Pablo Huertas Sánchez

Profesor Titular de Universidad
phuertas@us.es
Área de conocimiento: Genética
Departamento: Genética
Grupo: METABOLISMO DEL DNA (BIO-026)
Prog. doctorado: Prog.Doct.en Biología Molecular, Biomedicina e Investigac.Clínica (RD.2011)
Tipo Año Título Fuente
Artículo2021 ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair. NATURE COMMUNICATIONS
Artículo2021 Cationic single-chained surfactants with a functional group at the end of the hydrophobic tail DNA compacting efficiency. PHARMACEUTICS
Artículo2021 CtIP -mediated alternative mRNA splicing finetunes the DNA damage response RNA-A PUBLICATION OF THE RNA SOCIETY
Artículo2021 MRGBP, a member of the NuA4 complex, inhibits DNA double strand break repair FEBS OPEN BIO
Artículo2021 Multivalent calixarene-based liposomes as platforms for gene and drug delivery. PHARMACEUTICS
Artículo2021 Properties of polyplexes formed between a cationic polymer derived from l-arabinitol and nucleic acids NEW JOURNAL OF CHEMISTRY
Artículo2021 The effect of atypical nucleic acids structures in DNA double strand break repair: a tale of R-loops and G-quadruplexes FRONTIERS IN GENETICS
Revisión2021 The emerging role of RNA modifications in DNA double-strand break repair FRONTIERS IN MOLECULAR BIOSCIENCES
Artículo2021 Trim37 prevents formation of centriolar protein assemblies by regulating centrobin eLife
Artículo2020 ALC1/eIF4A1-mediated regulation of CtIP mRNA stability controls DNA end resection PLOS GENETICS
Artículo2020 Metallo-liposomes of ruthenium used as promising vectors of genetic material PHARMACEUTICS
Artículo2020 Methylation of the central transcriptional regulator KLF4 by PRMT5 is required for DNA end resection and recombination DNA REPAIR
Artículo2020 PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks NUCLEIC ACIDS RESEARCH
Artículo2020 Preparation of a radiobiology beam line at the 18 MeV proton cyclotron facility at CNA PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
Revisión2020 Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox FRONTIERS IN MOLECULAR BIOSCIENCES
Capítulo2019 Controlling the balance between chromosome break repair pathways DNA REPAIR
Artículo2019 EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks NATURE COMMUNICATIONS
Revisión2019 The role of RNA and RNA-related proteins in the regulation of DNA double strand break repair pathway choice DNA REPAIR
Artículo2019 UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors CELL
Editorial2018 Chromosome instability: From molecular mechanisms to disease DNA REPAIR
Artículo2018 Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1 NATURE COMMUNICATIONS
Artículo2018 Importance of hydrophobic interactions in the single-chained cationic surfactant-DNA complexation JOURNAL OF COLLOID AND INTERFACE SCIENCE
Artículo2018 Multiple roles of the splicing complex SF3B in DNA end resection and homologous recombination DNA REPAIR
Artículo2018 Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair NUCLEIC ACIDS RESEARCH
Capítulo2018 Single molecule analysis of resection tracks GENOME INSTABILITY: METHODS AND PROTOCOLS
Artículo2018 The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures CELL REPORTS
Corrección2018 The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures (vol 24, 3262, 2018) CELL REPORTS
Artículo2018 The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair MOLECULAR CELL
Artículo2017 CtIP-Specific Roles during Cell Reprogramming Have Long-Term Consequences in the Survival and Fitness of Induced Pluripotent Stem Cells STEM CELL REPORTS
Artículo2017 DNA end resection requires constitutive sumoylation of CtIP by CBX4 NATURE COMMUNICATIONS
Artículo2017 Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer ONCOTARGET
Artículo2016 A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection NATURE COMMUNICATIONS
Artículo2015 Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice NUCLEIC ACIDS RESEARCH
Artículo2015 Speed matters: How subtle changes in DNA end resection rate affect repair MOLECULAR & CELLULAR ONCOLOGY
Artículo2015 The COP9 signalosome is vital for timely repair of DNA double-strand breaks NUCLEIC ACIDS RESEARCH
Artículo2014 BRCA1 Accelerates CtIP-Mediated DNA-End Resection CELL REPORTS
Capítulo2014 Introducción de componentes procedimentales al modelo metodológico en la asignatura de genética II del Grado de Biología I Seminario Iberoamericano de Innovación Docente de la Universidad Pablo de Olavide.
Póster2014 Sumoylation of CtIP controls DNA end resection Nuclear Regulation by Ubiquitin. 60 Benzon Symposium: (2014),
Artículo2013 Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination NUCLEIC ACIDS RESEARCH
Artículo2013 New Tools to Study DNA Double-Strand Break Repair Pathway Choice PLOS ONE
Artículo2013 Prognostic value of CtIP/RBBP8 expression in breast cancer CANCER MEDICINE
Ponencia2012 Uncovering the network that controls double strand break repair pathway choice FEBS JOURNAL
Artículo2011 CtIP Mutations Cause Seckel and Jawad Syndromes PLOS GENETICS
Artículo2010 DNA resection in eukaryotes: deciding how to fix the break NATURE STRUCTURAL & MOLECULAR BIOLOGY
Artículo2009 Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo2008 CDK targets Sae2 to control DNA-end resection and homologous recombination NATURE
Artículo2008 Different physiological relevance of yeast THO/TREX subunits in gene expression and genome integrity MOLECULAR GENETICS AND GENOMICS
Artículo2008 The THP1-SAC3-SUS1-CDC31 Complex Works in Transcription Elongation-mRNA Export Preventing RNA-mediated Genome Instability MOLECULAR BIOLOGY OF THE CELL
Artículo2006 An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination MOLECULAR AND CELLULAR BIOLOGY
Artículo2005 Interdependence between transcription and mRNP processing and export, and its impact on genetic stability MOLECULAR CELL
Artículo2003 Cotranscriptionally formed DNA : RNA hybrids mediate transcription elongation impairment and transcription-associated recombination MOLECULAR CELL
Revisión2003 Mitotic recombination in Saccharomyces cerevisiae CURRENT GENETICS
Artículo2003 Recombinogenic effects of DNA-damaging agents are synergistically increased by transcription in Saccharomyces cerevisiae: New insights into transcription-associated recombination GENETICS
Ponencia2001 Isolation and genetic analysis of novel HPR1 and THO2 mutations that differentially affect transcription and recombination. YEAST

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
30/12/2016 29/12/2019 Responsable Regulación de la Recombinación en el Contexto Celular (SAF2016-74855-P) Ministerio de Economía y Competitividad (Nacional)
01/01/2020 31/12/2022 Investigador/a Nuclear physics developments for proton therapy: delivering the right effective dose to the right place (NucPhysPT) (P18-RT-1900) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico)
01/01/2011 31/12/2013 Responsable Modulación en el Contexto del Ciclo Celular del Tipo de Reparación de Cortes de Doble Cadena en el DNA en Eucariotas Superiores (SAF2010-14877) Ministerio de Ciencia e Innovación (Nacional)
01/01/2014 31/12/2016 Responsable Regulación del Procesamiento de los Cortes de Doble Cadena en el ADN y su Implicación en el Desarrollo Tumoral (SAF2013-43255-P) Ministerio de Economía y Competitividad (Nacional)
01/01/2020 31/12/2022 Responsable Regulation of DNA break repair by the circadian clock (P18-RT-1204) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico)
01/10/2021 30/09/2023 Responsable Regulation of DNA resection, DNA repair and genomic stability by cohesin in undifferentiated Caenorhabditis elegans germ cells – coDNAres (101023902) Comisión Europea (Europeo)
15/11/2003 14/04/2007 Investigador/a Inestabilidad genética asociada a transcripción en eucariotas (SAF2003-00204) Ministerio de Ciencia y Tecnología (Nacional)
01/01/2012 31/12/2016 Responsable Relevance of double strand break repair pathway choice in human disease and cancer (FP7-IDEAS-ERC-SG-LS2-278867) Comisión Europea (Europeo)
01/02/2020 31/01/2022 Responsable Unraveling the connection between centrosomes and the DNA damage response (US-1255532) Junta de Andalucía (Consejería de Economía y Conocimiento) (Autonómico)
01/06/2020 31/05/2023 Responsable Consecuencias para la Homeostasis Celular del Desequilibrio en la Reparación del DNA (PID2019-104195GB-I00) Ministerio de Ciencia, Innovación y Universidades (Nacional)
20/12/2000 20/12/2003 Investigador/a Recombinación entre secuencias repetidas e inestabilidad genética en saccharomyces cerevisiae: un modelo funcional eucarionte (BMC2000-0439) Ministerio de Ciencia y Tecnología (Nacional)
01/10/2018 30/09/2020 Responsable Mechanistic analysis of DNA damage signaling and bypass upon replication of damaged DNA template in human cells (DNACHECK) (H2020-794054) Comisión Europea (Europeo)
03/04/2019 03/04/2022 Responsable Nuevas pistas sobre el síndrome de Aicardi-Goutières Syndrome, una conexión original con la reparación del ADN (2019/FARECES /PHUERTAS) Fundación Ramón Areces (Nacional)
30/01/2014 31/12/2017 Responsable Relación del Daño en Fase S y los Defectos de Segregación en Mitosis en los Síndromes Recesivos con Microcefalia (P12-BIO-515) Consejería de Economía, Innovación y Ciencia (Autonómico)

Ayudas

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2017 31/12/2019 Responsable Embo yip Huertas (EMBO YIP HUERTAS) Embo (Europeo)