Chaperonas, Inhibidores y Nutracéuticos Basados en Carbohidratos para Aplicaciones Biomédicas: Desórdenes de Depósito Lisosomal, Cáncer y Enfermedad de Crohn

Referencia: SAF2013-44021-R

Tipo: Proyecto de investigación
Programa financiador: Plan Estatal 2013-2016 Retos - Proyectos I+D+i
Entidad financiadora: Ministerio de Economía y Competitividad
Ámbito: Nacional
Convocatoria competitiva:
Fecha de inicio: 01/01/2014
Fecha de fin: 31/12/2017
Participantes en la financiación
Nombre Rol
Ortiz Mellet, Carmen Responsable
Compain, Philippe Investigador/a
Ouadid-Ahidouch, Halima Investigador/a
Rodríguez Lavado, Julio Investigador/a
Ortega Caballero, Fernando Investigador/a
Mena Barragan, Teresa Investigador/a
Jiménez Blanco, José Luis Investigador/a
Nierengarten, Jean-Francoise Investigador/a
Katsumi, Higaki Investigador/a
Atencio Genes, Loyda Esther Investigador/a
Sánchez Fernández, Elena Matilde Investigador/a
Gallego Yerga, Laura Investigador/a
García Moreno, María Isabel Investigador/a
Tiscornia, Gustavo Investigador/a
Publicaciones relacionadas
Tipo Año Título Fuente
Artículo 2018 Revealing cooperative binding of polycationic cyclodextrins with DNA oligomers by capillary electrophoresis coupled to mass spectrometry ANALYTICA CHIMICA ACTA
Ponencia 2017 Fluorinated chaperone-beta-cyclodextrin formulations for neuronopathic Gaucher disease MOLECULAR GENETICS AND METABOLISM
Artículo 2016 Cholesterol-Targeted Anticancer and Apoptotic Effects of Anionic and Polycationic Amphiphilic Cyclodextrin Nanoparticles JOURNAL OF PHARMACEUTICAL SCIENCES
Artículo 2016 Conformationally-locked C-glycosides: tuning aglycone interactions for optimal chaperone behaviour in Gaucher fibroblasts ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo 2016 Cyclodextrin-based facial amphiphiles: assessing the impact of the hydrophilic-lipophilic balance in the self-assembly, DNA complexation and gene delivery capabilities ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo 2016 Dual drug-loaded halloysite hybrid-based glycocluster for sustained release of hydrophobic molecules RSC ADVANCES
Artículo 2016 Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, G(M1)-gangliosidosis and Fabry diseases CHEMICAL COMMUNICATIONS
Artículo 2016 Impact of Nonthermal Atmospheric Plasma on the Structure of Cellulose: Access to Soluble Branched Glucans CHEMISTRY-A EUROPEAN JOURNAL
Artículo 2016 Influence of the configurational pattern of sp(2)-iminosugar pseudo N-, S-, O- and C-glycosides on their glycoside inhibitory and antitumor properties CARBOHYDRATE RESEARCH
Artículo 2016 Inhibitor versus chaperone behaviour of D-fagomine, DAB and LAB sp2-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo 2016 Modulation of microglia polarization dynamics during diabetic retinopathy in db/db mice BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Artículo 2016 Potent Glycosidase Inhibition with Heterovalent Fullerenes: Unveiling the Binding Modes Triggering Multivalent Inhibition CHEMISTRY-A EUROPEAN JOURNAL
Artículo 2016 Tn Antigen Mimics Based on sp(2)-Iminosugars with Affinity for an anti-MUC1 Antibody ORGANIC LETTERS
Artículo 2016 Toward a suitable structural analysis of gene delivery carrier based on polycationic carbohydrates by electron transfer dissociation tandem mass spectrometry ANALYTICA CHIMICA ACTA
Artículo 2016 Trehalose-based Janus cyclooligosaccharides: the "Click" synthesis and DNA-directed assembly into pH-sensitive transfectious nanoparticles CHEMICAL COMMUNICATIONS
Artículo 2016 Understanding multivalent effects in glycosidase inhibition using C-glycoside click clusters as molecular probes NEW JOURNAL OF CHEMISTRY
Artículo 2015 Cell uptake mechanisms of glycosylated cationic pDNA-cyclodextrin nanoparticles RSC ADVANCES
Artículo 2015 Conformationally-locked N-glycosides: Exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Artículo 2015 Correlations between changes in intestinal microbiota composition and performance parameters in broiler chickens JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
Artículo 2015 Cyclodextrin- and calixarene-based polycationic amphiphiles as gene delivery systems: a structure-activity relationship study ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo 2015 Effects of feed additives on ileal mucosa-associated microbiota composition of broiler chickens JOURNAL OF ANIMAL SCIENCE
Artículo 2015 Harmonized tuning of nucleic acid and lectin binding properties with multivalent cyclodextrins for macrophage-selective gene delivery RSC ADVANCES
Artículo 2015 Host-Guest-Mediated DNA Templation of Polycationic Supramolecules for Hierarchical Nanocondensation and the Delivery of Gene Material CHEMISTRY-A EUROPEAN JOURNAL
Artículo 2015 Inhibition of type 1 fimbriae-mediated Escherichia coli adhesion and biofilm formation by trimeric cluster thiomannosides conjugated to diamond nanoparticles NANOSCALE
Artículo 2015 pH-Responsive Pharmacological Chaperones for Rescuing Mutant Glycosidases ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Artículo 2015 Pharmacological Chaperones and Coenzyme Q(10) Treatment Improves Mutant beta-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease SCIENTIFIC REPORTS
Artículo 2015 Synthesis of High-Mannose Oligosaccharide Analogues through Click Chemistry: True Functional Mimics of Their Natural Counterparts Against Lectins? CHEMISTRY-A EUROPEAN JOURNAL
Artículo 2014 Synthesis of Multibranched Australine Derivatives from Reducing Castanospermine Analogues through the Amadori Rearrangement of gem-Diamine Intermediates: Selective Inhibitors of beta-Glucosidase JOURNAL OF ORGANIC CHEMISTRY
Artículo 2014 Trehalose- and Glucose-Derived Glycoamphiphiles: Small-Molecule and Nanoparticle Toll-Like Receptor 4 (TLR4) Modulators JOURNAL OF MEDICINAL CHEMISTRY
Nota: la fuente de financiación de las publicaciones se ha obtenido de WOS