Patricia Judith Lardone

Profesora Titular de Universidad
plardone@us.es
Área de conocimiento: Bioquímica y Biología Molecular
Departamento: Bioquímica Méd.y Biol.Molecular e Inmun.
Grupo: NEUROENDOCRINOLOGIA MOLECULAR (CTS-160)
Instituto de Inv.: IBIS
Tipo Año Título Fuente
Artículo2021 Lupinus angustifolius protein hydrolysates reduce abdominal adiposity and ameliorate metabolic associated fatty liver disease (Mafld) in western diet fed-apoe−/− mice ANTIOXIDANTS
Artículo2021 Safety and efficacy of a beverage containing lupine protein hydrolysates on the immune, oxidative and lipid status in healthy subjects: an intervention study (the lupine-1 trial). MOLECULAR NUTRITION & FOOD RESEARCH
Artículo2020 Homocysteine and C-Reactive Protein Levels Are Associated With Frailty in Older Spaniards: The Toledo Study for Healthy Aging JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Artículo2020 Immunomodulatory and antioxidant properties of wheat gluten protein hydrolysates in human peripheral blood mononuclear cells NUTRIENTS
Resumen congreso2020 Melatonin reduces disability in experimental autoimmune encephalomyelitis by impairing immune cells migration and entry into the CNS MULTIPLE SCLEROSIS
Artículo2020 Seasonal variations in macrophages/microglia underlie changes in the mouse model of multiple sclerosis severity MOLECULAR NEUROBIOLOGY
Artículo2019 Lupine protein hydrolysates decrease the inflammatory response and improve the oxidative status in human peripheral lymphocytes FOOD RESEARCH INTERNATIONAL
Artículo2019 Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients SCIENTIFIC REPORTS
Artículo2019 Temporal expression patterns of the melatoninergic system in the human thymus of children Molecular Metabolism
Artículo2018 Current evidences on melatonin role on multiple sclerosis APPROACHES TO AGING CONTROL
Artículo2018 Homocysteine levels are associated with bone resorption in pre-frail and frail Spanish women: The Toledo Study for Healthy Aging EXPERIMENTAL GERONTOLOGY
Artículo2017 Melatonin reduces inflammatory response in peripheral T helper lymphocytes from relapsing-remitting multiple sclerosis patients JOURNAL OF PINEAL RESEARCH
Artículo2015 Evaluation of the immunomodulatory effect of melatonin on the T-cell response in peripheral blood from systemic lupus erythematosus patients JOURNAL OF PINEAL RESEARCH
Artículo2015 Melatonin controls experimental autoimmune encephalomyelitis by altering the T effector/regulatory balance BRAIN BEHAVIOR AND IMMUNITY
Artículo2015 Melatonin treatment improves primary progressive multiple sclerosis: a case report JOURNAL OF PINEAL RESEARCH
Artículo2014 Melatonin and Glucose Metabolism: Clinical Relevance CURRENT PHARMACEUTICAL DESIGN
Capítulo2014 Multiple facets of melatonin in immunity: Clinical applications Melatonin and Melatonergic Drugs in Clinical Practice
Revisión2013 Melatonin: Buffering the Immune System INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Artículo2011 Melatonin synthesized by T lymphocytes as a ligand of the retinoic acid-related orphan receptor JOURNAL OF PINEAL RESEARCH
Artículo2010 Blocking of melatonin synthesis and MT1 receptor impairs the activation of Jurkat T cells CELLULAR AND MOLECULAR LIFE SCIENCES
Artículo2009 A novel interplay between membrane and nuclear melatonin receptors in human lymphocytes: significance in IL-2 production CELLULAR AND MOLECULAR LIFE SCIENCES
Artículo2009 Decreased MT1 and MT2 melatonin receptor expression in extrapineal tissues of the rat during physiological aging JOURNAL OF PINEAL RESEARCH
Artículo2009 Evidence of immune system melatonin production by two pineal melatonin deficient mice, C57BL/6 and Swiss strains JOURNAL OF PINEAL RESEARCH
Artículo2007 Evidence for melatonin synthesis in the rat brain during development JOURNAL OF PINEAL RESEARCH
Artículo2007 La melatonina Investigación y Ciencia
Revisión2007 Melatonin as pharmacologic support in burn patients: A proposed solution to thermal injury-related lymphocytopenia and oxidative damage CRITICAL CARE MEDICINE
Artículo2007 Melatonin biosynthesis in the thymus of humans and rats CELLULAR AND MOLECULAR LIFE SCIENCES
Artículo2007 Melatonin is a phytochemical in olive oil FOOD CHEMISTRY
Artículo2006 Inverse correlation between endogenous melatonin levels and oxidative damage in some tissues of SAM P8 mice JOURNAL OF PINEAL RESEARCH
Artículo2006 Melatonin synthesized by Jurkat human leukemic T cell line is implicated in IL-2 production JOURNAL OF CELLULAR PHYSIOLOGY
Revisión2006 The modulatory role of melatonin on immune responsiveness CURRENT OPINION IN INVESTIGATIONAL DRUGS
Revisión2005 A review of the multiple actions of melatonin on the immune system ENDOCRINE
Artículo2005 Beneficial pleiotropic actions of melatonin in an experimental model of septic shock in mice: regulation of pro-/anti-inflammatory cytokine network, protection against oxidative damage and anti-apoptotic effects JOURNAL OF PINEAL RESEARCH
Artículo2005 Biphasic effects of adrenal steroids on learned helplessness behavior induced by inescapable shock NEUROPSYCHOPHARMACOLOGY
Artículo2005 Human lymphocyte-synthesized melatonin is involved in the regulation of the interleukin-2/interleukin-2 receptor system JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Artículo2005 Melatonin synthesis and melatonin-membrane receptor (MT1) expression during rat thymus development: role of the pineal gland JOURNAL OF PINEAL RESEARCH
Artículo2004 Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance. FASEB JOURNAL

Este investigador no ha dirigido/tutorizado tesis

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
13/01/2009 13/01/2012 Investigador/a Estudio del Papel Regulador de los Péptidos Orexigénicos y Anorexigénicos Producidos por las Células C a Nivel del Tiroides sobre la Síntesis de Hormonas Tiroideas (P08-CVI-03598) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
13/04/2007 12/04/2010 Investigador/a Estudios inmunobiológicos y de degeneración neuronal parkinsoniana tras la inactivación génica de la biosíntesis (P06-CTS-01604) Junta de Andalucía (Plan Andaluz de Investigación) (Autonómico)
01/02/2020 30/04/2022 Investigador/a Evaluación de la Terapia con Melatonina sobre la Respuesta Inmune y la Neurodegeneración en la Esclerosis Múltiple Primaria Progresiva (US-1263804) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico)
30/12/2017 29/12/2020 Responsable Valoración de la melatonina como herramienta terapéutica en la esclerosis múltiple primaria progresiva (PC-0019-2017) Fundación Progreso y Salud (Autonómico)

Contratos

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
30/09/2010 29/03/2011 Investigador/a Análisis de la expresión de nuevos marcadores en células del cúmulo como descriptores de éxito en el proceso de implantación embrionaria. (0904/0401) FUNDACIÓN GUADALQUIVIR DE INVESTIGACIÓN MÉDICA (Local)