María Isabel García Moreno

Profesora Titular de Universidad
isagar@us.es
Área de conocimiento: Química Orgánica
Departamento: Química Orgánica
Grupo: QUIMICA BIOORGANICA DE CARBOHIDRATOS (FQM-308)
Prog. doctorado: Programa de Doctorado en Química (RD. 99/2011)
Tipo Año Título Fuente
Artículo2021 A versatile stereocontrolled synthesis of 2-deoxyiminosugarC-glycosides and their evaluation as glycosidase inhibitors ORGANIC & BIOMOLECULAR CHEMISTRY
Capítulo2020 sp2-Iminosugars as chemical mimics for glycodrug design Small molecule drug discovery: methods, molecules and applications
Artículo2019 Synthesis of polyfluoroalkyl sp2-iminosugar glycolipids and evaluation of their immunomodulatory properties towards anti-tumor, anti-leishmanial and anti-inflammatory therapies EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2019 Tailoring the inhibitory versus chaperoning behavior of amphiphilic sp(2)-iminosugar glycomimetics targeting beta-glucocerebrosidase: From micromolar to picomolar chaperones for Gaucher disease MOLECULAR GENETICS AND METABOLISM
Artículo2019 Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp(2)-Iminosugar Glycolipids MOLECULES
Artículo2018 Giant Glycosidase Inhibitors: First- and Second-Generation Fullerodendrimers with a Dense Iminosugar Shell CHEMISTRY-A EUROPEAN JOURNAL
Artículo2018 Probing the Inhibitor versus Chaperone Properties of sp(2)-Iminosugars towards Human beta-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease MOLECULES
Artículo2017 Construction of giant glycosidase inhibitors from iminosugar-substituted fullerene macromonomers JOURNAL OF MATERIALS CHEMISTRY B
Artículo2017 Fluorinated Chaperone-beta-Cyclodextrin Formulations for beta-Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease JOURNAL OF MEDICINAL CHEMISTRY
Ponencia2017 Fluorinated chaperone-beta-cyclodextrin formulations for neuronopathic Gaucher disease MOLECULAR GENETICS AND METABOLISM
Artículo2017 Synthesis of beta-galactosylamides as ligands of the peanut lectin. Insights into the recognition process CARBOHYDRATE RESEARCH
Artículo2017 The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study CHEMISTRY-A EUROPEAN JOURNAL
Corrección2016 Generalized Anomeric Effect in gem-Diamines: Stereoselective Synthesis of alpha-N-Linked Disaccharide Mimics (vol 11, pg 3306, 2009) ORGANIC LETTERS
Artículo2016 Inhibitor versus chaperone behaviour of D-fagomine, DAB and LAB sp2-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo2016 Potent Glycosidase Inhibition with Heterovalent Fullerenes: Unveiling the Binding Modes Triggering Multivalent Inhibition CHEMISTRY-A EUROPEAN JOURNAL
Artículo2016 Understanding multivalent effects in glycosidase inhibition using C-glycoside click clusters as molecular probes NEW JOURNAL OF CHEMISTRY
Artículo2014 Targeted delivery of pharmacological chaperones for Gaucher disease to macrophages by a mannosylated cyclodextrin carrier ORGANIC & BIOMOLECULAR CHEMISTRY
Corrección2014 Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases (vol 135, pg 18427, 2013) JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Artículo2013 A Bicyclic 1-Deoxygalactonojirimycin Derivative as a Novel Pharmacological Chaperone for GM(1) Gangliosidosis MOLECULAR THERAPY
Artículo2013 Bicyclic Derivatives of L-Idonojirimycin as Pharmacological Chaperones for Neuronopathic Forms of Gaucher Disease CHEMBIOCHEM
Artículo2013 o-Xylylene Protecting Group in Carbohydrate Chemistry: Application to the Regioselective Protection of a Single vic-Diol Segment in Cyclodextrins JOURNAL OF ORGANIC CHEMISTRY
Artículo2013 Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Artículo2012 Synthesis and glycosidase inhibitory activity of isourea-type bicyclic sp(2)-iminosugars related to galactonojirimycin and allonojirimycin TETRAHEDRON
Artículo2012 Tuning glycosidase inhibition through aglycone interactions: pharmacological chaperones for Fabry disease and GM(1) gangliosidosis CHEMICAL COMMUNICATIONS
Artículo2011 Amphiphilic 1-Deoxynojirimycin Derivatives through Click Strategies for Chemical Chaperoning in N370S Gaucher Cells JOURNAL OF ORGANIC CHEMISTRY
Artículo2011 Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: Effect of structural modifications in their pharmacological chaperone potential towards beta-glucocerebrosidase ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2010 A Fluorescent sp(2)-Iminosugar With Pharmacological Chaperone Activity for Gaucher Disease: Synthesis and Intracellular Distribution Studies CHEMBIOCHEM
Artículo2010 Fluorescent-tagged sp(2)-iminosugars with potent beta-glucosidase inhibitory activity BIOORGANIC & MEDICINAL CHEMISTRY
Artículo2009 6-Amino-6-deoxy-5,6-di-N-(N '-octyliminomethylidene)nojirimycin: Synthesis, Biological Evaluation, and Crystal Structure in Complex with Acid beta-Glucosidase CHEMBIOCHEM
Artículo2009 Chaperone Activity of Bicyclic Nojirimycin Analogues for Gaucher Mutations in Comparison with N-(n-nonyl)-Deoxynojirimycin CHEMBIOCHEM
Artículo2009 Generalized Anomeric Effect in gem-Diamines: Stereoselective Synthesis of alpha-N-Linked Disaccharide Mimics ORGANIC LETTERS
Artículo2009 Glycosidase inhibition by ring-modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoring ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2009 Multivalent iminosugars to modulate affinity and selectivity for glycosidases ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo2009 Regioselective synthesis and biological evaluation of spiro-sulfamidate glycosides from exo-glycals TETRAHEDRON-ASYMMETRY
Artículo2009 Synthesis of Thiohydantoin-Castanospermine Glycomimetics as Glycosidase Inhibitors JOURNAL OF ORGANIC CHEMISTRY
Revisión2008 Chemical and enzymatic approaches to carbohydrate-derived spiroketals: Di-D-fructose dianhydrides (DFAs) MOLECULES
Artículo2008 Molecular Basis for beta-Glucosidase Inhibition by Ring-Modified Calystegine Analogues CHEMBIOCHEM
Artículo2008 Stereoselective synthesis of nonsymmetrical difructose dianhydrides from xylylene-tethered D-fructose precursors TETRAHEDRON
Artículo2008 Synthesis and biological evaluation of guanidine-type iminosugars JOURNAL OF ORGANIC CHEMISTRY
Artículo2008 Synthesis and evaluation of sulfamide-type indolizidines as glycosidase inhibitors BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Artículo2007 Bis antennae amphiphilic cyclodextrins: the first examples TETRAHEDRON LETTERS
Artículo2007 Spacer-mediated synthesis of bis-spiroketal disaccharides: Nonsymmetrical furanose-pyranose difructose dianhydrides SYNLETT
Artículo2007 Synthesis and biological evaluation of 6-oxa-nor-tropane glycomimetics as glycosidase inhibitors TETRAHEDRON
Artículo2006 Intramolecular benzyl protection delivery: A practical synthesis of DMDP and DGDP from D-fructose ORGANIC LETTERS
Artículo2006 Spacer-mediated synthesis of contra-thermodynamic spiroacetals: Stereoselective synthesis of C-2-symmetric difructose dianhydrides JOURNAL OF ORGANIC CHEMISTRY
Artículo2005 1,2,3-Triazoles and related glycoconjugates as new glycosidase inhibitors TETRAHEDRON
Artículo2005 Rigid spacer-mediated synthesis of bis-spiroketal ring systems: stereoselective synthesis nonsymmetrical spiro of disaccharides ORGANIC LETTERS
Artículo2005 Synthesis and comparative glycosidase inhibitory properties of reducing castanospermine analogues EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2004 Pseudoamide-type pyrrolidine and pyrrolizidine glycomimetics and their inhibitory activities against glycosidases JOURNAL OF ORGANIC CHEMISTRY
Artículo2004 Synthesis of calystegine B-2, B-3, and B-4 analogues: Mapping the structure-glycosidase inhibitory activity relationships in the 1-deoxy-6-oxacalystegine series EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo2003 Synthesis and evaluation of isourea-type glycomimetics related to the indolizidine and trehazolin glycosidase inhibitor families JOURNAL OF ORGANIC CHEMISTRY
Artículo2003 Synthesis of (1S,2S,3R,8S,8aR)-1,2,3,8-tetrahydroxy-6-oxa-5-thioxoindolizidine: A stable reducing swainsonine analog with controlled anomeric configuration SYNLETT
Artículo2002 Castanospermine-trehazolin hybrids: a new family of glycomimetics with tuneable glycosidase inhibitory properties CHEMICAL COMMUNICATIONS
Artículo2002 One-step synthesis of non-anomeric sugar isothiocyanates from sugar azides CARBOHYDRATE RESEARCH
Artículo2001 Synthesis and evaluation of calystegine B-2 analogues as glycosidase inhibitors JOURNAL OF ORGANIC CHEMISTRY
Artículo2000 Generalized anomeric effect in action: Synthesis and evaluation of stable reducing indolizidine glycomimetics as glycosidase inhibitors JOURNAL OF ORGANIC CHEMISTRY
Artículo2000 Nitrogen versus sulfur acylation in sugar thioureas: regioselectivity and conformational consequences TETRAHEDRON-ASYMMETRY
Artículo1999 Polyhydroxylated N-(thio)carbamoyl piperidines: nojirimycin-type glycomimetics with controlled anomeric configuration TETRAHEDRON-ASYMMETRY

Este investigador no ha dirigido/tutorizado tesis

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/06/2020 31/05/2023 Investigador/a Miméticos de Glicoconjugados: Nuevas Estrategias en Glicomedicina Dirigidas a Enfermedades Neurológicas y del Sistema Immune (PID2019-105858RB-I00) Ministerio de Ciencia, Innovación y Universidades (Nacional)
28/12/2001 27/06/2005 Investigador/a Síntesis y evaluación de glicomiméticos como inhibidores de glicosidasas. Aplicaciones al estudio del modo de acción de invertasas y sacarosa sintasa en plantas (BMC2001-2366-C03-03) Ministerio de Ciencia y Tecnología (Nacional)
16/03/2010 16/03/2013 Investigador/a Iminoazúcares sp2 como chaperonas químicas: una estrategia general para el tratamiento de desórdenes de almacenamiento lisosomial (FRA2009-001) Fundación Ramón Areces (Nacional)
30/12/2016 31/12/2020 Investigador/a Terapias Basadas en Glicomiméticos para el Tratamiento de Enfermedades de Plegamiento de Proteínas, Inflamación y Cáncer. (SAF2016-76083-R) Ministerio de Economía y Competitividad (Nacional)
13/12/2004 13/12/2007 Investigador/a Glicomiméticos mono y ologosacarídicos y estudio de sus interacciones con biomoléculas (CTQ2004-05854) Ministerio de Ciencia y Tecnología (Nacional)
13/01/2009 31/12/2013 Responsable Diseño de Inhibidores de Glicosidasas para el Tratamiento de Enfermedades Lisosomiales: Sintesis de Sp2-Azucares y Evaluación en Terapias de Acompañante Químico (P08-FQM-03711) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
01/01/2014 31/12/2017 Investigador/a Chaperonas, Inhibidores y Nutracéuticos Basados en Carbohidratos para Aplicaciones Biomédicas: Desórdenes de Depósito Lisosomal, Cáncer y Enfermedad de Crohn (SAF2013-44021-R) Ministerio de Economía y Competitividad (Nacional)
13/04/2007 12/04/2010 Investigador/a Preparación, análisis y evaluación de oligosacáridos prebióticos derivados de sacarosa, fructosa y lactosa (P06-AGR-02150) Junta de Andalucía (Plan Andaluz de Investigación) (Autonómico)
01/10/2007 31/03/2011 Investigador/a Glicobióticos y glicofármacos: preparación y evaluación de carbohidratos con actividad probiótica (DAFs) y biomédica (ganglosidosis GM1 y ántrax) (CTQ2007-61180) Ministerio de Educación y Ciencia (Nacional)
01/01/2011 30/06/2014 Investigador/a Glicobióticos, Glicofármacos y Glicotransportadores: Aplicaciones en Nutrición y Biomedicina (SAF2010-15670) Ministerio de Ciencia e Innovación (Nacional)

Contratos

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
21/12/2005 21/12/2007 Investigador/a Puesta a punto de métodos eficaces para la transformación de productos derivados de las industrias azucarera y láctea en oligosacáridos prebióticos (OG-150/05) Chirosep, S.A. (Europeo)

Ayudas

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2008 31/12/2009 Investigador/a Synthesis and biologicla evalutation of polyvalente glycosidase inhibitors as chemical chaperons for the treatment of lysosomal disorders (HU2007-0006) Ministerio de Educación y Ciencia (Nacional)