José Manuel García Heredia

Profesor Titular de Universidad
jmgheredia@us.es
Área de conocimiento: Bioquímica y Biología Molecular
Departamento: Bioquímica Vegetal y Biología Molecular
Grupo: BIOLOGIA MOLECULAR DEL CANCER (CTS-025)
Instituto de Inv.: IBIS
Tipo Año Título Fuente
Artículo2020 Autoencoded DNA methylation data to predict breast cancer recurrence: machine learning models and gene-weight significance Artificial Intelligence in Medicine
Artículo2020 Breast tumor cells promotes the horizontal propagation of EMT, stemness, and metastasis by transferring the MAP17 protein between subsets of neoplastic cells Oncogenesis
Artículo2020 PAI1 is a Marker of Bad Prognosis in Rectal Cancer but Predicts a Better Response to Treatment with PIM Inhibitor AZD1208 Cells
Revisión2020 Role of Mitochondria in Cancer Stem Cell Resistance Cells
Artículo2020 Sarcoma stratification by combined pH2AX and MAP17 (PDZK1IP1) levels for a better outcome on doxorubicin plus olaparib treatment Signal Transduction and Targeted Therapy
Artículo2019 New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Revisión2018 Dr. Jekyll and Mr. Hyde: MAP17's up-regulation, a crosspoint in cancer and inflammatory diseases MOLECULAR CANCER
Artículo2018 MAP17 predicts sensitivity to platinum-based therapy, EGFR inhibitors and the proteasome inhibitor bortezomib in lung adenocarcinoma JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Artículo2018 NUMB and NUMBL differences in gene regulation ONCOTARGET
Artículo2017 Coordinated downregulation of Spinophilin and the catalytic subunits of PP1, PPP1CA/B/C, contributes to a worse prognosis in lung cancer ONCOTARGET
Artículo2017 Machine learning techniques to discover genes with potential prognosis role in Alzheimer's disease using different biological sources INFORMATION FUSION
Artículo2017 The Cargo Protein MAP17 (PDZK1IP1) Regulates the Cancer Stem Cell Pool Activating the Notch Pathway by Abducting NUMB CLINICAL CANCER RESEARCH
Artículo2017 The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment ONCOTARGET
Ponencia2016 Discovery of Genes Implied in Cancer by Genetic Algorithms and Association Rules HYBRID ARTIFICIAL INTELLIGENT SYSTEMS
Artículo2016 Efficacy of bortezomib in sarcomas with high levels of MAP17 (PDZK1IP1) ONCOTARGET
Artículo2016 Numb-Like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy ONCOTARGET
Artículo2015 Decoding Warburg's hypothesis: tumor-related mutations in the mitochondrial respiratory chain ONCOTARGET
Artículo2015 Genetic modification of hypoxia signaling in animal models and its effect on cancer CLINICAL & TRANSLATIONAL ONCOLOGY
Ponencia2013 How redox proteins form transient complexes in photosynthesis and respiration EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
Revisión2013 Recent Methodological Advances in the Analysis of Protein Tyrosine Nitration CHEMPHYSCHEM
Artículo2012 A non-damaging method to analyze the configuration and dynamics of nitrotyrosines in proteins CHEMISTRY-A EUROPEAN JOURNAL
Ponencia2012 Construction of a mimetic mutant of cytochrome c phosphorylated at tyrosine 48 to further study its biological role in the transition from cell life to death FEBS JOURNAL
Ponencia2012 Cytochrome c(1): an old protein with novel functions FEBS JOURNAL
Ponencia2012 High spin nitrated cytochrome c is specifically degraded inside the cells FEBS JOURNAL
Artículo2012 Perturbation of the Redox Site Structure of Cytochrome c Variants upon Tyrosine Nitration JOURNAL OF PHYSICAL CHEMISTRY B
Artículo2012 Specific nitration of tyrosines 46 and 48 makes cytochrome c assemble a non-functional apoptosome FEBS LETTERS
Artículo2011 Cytochrome c signalosome in mitochondria EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
Artículo2011 Nitration of tyrosines 46 and 48 induces the specific degradation of cytochrome c upon change of the heme iron state to high-spin BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
Artículo2011 Tyrosine phosphorylation turns alkaline transition into a biologically relevant process and makes human cytochrome c behave as an anti-apoptotic switch Journal of Biological Inorganic Chemistry
Ponencia2011 Tyrosine phosphorylation turns alkaline transition into a biologically relevant process and makes human cytochrome c behave as an anti-apoptotic switch FEBS JOURNAL
Artículo2010 Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
Ponencia2010 Structural and functional changes induced by tyrosine nitration in cytochrome c, a bi-functional protein BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
Ponencia2009 Structural and functional features of post-translationally modified cytochrome c, a bifunctional protein FEBS JOURNAL
Artículo2008 Acetylsalicylic acid induces programmed cell death in Arabidopsis cell cultures PLANTA
Artículo2008 Effect of Nitration on the Physicochemical and Kinetic Features of Wild-Type and Monotyrosine Mutants of Human Respiratory Cytochrome c BIOCHEMISTRY
Artículo2006 A comparative kinetic analysis of the reactivity of plant, horse, and human respiratory cytochrome c towards cytochrome c oxidase BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Este investigador no ha dirigido/tutorizado tesis

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/10/2006 30/09/2009 Investigador/a Análisis evolutivo y relación estructura-función del citocromo c y su equivalente metabólico, el citocromo c6, como inductores de muerte celular programada (BFU2006-01361) Ministerio de Educación y Ciencia (Nacional)
01/01/2013 31/12/2015 Investigador/a Desvelando Nuevas Redes de Proteínas que Interaccionan con el Citocromo C: Análisis Comparativo Estructural y Funcional (BFU2012-31670) Ministerio de Economía y Competitividad (Nacional)
01/01/2010 31/12/2012 Investigador/a Bases estructurales, reconocimiento molecular y análisis evolutivo del citocromo C, una proteína bifuncional modificada post- tradiccionalmente (BFU2009-07190) Ministerio de Ciencia e Innovación (Nacional)

Patentes

Nº Solicitud Fecha Solicitud Fecha Concesión Nombre
P200402723 05/01/2004 16/12/2009 Construcción génica que codifica para el citocromo c y procedimiento de obtención.