José Luis Espartero Sánchez

Catedrático de Universidad
jles@us.es
Área de conocimiento: Química Orgánica
Departamento: Química Orgánica y Farmaceútica
Grupo: ESTEREOQUIMICA Y SINTESIS ASIMETRICA (FQM-102)
Prog. doctorado: Programa de Doctorado en Farmacia (RD. 99/2011)
Tipo Año Título Fuente
Artículo2020 A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers FOOD CHEMISTRY
Artículo2018 Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives FOOD & FUNCTION
Artículo2016 Evaluation of the Bioavailability and Metabolism of Nitroderivatives of Hydroxytyrosol Using Caco-2 and HepG2 Human Cell Models JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo2016 Isolation and Quantification of Pinitol, a Bioactive Cyclitol, in Retama spp. NATURAL PRODUCT COMMUNICATIONS
Artículo2016 Lipophilic hydroxytyrosol esters significantly improve the oxidative state of human red blood cells JOURNAL OF FUNCTIONAL FOODS
Artículo2016 Synthesis and Antioxidant Activity of Alkyl Nitroderivatives of Hydroxytyrosol MOLECULES
Artículo2015 Antioxidant activity of alkyl hydroxytyrosyl ethers in unsaturated lipids FOOD & FUNCTION
Artículo2015 Differences in the Neuroprotective Effect of Orally Administered Virgin Olive Oil (Olea europaea) Polyphenols Tyrosol and Hydroxytyrosol in Rats JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo2015 Effect of intracerebral hydroxytyrosol and its nitroderivatives on striatal dopamine metabolism: A study by in vivo microdialysis LIFE SCIENCES
Artículo2015 Role of the catechol group in the antioxidant and neuroprotective effects of virgin olive oil components in rat brain JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Artículo2015 Synthesis and antioxidant evaluation of isochroman-derivatives of hydroxytyrosol: Structure-activity relationship FOOD CHEMISTRY
Artículo2014 Comparative evaluation of the metabolic effects of hydroxytyrosol and its lipophilic derivatives (hydroxytyrosyl acetate and ethyl hydroxytyrosyl ether) in hypercholesterolemic rats FOOD & FUNCTION
Ponencia2014 Effect of nitroderivatives of hydroxytyrosol on oxidative status and catechol-O-methyl transferase activity in rat's tissue BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Artículo2014 In vivo striatal measurement of hydroxytyrosol, and its metabolite (homovanillic alcohol), compared with its derivative nitrohydroxytyrosol Neuroscience Letters
Artículo2014 Sucrose Esters from Physalis peruviana Calyces with Anti-Inflammatory Activity PLANTA MEDICA
Artículo2014 Synthesis and Antioxidant Activity of Nitrohydroxytyrosol and Its Acyl Derivatives JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo2014 The effect of hydroxytyrosol and its nitroderivatives on catechol-O-methyl transferase activity in rat striatal tissue RSC ADVANCES
Artículo2013 Anti-apoptotic activity of hydroxytyrosol and hydroxytyrosyl laurate FOOD AND CHEMICAL TOXICOLOGY
Artículo2013 Antiplatelet effect of new lipophilic hydroxytyrosol alkyl ether derivatives in human blood EUROPEAN JOURNAL OF NUTRITION
Ponencia2013 Bioavailability and metabolism of nitroderivatives of hydroxytyrosol by human cell model systems BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Artículo2013 Cytotoxic activity of dihydrochalcones isolated from corema album leaves against HT-29 colon cancer cells NATURAL PRODUCT COMMUNICATIONS
Artículo2013 Hydroxytyrosyl alkyl ether derivatives inhibit platelet activation after oral administration to rats FOOD AND CHEMICAL TOXICOLOGY
Artículo2013 Selective Cytotoxic Activity of New Lipophilic Hydroxytyrosol Alkyl Ether Derivatives JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo2012 Cytoprotective Effect of Hydroxytyrosyl Alkyl Ether Derivatives after Oral Administration to Rats in a Model of Glucose-Oxygen Deprivation in Brain Slices JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo2012 Digestive stability of hydroxytyrosol, hydroxytyrosyl acetate and alkyl hydroxytyrosyl ethers INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
Artículo2012 Neuroprotective effect of alkyl hydroxytyrosyl ethers in rat brain slices subjected to a hypoxia-reoxygenation model FOOD CHEMISTRY
Artículo2011 Alkyl Hydroxytyrosyl Ethers Show Protective Effects against Oxidative Stress in HepG2 Cells JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo2011 An efficient, economical synthesis of hydroxytyrosol and its protected forms via Baeyer-Villiger oxidation TETRAHEDRON LETTERS
Ponencia2011 Antiplatelet effects of alkyl hydroxytyrosyl ethers in human whole blood samples BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Ponencia2011 Olive polyphenols: from the almazara to therapeutic BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Ponencia2011 Oral administration of alkyl hydroxytyrosyl ethers exerts a neuroprotective effect BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Artículo2011 Preparation and antioxidant activity of tyrosyl and homovanillyl ethers FOOD CHEMISTRY
Ponencia2011 Synthesis of hydroxytyrosol nitroderivatives as COMT inhibitors BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Artículo2010 Transepithelial Transport and Metabolism of New Lipophilic Ether Derivatives of Hydroxytyrosol by Enterocyte-like Caco-2/TC7 Cells JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo2010 Uptake and Metabolism of New Synthetic Lipophilic Derivatives, Hydroxytyrosyl Ethers, by Human Hepatoma HepG2 Cells JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo2009 (+)-Dihydrorobinetin: a Marker of Vinegar Aging in Acacia (Robinia pseudoacacia) Wood JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo2009 Antioxidant activity evaluation of alkyl hydroxytyrosyl ethers, a new class of hydroxytyrosol derivatives FOOD CHEMISTRY
Artículo2009 Isolation of a powerful antioxidant from Olea europaea fruit-mill waste: 3,4-Dihydroxyphenylglycol LWT-FOOD SCIENCE AND TECHNOLOGY
Artículo2009 Synthesis of Hydroxytyrosyl Alkyl Ethers from Olive Oil Waste Waters MOLECULES
Artículo2009 Virgin olive oil polyphenol hydroxytyrosol acetate inhibits in vitro platelet aggregation in human whole blood: comparison with hydroxytyrosol and acetylsalicylic acid BRITISH JOURNAL OF NUTRITION
Artículo2008 Neuroprotective effect of hydroxytyrosol and hydroxytyrosol acetate in rat brain slices subjected to hypoxia-reoxygenation Neuroscience Letters
Artículo2008 New Lipophilic Tyrosyl Esters. Comparative Antioxidant Evaluation with Hydroxytyrosyl Esters JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo2007 Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines PHYTOMEDICINE
Artículo2007 Synthesis and conformational analysis of novel trimeric maleimide cross-linking reagents JOURNAL OF ORGANIC CHEMISTRY
Artículo2006 Lipophilic hydroxytyrosyl esters. Antioxidant activity in lipid matrices and biological systems JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo2006 Structural determination of the Nod factors produced by Rhizobium gallicum bv. gallicum R602 FEMS MICROBIOLOGY LETTERS
Artículo2005 Aromatic homo- and copolyesters from naturally occurring monosaccharides: PET and PEI analogs derived from L-arabinitol and xylitol JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
Artículo2005 Carbohydrate-based polycarbonates. Synthesis, structure, and biodegradation studies MACROMOLECULES
Artículo2004 Natural lycopene from Blakeslea trispora: all-trans lycopene thermochemical and structural properties THERMOCHIMICA ACTA
Artículo2003 Antioxidant effect of phenolic compounds, alpha-tocopherol, and other minor components in virgin olive oil JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo2003 NMR and Monte Carlo studies on the solution conformation of a linear capsular polysaccharide from a soybean-nodulating bacterium (Strain B33) JOURNAL OF CARBOHYDRATE CHEMISTRY
Artículo2003 Structural determination of the lipo-chitin oligosaccharide nodulation signals produced by Rhizobium giardinii bv. giardinii H152 CARBOHYDRATE RESEARCH
Artículo2001 Determination of phenols, flavones, and lignans in virgin olive oils by solid-phase extraction and high-performance liquid chromatography with diode array ultraviolet detection JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Artículo2001 Determination of the chemical structure of the capsular polysaccharide of strain B33, a fast-growing soya bean-nodulating bacterium isolated from an arid region of China BIOCHEMICAL JOURNAL
Artículo2000 Dynamic kinetic resolution of bis-sulfinyl chlorides: A general enantiodivergent synthesis of C-2-symmetric bis-sulfinate esters and bis-sulfoxides JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Artículo2000 Retamatrioside, a new flavonol triglycoside from Retama sphaerocarpa JOURNAL OF NATURAL PRODUCTS
Artículo2000 Studies on the solution conformation and dynamics of a polysaccharide from Sinorhizobium fredii HH103 and its monosaccharide repeating unit JOURNAL OF MOLECULAR GRAPHICS & MODELLING
Artículo1999 A generalization of the base effect on the diastereoselective synthesis of sulfinic and phosphinic esters TETRAHEDRON LETTERS
Artículo1999 Structural determination of a 5-acetamido-3,5,7,9-tetradeoxy-7(3-hydroxybutyramido)-l-glycero-l-manno-nonulosonic acid-containing homopolysaccharide isolated from Sinorhizobium fredii HH103 BIOCHEMICAL JOURNAL
Artículo1999 Studies on the solution conformation and dynamics of the trisaccharide repeating unit of the KPS from Sinorhizobium fredii SVQ293 JOURNAL OF CARBOHYDRATE CHEMISTRY
Artículo1998 Structural analysis of the exopolysaccharides produced by Lactobacillus spp. G-77 CARBOHYDRATE RESEARCH
Artículo1998 Structural determination of a 5-O-methyl-deaminated neuraminic acid (Kdn)-containing polysaccharide isolated from Sinorhizobium fredii BIOCHEMICAL JOURNAL
Artículo1997 Structural analysis of the exopolysaccharide produced by Pediococcus damnosus 2.6 CARBOHYDRATE RESEARCH
Artículo1996 NMR analysis of low molecular weight poly(lactic acid)s MACROMOLECULES
Artículo1996 Structural characterization and hydrolytic degradation of a Zn metal initiated copolymer of L-lactide and epsilon-caprolactone Journal of biomaterials science. Polymer ed
Artículo1996 Synthesis, characterization, and hydrolytic degradation of PLA/PEO/PLA triblock copolymers with long poly(L-lactic acid) blocks MACROMOLECULES
Artículo1996 Synthesis, characterization, and hydrolytic degradation of PLA/PEO/PLA triblock copolymers with short poly(L-lactic acid) chains MACROMOLECULES
Artículo1995 Electron-impact and chemical-ionization mass-spectra of N-alkyl and N,N-dialkylaminosugar derivatives European Mass Spectrometry (Print)
Artículo1994 A novel general-method for 2-aminoglycal synthesis TETRAHEDRON LETTERS
Artículo1993 Mass-spectra of oxazolidines derived from sugars ORGANIC MASS SPECTROMETRY
Artículo1993 Oxazolidines from sugars .3. A new method for n-alkyl and n,n-dialkyl-d-glucosamine derivatives JOURNAL OF CARBOHYDRATE CHEMISTRY
Artículo1993 Oxazolidines from sugars.4. Conformationally restricted analogues of the muramyldipeptide MDP CARBOHYDRATE RESEARCH
Artículo1993 Synthesis of a polyamide from l-aspartic acid and l-lysine POLYMER BULLETIN
Artículo1992 Oxazolidinas derivadas de azúcares: síntesis de análogos conformacionalmente rígidos de N-Acetilmuramil-L-alanil-D-Isoglutamina (MDP) [tesis doctoral] Industria Farmacéutica
Nota1992 Oxazolidines from sugars .2. A new method for N-alkyl and N,N-dialkyl-d-glucosamines CARBOHYDRATE RESEARCH
Artículo1992 Oxazolidines from sugars: conformationally restricted derivatives of muramic acid CARBOHYDRATE RESEARCH

Proyectos de Investigación

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
13/12/2004 13/12/2007 Investigador/a Síntesis estereoselectivas a partir de organosulfurados y carbohidratos. Aplicaciones de interés terapéutico (CTQ2004-01057) Ministerio de Ciencia y Tecnología (Nacional)
13/12/2004 13/12/2007 Responsable Síntesis y purificación de esteres de hidroxitirosilo y 3´, 4´-dihidroxifenilglicol (AGL2004-07935-C03-03) Ministerio de Ciencia y Tecnología (Nacional)
01/10/2007 30/06/2011 Investigador/a Aplicaciones de carbohidratos y derivados quirales de azufre en las síntesis estereolectivas de compuestos de interés terapéutico (CTQ2007-61185) Ministerio de Educación y Ciencia (Nacional)
01/10/2007 04/07/2011 Responsable Obtención de alquiléteres de hidroxitirosilo para su evaluación como componentes funcionales de alimentos. Preparación de sus metabolitos 3-O-metilderivados (AGL2007-66373-C04-02) Ministerio de Educación y Ciencia (Nacional)
01/10/1998 01/10/2001 Investigador/a SÍNTESIS ESTEREOSELECTIVAS Y PREPARACIÓN DE SUSTANCIAS CON ACTIVIDAD FARMACOLÓGICA POTENCIAL A TRAVÉS DE AMINOAZÚCARES Y COMPUESTO DE AZUFRE O FÓSFORO ÓPTICAMENTE ACTIVOS (PB97-0731)
13/04/2007 12/04/2010 Investigador/a Nuevos antagonistas de los receptores NK-1: diseño, síntesis y aplicación en el tratamiento contra el cáncer (P06-FQM-01852) Junta de Andalucía (Plan Andaluz de Investigación) (Autonómico)
28/12/2001 27/12/2004 Investigador/a Compuestos de interés terapéutico: síntesis estereoselectivas a partir de carbohidratos y compuestos de azufre (BQU2001-2425) Ministerio de Ciencia y Tecnología (Nacional)
03/02/2010 02/08/2014 Responsable Aprovechamiento de Subproductos de la Industria Olivarera. Síntesis y Evaluación de Nuevos Antioxidantes con Potencial Aplicación en el Tratamiento del Parkinson (P09-AGR-5098) Junta de Andalucía - Consejería de Innovación, Ciencia y Empresas (Autonómico)
01/01/2004 30/06/2007 Investigador/a Targeting Replication and Integration of HIV (TRIoH) (LSHB-CT-2003-503480) Commission of the European Communities (Europeo)

Contratos

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
07/09/2000 07/09/2002 Investigador/a La síntesis de hidroxitirosol (OG-088/00) Universidad de Barcelona (Nacional)

Ayudas

Fecha de inicio Fecha de fin Rol Denominación Agencia financiadora
01/01/2006 01/01/2007 Investigador/a Targeting replication and integration of hiv (SAF2004-22949-E) Ministerio de Educación y Ciencia (Nacional)
22/03/2010 05/04/2010 Responsable Estancia. Universidad de Urbino (PP2010-05-023) Universidad de Sevilla (Local)
09/09/2011 09/09/2011 Responsable Simposio de Resonancia Magnética Nuclear en Estado Sólido (PP2011-01-046) Universidad de Sevilla (Local)