Ca2+ Channels New Mechanism for Depolarization-Evoked Mammalian Arterial Contraction CIRCULATION RESEARCH
Capítulo2011 Neuroprotection in Parkinson's disease ANIMAL MODELS FOR NEURODEGENERATIVE DISEASE
Ponencia2011 PSMC1 gene in Parkinson's disease MOVEMENT DISORDERS
Artículo2010 AQP1 mediates water transport in the carotid body PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Artículo2010 Brain-derived neurotrophic factor G196A polymorphism and clinical features in Parkinson's disease ACTA NEUROLOGICA SCANDINAVICA
Artículo2010 Carotid body chemosensory responses in mice deficient of TASK channels JOURNAL OF GENERAL PHYSIOLOGY
Artículo2010 First Aid Kit for Hypoxic Survival: Sensors and Strategies PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY
Artículo2010 Genetic Ablation of L-Type Ca2+ Channels Abolishes Depolarization-Induced Ca2+ Release in Arterial Smooth Muscle CIRCULATION RESEARCH
Artículo2010 Mesencephalic and striatal protein profiles in mice over-expressing glucose-6-phosphate dehydrogenase in dopaminergic neurons JOURNAL OF PROTEOMICS
Artículo2010 Mitochondrial complex II participates in normoxic and hypoxic regulation of alpha-keto acids in the murine heart JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Revisión2010 The carotid body, a neurogenic niche in the adult peripheral nervous system ARCHIVES ITALIENNES DE BIOLOGIE
Artículo2009 Developmental change of T-type Ca2+ channel expression and its role in rat chromaffin cell responsiveness to acute hypoxia JOURNAL OF PHYSIOLOGY-LONDON
Artículo2009 Differential proteomic analysis of adrenal gland during postnatal development PROTEOMICS
Artículo2009 Hypoxia Inducible Factor-2 alpha Stabilization and Maxi-K+ Channel beta(1)-Subunit Gene Repression by Hypoxia in Cardiac Myocytes Role in Preconditioning CIRCULATION RESEARCH
Artículo2009 Hypoxia inhibits vasoconstriction induced by metabotropic Ca2+ channel-induced Ca2+ release in mammalian coronary arteries CARDIOVASCULAR RESEARCH
Artículo2009 Maxi-K+ Channel beta 1 Expression in Sleep Apnea Patients and Its Modulation by CPAP Treatment AMERICAN JOURNAL OF HYPERTENSION
Artículo2009 Oxygen Sensing in the Carotid Body ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Artículo2009 Prevalence and clinical features of LRRK2 mutations in patients with Parkinson's disease in southern Spain EUROPEAN JOURNAL OF NEUROLOGY
Ponencia2009 Substantia Nigra Dopaminergic Neurons Are Protected by Intraestriatal Carotid Body Grafts in a Chronic MPTP Mouse Model of Parkinson's Disease HUMAN GENE THERAPY
Artículo2009 The neurogenic niche in the carotid body and its applicability to antiparkinsonian cell therapy JOURNAL OF NEURAL TRANSMISSION
Artículo2008 Abnormal sympathoadrenal development and systemic hypotension in PHD3(-/-) mice MOLECULAR AND CELLULAR BIOLOGY
Artículo2008 Absolute requirement of GDNF for adult catecholaminergic neuron survival NATURE NEUROSCIENCE
Ponencia2008 Brain-derived neurotrophic factor G196A polymorphism and clinical features in Parkinson's disease MOVEMENT DISORDERS
Revisión2008 Carotid body oxygen sensing EUROPEAN RESPIRATORY JOURNAL
Letter2008 Glucose-6-phosphate dehydrogenase activity in Parkinson's disease JOURNAL OF NEUROLOGY
Capítulo2008 Oxygen-Sensing by Ion Channels and Mitochondrial Function in Carotid Body Glomus Cells Signalling Pathways in Acute Oxygen Sensing
Artículo2008 Transplantes del cuerpo carotídeo en la enfermedad de Parkinson Boletín del Instituto de Estudios Giennenses
Artículo2007 Aplicaciones terapéuticas de las células madre, ¿mito o realidad? Transatlántica de educación
Artículo2007 Carotid body autotransplantation in Parkinson disease: a clinical and positron emission tomography study JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Artículo2007 Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2007 Developmental changes of chromaffin cell secretory response to hypoxia studied in thin adrenal slices PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Artículo2007 Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body CELL
Ponencia2007 Glucose-6-phosphate dehydrogenase in the peripheral blood of patients with Parkinson's disease MOVEMENT DISORDERS
Ponencia2007 LRRK2 mutations in patients with Parkinson's disease in southern Spain MOVEMENT DISORDERS
Artículo2007 Mechanisms of acute oxygen sensing by the carotid body: Lessons from genetically modified animals RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Artículo2007 Mechanisms of low-glucose sensitivity in carotid body glomus cells DIABETES
Artículo2007 Metabotropic Ca2+ channel-induced calcium release in vascular smooth muscle CELL CALCIUM
Artículo2007 Torredonjimeno, nostalgia cargada de futuro Jaén y el olivo en la pintura de Alfonso Parras: catálogo de exposición
Artículo2006 Acute oxygen sensing in heme oxygenase-2 null mice JOURNAL OF GENERAL PHYSIOLOGY
Ponencia2006 Discussion Novartis Foundation Symposium
Ponencia2006 Discussion Novartis Foundation Symposium
Ponencia2006 Discussion Novartis Foundation Symposium
Ponencia2006 Discussion Novartis Foundation Symposium
Ponencia2006 Discussion Novartis Foundation Symposium
Ponencia2006 Discussion Novartis Foundation Symposium
Ponencia2006 Discussion Novartis Foundation Symposium
Ponencia2006 Discussion Novartis Foundation Symposium
Ponencia2006 Discussion Novartis Foundation Symposium
Ponencia2006 Discussion Novartis Foundation Symposium
Ponencia2006 Discussion Novartis Foundation Symposium
Ponencia2006 Final general discussion Novartis Foundation Symposium
Ponencia2006 General discussion I Novartis Foundation Symposium
Ponencia2006 General discussion II Novartis Foundation Symposium
Ponencia2006 General discussion III Novartis Foundation Symposium
Artículo2006 Metabotropic Ca(2+) channel-induced Ca(2+) release and ATP-dependent facilitation of arterial myocyte contraction PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Artículo2006 Neuroprotection by transgenic expression of glucose-6-phosphate dehydrogenase in dopaminergic nigrostriatal neurons of mice JOURNAL OF NEUROSCIENCE
Ponencia2006 Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells Novartis Foundation Symposium
Libro2006 Sensibilidad al oxígeno y neurodegeneración: un encuentro recurrente : autotrasplantes de células del cuerpo carotídeo en la enfermedad de Parkinson Sensibilidad al oxígeno y neurodegeneración: un encuentro recurrente : autotrasplantes de células del cuerpo carotídeo en la enfermedad de Parkinson
Letter2006 The authors reply [12] NEW ENGLAND JOURNAL OF MEDICINE
Capítulo2006 Trasplantes de tejido del cuerpo carotídeo en modelos de enfermedad de Parkinson Trasplante de órganos y células : dimensiones éticas regulatorias
Artículo2005 Decreased expression of maxi-K+ channel beta(1)-subunit and altered vasoregulation in hypoxia CIRCULATION
Revisión2005 Mechanisms of disease - Acute oxygen-sensing mechanisms NEW ENGLAND JOURNAL OF MEDICINE
Artículo2005 Mitos y realidades de la investigación con células madre Revista de Libros
Editorial2005 Multiple facets of maxi-K+ channels: The heme connection JOURNAL OF GENERAL PHYSIOLOGY
Artículo2005 Oxygen tension regulates mitochondrial DNA-encoded complex I gene expression JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2005 Rat adrenal chromaffin cells are neonatal CO2 sensors JOURNAL OF NEUROSCIENCE
Artículo2005 Selective glial cell line-derived neurotrophic factor production in adult dopaminergic carotid body cells in situ and after intrastriatal transplantation JOURNAL OF NEUROSCIENCE
Ponencia2004 Changes in visual memory after autotransplantation of human carotid body cell aggregates in patients with Parkinson's disease ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
Artículo2004 Combined oxygen and glucose sensing in the carotid body UNDERSEA & HYPERBARIC MEDICINE
Artículo2004 Differential functional properties of Ca2+ stores in pulmonary arterial conduit and resistance myocytes CELL CALCIUM
Artículo2004 Induction of the glucose-6-phosphate dehydrogenase gene expression by chronic hypoxia in PC12 cells FEBS LETTERS
Revisión2004 Regulation of oxygen sensing by ion channels JOURNAL OF APPLIED PHYSIOLOGY
Artículo2004 The mitochondrial SDHD gene is required for early embryogenesis, and its partial deficiency results in persistent carotid body glomus cell activation with full responsiveness to hypoxia MOLECULAR AND CELLULAR BIOLOGY
Editorial2004 The need for a State Pact for Science in Spain CLINICAL & TRANSLATIONAL ONCOLOGY
Artículo2003 Autotransplantation of human carotid body cell aggregates for treatment of Parkinson's disease Neurosurgery
Artículo2003 Ca2+ channel-sarcoplasmic reticulum coupling: a mechanism of arterial myocyte contraction without Ca2+ influx EMBO JOURNAL
Capítulo2003 Carotid body thin slices: New answers for old questions Oxygen Sensing: Responses and Adaption to Hypoxia
Artículo2003 Glucose sensing cells in the carotid body Advances in Experimental Medicine and Biology
Artículo2003 Induction of T-type calcium channel gene expression by chronic hypoxia JOURNAL OF BIOLOGICAL CHEMISTRY
Revisión2003 Oxygen and glucose sensing by carotid body glomus cells CURRENT OPINION IN NEUROBIOLOGY
Artículo2003 Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells JOURNAL OF PHYSIOLOGY-LONDON
Artículo2003 Studies on glomus cell sensitivity to hypoxia in carotid body slices Advances in Experimental Medicine and Biology
Artículo2003 Trophic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body-grafted parkinsonian rats JOURNAL OF NEUROSCIENCE
Artículo2002 Carotid body thin slices: responses of glomus cells to hypoxia and K+-channel blockers RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Artículo2002 Dopaminergic cells of the carotid body: Physiological significance and possible therapeutic applications in Parkinson's disease BRAIN RESEARCH BULLETIN
Ponencia2002 Glucose Sensing Cells in the Carotid Body Advances in Experimental Medicine and Biology
Artículo2002 Low glucose-sensing cells in the carotid body NATURE NEUROSCIENCE
Artículo2002 Reduction of Ca2+ channel activity by hypoxia in human and porcine coronary myocytes CARDIOVASCULAR RESEARCH
Artículo2002 Studies on glomus cell sensitivity to hypoxia in carotid body slices Advances in Experimental Medicine and Biology
Artículo2002 Tyrosine phosphorylation of the inactivating peptide of the shaker B potassium channel: A structural-functional correlate BIOCHEMISTRY
Revisión2001 Cellular mechanisms of oxygen sensing ANNUAL REVIEW OF PHYSIOLOGY
Artículo2001 Differential segmental activation of Ca2+-dependent Cl- and K+ channels in pulmonary arterial myocytes CELL CALCIUM
Artículo2001 Estado actual y perspectivas de la Neurología en España ARBOR-CIENCIA PENSAMIENTO Y CULTURA
Ponencia2001 Transplantation of carotid body cell aggregates in patients with Parkinson's disease: a pilot study. PARKINSONISM & RELATED DISORDERS
Artículo2000 Collapse of conductance is prevented by a glutamate residue conserved in voltage-dependent K+ channels JOURNAL OF GENERAL PHYSIOLOGY
Artículo2000 Secretory responses of intact glomus cells in thin slices of rat carotid body to hypoxia and tetraethylammonium PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Artículo1999 A small domain in the N terminus of the regulatory α-subunit Kv2.3 modulates Kv2.1 potassium channel gating JOURNAL OF NEUROSCIENCE
Artículo1999 K+ and Ca2+ channel activity and cytosolic [Ca2+] in oxygen-sensing tissues RESPIRATION PHYSIOLOGY
Artículo1999 Recovery of chronic parkinsonian monkeys by autotransplants of carotid body cell aggregates into putamen NEURON
Ponencia1998 A Region of the amino terminal in Kv2 potassium channels is involved in deactivation. EUROPEAN JOURNAL OF NEUROSCIENCE
Artículo1998 Cellular and functional recovery of Parkinsonian rats after intrastriatal transplantation of carotid body cell aggregates NEURON
Ponencia1998 Differential properties of Ca2+ stores and Ca2+-dependent ionic conductances in conduit and resistance pulmonary arterial myocytes JOURNAL OF PHYSIOLOGY-LONDON
Ponencia1998 Diversification of potassium channel function by regulatory alpha subunits JOURNAL OF PHYSIOLOGY-LONDON
Ponencia1998 Studies on native and recombinant potassium channel modulation by hypoxia in cell lines. EUROPEAN JOURNAL OF NEUROSCIENCE
Artículo1997 Identification and functional characterization of a K+ channel α- subunit with regulatory properties specific to brain JOURNAL OF NEUROSCIENCE
Artículo1997 NMDA-glutamate receptors regulate phosphorylation of dendritic cytoskeletal proteins in the hippocampus BRAIN RESEARCH
Artículo1997 Oxygen sensing by ion channels KIDNEY INTERNATIONAL
Artículo1997 Pore mutations in Shaker K+ channels distinguish between the sites of tetraethylammonium blockade and C-type inactivation JOURNAL OF PHYSIOLOGY-LONDON
Artículo1997 Recombinant Ca2+ channels get O2 sensitive. JOURNAL OF PHYSIOLOGY-LONDON
Artículo1996 Contrasting effects of hypoxia on cytosolic Ca2+ spikes in conduit and resistance myocytes of the rabbit pulmonary artery JOURNAL OF PHYSIOLOGY-LONDON
Artículo1996 Differential oxygen sensitivity of calcium channels in rabbit smooth muscle cells of conduit and resistance pulmonary arteries JOURNAL OF PHYSIOLOGY-LONDON
Corrección1996 Erratum: (Journal of Physiology (1996) 491 (511-518)) JOURNAL OF PHYSIOLOGY-LONDON
Artículo1996 Low PO2 inhibits calcium channel activity in arterial smooth muscle cells American Journal of Physiology - Heart and Circulatory Physiology
Ponencia1996 Modulation of voltage-gated Ca2+ channels by O2 tension: Significance for arterial oxygen chemoreception Advances in Experimental Medicine and Biology
Artículo1996 Oxygen sensing by ion channels and chemotransduction in single Glomus cells JOURNAL OF GENERAL PHYSIOLOGY
Revisión1996 Oxygen-sensing by ion channels and the regulation of cellular functions TRENDS IN NEUROSCIENCES
Artículo1996 Synthesis of a photoaffinity labeling analogue of the inactivating peptide of the Shaker B potassium channel FEBS LETTERS
Artículo1995 La investigación cerebral Seminario médico
Artículo1995 OXYGEN-SENSITIVE CALCIUM CHANNELS IN VASCULAR SMOOTH-MUSCLE AND THEIR POSSIBLE ROLE IN HYPOXIC ARTERIAL RELAXATION PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Artículo1994 HYPOXIA INDUCES VOLTAGE-DEPENDENT CA2+ ENTRY AND QUANTAL DOPAMINE SECRETION IN CAROTID-BODY GLOMUS CELLS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Editorial1994 OXYGEN-SENSITIVE ION CHANNELS - HOW UBIQUITOUS ARE THEY TRENDS IN NEUROSCIENCES
Artículo1993 Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors & channels
Artículo1993 HIGH EXTERNAL POTASSIUM INDUCES AN INCREASE IN THE PHOSPHORYLATION OF THE CYTOSKELETAL PROTEIN MAP2 IN RAT HIPPOCAMPAL SLICES EUROPEAN JOURNAL OF NEUROSCIENCE
Artículo1993 N-METHYL-D-ASPARTATE STIMULATES THE DEPHOSPHORYLATION OF THE MICROTUBULE-ASSOCIATED PROTEIN-2 AND POTENTIATES EXCITATORY SYNAPTIC PATHWAYS IN THE RAT HIPPOCAMPUS NEUROSCIENCE
Artículo1992 EXCITATORY AND INHIBITORY SYNAPTIC CURRENTS AND RECEPTORS IN RAT MEDIAL SEPTAL NEURONS JOURNAL OF PHYSIOLOGY-LONDON
Artículo1992 GATING OF O2-SENSITIVE K+ CHANNELS OF ARTERIAL CHEMORECEPTOR CELLS AND KINETIC MODIFICATIONS INDUCED BY LOW PO2 JOURNAL OF GENERAL PHYSIOLOGY
Artículo1992 PATCH-CLAMP ANALYSIS OF VOLTAGE-GATED CURRENTS IN INTERMEDIATE LOBE CELLS FROM RAT PITUITARY THIN SLICES PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Artículo1992 POTASSIUM CHANNEL TYPES IN ARTERIAL CHEMORECEPTOR CELLS AND THEIR SELECTIVE MODULATION BY OXYGEN JOURNAL OF GENERAL PHYSIOLOGY
Artículo1991 El lenguaje eléctrico de las neuronas Política científica
Artículo1991 SINGLE K+ CHANNELS IN MEMBRANE PATCHES OF ARTERIAL CHEMORECEPTOR CELLS ARE MODULATED BY O2 TENSION PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Artículo1991 SODIUM AND CALCIUM CURRENTS IN DISPERSED MAMMALIAN SEPTAL NEURONS JOURNAL OF GENERAL PHYSIOLOGY
Nota1990 FEEDBACK INHIBITION OF CA-2+ CURRENTS BY DOPAMINE IN GLOMUS CELLS OF THE CAROTID-BODY EUROPEAN JOURNAL OF NEUROSCIENCE
Artículo1989 IONIC CURRENTS IN DISPERSED CHEMORECEPTOR CELLS OF THE MAMMALIAN CAROTID-BODY JOURNAL OF GENERAL PHYSIOLOGY
Artículo1989 LOW PO2 SELECTIVELY INHIBITS K-CHANNEL ACTIVITY IN CHEMORECEPTOR CELLS OF THE MAMMALIAN CAROTID-BODY JOURNAL OF GENERAL PHYSIOLOGY
Nota1989 LOW-COST SYSTEM FOR AUTOMATED ACQUISITION, DISPLAY AND ANALYSIS OF TRANSMEMBRANE IONIC CURRENTS MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
Artículo1989 PROPERTIES OF CALCIUM AND POTASSIUM CURRENTS OF CLONAL ADRENOCORTICAL-CELLS JOURNAL OF GENERAL PHYSIOLOGY
Artículo1988 CHEMOTRANSDUCTION IN THE CAROTID-BODY - K+ CURRENT MODULATED BY PO2 IN TYPE-I CHEMORECEPTOR CELLS SCIENCE
Nota1988 DIFFERENTIAL BURST FIRING MODES IN NEURONS OF THE MAMMALIAN VISUAL-CORTEX INVITRO BRAIN RESEARCH
Artículo1988 Ionic basis of the differential neuronal-activity of guinea-pig septal nucleus studied invitro JOURNAL OF PHYSIOLOGY-LONDON
Artículo1987 CA-2+ AND VOLTAGE-DEPENDENT K+ CONDUCTANCE IN DISPERSED PARATHYROID CELLS CELL CALCIUM
Artículo1986 Calcium action potentials in cultured adrenocortical cells PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Artículo1986 EFFECTS OF MEMBRANE DEPOLARIZATION AND DIVALENT-CATIONS ON ANAPHYLACTIC HISTAMINE-SECRETION CELL CALCIUM
Artículo1985 CALCIUM-ACTIVATED AND VOLTAGE-ACTIVATED POTASSIUM CHANNELS IN ADRENOCORTICAL CELL-MEMBRANES BIOCHIMICA ET BIOPHYSICA ACTA
Nota1985 ELECTROPHYSIOLOGICAL PROPERTIES OF GUINEA-PIG SEPTAL NEURONS INVITRO BRAIN RESEARCH
Artículo1984 Single channel currents in adrenocortical cells Revista Española de Fisiología
Artículo1984 SINGLE CHANNEL CURRENTS IN ADRENOCORTICAL-CELLS Revista Española de Fisiología
Artículo1983 DEPOLARIZING RESPONSE OF RAT PARATHYROID CELLS TO DIVALENT-CATIONS JOURNAL OF GENERAL PHYSIOLOGY
Artículo1983 Electrophysiological and functional identification of different neuronal types within the ambiguus nucleus in the cat BRAIN RESEARCH
Artículo1983 Proyecciones del núcleo praeositus hypoglossi al cerebelo en el gato Revista Española de Fisiología
Artículo1982 Estudio de la actividad funcional de las motoneuronas laríngeas en el gato anestesiado Revista Española de Fisiología
Artículo1982 NEURONAL-ACTIVITY IN PREPOSITUS NUCLEUS CORRELATED WITH EYE-MOVEMENT IN THE ALERT CAT JOURNAL OF NEUROPHYSIOLOGY
Artículo1981 ASYMMETRIES OF VERTICAL VESTIBULAR-NYSTAGMUS IN THE CAT EXPERIMENTAL BRAIN RESEARCH
Nota1981 CURRENTS RECORDED THROUGH SMALL AREAS OF SQUID AXON MEMBRANE WITH AN INTERNAL VIRTUAL GROUND VOLTAGE CLAMP BIOPHYSICAL JOURNAL
Artículo1981 Estudio neurofisiológico de las neuronas del núcleo prepositus hipopglossi que proyectan al motor ocular común en el gato Revista Española de Fisiología
Nota1981 IDENTIFICATION OF PREPOSITUS NEURONS PROJECTING TO THE OCULOMOTOR NUCLEUS IN THE ALERT CAT BRAIN RESEARCH
Artículo1981 Neuronas de la formación reticular ponto-bulbar sensibles a los movimientos de los ojos y del cuello y a la estimulación vestibular en el gato despierto Revista Española de Fisiología
Artículo1979 Functional Role of the Prepositus Hypoglossi Nucleus in the Control of Gaze Progress in brain research
Artículo1978 Effects of drugs on the characteristics of cat's saccadic eye movements Neuroscience Letters

Tesis dirigidas/tutorizadas:29
Fecha lectura Título Rol
23/05/2019 INTERNEURONAS ESTRIATALES PRODUCTORAS DE GDNF: CARACTERÍSTICAS MOLECULARES Y ROL EN LA NEUROPROTECCIÓN CATECOLAMINÉRGICA Tutor/a, Director/a
10/01/2019 ACTIVACIÓN DE LAS CÉLULAS GLÓMICAS POR HIPOXIA Y LACTATO. EL CUERPO CAROTÍDEO COMO SENSOR METABÓLICO Tutor/a, Director/a
27/09/2017 SEGURIDAD Y EFICACIA DE LA VACUNACIÓN ANTIGRIPAL EN PACIENTES PEDIÁTRICOS CON ARTRITIS IDIOPÁTICA JUVENIL Tutor/a
22/09/2017 NUEVAS MODALIDADES DE INMUNOPROFILAXIS EN TRASPLANTE: INHIBIDORES DEL PROTEOSOMA Tutor/a
05/09/2017 STRATEGIES TO OBTAIN TUMOR-REACTIVE CELLS FOR CANCER IMMUNOTHERAPY BY CELL SORTING AND GENETIC MODIFICATIONS OF T LYMPHOCYTES Tutor/a
19/06/2017 NUEVAS ESTRATEGIAS Y MECANISMOS DE INMUNOMODULACIÓN EN EL TRATAMIENTO DE LAS HEMOPATÍAS MALIGNAS Tutor/a
17/06/2015 MECANISMOS MOLECULARES DE LA SENSIBILIDAD AGUDA AL OXIGENO EN LOS QUIMIORRECEPTORES ARTERIALES: FUNCIÓN DEL COMPLEJO I MITOCONDRIAL Director/a
25/04/2014 Hipertrofia del cuerpo carotídeo en hipoxia crónica: mecanismos de activación, proliferación y diferenciación de los progenitores neurales en el sistema nervioso periférico Director/a
20/07/2012 GENERACIÓN Y ANÁLISIS DEL RATÓN MUTANTE CONDICIONAL EN LA SUBUNIDAD D DEL COMPLEJO II MITOCONDRIAL : EFECTO SOBRE EL SISTEMA NERVIOSO CENTRAL Y EL PERIFÉRICO Director/a
21/03/2012 FUNCIÓN TRÓFICA DE GDNF SOBRE NEURONAS CATECOLAMINÉRGICAS Y DESCRIPCIÓN DE SU EXPRESIÓN EN EL CEREBRO DE RATÓN Director/a
26/09/2011 PARTICIPACIÓN DE HEMOPROTEÍNAS EN LA FUNCIÓN QUIMIOSENSORA DE CÉLULAS NEUROSECRETORAS Director/a
09/03/2009 HIPOXIA EN CARDIOMIOCITOS; REGULACIÓN DE LA EXPRESIÓN DE LA SUBUNIDAD B1 DEL CANAL MAXI-K Y PARTICIPACIÓN EN EL PRECONDICIONAMIENTO CARDÍACO Director/a
19/04/2007 GDNF Y CUERPO CAROTÍDEO: IMPLICACIONES FUNCIONALES Y USO EN TERAPIA CELULAR Director/a
02/02/2007 QUIMIORRECEPCIÓN DEL CO2 EN LA MÉDULA ADRENAL Y FACILITACIÓN DE LA PERMEABILIDAD A O2 POR LA ACUAPORINA-1 Director/a
20/06/2006 NEUROPROTECCIÓN EN UN NUEVO MODELO DE ANIMAL TRANSGÉNICO Director/a
17/01/2006 ACOPLAMIENTO EXCITACIÓN-CONTRACCIÓN EN MÚSCULO LISO: NUEVO PAPEL METABOTRÓPICO DE LOS CANALES DE CALCIO EN LA REGULACIÓN DEL TONO VASCULAR Director/a
12/12/2005 REGULACIÓN DE LA EXPRESIÓN GÉNICA DE CANALES IÓNICOS POR HIPOXIA CRÓNICA EN CÉLULAS CROMAFINES Director/a
20/04/2005 CÉLULAS NEUROSECRETORAS SENSORAS DE OXÍGENO Y GLUCOSA Director/a
31/05/2004 TRANSPLANTE DE CUERPO CAROTÍDEO EN MODELOS ANIMALES DE ENFERMEDAD DE PARKINSON Director/a
04/12/2000 SENSIBILIDAD A HIPOXIA E HIPOGLUCEMIA DE CÉLULAS GLÓMICAS EN RODAJAS DE CUERPO CAROTÍDEO Director/a
24/07/2000 HOMEOSTASIS DEL CALCIO EN MIOCITOS DEL ÁRBOL ARTERIAL PULMONAR Director/a
1989 Adaptacion morfofuncional renal tras nefrectomia unilateral en el adulto Director/a
1993 Adaptación y modificaciones de corta y larga duración en la actividad eléctrica de neuronas de la corteza cerebral in vitro Director/a
1991 Canales de calcio de las celulas glomicas y su modulacion por dopamina Director/a
1990 Efecto de la estimulación eléctrica periférica sobre la evolución del dolor lumbar Director/a
1997 Regulación estructural y funcional de canales de K+ por mutaciones en el poro y una subunidad alfa reguladora Director/a
1988 Repercusión de las alteraciones en la función respiratoria sobre el síndrome de apnea del sueño Director/a
1987 Sistema para la adquisición, almacenamiento y análisis de corrientes iónicas transmembrana Director/a
2005 Trasplante de agregados celulares del cuerpo carotídeo en pacientes con enfermedad de Parkinson Director/a

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/11/2015 31/10/2020 Responsable Molecular mechanisms of acute oxygen sensing (OXYGENSENSING) (2629/0805) Comisión Europea (Europeo)
16/12/2020 15/12/2023 Investigador/a Ingenieria de la neurogenesis aplicada a la regeneración del tejido cerebral (P18-RTJ-1088) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico)
01/10/2006 30/09/2009 Responsable Sensibilidad al oxígeno y neurodegeneración (SAF2006-08311) Ministerio de Educación y Ciencia (Nacional)
01/01/2012 01/01/2014 Responsable Convenio de colaboración en materia de apoyo a la transferencia tecnológica en el campo de la biotecnología (CVFB12/005) Fundación Marcelino Botín (Nacional)
30/12/2016 29/12/2019 Responsable Sensibilidad al Oxígeno y Neurodegeneración (SAF2016-74990-R) Ministerio de Economía y Competitividad (Nacional)
01/09/2020 31/08/2022 Investigador/a Ingeniería de la neurogénesis y regeneración cerebral: desarrollo de una tecnología basada en la reprogramación celular para activar la formación de nuevas neuronas en el cerebro adulto. (US-1262881) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico)
01/11/2005 31/10/2009 Responsable Network of European Neuroscience Institutes (ENINET) (LSHM-CT-2005-019063) Commission of the European Communities (Research Directorate-General) (Europeo)
01/01/2013 31/12/2015 Responsable Sensibilidad al Oxígeno y Neurodegeneración (SAF2012-39343) Ministerio de Economía y Competitividad (Nacional)
01/01/2015 31/12/2018 Investigador/a Desarrollo de una terapia para el tratamiento de variantes genéticas de alfa-sinucleína en la enfermedad de parkinson (RTC-2015-3309-1) Ministerio de Economía y Competitividad (Nacional)
01/02/2020 31/01/2022 Responsable Intolerancia a la hipoxia; efecto sobre la neurogénesis en el cerebro adulto. (US-1261055) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico)
01/01/2006 31/12/2009 Responsable Pulmonary Hypertension: Functional Genomics and Therapy ol Lung Vascular Remodelling (PULMOTENSION) (LSHM-CT-2005-018725) Commission of the European Communities (Research Directorate-General) (Europeo)
01/01/2010 31/12/2012 Responsable Sensibilidad al oxígeno y neurodegeneración (SAF2009-12409) Ministerio de Ciencia e Innovación (Nacional)
01/02/2020 30/04/2022 Investigador/a Molecular Basis for Acute Hypoxia-Related Diseases: Understanding the Role of Cytochrome c in Respirasome Assembly and Functioning (US-1257019) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico)
01/08/2002 31/01/2004 Responsable Estancias de doctores y tecnólogos extranjeros en España (SB2000-0100) Ministerio de Educación y Ciencia (Nacional)
01/06/2020 31/05/2023 Responsable Sensibilidad a Oxígeno y Neurodegeneración (PID2019-106410RB-I00) Ministerio de Ciencia, Innovación y Universidades (Nacional)
01/01/2007 31/12/2012 Responsable Sensibilidad al oxígeno y neurodegeneración (CONFMB-001/2006) Fundación Marcelino Botín (Nacional)
01/01/2014 31/12/2014 Responsable Apoyo a la transferencia tecnológica en el campo de la biotecnología (CBUS/FB/2014/001) Fundación Botín (Nacional)

Contratos

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2010 31/03/2010 Responsable Determinación de la eficacia de un compuesto de NOSCIRA tras administración crónica en un modelo murino de muerte neuronal inducida por MPTP (0639/0321) NOSCIRA, S.A. (Nacional)
01/06/2010 31/12/2010 Responsable Estudio del potencial efecto neuroprotector in vivo de un compuesto de Noscira. (0798/0321) NOSCIRA, S.A. (Nacional)

Ayudas

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/06/2006 30/11/2007 Responsable Estancias de jóvenes doctores extranjeros en España (SB2005-0168) Ministerio de Educación y Ciencia (Nacional)
24/05/2004 24/05/2005 Investigador/a XXXIII Congress of the Spanich Physiological Society of Physiological Sciences. International joint meeting with the Physiological society and the Dutch Society of Physiology (BFI2002-12571-E) Ministerio de Educación y Ciencia (Nacional)