Fernando Iglesias Guerra

Catedrático de Universidad
iglesias@us.es
Área de conocimiento: Química Orgánica
Departamento: Química Orgánica y Farmaceútica
Grupo: ESTEREOQUIMICA Y SINTESIS ASIMETRICA (FQM-102)
Prog. doctorado: Programa de Doctorado en Farmacia (RD. 99/2011)
Tipo Año Título Fuente
Artículo2022 In vitro anticancer activity and mechanism of action of an aziridinyl galactopyranoside Biomedicines
Artículo2021 Design, synthesis and in vitro biological evaluation of a novel class of anti-adenovirus agents based on 3-amino-1,2-propanediol BIOORGANIC CHEMISTRY
Artículo2021 GPR120/FFAR4 pharmacology: focus on agonists in type 2 diabetes mellitus drug discovery. JOURNAL OF MEDICINAL CHEMISTRY
Artículo2021 Serinol-based benzoic acid esters as new scaffolds for the development of adenovirus infection inhibitors: design, synthesis, and in vitro biological evaluation ACS Infectious Diseases
Artículo2020 Exploration of piperazine-derived thioureas as antibacterial and anti-inflammatory agents. In vitro evaluation against clinical isolates of colistin-resistant Acinetobacter baumannii BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Artículo2020 Optimization of piperazine-derived ureas privileged structures for effective antiadenovirus agents EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2018 Selective cytotoxic activity and DNA damage by an epoxyalkyl galactopyranoside DRUG DEVELOPMENT RESEARCH
Artículo2016 New 4-Acyl-1-phenylaminocarbonyl-2-phenylpiperazine Derivatives as Potential Inhibitors of Adenovirus Infection. Synthesis, Biological Evaluation, and Structure-activity Relationships JOURNAL OF MEDICINAL CHEMISTRY
Artículo2015 Evaluación de la actividad anti-adenovirus de diferentes librerías químicas de pequeñas moléculas y caracterización de su mecanismo de acción Biosaia
Artículo2014 Búsqueda de nuevas alternativas terapéuticas para el tratamiento de infecciones por adenovirus: cribado de pequeñas moléculas generadas por química combinatoria Biosaia
Artículo2014 THDP17 Decreases Ammonia Production through Glutaminase Inhibition. A New Drug for Hepatic Encephalopathy Therapy PLOS ONE
Artículo2013 Aziridines from alkenyl-beta-D-galactopyranoside derivatives: Stereoselective synthesis and in vitro selective anticancer activity EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2013 Temperature- and Salinity-Decoupled Overproduction of Hydroxyectoine by Chromohalobacter salexigens APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Artículo2012 Isoprenyl-thiourea and urea derivatives as new farnesyl diphosphate analogues: Synthesis and in vitro antimicrobial and cytotoxic activities EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2012 Role of trehalose in heat and desiccation tolerance in the soil bacterium Rhizobium etli BMC MICROBIOLOGY
Artículo2012 Role of Trehalose in Salinity and Temperature Tolerance in the Model Halophilic Bacterium Chromohalobacter salexigens PLOS ONE
Artículo2012 Stereoselective Dihydroxylation Reaction of Alkenyl ss-D-Hexopyranosides: A Methodology for the Synthesis of Glycosylglycerol Derivatives and 1-O-Acyl-3-O-ss-D-glycosyl-sn-glycerol Analogues EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Ponencia2011 Análisis, desarrollo e implantación de un sistema web de consulta yreserva on-line de grupos de prácticas para el alumnado VIII Foro sobre Evaluación de la Calidad de la Investigación y de la Educación Superior: libro de capítulos
Artículo2011 New mannose-derived ketones as organocatalysts for enantioselective dioxirane-mediated epoxidation of arylalkenes. Part 3: Chiral ketones from sugars TETRAHEDRON
Artículo2011 Synthesis of new carbohydrate-derived ketones as organocatalysts in the enantioselective epoxidation of arylalkenes. Part 2: Chiral ketones from sugars TETRAHEDRON
Ponencia2011 THDP-17 inhibits selectively the k-type intestinal glutaminase, but not the type-l in vitro and in vivo JOURNAL OF HEPATOLOGY
Artículo2010 Alkenyl beta-D-galactopyranoside derivatives as efficient chiral templates in stereoselective cyclopropanation and epoxidation reactions TETRAHEDRON-ASYMMETRY
Artículo2010 Biosynthesis of compatible solutes in rhizobial strains isolated from Phaseolus vulgaris nodules in Tunisian fields BMC MICROBIOLOGY
Artículo2010 Interplay between Iron Homeostasis and the Osmotic Stress Response in the Halophilic Bacterium Chromohalobacter salexigens APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Artículo2010 Involvement of EupR, a response regulator of the NarL/FixJ family, in the control of the uptake of the compatible solutes ectoines by the halophilic bacterium Chromohalobacter salexigens BMC MICROBIOLOGY
Artículo2010 Synthesis of 2-Amino glycal Derivatives and their Conversion into Highly Functionalised beta-Enamino Ketones EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Ponencia2010 THDP-17 inhibits the glutaminase activity in caco-2 cell cultures JOURNAL OF HEPATOLOGY
Artículo2010 The extremely halophilic bacterium Salicola marasensis IC10 accumulates the compatible solute betaine SYSTEMATIC AND APPLIED MICROBIOLOGY
Póster2009 INHIBICIÓN DE LA GLUTAMINASA INTESTINAL GASTROENTEROLOGIA Y HEPATOLOGIA
Artículo2009 Synthesis of New Chiral Ketones from D-Glucose Derivatives and Their Use in the Enantioselective Epoxidation of Arylalkenes EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2009 The use of 1,2-O-isopropylidene-alpha-D-xylofuranose as a chiral auxiliary in asymmetric cyclopropanation reactions TETRAHEDRON-ASYMMETRY
Artículo2008 Stereoselective cyclopropanation of unsaturated acetals, using carbohydrates with D-gluco, L-rhamno and D-xylo configurations as chiral auxiliaries TETRAHEDRON-ASYMMETRY
Ponencia2008 Studies on the recombinant expression of the ectoine pathway in Zymomonas mobilis FEBS JOURNAL
Artículo2007 Stereoselective epoxidation of alkenylidene acetals derived from carbohydrates with D-allo, D-altro, D-galacto, D-gluco and D-xylo configurations TETRAHEDRON-ASYMMETRY
Artículo2006 Ectoines as compatible solutes and carbon and energy sources for the halophilic bacterium Chromohalobacter salexigens JOURNAL OF APPLIED MICROBIOLOGY
Artículo2006 Osmoprotection of Salmonella enterica serovar Typhimurium by N-gamma-acetyldiaminobutyrate, the precursor of the compatible solute ectoine SYSTEMATIC AND APPLIED MICROBIOLOGY
Artículo2006 The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens JOURNAL OF BACTERIOLOGY
Artículo2005 Contribution of chemical changes in membrane lipids to the osmoadaptation of the halophilic bacterium Chromohalobacter salexigens SYSTEMATIC AND APPLIED MICROBIOLOGY
Artículo2004 Complex regulation of the synthesis of the compatible solute ectoine in the halophilic bacterium Chromohalobacter salexigens DSM 3043 MICROBIOLOGY-SGM
Artículo2004 Stereoselective synthesis of oxiranes as a source of isoserine analogues using D-glucosamine and D-glucose derivatives as chiral templates TETRAHEDRON-ASYMMETRY
Artículo2002 Alkylating agents from sugars: Synthesis of chlorambucil derivatives carried by chiral glycosyl glycerols derived from D-glucosamine CHIRALITY
Artículo2002 Flavonoids from Dorycnium rectum BIOCHEMICAL SYSTEMATICS AND ECOLOGY
Artículo2002 Potential anticancer drugs, Part 6. Stereoselective synthesis of epoxyalkyl glycoside precursors of glycosyl glycerol analogues from alkenyl glycosides of N-acetyl-D-glucosamine derivatives TETRAHEDRON-ASYMMETRY
Artículo2001 Preparation of crayfish chitin by in situ lactic acid production PROCESS BIOCHEMISTRY
Artículo2001 Stereoselective synthesis of oxazolidines from 2-amino-2-deoxy-D-allose derivatives and their reactivity with nucleophiles TETRAHEDRON-ASYMMETRY
Artículo2001 Stereoselective synthesis of oxiranes using oxazolidines derived from 2-amino-2-deoxy-D-allose as chiral auxiliaries TETRAHEDRON-ASYMMETRY
Artículo2000 Potential anticancer drugs, 4 - Glycosyl glycerol derivatives as drug carrier system. Stereoselective synthesis of epoxyalkyl N-acyl-beta-D-glucopyranosides and their reactivity with nucleophiles EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo1999 Alkylating agents from sugars. Alkyl hexopyranoside derivatives as carrier systems for chlorambucil CARBOHYDRATE RESEARCH
Artículo1999 Alkylating agents from sugars. Stereoselective synthesis of 2,3-diaminoglucoses from 2-nitroalkenes, as intermediates in the synthesis of carriers of chlorambucil TETRAHEDRON
Artículo1999 Study of the m/z [H-1(2)+13](+) ion in 2-aminopyranoside derivatives European Mass Spectrometry (Print)
Artículo1998 Alkylating agents from sugars. Cyclophosphamides derived from 2-amino-2-deoxy-D-allose CARBOHYDRATE RESEARCH
Artículo1998 An isoflavone glucoside from Retama sphaerocarpa Boissier PHYTOCHEMISTRY
Corrección1998 Isolation and characterization of salt-sensitive mutants of the moderate halophile Halomonas elongata and cloning of the ectoine synthesis genes (vol 272, pg 25794, 1997) JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1997 A facile synthesis of saturated 2-nitrosugar derivatives JOURNAL OF ORGANIC CHEMISTRY
Artículo1997 Isolation and characterization of salt-sensitive mutants of the moderate halophile Halomonas elongata and cloning of the ectoine synthesis genes JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo1996 Mass spectra of N-alkyl and N,N-dialkylaminosugar derivatives. Chemical evidence for the different pathways of fragmentation JOURNAL OF MASS SPECTROMETRY
Artículo1995 A general method for synthesis of alkyl 2-N-substituted and 2-N,N-disubstituted D-altrosamines CARBOHYDRATE RESEARCH
Artículo1995 Electron-impact and chemical-ionization mass-spectra of N-alkyl and N,N-dialkylaminosugar derivatives European Mass Spectrometry (Print)
Artículo1994 A novel general-method for 2-aminoglycal synthesis TETRAHEDRON LETTERS
Artículo1989 Conformations in crystals and solutions of D(CACGTG), D(CCGCGG) and D(GGCGCC) studied by vibrational spectroscopy NUCLEIC ACIDS RESEARCH
Artículo1989 Synthesis and transmembrane transport studies by NMR of a glucosyl phospholipid of thymidine JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Artículo1987 Síntesis de 5-(2-bromoacil)-d-xilosas y 5-[(2-s-acetil)-2-tioacil]-d-xilosas GRASAS Y ACEITES
Artículo1987 Synthesis of special surfactans xii. synthesis of 2-o-acyl-d-xylopyranoses Tenside Surfactants Detergents
Artículo1987 Synthetic 6-glucosyl phospholipid as a drug transport system TETRAHEDRON LETTERS
Artículo1986 Synthesis of special surfactans viii. synthesis of 3-o-acyl-d-xylopyranoses, 5-o-acyl-d-xylofuranoses and 3,5-di-o-acyl-d-xylofuranoses Tenside Detergents
Artículo1984 Tensioactividad de productos derivados de grasas e hidratos de carbono. i. 2(3; 5)-o-lauroil (miristoil; palmitoil)-d-xilosas GRASAS Y ACEITES
Artículo1981 Azúcares en aceitunas verdes. I. Determinación enzimática de glucosa GRASAS Y ACEITES

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
28/12/2001 27/12/2004 Investigador/a Compuestos de interés terapéutico: síntesis estereoselectivas a partir de carbohidratos y compuestos de azufre (BQU2001-2425) Ministerio de Ciencia y Tecnología (Nacional)
01/01/2014 31/08/2017 Investigador/a Diseño y Síntesis de Nuevos Sistemas Moleculares y Supramoleculares Nanométricos como Herramientas Útiles en Síntesis Asimétrica y Biomedicina (CTQ2013-49066-C2-2-R) Ministerio de Economía y Competitividad (Nacional)
01/10/1998 01/10/2001 Investigador/a SÍNTESIS ESTEREOSELECTIVAS Y PREPARACIÓN DE SUSTANCIAS CON ACTIVIDAD FARMACOLÓGICA POTENCIAL A TRAVÉS DE AMINOAZÚCARES Y COMPUESTO DE AZUFRE O FÓSFORO ÓPTICAMENTE ACTIVOS (PB97-0731)
13/04/2007 12/04/2010 Investigador/a Compuestos anticancerosos derivados de azúcares: preparación química y evaluación terapéutica in vitro e in vivo (P06-FQM-01885) Junta de Andalucía (Plan Andaluz de Investigación) (Autonómico)
01/10/2007 30/06/2011 Investigador/a Aplicaciones de carbohidratos y derivados quirales de azufre en las síntesis estereolectivas de compuestos de interés terapéutico (CTQ2007-61185) Ministerio de Educación y Ciencia (Nacional)
01/06/2020 31/05/2023 Investigador/a Los Carbohidratos y el Azufre como Herramientas Básicas en el Diseño y Síntesis de Nuevos Sistemas Moleculares Privilegiados de Interés Terapéutico y/o Sintético (PID2019-104767RB-I00) Ministerio de Ciencia, Innovación y Universidades (Nacional)
13/12/2004 13/12/2007 Investigador/a Síntesis estereoselectivas a partir de organosulfurados y carbohidratos. Aplicaciones de interés terapéutico (CTQ2004-01057) Ministerio de Ciencia y Tecnología (Nacional)
30/12/2016 31/12/2020 Investigador/a Desarrollo de Nuevos Sistemas Moleculares y Supramoleculares para una Catálisis Asimétrica Sostenible. Síntesis de Compuestos Antitumorales, Antivíricos y Antibacterianos (CTQ2016-78580-C2-2-R) Ministerio de Economía y Competitividad (Nacional)