Glicobióticos, Glicofármacos y Glicotransportadores: Aplicaciones en Nutrición y Biomedicina

Referencia: SAF2010-15670

Tipo: Proyecto de investigación
Programa financiador: Plan Nacional del 2010
Entidad financiadora: Ministerio de Ciencia e Innovación
Ámbito: Nacional
Convocatoria competitiva:
Fecha de inicio: 01/01/2011
Fecha de fin: 30/06/2014
Participantes en la financiación
Nombre Rol
Ortiz Mellet, Carmen Responsable
Ortega Caballero, Fernando Investigador/a
Gallego Yerga, Laura Investigador/a
Suárez Pereira, Elena Investigador/a
Butera, Anna Paola Investigador/a
Jiménez Blanco, José Luis Investigador/a
Ohno, Kousako Investigador/a
Risquez Cuadro, Rocío Investigador/a
García Moreno, María Isabel Investigador/a
Domínguez Arguisjuela, M. Lourdes Investigador/a
Rodríguez Lavado, Julio Investigador/a
Mena Barragan, Teresa Investigador/a
Suzuki, Yoshiyuki Investigador/a
Mendez Ardoy, Alejandro Investigador/a
Aguilar Moncayo, Matilde Investigador/a
Publicaciones relacionadas
Tipo Año Título Fuente
Artículo 2015 Correlations between changes in intestinal microbiota composition and performance parameters in broiler chickens JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
Artículo 2014 Cyclodextrin-scaffolded amphiphilic aminoglucoside clusters: self-assembling and gene delivery capabilities NEW JOURNAL OF CHEMISTRY
Artículo 2014 Dynamic Self-Assembly of Polycationic Clusters Based on Cyclodextrins for pH-Sensitive DNA Nanocondensation and Delivery by Component Design CHEMISTRY-A EUROPEAN JOURNAL
Artículo 2014 Glycoligand-targeted core-shell nanospheres with tunable drug release profiles from calixarene-cyclodextrin heterodimers CHEMICAL COMMUNICATIONS
Artículo 2014 Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies CHEMICAL COMMUNICATIONS
Artículo 2014 Molecular Basis of 1-Deoxygalactonojirimycin Arylthiourea Binding to Human alpha-Galactosidase A: Pharmacological Chaperoning Efficacy on Fabry Disease Mutants ACS CHEMICAL BIOLOGY
Artículo 2014 Structural Basis of Pharmacological Chaperoning for Human beta-Galactosidase JOURNAL OF BIOLOGICAL CHEMISTRY
Artículo 2014 Synthesis of substituted exo-glucals via a modified Julia olefination and identification as selective beta-glucosidase inhibitors ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo 2014 Targeted delivery of pharmacological chaperones for Gaucher disease to macrophages by a mannosylated cyclodextrin carrier ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo 2013 A Bicyclic 1-Deoxygalactonojirimycin Derivative as a Novel Pharmacological Chaperone for GM(1) Gangliosidosis MOLECULAR THERAPY
Artículo 2013 Amphiphilic Oligoethyleneimine-beta-Cyclodextrin "Click" Clusters for Enhanced DNA Delivery JOURNAL OF ORGANIC CHEMISTRY
Artículo 2013 Bicyclic Derivatives of L-Idonojirimycin as Pharmacological Chaperones for Neuronopathic Forms of Gaucher Disease CHEMBIOCHEM
Artículo 2013 Competitive processes of a chromophore modified alpha-cyclodextrin in the presence of a fluorescence polarity sensitive probe JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
Revisión 2013 Cyclodextrin-based multivalent glycodisplays: covalent and supramolecular conjugates to assess carbohydrate-protein interactions CHEMICAL SOCIETY REVIEWS
Artículo 2013 Fullerene-sp(2)-Iminosugar Balls as Multimodal Ligands for Lectins and Glycosidases: A Mechanistic Hypothesis for the Inhibitory Multivalent Effect CHEMISTRY-A EUROPEAN JOURNAL
Artículo 2013 Influence of the Macroring Size on the Self-Association Thermodynamics of Cyclodextrins with a Double-Linked Naphthalene at the Secondary Face JOURNAL OF PHYSICAL CHEMISTRY B
Revisión 2013 Multivalency in heterogeneous glycoenvironments: hetero-glycoclusters, -glycopolymers and -glycoassemblies CHEMICAL SOCIETY REVIEWS
Artículo 2013 N-Thiocarbonyl Iminosugars: Synthesis and Evaluation of Castanospermine Analogues Bearing Oxazole-2(3H)-thione Moieties EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Artículo 2013 Neuronopathic Gaucher's disease: induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds HUMAN MOLECULAR GENETICS
Artículo 2013 New Castanospermine Glycoside Analogues Inhibit Breast Cancer Cell Proliferation and Induce Apoptosis without Affecting Normal Cells PLOS ONE
Artículo 2013 o-Xylylene Protecting Group in Carbohydrate Chemistry: Application to the Regioselective Protection of a Single vic-Diol Segment in Cyclodextrins JOURNAL OF ORGANIC CHEMISTRY
Artículo 2013 Probing the Nature of the Cluster Effect Observed with Synthetic Multivalent Galactosides and Peanut Agglutinin Lectin CHEMISTRY-A EUROPEAN JOURNAL
Artículo 2013 Recent Developments on Synthetic Tools Towards Structural and Functional Glycodiversity CURRENT MEDICINAL CHEMISTRY
Artículo 2013 Stereoselective Synthesis of 2-Acetamido-1,2-dideoxyallonojirimycin (DAJNAc), a New Potent Hexosaminidase Inhibitor ORGANIC LETTERS
Artículo 2013 Targeted gene delivery by new folate-polycationic amphiphilic cyclodextrin-DNA nanocomplexes in vitro and in vivo EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Artículo 2013 The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Valency, Peripheral Ligand Structure, and Topology with Cyclodextrin-Based Iminosugar Click Clusters CHEMBIOCHEM
Artículo 2013 Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Artículo 2012 Conformationally-Locked N-Glycosides with Selective beta-Glucosidase Inhibitory Activity: Identification of a New Non-Iminosugar-Type Pharmacological Chaperone for Gaucher Disease JOURNAL OF MEDICINAL CHEMISTRY
Artículo 2012 Efficient transfection of hepatocytes mediated by mRNA complexed to galactosylated cyclodextrins BIOCONJUGATE CHEMISTRY
Artículo 2012 Improving inclusion capabilities of permethylated cyclodextrins by appending a cap-like aromatic moiety TETRAHEDRON
Artículo 2012 Monodisperse Nanoparticles from Self-Assembling Amphiphilic Cyclodextrins: Modulable Tools for the Encapsulation and Controlled Release of Pharmaceuticals MEDICINAL CHEMISTRY
Artículo 2012 Polycationic amphiphilic cyclodextrins as gene vectors: effect of the macrocyclic ring size on the DNA complexing and delivery properties ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo 2012 Probing Carbohydrate-Lectin Recognition in Heterogeneous Environments with Monodisperse Cyclodextrin-Based Glycoclusters JOURNAL OF ORGANIC CHEMISTRY
Artículo 2012 Scalable Syntheses of Both Enantiomers of DNJNAc and DGJNAc from Glucuronolactone: The Effect of N-Alkylation on Hexosaminidase Inhibition CHEMISTRY-A EUROPEAN JOURNAL
Artículo 2012 sp2-Iminosugar O-, S-, and N-Glycosides as Conformational Mimics of a-Linked Disaccharides; Implications for Glycosidase Inhibition CHEMISTRY-A EUROPEAN JOURNAL
Artículo 2012 Synthesis and glycosidase inhibitory activity of isourea-type bicyclic sp(2)-iminosugars related to galactonojirimycin and allonojirimycin TETRAHEDRON
Artículo 2012 Tuning glycosidase inhibition through aglycone interactions: pharmacological chaperones for Fabry disease and GM(1) gangliosidosis CHEMICAL COMMUNICATIONS
Artículo 2011 Amphiphilic 1-Deoxynojirimycin Derivatives through Click Strategies for Chemical Chaperoning in N370S Gaucher Cells JOURNAL OF ORGANIC CHEMISTRY
Artículo 2011 beta-Cyclodextrin-Based Polycationic Amphiphilic "Click" Clusters: Effect of Structural Modifications in Their DNA Complexing and Delivery Properties JOURNAL OF ORGANIC CHEMISTRY
Artículo 2011 Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: Effect of structural modifications in their pharmacological chaperone potential towards beta-glucocerebrosidase ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo 2011 Cyclodextrin-mediated crystallization of acid beta-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues ORGANIC & BIOMOLECULAR CHEMISTRY
Artículo 2011 Mannosyl-coated nanocomplexes from amphiphilic cyclodextrins and pDNA for site-specific gene delivery BIOMATERIALS
Revisión 2011 Pharmacological chaperone therapy for Gaucher disease: a patent review EXPERT OPINION ON THERAPEUTIC PATENTS
Artículo 2011 The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Architectural Parameters with Cyclodextrin-based Iminosugar Click Clusters CHEMISTRY-A EUROPEAN JOURNAL
Nota: la fuente de financiación de las publicaciones se ha obtenido de WOS