Diseño y Síntesis de Moléculas de Interés Biológico Mediante el Desarrollo de Metodologías Sintéticas

Referencia: CTQ2016-77270-R

Tipo: Proyecto de investigación
Programa financiador: Plan Estatal 2013-2016 Retos - Proyectos I+D+i
Entidad financiadora: Ministerio de Economía y Competitividad
Ámbito: Nacional
Convocatoria competitiva:
Fecha de inicio: 30/12/2016
Fecha de fin: 31/12/2020
Participantes en la financiación
Publicaciones relacionadas
Tipo Año Título Fuente
Artículo 2020 Differential modulation of SIRT6 deacetylase and deacylase activities by lysine-based small molecules MOLECULAR DIVERSITY
Artículo 2020 Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B CHEMISTRY-A EUROPEAN JOURNAL
Artículo 2020 Regioselectivity of the 1,3-Dipolar Cycloaddition of Organic Azides to 7-Heteronorbornadienes. Synthesis of beta-Substituted Furans/Pyrroles JOURNAL OF ORGANIC CHEMISTRY
Artículo 2020 Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Artículo 2019 Azabicyclic vinyl sulfones for residue-specific dual protein labelling Electronic supplementary information (ESI) available: Detailed methods and additional characterisation. See DOI: 10.1039/c9sc00125e CHEMICAL SCIENCE
Artículo 2019 Dual targeting of PTP1B and glucosidases with new bifunctional iminosugar inhibitors to address type 2 diabetes BIOORGANIC CHEMISTRY
Artículo 2019 Exploring substituent diversity on pyrrolidine-aryltriazole iminosugars: Structural basis of beta-glucocerebrosidase inhibition BIOORGANIC CHEMISTRY
Artículo 2019 Preparation of water-soluble glycopolymers derived from five-membered iminosugars EUROPEAN POLYMER JOURNAL
Artículo 2019 Structural basis of the inhibition of GH1 β-glucosidases by multivalent pyrrolidine iminosugars BIOORGANIC CHEMISTRY
Artículo 2018 Discovery of a Potent alpha-Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine-(Thio)urea Hybrid Molecules Generated via Click Chemistry JOURNAL OF ORGANIC CHEMISTRY
Artículo 2018 Harnessing pyrrolidine iminosugars into dimeric structures for the rapid discovery of divalent glycosidase inhibitors EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo 2018 Induction of cell killing and autophagy by amphiphilic pyrrolidine derivatives on human pancreatic cancer cells EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo 2018 Pyrrolidine-Based P,O Ligands from Carbohydrates: Easily Accessible and Modular Ligands for the Ir-Catalyzed Asymmetric Hydrogenation of Minimally Functionalized Olefins CHEMCATCHEM
Artículo 2017 Mechanistic Insight into the Binding of Multivalent Pyrrolidines to alpha-Mannosidases CHEMISTRY-A EUROPEAN JOURNAL
Artículo 2017 Tuning of beta-glucosidase and alpha-galactosidase inhibition by generation and in situ screening of a library of pyrrolidine-triazole hybrid molecules EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Nota: la fuente de financiación de las publicaciones se ha obtenido de WOS